Patents Examined by Alton D. Rollins
  • Patent number: 4398943
    Abstract: There is provided a new herbicidal compound of the formula, ##STR1## wherein R.sup.1 is an alkyl group; R.sup.2 is an alkynyl group, a halomethyl group, or a haloethyl group; and X is an alkoxy group, an alkenyloxy group, an alkoxy-alkoxy group, an alkynyloxy group, a hydroxy group, a halomethyloxy group, or a haloethyloxy group.
    Type: Grant
    Filed: December 15, 1981
    Date of Patent: August 16, 1983
    Assignee: Nikon Nohyaku Co., Ltd.
    Inventors: Mitsuru Kajioka, Katsumasa Okawa, Kuniaki Taninaka
  • Patent number: 4395558
    Abstract: Mitomycin compounds of the general formula (I): ##STR1## wherein X is selected from an alkoxy group having 1 to 4 carbon atoms and amino group; and Z is selected from --OH, --OCONH.sub.2 and --OCO.sub.2 C.sub.6 H.sub.5 groups. The compounds of this formula may be used as starting materials for the preparation of various mitomycin compounds. When X is as hereinbefore defined and Z is --OCONH.sub.2, the compounds exhibit antibacterial activity and are of potential interest as medicaments. Preferred examples of the compounds are 9-Epi-mitomycin B and 9-epi-mitomycin D. The compounds of the formula (I) may be obtained from known mitomycin B or mitomycin D.
    Type: Grant
    Filed: November 23, 1981
    Date of Patent: July 26, 1983
    Assignee: Kyowa Hakko Kogyo Kabushiki Kaisha
    Inventors: Masaji Kasai, Kunikatsu Shirahata, Motomichi Kono
  • Patent number: 4395559
    Abstract: 2,3-Indoledione derivatives of the formula ##STR1## wherein R is isopropyl or tert.butyl, R.sup.1 is hydrogen or lower alkyl and R.sup.2 is lower alkyl or lower aralkyl, and their pharmaceutically acceptable acid addition salts, prepared from a compound of the formula ##STR2## wherein R.sup.3 is hydroxy and R.sup.4 is chlorine or bromine or R.sup.3 and R.sup.4, taken together, are oxygen, and R.sup.1 and R.sup.2 are as previously set forth, are described. The compounds of formula I and their pharmaceutically acceptable addition salts are useful as .beta.-adrenergic blocking agents and antihypertensive agents.
    Type: Grant
    Filed: December 1, 1980
    Date of Patent: July 26, 1983
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Graham A. Fothergill, John M. Osbond
  • Patent number: 4394151
    Abstract: Compounds of formula ##STR1## useful as fungicides and plant growth regulators.
    Type: Grant
    Filed: July 29, 1981
    Date of Patent: July 19, 1983
    Assignee: Imperial Chemical Industries PLC
    Inventors: Paul de Fraine, John M. Clough, Paul A. Worthington
  • Patent number: 4394380
    Abstract: Fungicidal compounds of the general formula (I): ##STR1## wherein each of R.sub.1 and R.sub.2, which may be the same or different, is hydrogen, halogen, nitro or alkyl (e.g. methyl, ethyl, propyl or butyl); R.sub.3 is hydrogen, alkoxycarbonyl (e.g. methoxy or ethoxy-carbonyl) or substituted or unsubstituted hydrocarbyl or hydrocarboxyloxy, R.sub.4 is phenyl or halophenyl, R.sub.5 is hydrogen, alkanoyl (e.g. acetyl or propionyl) or substituted or unsubstituted hydrocarbyl, n is 0 or 1, R.sub.5 being substituted or unsubstituted hydrocarbyl when n is 0 and R.sub.3 being other than substituted or unsubstituted hydrocarbyl when n is 1; or salts of such compounds.
    Type: Grant
    Filed: July 24, 1981
    Date of Patent: July 19, 1983
    Assignee: Imperial Chemical Industries PLC
    Inventors: Sugavanam Balasubramanyan, Margaret C. Shephard
  • Patent number: 4393004
    Abstract: This disclosure describes certain novel 3-(.alpha.-substituted-benzyl)-2,3-dihydrothiazolo[3,2-a][1,3]diazacyclan- 3-ols which are useful as diuretic agents.
    Type: Grant
    Filed: January 29, 1982
    Date of Patent: July 12, 1983
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, William B. Wright, Jr., Joseph W. Marsico, Jr.
  • Patent number: 4390704
    Abstract: Preparation of 1,2,4-triazole by reacting formamide and hydrazine in a molar ratio of 2:1 to 2.2:1, hydrazine or its hydrate being metered into excess formamide, preheated to 160.degree.-200.degree., while maintaining the temperature, and then completing the reaction at 160.degree.-240.degree. C.
    Type: Grant
    Filed: July 7, 1981
    Date of Patent: June 28, 1983
    Assignee: Chemie Linz Aktiengesellschaft
    Inventor: Hans Beer
  • Patent number: 4388464
    Abstract: A process for protecting cultivated plants against aggressive agricultural chemicals is described in which oxime derivatives of the formula ##STR1## are used as antidotes. Either the cultivated area for the cultivated plants or the cultivated plants themselves or parts of the plant (seeds, tubers, stem parts and the like), as desired, can be treated with these oxime derivatives, which are used as a dressing.Ar is a phenyl radical of the formula ##STR2## or Ar is also a 5-membered to 10-membered heterocyclic radical which contains not more than three identical or different hetero-atoms N, O and/or S and which can be bonded via a C.sub.1 - to C.sub.3 -aliphatic chain to the remainder of the molecule and which is substituted by R.sub.1, R.sub.2 or R.sub.3 and can be substituted by oxo or thiono; X is hydrogen, CN, halogen, C.sub.1 -C.sub.
    Type: Grant
    Filed: February 9, 1981
    Date of Patent: June 14, 1983
    Assignee: Ciba-Geigy Corporation
    Inventors: Haukur Kristinsson, Beat Muller, Johannes P. Pachlatko
  • Patent number: 4388468
    Abstract: A process for the preparation of certain 4-alkyl substituted 5-aroyl-pyrrole alkanoic acids useful as intermediates for anti-inflammatory agents.
    Type: Grant
    Filed: August 18, 1981
    Date of Patent: June 14, 1983
    Assignee: Ethyl Corporation
    Inventor: Michael J. Dagani
  • Patent number: 4388465
    Abstract: In the preparation of a phenoxy-azolyl-butanone derivative of the formula ##STR1## in which X is a halogen atom,Y is a hydrogen or halogen atom, andAz is an imidazolyl radical or a 1,2,4-triazolyl radical,wherein dichloropinacolin of the formulaCl.sub.2 CH--CO--C(CH.sub.3).sub.3is reacted with an azole of the formulaAz--Hand a phenol of the formula ##STR2## in the presence of an acid-binding agent, the improvement which comprises carrying out the reaction in the presence of a water-immiscible organic solvent at a temperature between about 40.degree. and 150.degree. C., adding to the solvent at a temperature between about 0.degree. and +80.degree. C. a mineral acid, thereby to precipitate the mineral acid salt of the phenoxy-azolyl-butanone derivative, and separating such salt. Surprisingly the product does not hydrolyze when standing in contact with the mineral acid solution. The product is a known fungicide.
    Type: Grant
    Filed: September 8, 1981
    Date of Patent: June 14, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans-Ludwig Elbe, Hermann Arold, Eckart Kranz, Claus Stolzer
  • Patent number: 4387100
    Abstract: Phenoxy-aminopropanol derivatives of the formula ##STR1## wherein R is lower alkyl, X is oxygen or sulfur, n is the integer zero or 1, Y is methylene, ethylene or propylene or, when n is zero, Y can also be a group of the formula--CH.dbd.CH--C*H.sub.2 -- (a), wherein the double-bond is trans and the carbon atom marked with an asterisk is linked to Z, and Z is a 5-membered aromatic heterocyclic ring which contains one or more nitrogen atoms as the sole hetero atom (s), said heterocyclic ring is linked to Y via a nitrogen atom, and may be substituted by halogen, lower alkyl, lower alkoxy, aryl, cyano or carboxamido, or on adjacent carbon atoms by a group of the formula ##STR2## and pharmaceutically acceptable acid addition salts thereof are described. A process for the preparation of the compound of formula I and pharmaceutical preparations containing them are also described. The aforementioned compounds and salts possess .beta.-adrenergic blocking activity and antihypertensive activity.
    Type: Grant
    Filed: February 24, 1981
    Date of Patent: June 7, 1983
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Peter J. Machin
  • Patent number: 4387222
    Abstract: Acidic cyclic perfluoroaliphaticdisulfonimides, salts thereof, a process for making the same, curable compositions containing acidic cyclic perfluoroaliphaticdisulfonimides or salts thereof and cationically-sensitive monomers, and a process for using acidic cyclic perfluoroaliphaticdisulfonimides and salts thereof as catalysts for the cure of cationically-sensitive monomers.
    Type: Grant
    Filed: January 30, 1981
    Date of Patent: June 7, 1983
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Robert J. Koshar
  • Patent number: 4385925
    Abstract: Compounds of the formula ##STR1## where Ar, R.sup.1, R.sup.2 and X have the meanings given in the claims, their preparation and their use as plant growth regulators.
    Type: Grant
    Filed: July 1, 1981
    Date of Patent: May 31, 1983
    Assignee: BASF Aktiengesellschaft
    Inventors: Costin Rentzea, Karl-Heinz Feuerherd, Bernd Zeeh, Johann Jung
  • Patent number: 4386088
    Abstract: An .alpha.-azolyl-keto derivative of the formula ##STR1## in which R.sup.1 represents optionally substituted alkyl or optionally substituted phenyl,R.sup.2 represents the grouping --CX.sup.1 X.sup.2 R.sup.3 or alkoxycarbonyl,R.sup.3 represents halogen, halogenoalkyl or optionally substituted phenyl,R.sup.4 represents the grouping --O--CO--R.sup.5, --O(S)--R.sup.6 or --O--S(O).sub.n --R.sup.7, or alkylamino, dialkylamino, optionally substituted phenylamino or halogen,R.sup.5 represents alkyl, halogenoalkyl, alkenyl, alkynyl, cycloalkyl, optionally substituted phenyl, optionally substituted phenylalkyl, alkylamino, dialkylamino or optionally substituted phenylamino,R.sup.6 represents alkyl, alkenyl, alkynyl, cycloalkyl, optionally substituted phenyl or optionally substituted benzyl,R.sup.7 represents alkyl, halogenoalkyl, optionally substituted phenyl or dialkylamino,n represents 1 or 2,X.sup.1 and X.sup.
    Type: Grant
    Filed: September 21, 1981
    Date of Patent: May 31, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Eckart Kranz, Wolfgang Kramer, Karl H. Buchel, Wilhelm Brandes, Paul-Ernst Frohberger
  • Patent number: 4385069
    Abstract: N-allenyl-acetanilides of the formula ##STR1## in which R.sup.1 represents hydrogen, alkyl or halogen,R.sup.2 represents hydrogen or alkyl,R.sup.3 represents hydrogen or alkyl,R.sup.4 represents hydrogen or alkyl,R.sup.5 represents hydrogen or alkyl andR.sup.6 represents furyl, tetrahydrofuryl, thiophenyl or tetrahydrothiophenyl; isoxazolyl which is optionally substituted by alkyl; alkyl, alkenyl or alkynyl, in each case optionally substituted by cyano or thiocyano; dihalogenoalkyl; or the grouping --CH.sub.2 --Az, --CH.sub.2 --OR.sup.7, --OR.sup.7 --SR.sup.7, --CH.sub.2 --OSO.sub.2 R.sup.7, --COOR.sup.7 or ##STR2## wherein R.sup.7 represents an optionally substituted alkyl, alkenyl, alkynyl or alkoxyalkyl radical and Az represents pyrazol-1-yl, 1,2,4-triazol-1-yl or imidazol-1-yl.which possess fungicidal properties.
    Type: Grant
    Filed: March 31, 1980
    Date of Patent: May 24, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jorg Stetter, Winfried Lunkenheimer, Wilhelm Brandes
  • Patent number: 4384879
    Abstract: The invention relates to novel 4-(1H-azolylmethyl)-1,3-dioxolan-5-one derivatives of the formula I ##STR1## and to the production and use of these compounds. In formula I, R.sub.1 and R.sub.2 are unsubstituted or substituted alkyl or phenyl, or together form a 3- to 7-membered carbocyclic ring which is unsubstituted or substituted, A is an unsubstituted or substituted phenyl radical, and X is --CH.dbd. or --N.dbd.. The compounds of the formula I can be used in the form of appropriate compositions for regulating plant growth and/or for controlling and/or protecting plants from attack by phytopathogenic microorganisms.
    Type: Grant
    Filed: July 6, 1981
    Date of Patent: May 24, 1983
    Assignee: Ciba-Geigy Corporation
    Inventor: Walter Kunz
  • Patent number: 4382944
    Abstract: 1-Phenoxy-1-triazolyl-3-fluoromethyl-butane derivatives of the formula ##STR1## in which Az is 1,2,4-triazol-1-yl or 1,2,4-triazol-4-yl,B is --CO-- or --CH(OH)--,X is hydrogen or fluorine,Z each independently is halogen, alkyl, nitro, cyano, alkoxy-carbonyl or optionally substituted phenyl, andn is 0, 1, 2 or 3,or an acid or metal salt adduct thereof which possess fungicidal properties.
    Type: Grant
    Filed: October 2, 1981
    Date of Patent: May 10, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Kramer, Karl H. Buchel, Jorg Stetter, Paul-Ernst Frohberger, Wilhelm Brandes, Hans Scheinpflug
  • Patent number: 4381306
    Abstract: The invention relates to hydroxypropyl-triazole compounds and methods for their preparation. Also included are compositions containing said hydroxypropyl-triazoles and methods for the use of the said active compounds and compositions, as antimycotic agents.
    Type: Grant
    Filed: November 9, 1979
    Date of Patent: April 26, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Erik Regel, Karl H. Buchel, Ingo Haller, Manfred Plempel
  • Patent number: 4380546
    Abstract: Azole compounds of the formula ##STR1## where X is hydrogen, halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, trifluoromethyl or phenyl and m is an integer from 1 to 5, and, if m is greater than 1, the X's can be identical or different, n is an integer from 2 to 5, Z is N or CH and Y is CO or CR.sup.1 OR.sup.2, where R.sup.1 is hydrogen or C.sub.1 -C.sub.4 -alkyl and R.sup.2 is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.2 -C.sub.4 -alkenyl, C.sub.2 -C.sub.4 -alkynyl or C.sub.1 -C.sub.4 -alkanoyl, and their crop-tolerated addition salts with acids, and metal complexes.The compounds act as fungicides and growth regulators.
    Type: Grant
    Filed: April 29, 1981
    Date of Patent: April 19, 1983
    Assignee: BASF Aktiengesellschaft
    Inventors: Hubert Sauter, Eberhard Ammermann, Costin Rentzea, Bernd Zeeh, Johann Jung, Ernst-Heinrich Pommer
  • Patent number: 4380545
    Abstract: Triazolyl-benzyloxy-ketones or carbinols of the formula ##STR1## in which A is a keto group or a CH(OH) group,X is a halogen atom or an alkyl or halogenoalkyl radical, andn is 0, 1, 2, 3, 4 or 5,or an addition product thereof with a physiologically acceptable acid or metal salt, which possess fungicidal properties. Intermediates wherein A is a keto group and the azole group is replaced by chloride or bromine are also new.
    Type: Grant
    Filed: March 19, 1981
    Date of Patent: April 19, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Udo Kraatz, Gerhard Jager, Karl H. Buchel, Paul-Ernst Frohberger