Abstract: .alpha.-Azolylglycols of the formula ##STR1## where R.sup.1 is alkyl, R.sup.2 is alkyl or unsubstituted or substituted phenyl or biphenyl, R.sup.3 is hydrogen, alkyl, alkenyl, alkynyl or unsubstituted or substituted benzyl and X is CH or N, their plant-tolerated salts and metal complexes, their preparation, and their use as plant growth regulators.
Type:
Grant
Filed:
November 23, 1981
Date of Patent:
March 13, 1984
Assignee:
BASF Aktiengesellschaft
Inventors:
Bernd Zeeh, Norbert Goetz, Eberhard Ammermann, Johann Jung
Abstract: A 1-phenyl-2-(1,2,4-triazol-1-yl)-prop-2-en-1-one of the formula ##STR1## in which R is methyl, ethyl, isopropyl, alkyl with more than 3 carbon atoms, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted phenoxyphenyl, or phenylalkyl which is optionally substituted in the alkyl part and/or in the phenyl part,X each independently is halogen, optionally substituted phenyl or optionally substituted phenoxy, andn is 0, 1, 2 or 3,or an addition product thereof with a physiologically acceptable acid or a metal salt which possesses fungicidal activity.
Type:
Grant
Filed:
April 30, 1981
Date of Patent:
March 6, 1984
Assignee:
Bayer Aktiengesellschaft
Inventors:
Wolf Reiser, Hans-Ludwig Elbe, Karl Buchel, Paul-Ernst Frohberger, Wilhelm Brandes
Abstract: This invention relates to a triazolyl alcohol derivative having an optical activity of (-) or (+) and represented by the general formula (I), ##STR1## wherein X represents a hydrogen atom or a chlorine atom and the asterisk indicates an asymmetric carbon atom, a process for preparing same, and a fungicide containing same as active ingredient.
Abstract: A 2,5-benzodiazocine derivative represented by a formula ##STR1## wherein R.sub.1 is phenyl or p-methoxyphenyl, R.sub.2 is hydrogen or methyl, and R.sub.3 is p-methoxyphenethyl, 3-(p-fluorobenzoyl)-propyl, cyclopropylmethyl or ##STR2## or a salt of such novel compound as well as a CNS-active pharmaceutical agent containing as an effective component at least one of said derivatives and salts.
Abstract: N-(Heterocycliccarbamoyl)arylsulfonamides, such as N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-hydroxybenzenesulfonamide , methanesulfonate are useful for plant growth retardation, brush control and weed control in crops.
Abstract: Poly sulfoxides of the general formula ##STR1## where each R is a monovalent aliphatic radical bound to a sulfoxy group. Each R is defined as being individually selected from the group consisting of ##STR2## wherein R', R" and R"' are individually selected from the group consisting of alkyl moieties containing 1 to 22 carbon atoms, and aralkyl moieties, alkylated aryl moieties, heterocyclic alkyl moieties, cycloalkyl moieties containing 4 to 40 carbon atoms wherein the said moieties are joined to the sulfoxy group through the alkyl chain, the said moieties being unsubstituted and substituted, said substitutions being individually selected from the group consisting of halogen moieties, nitro moieties, alkoxy moieties, alkyl moieties, and dialkylamino moieties.
Abstract: 2,4-Disubstituted-1,2,5-thiadiazol-3(2H)-one antimicrobials have broad spectrum antibacterial and antifungal activity. They are found to be especially useful in agriculture to protect plants against diseases such as leaf, stem, and fruit spotting, internal discoloration and decay of fruits and vegetables. These compounds are particularly active against diseases caused by the genera Pseudomonas, Xanthomonas, Erwinia, and Corynebacterium.
Type:
Grant
Filed:
July 12, 1982
Date of Patent:
February 14, 1984
Assignee:
Merck & Co., Inc.
Inventors:
Richard A. Dybas, Bruce E. Witzel, Nathaniel Grier
Abstract: Novel benzimidazole derivatives of the formula: ##STR1## wherein R.sup.1 is an alkyl group having 1 to 3 carbon atoms, allyl group, propargyl group, or phenyl group; R.sup.2 is hydrogen atom or an alkyl group having 1 to 3 carbon atoms; and n is 2 or 3, or pharmaceutically acceptable acid addition salts thereof, which have excellent antihistaminic activities and are useful as antiallergics for various allergic diseases, and a process for the preparation thereof, and an antihistaminic composition containing the compound as an active ingredient.
Abstract: Novel pleuromutilin derivatives of formula I, ##STR1## in which R.sub.1 is ethyl or vinyl,m is 0 or 1, andR.sub.2 is a heterocyclic radical, in which a 5- or 6-membered, unsaturated or saturated heterocyclic ring containing one or more hetero atoms selected from oxygen, sulphur and nitrogen, is attached to the --S(CH.sub.2).sub.m --group,provided that when m is 0, R.sub.2 is other than pyridyl,their production and use as antimicrobial agents are described.
Type:
Grant
Filed:
March 8, 1982
Date of Patent:
January 31, 1984
Assignee:
Sandoz, Ltd.
Inventors:
Heinz Berner, Friederike Turnowsky, Georg Laber, Johannes Hildebrandt
Abstract: A 4-fluoro-1-azolyl-1-phenoxy-butan-2-one or -ol of the formula ##STR1## in which Az is an imidazol-1-yl, 1,2,4-triazol-1-yl or 1,2,4-triazol-4-yl radical,B is a keto or CH(OH) group,X is a hydrogen or fluorine atom,Y is an alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio radical,Z is a halogen atom or an alkyl radical,m is 1, 2 or 3 andn is 0, 1 or 2,or an addition product thereof with a physiologically acceptable acid or a metal salt, which possesses fungicidal activity.
Type:
Grant
Filed:
August 25, 1981
Date of Patent:
January 31, 1984
Assignee:
Bayer Aktiengesellschaft
Inventors:
Wolfgang Kramer, Karl H. Buchel, Jorg Stetter, Paul-Ernst Frohberger, Wilhelm Brandes
Abstract: Fungicidally active novel azolylalkyl derivatives of the formula ##STR1## in which R.sup.1 is an alkyl or aryl group,R.sup.2 is a hydrogen atom or an alkyl or aryl group,R.sup.3 is cyano or --CO--OR.sup.4,R.sup.4 is alkyl or aralkyl group,A is a keto group or a CH(OH) group,X is a nitrogen atom or the CH group, andm and n are identical and represent 0 to 1,or a physiologically acceptable addition product thereof with an acid or a metal salt.
Type:
Grant
Filed:
August 7, 1981
Date of Patent:
January 24, 1984
Assignee:
Bayer Aktiengesellschaft
Inventors:
Wolfgang Kramer, Karl H. Buchel, Wilhelm Brandes, Paul-Ernst Frohberger
Abstract: A compound of the formula (I): ##STR1## wherein R.sub.1 is hydrogen or C.sub.1-6 alkyl;R.sub.2, R.sub.3 and R.sub.4 are the same or different and are chosen from hydrogen, hydroxyl, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy and C.sub.1-4 alkanoyl;G is H or OH; andm and n are independently 1 to 3; with the proviso that when G is OH, one of m or n is 1; is useful in the prophylaxis and treatment of diseases whose symptoms are controlled by the mediators of the allergic response, for example asthma, hay fever, rhinitis and allergic eczema.
Abstract: Substituted triazolylalkyl pyridyl ethers of the formula ##STR1## in which R.sup.1 is a halogen atom,R.sup.2 is a hydrogen or halogen atom,X is a keto group or a CH(OH) group,Y each independently is a halogen atom or an alkyl, alkoxy or cyano group, andn is 0, 1, 2, 3 or 4,or an addition product thereof with a physiologically acceptable acid or metal salt which possesses fungicidal activity. Intermediates therefor wherein X is a keto group and with a halogen atom in place of either the pyridinyloxy group or the azole group are also new.
Type:
Grant
Filed:
July 9, 1981
Date of Patent:
January 24, 1984
Assignee:
Bayer Aktiengesellschaft
Inventors:
Udo Kraatz, Jorg Stetter, Karl H. Buchel, Paul-Ernst Frohberger, Wilhelm Brandes
Abstract: Compounds of the class of 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-lower alkanols, and their ethers and esters, 1-(fluoro-lower alkyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines and the 5-oxides and pharmaceutically acceptable acid addition salts thereof have central depressant properties, in particular antiaggressive and anticonvulsant actions, and are active ingredients for pharmaceutical compositions. Specific embodients are 6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-methanol and 1-(fluoromethyl)6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine.
Abstract: Optical brighteners of the formula ##STR1## wherein B denotes a direct bond or the 1,4-phenylene radical andR.sub.1 and R.sub.2 independently of one another denote hydrogen, optionally substituted alkyl, aralkyl, cycloalkyl or aryl, or together form a fused aromatic ring,or the quaternisation products and protonation products thereof, are outstandingly suitable for the white tinting of polyester fibres or acrylic fibres. They are distinguished by a good build-up capacity and a small tendency to develop a green tone.
Abstract: The invention relates to new 3,4-dihydro-5H-2,3-benzodiazepine derivatives of general formula (I) and pharmaceutically acceptable acid addition salts thereof, ##STR1## wherein R represents a phenyl group optionally carrying one or two substituents selected from the group consisting of halogen, hydroxy, C.sub.1-4 alkoxy and benzyloxy; a furyl or a thienyl group,R.sup.1 stands for a hydrogen atom or a C.sub.1-4 alkyl group,R.sup.2 and R.sup.3 each represent hydrogen atom, C.sub.1-4 alkoxy, C.sub.4-7 cycloalkoxy or benzyloxy group.The new compounds of the general formula (I) can be prepared by reducing a 5H-2,3-benzodiazepine derivative of the general formula (II) ##STR2## wherein R, R.sup.1, R.sup.2 and R.sup.3 have the above-defined meanings, with an inorganic or organic hydride and/or complex metal hydride.The new compounds of the general formula (I) possess significant central nervous effects and can advantageously be used in the therapy.
Type:
Grant
Filed:
February 25, 1982
Date of Patent:
December 27, 1983
Assignee:
Egyt Gyogyszervegyeszeti Gyar
Inventors:
Jeno Korosi, Tibor Lang, Ferene Andrasi, Jozsef Szekely, Tamas Hamori, Tibor Balogh, Lajos Ila, Katalin Goldschmidt, Eleonora Sineger, Imre Moravcsik
Abstract: Fungicidal compounds of the formula: ##STR1## wherein R.sup.1 is an optionally substituted-alkyl, -cycloalkyl, -aryl or -aralkyl group, Y.sup.1 and Y.sup.2 are .dbd.CH-- or .dbd.N--; and salts, metal complexes, ethers and esters thereof.
Abstract: N-allenyl-acetanilides of the formula ##STR1## in which R.sup.1 represents hydrogen, alkyl or halogen,R.sup.2 represents hydrogen or alkyl,R.sup.3 represents hydrogen or alkyl,R.sup.4 represents hydrogen or alkyl,R.sup.5 represents hydrogen or alkyl andR.sup.6 represents furyl, tetrahydrofuryl, thiophenyl or tetrahydrothiophenyl; isoxazolyl which is optionally substituted by alkyl; alkyl, alkenyl or alkynyl, in each case optionally substituted by cyano or thiocyano; dihalogenoalkyl; or the grouping ##STR2## wherein R.sup.7 represents an optionally substituted alkyl, alkenyl, alkynyl or alkoxyalkyl radical andAz represents pyrazol-1-yl, 1,2,4-triazol-1-yl or imidazol-1-yl.which possess fungicidal properties.
Type:
Grant
Filed:
September 20, 1982
Date of Patent:
November 22, 1983
Assignee:
Bayer Aktiengesellschaft
Inventors:
Jorg Stetter, Winfried Lunkenheimer, Wilhelm Brandes
Abstract: The compounds of the formula: ##STR1## wherein R.sup.1 represents phenyl substituted in at least the 2-position by fluorine, chlorine, bromine or iodine, R.sup.2 represents a group R.sup.3, --OR.sup.3, --SR.sup.3 or --NR.sup.3 R.sup.4 where R.sup.3 represents hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, alkenyl of 2 to 6 carbon atoms, cycloalkenyl of 3 to 7 carbon atoms, alkynyl of 2 to 6 carbon atoms, phenyl, phenylalkyl of 7 to 10 carbon atoms or naphthyl, each of which may be unsubstituted or substituted by one or more halogen atoms, alkyl or alkoxy or alkylthio groups of 1 to 6 carbon atoms, nitro groups, cyano groups or mercapto groups, R.sup.4 represents a group as defined for R.sup.