Abstract: Devices, systems, and methods for visually depicting a vessel and evaluating treatment options are disclosed. The methods can include introducing instruments into the vessel of a patient and obtaining proximal and distal pressure measurements of a stenosis of the vessel, calculating a pressure ratio based on the obtained proximal and distal pressure measurements, applying a correlation factor to the calculated pressure ratio to produce a predicted diagnostic pressure ratio, and displaying the predicted diagnostic pressure ratio to a user.

Abstract: A wearable analyte breath alert device and method for non-invasive monitoring of an analyte in a sample from a user. The device comprises an outer casing, a forward face having an in-line insignia, a front port and an activation button, a rear face having a detector threshold region, a side port and a LED indicator, a reversible core having a main processor module and a volatile organic compound (VOC) sensor adaptable to detect at least one volatile organic compound of the user. The VOC sensor further comprises a central sensor circuit having at least one nano gas sensor, a sensor signal conditioning unit and an A/D interface. The central sensor circuit is operably connected to a Bluetooth Low Energy (BLE) element having a microcontroller. An alarm component is coupled with the BLE element that alerts the user based on the analyte detected by the nano gas sensor.

Abstract: A breath analyzer for detecting breathing events of a person ventilated with a respiratory gas, comprising an electronic computing and storage unit configured to receive a signal corresponding to a ventilation pressure and/or a respiratory flow and/or a tidal volume of the respiratory gas delivered to the person and, during a predetermined analysis duration, to detect a curve of the signal by a curve analyzer. A ventilator for ventilating a person with a respiratory gas, which ventilator comprises the breath analyzer and a method for detecting breathing events of a person ventilated with a respiratory gas is also described.

Abstract: An apparatus for determining a force Ftip applied to a tip of an electrical impedance spectroscopy probe includes a load cell, accelerometer, and a processing means. The probe tip has a substantially planar distal end for contacting human or animal tissue. The load cell measures the force Floadcell applied axially along a longitudinal axis when the probe tip is in contact with human or animal tissue. The accelerometer measures a gravity vector Aaxial. The apparatus includes a means for compensating for the mass of the probe tip using the measured force and the gravity vector to produce a calibrated measurement force F applied to the probe tip.

Abstract: Apparatus, system, and computer readable media determine the probability of visual recognition of an image by a subject using electroencephalography (EEG) corresponding to a Visual Evoked Potential (VEP). The apparatus comprises means for presenting a series of visual stimuli corresponding to said image to evoke EEG signals. The visual stimuli of the image are presented in an orientation sequence based on a timing cycle. At least one prism is provided for placement in front of the series of visual stimuli corresponding to said image. The EEG signals evoked in response to said visual stimuli and said prism placed in front of said visual stimuli are recorded and processed by a processor. VEP is generated corresponding to the presence of a shift and thereby provides object statistic reliability of the visual recognition of the image by the subject.

Abstract: This disclosure relates to wireless electronics designed for use within the oral cavity to measure biological or chemical variables, including pH or analyte concentrations, and transmit the measurements. More particularly, the disclosure relates to a wearable intraoral sensor comprising sensing electronics arranged within a flexible circuit mounted onto a molar band, a wireless transmission unit coupled to the sensing electronics and configured to wirelessly transmit electrical data signals to a receiver outside of the oral cavity, and a power source operably coupled to the sensing electronics and wireless transmission unit. The wearable intraoral sensor can be installed around a tooth and continually measure and wirelessly transmit measurement data for extended periods of time without user action.

Abstract: Systems and methods are provided for determining levels of an analyte in a biological fluid sample. A transdermal sampling and analysis device may include a substrate, at least one disruptor mounted on the substrate, a reservoir configured to collect and contain a biological fluid sample; a sensing element comprising at least two sensing electrodes, and at least one layer of a cofactor covering the sensing element in which the cofactor catalyzes a reaction to determine levels of an analyte in the biological fluid sample. The at least one disruptor of the transdermal sampling and analysis device may generate a localized heat capable of altering permeability characteristics of a stratum corneum layer of skin of an organism. The surface of at least one of the sensing electrodes of the transdermal sampling and analysis device may be coated with a sensing layer in which an enzyme immobilized within a hydrogel.

Abstract: Systems and methods are provided for determining levels of an analyte in a biological fluid sample. A transdermal sampling and analysis device may include a substrate, at least one disruptor mounted on the substrate, a reservoir configured to collect and contain a biological fluid sample; a sensing element comprising at least two sensing electrodes, and at least one layer of a cofactor covering the sensing element in which the cofactor catalyzes a reaction to determine levels of an analyte in the biological fluid sample. The at least one disruptor of the transdermal sampling and analysis device may generate a localized heat capable of altering permeability characteristics of a stratum corneum layer of skin of an organism. The surface of at least one of the sensing electrodes of the transdermal sampling and analysis device may be coated with a sensing layer in which an enzyme immobilized within a hydrogel.

Abstract: The present disclosure describes a system for metabolic monitoring comprising: collecting exhaled gas from nasal airways of a subject; a mixing chamber for receiving a portion of the exhaled gas; a plurality of sensors for outputting signals related to gas parameters related to inhaled gas and exhaled gas during one or more breaths; and processors configured to determine a flow rate of gas in the interface appliance; determine pressure changes near the mouth of the subject to detect mouth breathing of the subject; determine concentration measurements of O2 and CO2 of the portion of the exhaled gas in the mixing chamber, and discard concentration measurements corresponding to mouth breathing; determine a rate of oxygen consumption VO2 and a carbon dioxide production VCO2 of the subject based on the determined flow rate, the CO2 concentration, and the determined O2 concentration.

Abstract: A system (1) for estimating the brain blood volume and/or brain blood flow and/or depth of anesthesia of a patient, comprises at least one excitation electrode (110E) to be placed on the head (20) of a patient (2) for applying an excitation signal, at least one sensing electrode (110S) to be placed on the head (20) of the patient (2) for sensing a measurement signal caused by the excitation signal, and a processor device (12) for processing said measurement signal (VC) sensed by the at least one sensing electrode (110S) for determining an output indicative of the brain blood volume and/or the brain blood flow. Herein, the processor device (12) is constituted to reduce noise in the measurement signal (VC) by applying a non-linear noise-reduction algorithm. In this way a system for estimating the brain blood volume and/or the brain blood flow of a patient is provided which may lead to an increased accuracy and hence more exact estimates.

Abstract: Methods and apparatuses for heart rate detection are described. In one example, a headphones apparatus and method includes emitting a first light in a first light direction directed at a left ear location from a left ear light emitter, and detecting a detected first light at a left ear light detector following interaction of the first light with a left ear tissue. The method includes emitting a second light in a second light direction directed at a right ear location from a right ear light emitter, the right ear location different from the left ear location. The method further includes detecting a detected second light at a right ear light detector following interaction of the second light with a right ear tissue, and estimating a heart rate from the detected first light and the detected second light.

Abstract: Introduced here are diabetes management platforms able to guide people with diabetes toward a glycemic target. Rather than state the absolute amount of glucose within the blood, the diabetes management platform can instead produce personalized glycemic goals based on the physiological data associated with an individual. For example, if the diabetes management platform determines that the time spent within a first glycemic range exceeds a specified threshold, then the diabetes management platform may recommend that the individual attempt to keep their blood glucose level within a second glycemic range. Generally, the second glycemic range is closer than the first glycemic range to a target glycemic range corresponding to a healthy glycemic state.

Abstract: Various systems, devices, components, and methods are disclosed for measuring the concentration of an analyte, such as acetone, in a breath sample. The disclosed devices include a breath sample analysis device having a mouthpiece configured to facilitate engagement with a user's mouth to receive a breath sample. The disclosed devices also include a breath sample capture cartridge containing an interactant that extracts the analyte from a breath sample passed through the cartridge. Also disclosed are devices for routing the breath sample through the cartridge during exhalation, and for analyzing a reaction in the cartridge to measure a concentration of the analyte.

Abstract: A wearable analyte breath alert device and method for non-invasive monitoring of an analyte in a sample from a user. The device comprises an outer casing, a forward face having an in-line insignia, a front port and an activation button, a rear face having a detector threshold region, a side port and a LED indicator, a reversible core having a main processor module and a volatile organic compound (VOC) sensor adaptable to detect at least one volatile organic compound of the user. The VOC sensor further comprises a central sensor circuit having at least one nano gas sensor, a sensor signal conditioning unit and an A/D interface. The central sensor circuit is operably connected to a Bluetooth Low Energy (BLE) element having a microcontroller. An alarm component is coupled with the BLE element that alerts the user based on the analyte detected by the nano gas sensor.

Abstract: A sphygmomanometer includes: a sensing cuff that includes a second sheet disposed to face the pressing member's inner circumferential surface and a first sheet facing the second sheet; a fluid storage control part providing a control of supplying and storing the pressure-transmitting fluid into sensing cuff in a worn state wherein the pressing member and sensing cuff are worn on the wrist; and a blood-pressure calculating part calculating a blood pressure based on a pressure of the pressure-transmitting fluid stored in the sensing cuff. The fluid storage control part supplies fluid in the worn state such that the first and second sheets are in contact with each other in a region corresponding to an ulna, a region corresponding to a radius, and a region corresponding to a tendon while first and second sheets are separated from each other in regions corresponding to two arteries that are radial and ulnar arteries.

Abstract: The disclosure pertains to a system 100 and method for collecting and measuring particles in exhaled air. The system 100 is arranged to allow for examination of the full or substantially the full volume of each exhalation of a subject.

Abstract: A method of characterizing a patient's disordered breathing during a sleeping period includes performing a first partial characterization of a time axis of an audio signal in order to learn the most prominent and highly relevant events. Only at a later stage, i.e., after sufficient observation of the highly relevant events, is a full segmentation of the entire time axis actually carried out. Linear prediction is used to create an excitation signal that is employed to provide better segmentation than would be possible using the original audio signal alone. Warped linear prediction or Laguerre linear prediction is employed to create an accurate spectral representation with flexibility in the details provided in different frequency ranges. A resonance probability function is generated to further characterize the signals in order to identify disordered breathing. An output includes a characterization in any of a variety of forms of identified disordered breathing.

Abstract: The present invention is directed to system and method for effectively monitoring critical respiratory parameters including SpO2, PR, COHb, inspired CO2, expired CO2, respiration rate, respiration pattern, hyperventilation (hypocapnia), hypoventilation (hypercapnia), CO2 contamination, and CO2 rebreathing. The system according to the present invention comprises a pulse oximetry sensor and a CO2 sensor connected to a central portable unit. The central unit comprising a barometer, an accelerometer, a capnography circuit, and a control unit. The control unit including the method for effectively monitoring critical respiratory parameters.

Abstract: An apparatus for estimating bio-information is disclosed. The bio-information estimating apparatus includes: a sensor configured to measure a bio-signal; and a processor configured to obtain one or more characteristic points, related to one or more pulse waveform components constituting the bio-signal, based on a differential signal of the bio-signal, and to estimate bio-information based on the obtained one or more characteristic points.

Abstract: Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include an implantable microneedle array for use in measuring one or more analytes (e.g., glucose), such as in a continuous manner. The microneedle array may include, for example, at least one microneedle including a tapered distal portion having an insulated distal apex, and an electrode on a surface of the tapered distal portion located proximal to the insulated distal apex. At least some of the microneedles may be electrically isolated such that one or more electrodes is individually addressable.