Abstract: A noninvasive method of sensing an arterial pulse on a paw pad includes providing an instrument having a probe; placing the probe housing a tactile transducer and a reflective optical coupler comprising an infrared emitter and an infrared detector on a subject's metatarsal or metacarpal pad; emitting infrared light from the emitter; detecting infrared light with the detector; maintaining a linear direct current bias of the detector; converting a signal emitted by the infrared detector into a digital pulse that drives the tactile transducer to emit tactile pulses; and counting the tactile pulses over a predetermined time. An arterial pulse detection system includes a probe. The probe contains an optical sensor and a tactile transducer to which instrumentation is electrically connected. The optical sensor includes an infrared emitter and an infrared detector.

Abstract: A device (250) for estimating the risk of a future hypoglycemic event for a subject with a standing insulin regimen (206), wherein the standing insulin regimen comprises one or more types of insulin medicament dosage regimen (208), wherein each of the one or more types of insulin medicament dosage regimen (208) comprises a type of insulin medicament (210) defining one or more types of insulin medicaments. Using the evaluation of a glucose concentration, a first time derivative and an insulin on board for the subject in a current metabolic state, and the evaluation of a glucose concentration, a first derivative and a historical insulin on board to estimate a hypoglycemic risk measure.

Abstract: A method for contextually aware determination of respiration includes obtaining, by an electronic device, context information and selecting, by the electronic device, a set of sensor data associated with respiratory activity of a subject, based on the context information. The method further includes selecting, based on the selected set of sensor data, an algorithm from a plurality of algorithms for determining a respiration rate of the subject, and determining, by applying the selected algorithm to the selected set of sensor data associated with respiratory activity of the subject, the respiration rate for the subject.

Abstract: The present invention relates to physiological signal processing, and in particular to methods and systems for processing physiological signals to predict a fluid responsiveness of a patient. A medical monitor for monitoring a patient includes an input receiving a photoplethysmograph (PPG) signal representing light absorption by a patient's tissue. The monitor also includes a perfusion status indicator indicating a perfusion status of the PPG signal, and a fluid responsiveness predictor (FRP) calculator programmed to calculate an FRP value based on a respiratory variation of the PPG signal. The FRP calculator applies a correction factor based on the perfusion status indicator.

Abstract: A microcirculation detection system including a heating device, a photosensitive array and a processing unit is provided. The heating device is used to heat a skin area. The photosensitive array is used to detect outgoing light from the skin area, and output a plurality of brightness variation signals respectively at different time points within a heating period. The processing unit is used to calculate a change of an array energy distribution varied within the heating period according to the plurality of brightness variation signals to accordingly identify a microcirculation state.

Abstract: A device for collecting exhalation gas and aiding measurement of a trace component in the exhalation gas and the usage method thereof are disclosed. The device comprises an alveolar air bag for storing alveolar air collected from the breath of a subject, a cavity channel air bag for storing cavity channel air from the subject, a three-way pipe, and a mouthpiece. The three-way pipe comprises a first branch pipe, second branch pipe, and third branch pipe communicating with each other. The first branch pipe and the second branch pipe respectively extend in opposing directions along the same axis. The third branch pipe extends along a radial direction of the first branch pipe and the second branch pipe. The mouthpiece communicates with the first branch pipe. An air hole of the cavity channel air bag communicates with the second branch pipe.

Abstract: A bag-shaped structure excellent in both creep resistance and flexibility is provided. Provided is a bag-shaped structure (122) including a layer (122a) made of a thermoplastic elastomer foam. Also provided are a cuff for a blood pressure monitor and a blood pressure monitor each including the bag-shaped structure (122).

Abstract: Disclosed is apparatus for collecting a breath sample from a human subject, the apparatus comprising at least a mask portion which, in use, is positioned over the subject's mouth and nostrils so as to collect breath exhaled from the subject, the apparatus further comprising movement detection means for detecting movement of the mask portion, and an alarm signal generator, which alarm signal generator generates an alarm signal if the subject's head is outside a predetermined range of acceptable orientations during collection of a breath sample, but only after the subject's head has been outside the predetermined range of acceptable orientations for a defined or measurable period of time.

Abstract: To provide a bag-shaped structure that can suppress expansion of the side wall portion and improve the vascular compression property. A bag-shaped structure used in a cuff for a blood pressure monitor configured to be wrapped around a living body, inflate when a fluid is supplied to an internal space, and compress the living body includes: an inner wall portion provided on a living body side; an outer wall portion facing the inner wall portion; and a pair of side wall portions continuous with the inner wall portion and the outer wall portion and including a bent portion bent toward the internal space; and a reinforcing member provided on each of the pair of side wall portions, having a higher hardness than the side wall portion, and having shape followability in a direction of wrapping around the living body.

Abstract: A biological information analysis device including: an indicator extraction unit that is configured to extract, from time-series data regarding blood pressure waveforms consecutively measured by a sensor that is configured to be worn on a body part of a user and to be capable of non-invasively measuring a blood pressure waveform for each heartbeat, data regarding blood pressure waveforms corresponding to a period of time in which a change in blood pressure occurs, and extract an indicator that is related to the functionality of respiratory organs of the user, based on characteristics of the blood pressure waveforms corresponding to the period of time; and a processing unit that performs processing that is based on the indicator thus extracted.

Abstract: A physiological detection system including an array sensor and a processing unit is provided. The array sensor is configured to output array PPG signals. The processing unit is configured to construct a 3D energy distribution according to the array PPG signals to accordingly identify different microcirculation states.

Abstract: In some examples, devices, systems, and techniques are configured to compensate for changes in sensed blood pressure due to issues such as blood pressure sensor movement. For example, processing circuitry of a device may determine a difference value between a first blood pressure value representative of a blood pressure at a first time and a second blood pressure value representative of the blood pressure at a second time. Responsive to determining that the difference value is greater than or equal to a threshold value, the processing circuitry may generate updated blood pressure values by applying an offset value to the second blood pressure value and subsequently received blood pressure values that compensates for the difference value between the first blood pressure value and the second blood pressure value.

Abstract: Methods, structures, devices and systems are disclosed for fabricating and implementing electrochemical biosensors and chemical sensors. In one aspect, a method of producing an epidermal biosensor includes forming an electrode pattern onto a coated surface of a paper-based substrate to form an electrochemical sensor, the electrode pattern including an electrically conductive material and an electrically insulative material configured in a particular design layout, and attaching an adhesive sheet on a surface of the electrochemical sensor having the electrode pattern, the adhesive sheet capable of adhering to skin or a wearable item, in which the electrochemical sensor, when attached to the skin or the wearable item, is operable to detect chemical analytes within an external environment.

Abstract: A biological sound analyzing apparatus is provided with: an obtaining device configured to obtain biological sound information, which indicates a change in biological sounds with time; a first calculating device configured to calculate first information, which indicates a variation degree based on a first reference value of the biological sounds in a first period, on the basis of the biological sound information; a second calculating device configured to calculate second information, which indicates a variation degree based on a second reference value of the biological sounds in a second period, on the basis of the biological sound information, wherein the second period is longer than the first period; and an outputting device configured to output noise information, which indicates noise included in the biological sounds, on the basis of the first information and the second information. This makes it possible to preferably analyze the noise included in the biological sounds.

Abstract: A catheter for measuring a pressure distal of a stenosis includes a shaft including a housing in a distal portion of the shaft. A flexible printed circuit board is coupled to the housing. A pressure sensor is coupled to the flexible printed circuit board and is suspended within the housing. An aperture enables blood flow into the housing and into contact with the pressure sensor.

Abstract: Embodiments include methods and systems for regulating a user's glucose levels. Systems comprise a processing unit in communication with a glucose monitor, an accelerometer, and a user interface. The glucose monitor generates glucose readings corresponding to the user's glucose levels and the accelerometer generates acceleration readings corresponding to the user's activity. The processing unit determines if the glucose readings indicate a glucose state and whether the acceleration readings indicate an activity state. If the glucose state and the activity state coincide, the processing unit sends a message to the user interface recommending a behavior that would influence the user's glucose level.

Abstract: Embodiments of the invention provide compositions useful in analyte sensors as well as methods for making and using such compositions and sensors. In typical embodiments of the invention, the sensor is a glucose sensor comprising an analyte modulating membrane formed from a polymer composition having carbonate and aromatic isocyanate chains, a composition observed to provide such membranes with improved material properties such as enhanced thermal and hydrolytic stability.

Abstract: An electrochemical probe for in-vivo measurement of H2O2 oxidation within a living tissue. The electrochemical probe includes a sensing part and a handle. The sensing part includes a working electrode including a first biocompatible conductive needle, a counter electrode including a second biocompatible conductive needle, and a reference electrode including a third biocompatible conductive needle. The working electrode, the counter electrode, and the reference electrode are configured to be put in contact with the living tissue by inserting the sensing part into the living tissue. The handle includes an insertion part that may be configured to insert the sensing part into the living tissue. The sensing part is attached to the insertion part.

Abstract: Systems and methods for classifying breathing disorders of subjects are based on the respiratory response to a change in a pressure level of a pressurized flow of breathable gas. The change presents a breathing challenge to a subject. The challenge may be limited to the inspiratory breathing phase. The inspiratory pressure level may be lower than the expiratory pressure level during challenges.

Abstract: An electrochemical system for cancer diagnosis. The electrochemical system includes a sensor configured to be put in contact with a sample suspected to be cancerous, an electrochemical stimulator-analyzer, a processor electrically connected to the electrochemical stimulator-analyzer, and an array of electrically conductive connectors connecting the sensor to the electrochemical stimulator-analyzer.