Patents Examined by Anna Falkowitz
  • Patent number: 10258033
    Abstract: The present invention relates to compositions comprising terpenes which are particularly suitable for treating plant infections, to methods of making such compositions, and to methods of using them. The present invention also relates to compositions comprising terpenes and hollow glucan particles or cell wall particles and methods for preparing such compositions; such compositions increase terpene stability and activity and provide a suitable carrier for the terpenes. The invention also relates to methods of using such compositions in the medical, veterinary and agricultural fields. In particular, the terpenes disclosed are thymol, eugenol, geraniol, citral and L-carvone.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: April 16, 2019
    Assignee: Eden Research PLC
    Inventors: Lanny Franklin, Gary Ostroff
  • Patent number: 10071186
    Abstract: Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), and polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: September 11, 2018
    Assignee: Colorado State University Research Foundation
    Inventors: Susan P. James, Harold Dean, IV, Lakshmi Prasad Dasi, Marcio H. Forleo, Ketul C. Popat, Nicole R. Lewis, David Alois Prawel
  • Patent number: 10064978
    Abstract: There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: September 4, 2018
    Assignee: Carmeda AB
    Inventors: Stefan Oscarson, Martina Lahmann, Karin Leontein, Robert Vestberg
  • Patent number: 10039807
    Abstract: A heparin mimicking polymer, its conjugate with bFGF, and method of making and using the same are disclosed. In particular, described herein are conjugates of biologic agents (e.g., bFGF) and heparin mimicking polymers having superior stability while retaining full native activity after a variety of stressors.
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: August 7, 2018
    Assignee: The Regents of the University of California
    Inventors: Heather D. Maynard, Thi Nguyen
  • Patent number: 10039858
    Abstract: Provided herein are biodegradable poly(ester amide) elastomers, methods of making the elastomers, and methods of using the elastomers, for example for tissue engineering. The elastomers can be used for preparation of tissue prostheses, such as a heart valve leaflet, a heart valve, cartilage, myocardium, blood vessels, smooth muscle, skeletal muscle, or other tissues. Also provided herein are semiquantitative FTIR methods for determining structure of a poly(ester amide) elastomer.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: August 7, 2018
    Assignee: University of Pittsburgh—Of the Commonweatlh System of Higher Education
    Inventors: Shilpa Sant, Vinayak Sant
  • Patent number: 10039864
    Abstract: The invention features oligofluorinated cross-linked polymers and their use in the manufacture of articles and coating surfaces.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: August 7, 2018
    Assignee: Interface Biologics, Inc.
    Inventors: Roseita Esfand, J. Paul Santerre, Mark J. Ernsting, H. Hung Pham, Vivian Z. Wang, Meilin Yang
  • Patent number: 10010502
    Abstract: A non-degradable topical ocular drug delivery device includes about 0.001% to about 10% w/w of at least one myopia-suppressing agent complexed with an immobile acid within a crosslinked polymer matrix. The cross-linked polymer matrix is configured to deliver the least one myopia-suppressing agent over an extended period of time at a concentration and rate that controls myopia progression while preserving pupillary function and accommodation.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: July 3, 2018
    Inventors: Charles D. Leahy, Edward J. Ellis
  • Patent number: 9999224
    Abstract: Antimicrobial polymers, composition including the polymers, and methods of forming and using the polymers and compositions are disclosed. The compositions have reverse thermal gelling properties and transform from a liquid to a gel—e.g., near or below body temperature, such as a skin temperature in an operating room. The polymers and compositions can be applied to a surface, such as a surface of skin proximate an incision site prior to surgery, to provide a relatively sterile area near the site.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: June 19, 2018
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Daewon Park, Maria Bortot, Vikas Patel
  • Patent number: 9999633
    Abstract: Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: June 19, 2018
    Assignees: International Business Machines Corporation, Agency For Science, Technology And Research
    Inventors: Willy Chin, Daniel J. Coady, Amanda C. Engler, James L. Hedrick, Ashlynn L. Z. Lee, Victor W. L. Ng, Zhan-Yuin Ong, Yi Yan Yang
  • Patent number: 9993401
    Abstract: The invention provides a benefit agent delivery particle having an average diameter of less than 50 micron comprising; at least one shell formed by a step-growth polymerization reaction, preferably involving an isocyanate monomer, more preferably a urethane and/or a urea. interior said shell, at least one region formed by chain-growth polymerization reaction (preferably a free-radical polymerization) which does not involve an isocyanate, c) optionally, a benefit agent interior to said shell, and/or a deposition aid exterior to said shell. The invention further provides a process for the preparation of such particles wherein the shell is formed prior to the chain-growth polymerization of the at least one region interior of the shell, preferably be forming the shell at a temperature at which the chain-growth reaction is inhibited.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: June 12, 2018
    Assignee: Conopco, Inc.
    Inventors: Stuart Anthony Barnett, Craig Warren Jones, Adam John Limer, James Merrington, Jeremy Nicholas Winter
  • Patent number: 9987387
    Abstract: Aerosol odor eliminating compositions are described which are aqueous based and include at least one alkylene glycol, at least one surfactant wherein one or more of the at least one surfactant has an HLB of about 7 to about 20, compressed gas propellant, at least one fragrance, a buffering system and water. The composition excludes inclusion of a low molecular weight monohydric. The compositions have a volatile organic content (VOC) of less than 5.0% of the total composition based on 100 wt. %, or alternatively, a VOC of less than 0.1% as to the total composition based on 100 wt. % in absence of the wt. % of the active fragrant material of the fragrance. The compositions additionally have a consistent spray rate at multiple pressure ranges.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: June 5, 2018
    Assignee: S. C. Johnson & Son, Inc.
    Inventors: Peter N. Nguyen, Bhaveshkumar Shah
  • Patent number: 9987297
    Abstract: A method for bonding a polymeric fiber to tissue is provided which includes providing a polymeric fiber having a plurality of tissue reactive members linked to a surface of the fiber via a specific binding pair, and contacting the polymeric fiber to biological tissue, to covalently bond the fiber to the tissue.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: June 5, 2018
    Assignee: Sofradim Production
    Inventor: Sébastien Ladet
  • Patent number: 9980897
    Abstract: The present invention provides a novel organopolysiloxane in which a rich hydrophilic property is exhibited, not only superior miscibility with a hydrophilic component and but also a hydrophobic property are exhibited, and superior miscibility with both a silicone oil and a non-silicone oil such as a hydrocarbon oil, an ester oil or the like, and provide various usages of the aforementioned novel organopolysiloxane by developing the superior characteristics thereof such as good surface activity power, a distinctive sensation during use, increased stability and the like. A co-modified organopolysiloxane having a specified chemical structure in which a sugar alcohol-modified group and a long-chain hydrocarbon group are present in one molecule is produced.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: May 29, 2018
    Inventors: Seiki Tamura, Tomohiro Ilmura, Tatsuo Souda, Akito Hayashi, Sayuri Sawayama, Haruhiko Furukawa
  • Patent number: 9980915
    Abstract: An oral disintegrating tablet containing (1) D-mannitol, (2) an active ingredient, (3) one or more disintegrating agents selected from the group consisting of crospovidone and carmellose, and (4) one or more lubricants selected from the group consisting of sodium stearyl fumarate and sucrose esters of fatty acids. The oral disintegrating tablet of the present invention has some excellent properties of (1) allowing easy production in a common facility without necessitating a specialized pharmaceutical technique, (2) having an appropriate strength that does not breakdown in the process of distribution, (3) having a fast disintegrating ability in the oral cavity, and (4) also having excellent ingestion feel such as greatly reduced bitterness or gritty feel; therefore, the tablet can be suitably used as a dosage form that is suitable for aged individuals, children, and seriously ill patients.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: May 29, 2018
    Inventors: Makoto Matsuoka, Hiroyuki Nishii, Maki Sasaki
  • Patent number: 9976000
    Abstract: An aqueous gel that is prepared by gelling a polymer components, the polymer components containing polymer A, which is obtained by polymerizing a monomer component containing a betaine monomer represented by the formula (I): wherein R1 represents hydrogen atom or an alkyl group, R2 represents an alkylene, arylene, aralkylene, —COOH— or —CONH— group; R3 and R4 represent an alkyl group, and R5 represents an alkylene group, and a polymer B, which is obtained by polymerizing a monomer component containing an acidic monomer represented by the formula (II): wherein R1 represents hydrogen atom or an alkyl group; R6 represents an optionally neutralized sulfonate group, an optionally neutralized phosphate group, or an alkyl, aryl, aralkyl, carboxyl or amino group carrying an optionally neutralized sulfonate group or an optionally neutralized phosphate group.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: May 22, 2018
    Inventors: Jian Ping Gong, Takayuki Kurokawa, Haiyan Yin, Taigo Akasaki, Yoshiyuki Saruwatari
  • Patent number: 9968633
    Abstract: The present technology provides new compositions comprising at least one cross-linked co-polymer. In some embodiments, the polyacrylamide co-polymer comprises water soluble subunits, cross-linking subunits, and iron chelating subunits. In other embodiments, the co-polymer comprises water soluble units, cross-linking subunits, and substituted subunits, which can be conjugated with iron-chelating agents. When these new particles are exposed to certain environments, such the presence of strong acids or oxidation agents, these particles are capable of breaking up so that the iron chelating agents can chelate iron or other metals from their environments. Methods to prepare these new compositions are also provided. These compositions or compositions comprising nanogels of the present technology may be used to treat metal overload conditions such as iron overload resulting from chronic transfusions.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: May 15, 2018
    Inventors: May Pang Xiong, Zhi Liu, Yan Wang
  • Patent number: 9949921
    Abstract: The present invention relates to methods and compositions for the delivery of cosmetics and medicants. In some embodiments, the invention relates to compositions comprising both hydrophobic and hydrophilic polymers. In preferred embodiments, the invention relates to the delivery of peptides, small molecules and other bioactive compounds using the compositions and methods disclosed herein.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: April 24, 2018
    Assignee: Agigma, Inc.
    Inventors: Nevenka Golubovic-Liakopoulos, Bhavdeep Shah, Erik Andersen
  • Patent number: 9951194
    Abstract: An iron oxide containing effect pigment, and methods for producing and using the same are discussed. The iron oxide containing effect pigment may include an iron oxide coating in direct contact with a particulate substrate, which may have high levels of hematite, magnetite, or maghemite; and low amounts of toxic metals. A method for producing the pigment may include chemical vapor deposition of iron pentacarbonyl onto a particulate substrate. The iron oxide containing effect pigments may be incorporated into compositions, such as cosmetics.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: April 24, 2018
    Inventors: Juergen Walker, Gabe Uzunian, Raimund Schmid, Aron Wosylus, Christoph Schwidetzky
  • Patent number: 9943475
    Abstract: The present invention relates to a composition comprising a dispersion of particles of at least one polymer that is surface-stabilized with a stabilizer in a non-aqueous medium containing at least one hydrocarbon-based oil, the polymer of the particles being a C1-C4 alkyl (meth)acrylate polymer; the stabilizer being an isobornyl (meth)acrylate polymer chosen from isobornyl (meth)acrylate homopolymer and statistical copolymers of isobornyl (meth)acrylate and of C1-C4 alkyl (meth)acrylate present in an isobornyl (meth)acrylate/C1-C4 alkyl (meth)acrylate weight ratio of greater than 4, at least a first hydrocarbon-based oil and at least a second oil different from the first, and the saturating vapor pressure of which, measured at 25° C., is less than or equal to 15 Pa. The invention also relates to a process for making up and/or caring for keratin materials, in which said composition is applied.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: April 17, 2018
    Assignee: L'ORÉAL
    Inventors: Roshanak Debeaud, Roberto Cavazzuti
  • Patent number: 9945865
    Abstract: Disclosed herein is a composition comprising a crosslinked hydrogel; where the hydrogel comprises a polymer having a cleavable bond along a backbone of the polymer, along a substituent that undergoes crosslinking, or along the backbone of the polymer and along the substituent that undergoes crosslinking; where the cleavable bond is operative to be cleaved by an enzyme released in the body of a living being; and a semiconducting quantum dot that emits light in the visible portion of the electromagnetic spectrum.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: April 17, 2018
    Inventor: Jennifer Andrew