Abstract: Sterile aqueous humor from patients afflicted with the disease endogenous uveitis contains a previously unreported pathogenic microorganism, Micromyces intracellularis, which also has been found in tissue specimens from other diseases. When inoculated into an animal model (e.g., a mouse), the microorganism produces both chronic eye and systemic disease in addition to accelerated mortality and occasional psychotic animal behavior, metabolic disturbances, and neuro-muscular disorders, depending on the mode of inoculation. The animal model therefore provides the basis for a screening process to evaulate chemotherapeutic agents in the treatment of human disease. Using this animal model, a significant decrease in mortality associated with the introduction of Micromyces intracellularis is achieved by the application to the animal model of the chemotherapeutic agents d-2,2'-(ethylenediimino)-di-1-butanol, 4,4'sufonyldianiline, and 3[[(4-methyl-1-piperazinyl)-imino]methyl]-rifamycin SV.

Abstract: Using anti-IgG and anti-Fc sera which is reacted with gastric cancer juice from a patient by double diffusion on Ouchterlony agarose, there is repeatedly obtained a double precipitin line. Under immunoelectrophoresis, anodic displacement of anti-IgG and anti-Fc sera is observed. The .beta..sub.1 to .alpha..sub.1 precipitin line with anti-IgG and anti-Fc is thus formed to be characteristic of gastric cancer juice. These double precipitin lines correspond to an antigen-antibody complex which are uniquely identified by Ouchterlony immunodiffusion assay with these anti-immunoglobulin sera. Only a single precipitin line is formed between gastric cancer juice and anti-Fab serum.Both with anti-IgG and anti-Fc, various lines are obtained under immunoelectrophoresis with different mobilities, from gamma to .alpha..sub.1. With anti-Fab, however, there is no displacement toward the anode. Normally, Fc seldom moves beyond the site of origin.

Abstract: Certain N,N-dialkyl substituted derivatives of dopamine (DA) increase renal blood flow without affecting cardiac contractility. Particularly effective are N,N-di-n-propyl DA; N-n-propyl-N-n-butyl DA; N-n-propyl-N-n-pentyl DA; N-n-propyl-N-isobutyl DA; and N-n-propyl-N-phenethyl DA. Orally effective versions of these derivatives are obtained by acylating the hydroxyl functions.

Abstract: Therapeutic antihypertensive compositions containing N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine and N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine or their non-toxic, pharmaceutically acceptable salts are described as well as a method of reducing blood pressure in mammals.

Abstract: A local hemostatic comprising an active principle which is the incomplete ferric salt of polyacrylic acid of the formula: ##STR1## in combination with a pharmaceutical solvent which is water or physiological solution. The active principle content is 1 to 2 percent by weight.

Abstract: The proposed gastric secretion stimulator comprises an active principle which is 2-amino-5-(2-aminoethyl)-1,3,4-thiadiazole, and a pharmaceutical carrier for said active principle. The stimulator is used in the form of hydrochlorides. It displays a selective stimulating effect upon H.sub.2 -ceptors of secretory cells of the stomach and produces a maximum of gastric secretion, which is an important diagnostic factor. The gastric secretion stimulator of this invention is advantageous in that besides parenteral administration, it may be administered per os.

Abstract: A process for the isolation of cancer associated polypeptide antigen mainly by several steps of gel filtration and pH-gradient elution; a cancer associated polypeptide antigen based on a single peptide chain and denaturating irreversibly at pHs exceeding about 4.5; a composition comprising such antigen and a stabilizing amount of albumen in admixture therewith and a method of making such composition; a diagnostic composition comprising a particulate material labelled with albumen-stabilized antigen; process for preparing antibodies monospecific with regard to the cancer associated polypeptide antigen comprising preparing an oil emulsion, wherein an acid aqueous solution of the polypeptide is enclosed phase protected by a surrounding oil phase; a cancer diagnosis method based on determining the presence of cancer associated polypeptide antigen in a living animal body under examination; and composition useful as an immunizing agent containing as an active ingredient the cancer associated polypeptide antigen.

Abstract: Pharmaceutical composition for treatment of proliferating skin diseases, primarily psoriasis. The compositions comprise a pharmaceutical carrier with a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and selected from the group consisting of benzoyl, adamantane carboxylate or an acyl radical of an aliphatic carboxylic acid having from 2 to 18 carbon atoms inclusive including the pharmacologically acceptable acid addition salts thereof as the active compound.The compositions are administered to humans and animals systemically or topically.

Abstract: A process for improving the appearance of oily hair or skin, including the scalp, comprises applying thereto an effective amount of an aqueous or hydroalcoholic solution of gelatin present in an amount of about 0.5 to 1.5 percent by weight thereof.

Abstract: New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.

Abstract: New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.

Abstract: Derivatives of phenylisoquinoline, in particular 8-amino-2-methyl-4-phenyl-1,2,3,4-tetrahydro-iso-quinoline hydrogen maleate, are used as effective agents in the differential diagnosis of disorders of hypothalamo-pituitary function. The phenylisoquinoline derivatives are administered orally at a dose of about 1-5 mg/body wt. in order to differentiate between "functional" and "organic" (tumorous) diseases.

Abstract: New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.

Abstract: An assay method suitable for antigens (or haptens) including proteins and polypeptides utilizing antibodies for the unknown protein or polypeptide in which the antibodies are covalently bound to water insoluble hydrophylic polymeric particles. Appropriate fluorescently labeled immune reactants are introduced during the method and together with the unknown antigen are immunologically bound, directly or indirectly, to the particles for separation from the reaction liquid. The particles have a size of about 0.1-10 microns and can be resuspended for direct measurement of the fluorescent labels in a fluorometer from which the unknown can be determined.

Abstract: New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.

Abstract: Glyceryl-tri-3,5,5-trimethylhexanoate is particularly suitable for use in cosmetic preparations, particularly in skin creams used for protection against harmful outside agents.

Abstract: A method and system for a rapid and sensitive method for determining immunologically active materials in a biological fluid by observing an antigen-antibody reaction after application of reactants on the surface of a gel matrix and applying an alternating current thereto.

Abstract: An immunoassay for the sandwich technique is disclosed in which antibody (or antigen) is bound to a plastic strip, and after reaction with a test sample and then fluorescently tagged antibody (or antigen), fluorescense is read directly from the plastic strip in a fluorometer.

Abstract: Nitrogen derivatives of benzoyl ecgonine and cocaine are provided, particularly amino, diazonium, and diazo derivatives, the compounds finding use either directly or as intermediates for the preparation of reagents for use in immunoassays. Diazo compounds can be coupled with antigenic materials for the preparation of antibodies to benzoyl ecgonine and/or cocaine. The amino group can be combined with active non-oxo-carbonyl compounds to form reagents which find use in immunoassays.

Abstract: Malignant brain tumors may be diagnosed by comparing the amounts of certain proteins bound to a product, Malignin, derived from brain tumor cells, complexed to an inert carrier, such as bromacetylcellulose.