Patents Examined by Anna P. Fagelson
  • Method of detecting antibodies to human thyroglobulin
    Patent number: 4254097
    Abstract: A method of detecting antibodies to native deoxyribonucleic acid (n-DNA), anti-nuclear antibodies, antibodies to non-histone containing protein, rheumatoid factors, antibodies to thyroglobulin, and an immunofluorescent assay for such detection is described.
    Type: Grant
    Filed: November 5, 1979
    Date of Patent: March 3, 1981
    Assignee: American Hospital Supply Corporation
    Inventor: Delfin F. Rippe
  • Reagent combination for solid phase immunofluorescent assay
    Patent number: 4254096
    Abstract: An assay method suitable for antigens (or haptens) including proteins and polypeptides utilizing antibodies for the unknown protein or polypeptide in which the antibodies are covalently bound to water insoluble hydrophilic polymeric particles. Appropriate fluorescently labeled immune reactants are introduced during the method and together with the unknown antigen are immunologically bound, directly or indirectly, to the particles for separation from the reaction liquid. The particles have a size of about 0.1-10 microns and can be resuspended for direct measurement of the fluorescent labels in a fluorometer from which the unknown can be determined.
    Type: Grant
    Filed: October 4, 1979
    Date of Patent: March 3, 1981
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: James F. Monthony, Michael W. Burgett, Robert V. Dahlstrom
  • Method and composition for testing to predict and/or diagnose allergy to penicillins
    Patent number: 4252784
    Abstract: The invention relates to the testing of humans or other animals, such as horses, cattle or dogs, for allergic reaction or hypersensitivity to penicillins. The tests can be used both to predict and to diagnose allergy. The invention comprises new penicilloyl-polylysine (PPL) preparations, and novel test methods employing such materials.The new PPL preparations comprise homogeneous, high purity, maximally coupled, .alpha.-diastereoisomeric, penicilloyl conjugates of low molecular weight PPLs. The PPL materials of the invention have the molecular structure in accordance with the following generic formula: ##STR1## wherein: R is selected from the group consisting of H and penicilloyl groups or similar groups derived from cephalosporins or other .beta.-lactam antibiotics; andn is an integer of from 4 to 10, at least about 66% and up to 100% of the R groups are other than hydrogen.
    Type: Grant
    Filed: August 23, 1979
    Date of Patent: February 24, 1981
    Inventor: Bernard B. Levine
  • Reducing fluorescent background in fluorescent immunoassays
    Patent number: 4252783
    Abstract: Background fluorescence which interferes with the measurement of an analyte in fluorescent immunoassays in serum samples is substantially diminished by treating the serum sample with a sufficient amount of a peroxidic compound, either organic or inorganic, for a time sufficient to reduce the background fluorescence contributed by serum components. The peroxidic compound is readily quenched, without adversely affecting the assay composition.
    Type: Grant
    Filed: June 18, 1979
    Date of Patent: February 24, 1981
    Assignee: Syva Company
    Inventors: Jean Kam, Robert A. Yoshida
  • Compositions for treatment of cardiovascular conditions associated with overproduction of catecholamines
    Patent number: 4252825
    Abstract: Compositions having therapeutic value in the treatment of cardiovascular conditions associated with the overproduction of catecholamines include as the active ingredient 5-fluoro-2-(2-hydroxy-3-tertiary butyl-amino-propoxy) butyrophenone-, its optical isomers and non-toxic acid addition salts.
    Type: Grant
    Filed: January 5, 1979
    Date of Patent: February 24, 1981
    Assignee: C. M. Industries
    Inventor: Henri Demarne
  • Methods of treating cardiovascular diseases with phenyltetrazolyloxy propanolamines
    Patent number: 4252815
    Abstract: 1-Secondary-amino-3-(1-phenyl and substituted phenyl-5-tetrazolyloxy)-2-propanols are new compounds which are useful as cardiovascular agents having vasodilator, antiarrhythmic and .beta.-adrenergic blocking actions.
    Type: Grant
    Filed: August 15, 1979
    Date of Patent: February 24, 1981
    Assignee: Mead Johnson & Company
    Inventors: William E. Kreighbaum, William T. Comer
  • Insolubilized deoxyribonucleic acid (DNA)
    Patent number: 4251514
    Abstract: A method of detecting antibodies to native deoxyribonucleic acid (n-DNA), anti-nuclear antibodies, antibodies to non-histone containing protein, rheumatoid factors, antibodies to thyroglobulin, and an immunofluorescent assay for such detection is described.
    Type: Grant
    Filed: November 5, 1979
    Date of Patent: February 17, 1981
    Assignee: American Hospital Supply Corporation
    Inventor: Delfin F. Rippe
  • Production of antibody toward asbestos and immunoassay therewith
    Patent number: 4248854
    Abstract: The invention provides a reaction product of chrysotile asbestos with an antigenic serum protein, preferably albumin, that has particular utility as an antigen in producing antibody to asbestos. The reaction product of asbestos with an antigenic serum protein also can be used in a method for producing an antibody toward asbestos by immunizing a laboratory animal with the reaction product, of asbestos and a serum protein, allowing it to remain in the blood of the animal for a sufficient period of time and thereafter recovering antibody globulins from the laboratory animal.
    Type: Grant
    Filed: August 27, 1979
    Date of Patent: February 3, 1981
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: Herbert R. Lukens, Jr.
  • Arterial wall cholesterol ester reducing cyclopropanyl-bearing amides
    Patent number: 4248893
    Abstract: Cyclopropanyl-group-bearing-amides, eg N-[1-(benzyl)-2-(phenyl)ethyl]-cis-2-octyl-cyclopropanoctanamide and N-(.alpha.-methyl-benzyl)-(cis)-2-octyl-cyclopropanoctanamide, are useful as pharmaceutical agents and are obtainable, eg by reacting a mixed anhydride of a cyclopropanyl-group bearing-long chain carboxylic acid with an appropriate amino compound.
    Type: Grant
    Filed: February 5, 1979
    Date of Patent: February 3, 1981
    Assignee: Sandoz, Inc.
    Inventors: Faizulla G. Kathawala, John G. Heider
  • Method of preparing C3-sensitized erythrocytes
    Patent number: 4247536
    Abstract: A set of four cell suspensions containing erythrocytes monospecifically sensitized with IgG, IgM, C3, and C4. The suspensions provide control cells to determine the purity and strength of the antibodies to these immunoglobins or complement components contained in antisera used for clinical testing. Strict control of the pH, temperature, and EDTA concentration of a solution to which blood is added allows for the elective production of C3- or C4-sensitized cells. Selecting a serum with IgG or IgM antibodies and inactivating undesired proteins permits the production IgG- or IgM-sensitized cells. The resultant cells have agglutination reaction strengths of about 2-4+. Erythrocytes from humans or other animals may undergo the monospecific sensitization. Other human proteins, such as IgA or C5, and plasma proteins from other animals may similarly be attached monospecifically to red blood cells.
    Type: Grant
    Filed: March 20, 1978
    Date of Patent: January 27, 1981
    Assignee: American Hospital Supply Corporation
    Inventors: Mitchell J. Fruitstone, Jose Carro, Betty G. Pixton
  • Lowering the concentration of plasma triglycerides
    Patent number: 4246277
    Abstract: The present invention relates to a method of lowering the concentration of plasma triglycerides of a subject in need thereof, which comprises administering an effective but non toxic amount of each isomer or a mixture thereof of compound ##STR1## or pharmaceutically acceptable addition salt of said amine formed with an acid.
    Type: Grant
    Filed: June 22, 1979
    Date of Patent: January 20, 1981
    Assignee: Albert Rolland S.A.
    Inventor: Pierre Bessin
  • Cosmetic degreasing and matting composition
    Patent number: 4246257
    Abstract: Skin treatment product for greasy or oily skin comprising an unpigmented oil-in-water or water-in-oil emulsion having dispersed therein 3 to 10% by weight of spherical polymer or copolymer particles having an average size of 5 to 15 microns. The polymer or copolymer particles are cross-linked polystyrene, polymethylmethacrylate or polyethylene microspheres. The oil of the emulsion is a volatile organic liquid in the amount of 1 to 30% of the weight of the emulsion and may be a silicone or silicon glycol.
    Type: Grant
    Filed: February 2, 1979
    Date of Patent: January 20, 1981
    Assignee: Beecham Group Limited
    Inventors: Thomas J. Elliott, David Ford
  • Immunoassay employing an enzyme label
    Patent number: 4243749
    Abstract: According to the present invention there is provided a sensitive quantitative assay for the determination of a hapten "X" which comprises: preparing a conjugate of the hapten X which conjugate is adapted to ellicit antibody formation, and injecting a mammal with said conjugate, resulting in a specific antibody against the said hapten, "anti-X"; preparing a conjugate of the hapten X and of another entity Y, which is either another hapten or a larger molecule, injecting a mammal with the entity Y if it is a larger molecule, or with a conjugate thereof if it is a small molecule which does not by itself ellicit antibody formation, so as to form anti-Y antibodies, preparing a conjugate of a suitable enzyme and the antibody against Y, i.e. an (enzyme)-(anti-Y)-conjugate; adsorbing the antibodies against X, i.e.
    Type: Grant
    Filed: March 16, 1978
    Date of Patent: January 6, 1981
    Assignees: Miles Yeda Ltd., Hypolab S.A.
    Inventors: Dora Sadeh, Charles S. Hexter
  • Dysmenorrhea treatment
    Patent number: 4241087
    Abstract: Amidinoureas of the formula: ##STR1## when administered to females who suffer dysmenorrhea relieve discomfort and pain and prevent damage caused by abnormal uterine muscle spasms incident to dysmenorrhea.
    Type: Grant
    Filed: April 2, 1979
    Date of Patent: December 23, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: Ghulam N. Mir, Jacqueline B. Krebs, William L. Studt
  • Complement fixation test employing reactants in a disposable package
    Patent number: 4239746
    Abstract: A ready-for-use rapid test package for carrying out serological investigations in which at least two of the following reactants:(1) patients serum;(2) erythrocytes;(3) amboceptors specific for the erythrocytes;(4) complement and(5) a reactant selected from the groupconsisting of antigen and antibodies not belonging to reactant class (3)are reacted with each other, the package containing at least two of the reactants in a solid and preserved form, in quantities suitably adjusted to each other, to carry out the test.The package provides the clinician or serological laboratory with reliable and simple means of carrying out the complement binding reaction without the complicated adjustments of the activities of the different reactants.
    Type: Grant
    Filed: April 13, 1979
    Date of Patent: December 16, 1980
    Assignee: Dezso Istvan Bartos
    Inventors: Dezso I. Bartos, Jerzy Rybczynski
  • Oat flour-oil gel cosmetic creme
    Patent number: 4238509
    Abstract: A cosmetic creme is formed by dispersing ultra fine oat flour in a cosmetic oil gel. The creme is easily spreadable to form a thin non-greasy coating on the skin when it contains from 40 to 60% by weight of the oat flour.
    Type: Grant
    Filed: February 5, 1979
    Date of Patent: December 9, 1980
    Assignee: Alberto-Culver Company
    Inventors: Gregory S. Evans, Corinne R. Jembrzycki
  • Agglutination of lymphocytes for diagnosing malignant tumor
    Patent number: 4238474
    Abstract: The invention provides a process for the specific agglutination of sensitized lymphocytes by adding to a dispersion of at least 10.sup.5 ml.sup.-1 lymphocytes in a physiologically compatible medium at least 0.01 mg/ml of poly-lysine or at least 0.1 .mu.g/ml of poly-ornithine and keeping the mixture at a temperature of from 20.degree. to 40.degree. C. for 20 minutes. The product is used for the diagnosis of malignant diseases.
    Type: Grant
    Filed: March 28, 1978
    Date of Patent: December 9, 1980
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Wolfgang Ax, Hartwig W. Bauer, Sabine Schottler
  • Antibodies against creatinekinase-M8 and process for the production thereof
    Patent number: 4237044
    Abstract: Antibodies against the M subunit of CK isoenzymes having a molecular weight between about 130,000 and 210,000, and inhibiting the enzymatic activity of the M subunit, optionally also in the presence of CK substrates, without inactivating the enzymatic activity of the B subunit of any CK-MB which may be present, are described. A process for the production of these antibodies comprises inoculating animals with activated CK-MM and recovering the antibodies in a conventional manner.
    Type: Grant
    Filed: May 8, 1979
    Date of Patent: December 2, 1980
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Uwe Wurzburg, Norbert Hennrich, Hans-Dieter Orth, Hermann Lang
  • Treatment of carbohydrate metabolism disorders
    Patent number: 4237165
    Abstract: Pharmaceutical compositions containing a compound selected from 1-(3-trifluoromethyl phenyl)-2-(.beta.-hydroxyethyl)aminopropane and 1-(3-trifluoromethyl phenyl)-2-(.beta.-benzoyloxy ethyl)-aminopropane and physiologically acceptable acid addition salts thereof, useful in the treatment of metabolism disorders.
    Type: Grant
    Filed: June 4, 1976
    Date of Patent: December 2, 1980
    Assignee: Science Union et Cie
    Inventor: Jacques Duhault
  • Staining with nitrido-bridged osmium or ruthenium compounds
    Patent number: 4235868
    Abstract: This invention relates to the staining of cells, and in particular provides a novel reagent for the detection, for example, of DNA (deoxyribonucleic acid) and polysaccharides by electron microscopy.A reagent for staining cells in accordance with the present invention comprises an aqueous solution of a nitrido-bridged complex of osmium or ruthenium and having the general formula:[M.sub.2.sup.IV N(NH.sub.3).sub.8-2x X.sub.5-y (H.sub.2 O).sub.x ]Y.sub.y.where M represents either Os or Ru, X and Y are the same or different anions selected from nitrate, halide and pseudohalide, x is 0 or 1 and y is 2 or 3.
    Type: Grant
    Filed: February 12, 1979
    Date of Patent: November 25, 1980
    Assignee: Johnson, Matthey & Co., Limited
    Inventors: Michael J. Cleare, Paul C. Hydes