Patents Examined by Ba K. Trinh
  • Synthesis of taxol, taxol analogs and their intermediates with variable A-ring side chain structures and compositions thereof
    Patent number: 6307088
    Abstract: The present invention concerns alkyl esters of &bgr;-amino acid derivatives which are useful in the synthesis of taxol and analogs.
    Type: Grant
    Filed: April 11, 2000
    Date of Patent: October 23, 2001
    Assignees: NaPro BioTherapeutics, Inc., Bryn Mawr College
    Inventors: Charles S. Swindell, Nancy Krauss
  • Artemisinin derivatives, method for the preparation thereof and pharmaceutical compositions containing the same
    Patent number: 6307068
    Abstract: The invention relates to compound of the general formula (I): R—O—A  (I) wherein: R represents the radical of formula (II): A is as defined in the description, and medicinal products containing the same which are useful in treating or in preventing cancer.
    Type: Grant
    Filed: December 14, 2000
    Date of Patent: October 23, 2001
    Assignee: Adir et Compagnie
    Inventors: Ying Li, Feng Shan, Jin Ming Wu, Guangshao Wu, Jian Ding, Jianxian Han, Ghanem Atassi, Pierre Renard
  • Sesterterpene derivatives exhibiting antifungal activities
    Patent number: 6303797
    Abstract: A compound represented by the formula [I] wherein Y1 represents an oxygen atom, or a group represented by NH, O—CO, O—SO2, O—CO—NH, O—CS—NH, NH—CO, NH—SO2, NH—CO—NH or NH—CS—NH, R1 represents an alkyl group, an alkenyl group, an alkynyl group, an aryl group, an aralkyl group, an arylalkenyl group, an arylalkynyl group, a cycloalkyl group, a cycloalkylalkyl group, an alkylcarbonyl group, an alkoxycarbonyl group, an arylcarbonyl group or a heterocyclic group, each optionally having a substituent, or a pharmacologically acceptable salt or ester thereof. The compound shows an excellent antifungal activity on fungi on which existing antifungal agents cannot sufficiently display their effects, and thus is useful as an antifungal agent.
    Type: Grant
    Filed: January 30, 2001
    Date of Patent: October 16, 2001
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Atsushi Hirano, Eiji Sugiyama, Hisao Kondo, Hiroyuki Suda, Hidenori Ogawa, Katsuhisa Kojiri
  • &bgr;-diketone compounds &bgr;-diketone compounds coordinated to metal, method of organic synthesis with these, and catalyst
    Patent number: 6303796
    Abstract: The present invention provides a novel &bgr;-diketone compound represented by formula (3): [wherein X represents (CH2)n; n represents an integer of 2-20; and the CH2 of X may be replaced by an oxygen atom, a hetero ring, or an aromatic ring, but oxygen atoms are not sequentially arranged in X], and a metal-coordinated &bgr;-diketone compound in which a metal is coordinated with the &bgr;-diketone compound. The compound of the present invention can be easily synthesized, and serves as a catalyst for asymmetric synthesis which can provide high asymmetric yield and chemical yield.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: October 16, 2001
    Assignee: Chisso Corporation
    Inventors: Masahiko Yamaguchi, Masayuki Sato
  • Method for producing propene oxide
    Patent number: 6303800
    Abstract: Process for preparing propene oxide, in which a mixture of propene and oxygen or an oxygen-containing gas is reacted at a temperature in the range from 150 to 500° C., in the presence or absence of a catalyst, in a reactor, wherein all or part of the interior of the reactor is lined with inert materials. The inert material used is at least one of the materials of the following group: one or more noble metals of transition group VIII of the Periodic Table, in particular gold, titanium and tantalum, glass, enamel, quartz, ceramic and Teflon. The selectivity to propene oxide is >60%.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: October 16, 2001
    Assignee: Aventis Research & Technologies GmbH & Co KG
    Inventors: Uwe Dingerdissen, Holger Orzesek, Wilhelm Maier, Rolf Schulz
  • Benzamides with tetrahydrofuranyloxy substitutents as phosphodiesterase 4 inhibitors
    Patent number: 6303789
    Abstract: Compounds of the formula I in which R1, R2, R3, R4, R5, m and n have the meanings cited in the description, are novel effective PDE-inhibitors.
    Type: Grant
    Filed: December 7, 2000
    Date of Patent: October 16, 2001
    Assignee: Byk Gulden Lomberg Chemische Fabrik GmbH
    Inventor: Thomas Bär
  • Process of manufacturing ethylene oxide
    Patent number: 6300507
    Abstract: In manufacturing ethylene oxide by catalytic vapor phase oxidation of ethylene, a process comprising adding, as liquid, an organic halide as a reaction inhibitor into the ethylene raw material gas flow is provided. According to this process, ethylene oxide can be manufactured stably and in high selectivity.
    Type: Grant
    Filed: December 27, 2000
    Date of Patent: October 9, 2001
    Assignee: Nippon Shukubai Co Ltd
    Inventors: Yoshihisa Oka, Kenichi Takematsu
  • Process useful to produce vitamin D analogs
    Patent number: 6294688
    Abstract: A stereospecific method for accomplishing the below reaction: results in the compound of formula 2 having the same stereochemistry at both carbon 1 and carbon 3 as that in the compound of formula 1. Thus, if carbon 3 is in the R-configuration in the compound of formula 1, then carbon 3 will be in the R-configuration in the compound of resulting formula 2. In the above process, R1 is C1-C6 alkyl that can be straight-chain or branched. The process functions using a fluorinated alcohol having a pKa less than about 9, in the presence of a palladium catalyst. The compounds of formula 1, as well as novel intermediates in this process, are useful in manufacturing vitamin D analogs.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: September 25, 2001
    Assignee: Hoffman-La Roche Inc.
    Inventors: Andrzej Robert Daniewski, Marek Michal Kabat, Masami Okabe, Roumen Nikolaev Radinov
  • Hydrophobic taxane derivatives
    Patent number: 6291690
    Abstract: This invention provides a taxane derivative of the formula: wherein a hydrophobic organic moiety is attached to a taxane. R and R1 is each indepently H or a hydrophobic organic moiety, as long as at least one of R and R1 is not H. Attachment of a hydrophobic organic moiety to the taxane so as to obtain a taxane derivative generally stabilizes the association of the derivative with a lipid, including a liposomal lipid, carrier in the plasma of animals to which the derivative-carrier association is administered. Also provided herein is a composition containing the taxane derivative and a pharmaceutically acceptable medium; desirably, the medium also contains a lipid carrier, and the derivative is associated with the carrier. Further provided herein is a method of administering taxane derivatives to animals, for example, animals afflicted with cancers.
    Type: Grant
    Filed: May 9, 2000
    Date of Patent: September 18, 2001
    Assignee: The Liposome Company, Inc.
    Inventors: Eric Mayhew, J. Craig Franklin, Suresh Bhatia, Paul A. Harmon, Andrew S. Janoff
  • 9-desoxobaccatin III and analogs thereof
    Patent number: 6291692
    Abstract: Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C9 substituent other than keto in which the C9 keto substituent of taxol, a taxol analog, baccatin III or 10-desacetyl baccatin III is selectively reduced to the corresponding hydroxy group.
    Type: Grant
    Filed: October 12, 2000
    Date of Patent: September 18, 2001
    Assignee: Florida State University
    Inventors: Robert A. Holton, Carmen Somoza, Yukio Suzuki, Mitsuru Shindo
  • Use of efomycins
    Patent number: 6291515
    Abstract: The present invention relates to the use of known efomycins and elaiophylins for the treatment of autoimmune disorders, to new natural substances efomycins M and T, and processes for their preparation; in particular to their use as medicaments in psoriasis therapy.
    Type: Grant
    Filed: March 12, 1999
    Date of Patent: September 18, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst-Peter Antonicek, Erwin Bischoff, Daniel Gondol, Oliver Gutbrod, Thomas Krahn, Maria-Luisa Rodriguez, Helmuth Schütz
  • Process for selective derivatization of taxanes
    Patent number: 6291691
    Abstract: Processes for the preparation of taxol and other taxanes through selective derivatization of the C(7) and C(10) hydroxyl groups of 10-DAB, particularly a novel process using a new strategy in which the C(10) hydroxyl group is protected or derivatized prior to the C(7) hydroxyl group; and the provision of C(7) and C(10) derivatized 10-DAB compounds.
    Type: Grant
    Filed: June 7, 2000
    Date of Patent: September 18, 2001
    Assignee: Florida State University
    Inventors: Robert A. Holton, Zhuming Zhang, Paul A. Clarke
  • Process for manufacturing an optically active (S)-3,4-epoxybutyric acid salt
    Patent number: 6284902
    Abstract: This invention relates to a process for manufacturing an optically active (S)-3,4-epoxybutyric acid salt and more particularly, to a method for manufacturing (S)-3,4-epoxybutyric acid salt expressed by the following formula 1, wherein an optically active (S)-3-hydroxybutyrolactone is employed to undergo an economical ring-opening reaction and epoxvdation so that its chiral center is maintained in an original form, Wherein, R1 represents alkali metal atom, alkaline earth metal atom, alkylamine group or quarternary amine group.
    Type: Grant
    Filed: February 21, 2001
    Date of Patent: September 4, 2001
    Assignee: Samsung Fine Chemicals Co., Ltd.
    Inventors: Ho Sung Yu, Jae Young Bae, Yik Haeng Cho, Young Mi Park, Il Suk Byun
  • Hydrolysable and polymerizable oxetane silanes
    Patent number: 6284898
    Abstract: Polymerizable and hydrolysable oxetane silanes and in particular silicic acid condensates which can be prepared therefrom are described, which exhibit only a low volume shrinkage on polymerization and produce polymers with high mechanical strength and therefore can be used above all as dental material or constituent thereof.
    Type: Grant
    Filed: June 9, 2000
    Date of Patent: September 4, 2001
    Assignee: Ivoclar AG
    Inventors: Norbert Moszner, Thomas Voelkel, Sabine Stein, Volker Rheinberger
  • Simple and efficient hydrazinolysis of C-10 and C-13 ester functionalities of taxanes to obtain 10-DAB III
    Patent number: 6281368
    Abstract: A process for producing 10-deacetyl baccatin III from an acidic solution containing a spectrum of taxanes, comprising contacting the acidic solution containing the spectrum of taxanes with a hydrazine hydrate, thereby to convert into 10-deacetyl baccatin III some taxanes in said solution that are not 10-deacetyl baccatin III.
    Type: Grant
    Filed: March 16, 2000
    Date of Patent: August 28, 2001
    Assignee: NaPro BioTherapeutics, Inc.
    Inventors: James D. McChesney, Madhavi C. Chander, Douglas L. Rodenburg
  • Silver catalyst for production of ethylene oxide, method for production thereof, and method for production of ethylene oxide
    Patent number: 6281370
    Abstract: A catalyst for the production of ethylene oxide is formed by causing a carrier having &agr;-alumina as a main component thereof to incorporate therein silica and a metal or a compound of at least one element selected from the elements of the groups Ib and IIb in the periodic table of the elements such as, for example, silver oxide and depositing silver on the carrier. The carrier is obtained by mixing at least &agr;-alumina, a silicon compound, an organic binder, and a compound of at least one element selected from the elements of the groups Ib and IIb in the periodical table of the elements and then calcining the resultant mixture at a temperature in the range of 1,000°-1,800° C.
    Type: Grant
    Filed: November 2, 2000
    Date of Patent: August 28, 2001
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Masahide Shima, Hitoshi Takada
  • Epoxidation catalyst and process
    Patent number: 6281369
    Abstract: The stability of a noble metal/titanium zeolite catalyst is improved by elevated temperature calcination with an oxygen containing gas; the catalyst is useful in epoxidation involving the reaction of olefin, oxygen and hydrogen.
    Type: Grant
    Filed: December 7, 2000
    Date of Patent: August 28, 2001
    Assignee: Arco Chemical Technology, L.P.
    Inventors: Bernard Cooker, Jennifer D. Jewson, Wilson H. Onimus
  • Process for refining epoxy compounds, and heat-stable epoxy compounds prepared thereby
    Patent number: 6278003
    Abstract: A process for refining epoxy compounds, wherein the process comprises: (a) providing a washed and dried organic phase comprising at least one epoxide compound; (b) contacting the organic phase with at least one basic solid selected from the group consisting of aluminum oxides, aluminum hydroxides and alkali metal silicates; and (c) separating the organic phase and the at least one basic solid, is disclosed.
    Type: Grant
    Filed: June 27, 2000
    Date of Patent: August 21, 2001
    Assignee: Cognis Deutschland GmbH
    Inventor: Ralf Bohlander
  • Process for the preparation of chiral lactones
    Patent number: 6277997
    Abstract: The present invention relates to a process for the preparation of compounds of formula I wherein R1 and R2 are as defined in the specification as well as to the novel intermediates obtained by said process.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: August 21, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michelangelo Scalone, Ulrich Zutter
  • Process for the preparation of (2r,3s)-3-amino-1,2-oxirane
    Patent number: 6278002
    Abstract: A process for producing (2R,3S)-3-amino-4-phenylbutane-1,2-epoxide compounds which comprises treating a (2S,3S)-3-amino-1-halo-2-hydroxy-4-phenylbutane compound or a (2S,3S)-3-amino-4-phenylbutane-1,2-epoxide with a carboxylic acid quaternary ammonium salt or a carboxylic acid metal salt a quaternary ammonium salt and a quaternary ammonium salt, to give a (2S,3S)-1-acyloxy-3-amino-2-hydroxy-4-phenylbutane compound, further treating the same with a sulfonic acid halide in the presence of an organic base to give a (2S,3S)-1-acyloxy-3-amino-2-sulfonyloxy-4-phenylbutane compound, furthermore treating said compound with an inorganic base.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: August 21, 2001
    Assignee: Kaneka Corporation
    Inventors: Kazumi Okuro, Kenji Inoue