Patents Examined by Ba K. Trinh
  • Direct epoxidation process using pre-treated titanium zeolite
    Patent number: 6417378
    Abstract: The invention is a process for epoxidizing an olefin with hydrogen and oxygen in the presence of a catalyst comprising a noble metal and pretreated titanium zeolite. Titanium zeolite pretreatment comprises contacting the titanium zeolite with a leaching agent prior to use in epoxidation. Surprisingly, the process using the pretreated titanium zeolite shows decreased ring-opening to unwanted glycols and glycol ethers.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: July 9, 2002
    Assignee: Arco Chemical Technology, L.P.
    Inventor: Dan Hancu
  • Epoxidation of ricinic compounds using a phase-transfer catalyst
    Patent number: 6414168
    Abstract: Unsaturated or polyunsaturated, conjugated or nonconjugated hydrocarbons are reacted with an oxidizing agent including hydroperoxides and monopersulfate compounds in the presence of phase-transfer catalysts. Suitable hydrocarbons include ricinic compounds such as castor oil and dehydrated castor oil. The phase-transfer catalysts include novel tungsten peroxo complexes, such as quaternary ammonium tetrakis (diperoxotungsto) phosphates, and crown ethers. Other additives utilized include pH buffers and alkaline compounds including alkali metal and alkaline earth metal carbonates, and solvents.
    Type: Grant
    Filed: December 28, 1999
    Date of Patent: July 2, 2002
    Assignee: CasChem, Inc.
    Inventors: James V. Crivello, Srinivasan Chakrapani
  • Compounds having antitumor activity: process for their preparation and pharmaceutical compositions containing them
    Patent number: 6410590
    Abstract: The present invention relates to novel derivatives of Andrographolide, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The novel derivatives of Andrographolide have the general formula (I) The andrographolide derivatives represented by general formula (I) are useful for treating cancer, HSV, HIV, psoriasis, restonosis, atherosclerosis, other cardiovascular disorders, and can be used as antiviral, antimalarial, antibacterial, hepatoprotective, and immunomodulating agents and for treatment of other metabolic disorders.
    Type: Grant
    Filed: February 1, 2001
    Date of Patent: June 25, 2002
    Assignee: Dr. Reddy's Research Foundation
    Inventors: Srinivas Nanduri, Sriram Rajagopal, Sairam Pothukuchi, Sunilkumar Bhadramma Kochunarayana Pillai, Ranjan Chakrabarti
  • Family of Canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
    Patent number: 6410756
    Abstract: The present invention relates to a new taxane having the structure as in Formula I, and its analogs as depicted in Formula II and Formula III. The invention includes novel semi-synthetic and isolation methods for the preparation of these novel taxanes. Specifically, the present invention relates to the new taxane Canadensol isolated from plants of the Taxus genus in particular, Taxus canadensis. The present invention further relates to the use of these new taxanes as anticancer agents.
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: June 25, 2002
    Assignee: Institut National de la Recherche Scientifique
    Inventors: Lolita Zamir, Gaéton Caron, Yi Feng Zheng
  • Kinetic resolution of olefins
    Patent number: 6409769
    Abstract: A method for kinetically resolving a stereoisomer mixture of compounds using asymmetric epoxidation is provided. Compounds contain an olefin moiety providing one stereoisomer to be epoxidized at a higher rate than the other stereoisomer using a chiral ketone and an oxidizing agent.
    Type: Grant
    Filed: December 4, 2000
    Date of Patent: June 25, 2002
    Assignee: Colorado State University Research Foundation
    Inventor: Yian Shi
  • Baccatin derivatives and a process for producing the same
    Patent number: 6410757
    Abstract: The object of the invention is to develop baccatin derivatives useful for preparing taxoid compounds such as paclitaxel and a process for the producing the same. The invention provides baccatin derivatives represented by the general formula (I) as well as a process for producing baccatin derivatives represented by the general formula (I) above, which comprises allowing a baccatin represented by the general formula (II) to react with a &bgr;-ketoester in the absence of a catalyst or in the presence of a tin compound or an amine base, preferably under reduced pressure.
    Type: Grant
    Filed: February 7, 2000
    Date of Patent: June 25, 2002
    Assignees: Bio Research Corporation of Yokohama, Ensuiko Sugar Refining Co. Ltd.
    Inventors: Tadakatsu Mandai, Hiroshi Okumoto, Katsuyoshi Nakanishi, Koji Hara, Katsuhiko Mikuni, Kozo Hara
  • Substituted 4-benzoylpyrazoles
    Patent number: 6407268
    Abstract: 4-Benzoylpyrazoles of the formula I where: R1 and R2 are each hydrogen, mercapto, nitro, halogen, cyano, thiocyanato, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C2-C6-alkenyl, C2-C6-alkynyl, —OR10, —OCOR10, —OSO2R10, —S(O)nR10, —SO2OR10, —SO2NR3R10, —NR10SO2R10 or —NR10COR; Q is a pyrazole of the formula II,  which is attached in position 4 and, Substituted 4-benzoylpyralozoles.
    Type: Grant
    Filed: June 6, 2000
    Date of Patent: June 18, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Stefan Engel, Ernst Baumann, Wolfgang von Deyn, Regina Luise Hill, Uwe Kardorff, Guido Mayer, Martina Otten, Joachim Rheinheimer, Oliver Wagner, Matthias Witschel, Ulf Misslitz, Helmut Walter
  • Method of treating atherosclerosis or restenosis using microtubule stabilizing agent
    Patent number: 6403635
    Abstract: The present invention is a method of preventing or reducing atherosclerosis or restenosis, and a pharmaceutical preparation used therefor. In particular, it is a method of preventing or reducing atherosclerosis or restenosis after arterial injury by treatment with a low dose of a microtubule stabilizing agent such as taxol or a water soluble taxol derivative. The low dose used in the present invention prevents artery blockage while minimizing any negative side effects associated with the drug.
    Type: Grant
    Filed: August 17, 2000
    Date of Patent: June 11, 2002
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: James L. Kinsella, Steven J. Sollot
  • Direct epoxidation process using carbonate modifiers
    Patent number: 6399794
    Abstract: The invention is a process for epoxidizing an olefin with hydrogen and oxygen in the presence of a modifier and a catalyst comprising a noble metal and titanium zeolite. The modifier is (a) calcium carbonate in the presence of carbon dioxide or (b) ammonium bicarbonate. The process results in increased catalyst activity, selectivity to epoxide, and increased catalyst life.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: June 4, 2002
    Assignee: Arco Chemical Technology, L.P.
    Inventor: Dan Hancu
  • Paclitaxel derivatives for the treatment of cancer
    Patent number: 6395771
    Abstract: The invention provides novel paclitaxel derivatives obtained by effecting modifications at C2′, C3′ and/or C7 positions of paclitaxel, said derivatives being useful in inhibiting the growth of cancer of lung, breast, ovary, cervix or leukemia, and pharmaceutical compositions comprising such derivatives.
    Type: Grant
    Filed: May 31, 2000
    Date of Patent: May 28, 2002
    Assignee: Dabur Research Foundation
    Inventors: Sunder Ramadoss, Anand Vardhan, Manu Jaggi, Arvind Kumar Sharma
  • Recovery and purification of 3,4-epoxy-1-butene
    Patent number: 6395913
    Abstract: Disclosed is a method of recovering and purifying 3,4-epoxy-1-butene (epoxybutene) from a reaction product gas, obtained by the vapor phase catalytic partial oxidation of 1,3-butadiene with oxygen over a silver catalyst. The recovery and purification comprises absorption of the epoxybutene into a water-miscible solvent followed by separation of the absorbed epoxybutene from the absorbent by extraction into a water-immiscible solvent. A method of recovering and purifying epoxybutene from the extraction solvent and other reaction by-products by a novel combination of distillation and decantation steps also is disclosed.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: May 28, 2002
    Assignee: Eastman Chemical Company
    Inventors: Scott Donald Barnicki, Jerome Leonard Stavinoha, Jr., Robert Sterling Kline, Jackie Lee Hamilton
  • Anti-drug resistant strain agents and antichlamydia agents
    Patent number: 6395773
    Abstract: In order to provide antibacterial agents for drug-resistant bacteria and anti-Chlamydia agents, the furanonaphthoquinone derivative represented by the following formula (1): wherein each R may be the same or different, representing any one of the following (a) to (e): (wherein R′ is a hydrogen atom, alkyl group, hydroxyalkyl group, or alkoxyalkyl group), or two mutually adjacent Rs may be bonded via an oxygen atom to form a heterocyclic ring is used as the effective component.
    Type: Grant
    Filed: July 23, 2001
    Date of Patent: May 28, 2002
    Assignee: Japan Science and Technology Corporation
    Inventors: Keiichi Hirai, Kumiko Nagata, Junko Koyama, Toshio Kishimoto
  • Butenyl substituted &bgr;-lactams
    Patent number: 6395895
    Abstract: Taxane derivatives having a 3′ butenyl substituted C13 side chain.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: May 28, 2002
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai, Hossain Nadizadeh
  • Substituted benzopyran derivatives and their use as anticonvulsants
    Patent number: 6395909
    Abstract: This invention relates to 6-(hydroxyalkylcarbonyl) benzopyrans and their use as anticonvulsants.
    Type: Grant
    Filed: December 19, 2000
    Date of Patent: May 28, 2002
    Inventors: David Bell, Peter J. Cox, Mervyn Thompson, Gillian Turner
  • Enediyne derivatives
    Patent number: 6391916
    Abstract: Novel C3-substituted cyclodeca-1,5-diynes can be prepared through novel synthetic procedures using starting (E)-C3-substituted-4-(aryl- or heteroarylmethylidene)cyclodeca-1,5-diynes reagents. Both the C3-substituted cyclodeca-1,5-diyn-3-enes and the starting reagents have improved thermal stability compared to unsubstituted counterparts.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: May 21, 2002
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Wei-Min Dai, Anxin Wu, Yuk Ha Lee, Wataru Hamaguchi, Sei-ichi Nishimoto, Ling Zhou, Atsushi Ishii
  • Process for making (2S, 3S, 5S) oxetanone derivatives
    Patent number: 6392061
    Abstract: This invention relates to novel processes for making (2S, 3S, 5S) oxetanone derivative lipase inhibitor compounds and intermediates therefor, which processes for producing such derivatives that are useful as lipase inhibitors are capable of being scaled to commercial quantities. Further the invention relates to processes for producing salts and for producing pharmaceutical compositions compounds comprising at least one such oxetanone derivative or salt, as well as methods for using such compounds and compositions for inhibiting lipases.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: May 21, 2002
    Assignee: Zpro Chemical, Inc.
    Inventor: John Jason Gentry Mullins
  • Hydrolysis-promoting hydrophobic taxane derivatives
    Patent number: 6392063
    Abstract: Provided herein is a taxane having a hydrocarbon attached at the 2′ and/or 7 positions, the hydrocarbon's alpha position being occupied by a “hydrolysis-promoting group” (“HPG”). In one embodiment, the hydrolysis promoting group is stereospecifically attached to the a-carbon of the hydrophobic taxane. The Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers or inflammatory diseases.
    Type: Grant
    Filed: July 19, 2000
    Date of Patent: May 21, 2002
    Assignee: The Liposome Company, Inc.
    Inventors: Shaukat Ali, J. Craig Franklin, Imran Ahmad, Eric Mayhew, Soumendu Bhattacharya, Gil Koehane, Andrew S. Janoff
  • Method of synthesizing glycidyl ether compounds in the absence of water and organic solvents
    Patent number: 6392064
    Abstract: The present invention relates to a method of synthesizing glycidyl ether compounds without the addition of solvent. In particular, the present invention provides the improved preparation of the glycidyl ethers by using fatty alcohols with epichlorohydrin in the presence of alkali metal hydroxide and phase-transfer catalysts in the appropriate molar ratios of them without water and organic solvents.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: May 21, 2002
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Byung Min Lee, Ho-Cheol Kang, Jong-mok Park, Jung Ho Yoon
  • Process for preparing ascorbic acid-2-monophosphate salt
    Patent number: 6388098
    Abstract: A process for preparing a high-purity ascorbic acid-2-monophosphate salt in a convenient manner and in a high yield, comprising hydrolyzing an ascorbic acid-2-polyphosphate or a salt thereof in the presence of magnesium ion at a pH of 7 or more.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: May 14, 2002
    Assignee: Showa Denko Kabushiki Kaisha
    Inventors: Kazuhiro Ohmori, Yuji Kobayashi, Tomokazu Soda
  • 8-Acetylarteminolide and process for preparing same
    Patent number: 6387948
    Abstract: 8-Acetylarteminolide of the formula (I) having inhibitory activities against farnesyl-protein transferase(FPTase), a progression of the cell cycle and angiogenesis may be useful for the prevention and treatment of various cancers and angiogenesis-related diseases:
    Type: Grant
    Filed: June 17, 2000
    Date of Patent: May 14, 2002
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Byoung-Mog Kwon, Kwang-Hee Son, Ha-Won Jeong, Seung-Ho Lee, Mi-Young Han, Hyun-Mi Kang, Hyae-Kyeong Kim, Soo-Ik Chang