Patents Examined by Ba K. Trinh
  • Selective epoxidation of conjugated diolefins
    Patent number: 6388106
    Abstract: Disclosed is a process for the preparation of mono-epoxides of certain diolefins wherein a conjugated diolefin, or polyolefin, that contains allylic carbon-hydrogen bonds, is contacted with molecular oxygen in the presence of a modified silver catalyst.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: May 14, 2002
    Assignee: Eastman Chemical Company
    Inventors: John Robert Monnier, Kimberly Thornton Peters
  • Methods for treating pathological conditions of abnormal cell proliferation
    Patent number: 6387946
    Abstract: New taxoids of general formula (I): their preparation and pharmaceutical compositions containing them. The new products of general formula (I) in which Z represents a radical of general formula (II): display noteworthy antitumour and antileukaemic properties.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: May 14, 2002
    Assignee: Aventis Pharma S.A.
    Inventors: Hervé Bouchard, Jean-Dominique Bourzat, Alain Commerçon
  • Taxane prodrugs
    Patent number: 6380405
    Abstract: The present invention generally provides taxane prodrugs comprising at least one taxane joined by hydrolyzable bond(s) to one or more polyethylene glycol oligomer(s) selected from the group consisting of a straight or branched polyethylene glycol oligomer having from 1 to 25 polyethylene glycol units and optionally comprising a salt-forming moiety. The polyethylene glycol oligomer preferably comprises a salt-forming moiety, which is preferably selected from the group consisting of ammonium and carboxylate.
    Type: Grant
    Filed: December 31, 1999
    Date of Patent: April 30, 2002
    Assignee: Nobex Corporation
    Inventors: Nnochiri Ekwuribe, Gary S. Bartley, Christopher H. Price
  • Homogeneous epoxidation catalyst
    Patent number: 6380406
    Abstract: A process for forming an olefin epoxidation catalyst is described. The process comprises reacting a tert-alkyl trihydroxysilane with a titanium complex such that the ratio of Si:Ti is 7. The catalyst is very active and selective in olefin epoxidation.
    Type: Grant
    Filed: August 4, 2000
    Date of Patent: April 30, 2002
    Assignee: Arco Chemical Technology, L.P.
    Inventor: Kevin M. Carroll
  • Direct epoxidation process
    Patent number: 6376686
    Abstract: The invention is an olefin epoxidation process that comprises reacting olefin, oxygen, and hydrogen in a liquid medium in the presence of an epoxidation catalyst in a reactor system comprising a tank, a tube, a plurality of impellers, and means for inhibiting flow. The reactor system facilitates transfer of the hydrogen and oxygen to the liquid medium.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: April 23, 2002
    Assignee: ARCO Chemical Technology, L.P.
    Inventor: Prakash G. Balan
  • Process for operating the epoxidation of ethylene
    Patent number: 6372925
    Abstract: There is provided a process for the vapor phase oxidation of ethylene to ethylene oxide in the presence of a supported highly selective silver-based catalyst, the process comprising operating fresh catalyst for an initial operation phase, then operating at a further operation phase when the catalyst has reached an advanced aged defined by a cumulative ethylene oxide production exceeding 1.5 kT EO per m3 of catalyst. In the further operation phase the composition of the reaction mixture is changed to contain from 1.1 to 4 times the concentration of ethylene used in the initial operation phase and the corresponding optimised and safe concentration of oxygen.
    Type: Grant
    Filed: December 12, 2000
    Date of Patent: April 16, 2002
    Assignee: Shell Oil Company
    Inventors: Wayne Errol Evans, Peter Ingraham Chipman
  • Process for the production of (?) 3,4-divanillyl tetrahydrofuran
    Patent number: 6372922
    Abstract: The present invention relates to a process for the production of (−)3,4-divanillyl tetrahydrofiran of formula (2) which comprises (a) isolating) (−) secoisolariciresinol of formula (1) from the heartwood and roots of Taxus wallichiana by an improved process which consists of partitioning of the alcoholic extract of the heartwood and roots of T. wallichiana between water and chlorinated solvent, (b) extracting the chlorinated solvent extract with alkali and (c) isolating (−) secoisolariciresinol from the alkali extract upon neutralization with mineral acid and extracting with organic solvent and (d) crystallizing it from suitable organic solvent, (e) dissolving the isolated (−) secoisolariciresinol in suitable organic solvent and (f) reacting with triphenyl phosphine halide at 0-80° C. for 1-10 hours and (g) isolating (−) 3,4-divanillyl tetrahydrofuran by column chromatography.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: April 16, 2002
    Assignee: Council of Scientific and Industrial Research
    Inventors: Sunil Kumar Chattopadhyay, Sachin Srivastava, Vinayak Tripathi
  • Methods of treating cell lines expressing multidrug resistance P-glycoprotein
    Patent number: 6372780
    Abstract: Now taxoids of general formula (I) their preparation and pharmaceutical compositions containing them. The new products of general formula (I) in which Z represents a radical of general formula (II): display noteworthy antitumor and antileukaemic properties.
    Type: Grant
    Filed: January 3, 2001
    Date of Patent: April 16, 2002
    Assignee: Aventis Pharma S.A.
    Inventors: Hervé Bouchard, Jean-Dominique Bourzat, Alain Commerçon
  • C13 amido substituted taxane derivatives and pharmaceutical compositions containing them
    Patent number: 6369244
    Abstract: Taxane derivatives having an amino substituted C13 side chain.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: April 9, 2002
    Assignee: Florida State University
    Inventors: Robert A. Holton, Hossain Nadizadeh, Kasthuri Rengan, Chunlin Tao
  • Substituted tetrahydrofuran analogs of prostaglandins as ocular hypotensives
    Patent number: 6369102
    Abstract: Substituted tetrahydrofuran analogs of prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.
    Type: Grant
    Filed: March 6, 2001
    Date of Patent: April 9, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventor: Robert D. Selliah
  • Methods for the preparation of taxanes using oxazolidine intermediates
    Patent number: 6365750
    Abstract: Novel oxazolidines finding utility as intermediates in the preparation of C-13 acyloxy sidechain-bearing taxanes such as paclitaxel and analogs thereof. The present invention also relates to novel methods of coupling the oxazolidines to form the aforementioned taxanes, and to methods of preparing the oxazolidines.
    Type: Grant
    Filed: May 20, 1999
    Date of Patent: April 2, 2002
    Assignee: Bristol Myers Squibb Comp.
    Inventors: John K. Thottathil, Ivan D. Trifunovich
  • Process for preparing alkylene oxide
    Patent number: 6365761
    Abstract: Process for the preparation of alkylene oxide, which process comprises passing a feed comprising an organic hydroperoxide and alkene through a bank of at least two serially connected reactors all containing a bed of heterogeneous epoxidation catalyst particles and operated in a cyclic mode, in which process: (a) the first reactor of the cyclically operated bank is put in a position further down this bank, when the activity of the epoxidation catalyst contained therein has decreased to an undesirably low level; (b) in this position the catalyst with decreased activity is contacted with the effluent from the reactor in the preceding position at a temperature which is at least 5° C. higher than the final temperature at which the catalyst was in use in the first position of the bank and for sufficient time to restore its activity to the desired level.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: April 2, 2002
    Assignee: Shell Oil Company
    Inventors: Willem Derks, Hendrik Dirkzwager, Alexander Jan Van Der Veen, Rutger Johannes Franciscus Wermeling
  • Process for the direct oxidation of olefins to olefin oxides
    Patent number: 6362349
    Abstract: A process for the direct oxidation of an olefin by oxygen to the corresponding olefin oxide in the presence of a reducing agent and a catalyst. The catalyst comprises a metal component, such as a transition metal oxide, dispersed on a metal ion-exchanged metallosilicates, such as a Group 1 or Group 2 ion-exchanged porous aluminosilicate. Selectivity to the olefin oxide is high and the catalyst is readily regenerated.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: March 26, 2002
    Assignee: The Dow Chemical Company
    Inventors: Alex Kuperman, Robert G. Bowman, Howard W. Clark, George E. Hartwell
  • C7 carbamoyloxy substituted taxanes
    Patent number: 6359154
    Abstract: Taxanes having a carbamoyloxy substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: March 19, 2002
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Methods for the synthesis of dioxoalkanoic acid compounds
    Patent number: 6355812
    Abstract: The invention relates to improved methods of producing aryl dioxoalkanoic acid compounds and derivatives useful as intermediates for diarylpyrrole therapeutic agents by the alcoholysis of benzoylcyclohexanone ketal compounds.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: March 12, 2002
    Assignee: Orth-McNeil Pharmaceutical, Inc.
    Inventors: Michael P. Ferro, Kathleen A. McCoy
  • Process for the preparation of 3-hydroxymethyl tetrahydrofuran
    Patent number: 6355814
    Abstract: The present invention relates to a catalytic process for the preparation of 3-hydroxymethyl tetrahydrofuran of formula IV with hydroformylation as one of the key steps. The process comprises reacting 9-hydroxymethyl-7,12-dioxaspiro[5,6]dodecane of the formula III with an alcohol in the presence of an acid catalyst and recovering the 3-hydroxymethyl tetrahydrofuran.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: March 12, 2002
    Assignee: Council of Scientific and Industrial Research of India
    Inventors: Pardhasaradhi Malladi, Sri Nagesh Kumar Potluri
  • Process and intermediates useful to produce vitamin D analogs
    Patent number: 6353123
    Abstract: A stereospecific method for accomplishing the below reaction: results in the compound of formula 2 having the same stereochemistry at both carbon 1 and carbon 3 as that in the compound of formula 1. Thus, if carbon 3 is in the R-configuration in the compound of formula 1, then carbon 3 will be in the R-configuration in the compound of resulting formula 2. In the above process, R1 is C1-C6 alkyl that can be straight-chain or branched. The process functions using a fluorinated alcohol having a pKa less than about 9, in the presence of a palladium catalyst. The compounds of formula 1, as well as novel intermediates in this process, are useful in manufacturing vitamin D analogs.
    Type: Grant
    Filed: April 16, 2001
    Date of Patent: March 5, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andrzej Robert Daniewski, Marek Michal Kabat, Masami Okabe, Roumen Nikolaev Radinov
  • Separation of 2,5-dihydrofuran from water by extractive distillation
    Patent number: 6353121
    Abstract: Disclosed is a process for separating 2,5-dihydrofuran (2,5-DHF) from aqueous solution of 2,5-DHF by extractive distillation using certain organic liquids as the extraction agent.
    Type: Grant
    Filed: February 22, 2001
    Date of Patent: March 5, 2002
    Assignee: Eastman Chemical Company
    Inventor: Scott Donald Barnicki
  • Process for the preparation of a paclitaxel C-4 methyl carbonate analog
    Patent number: 6353120
    Abstract: A process for the synthesis of a C-4 methyl carbonate paclitaxel analog from 10-deacetylbaccatin III by the selective reduction of the acetate at the C-4 position of 10-deacetylbaccatin using Red-Al.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: March 5, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventor: Joydeep Kant
  • &bgr;-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
    Patent number: 6350886
    Abstract: Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: February 26, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: John K. Thottathil, Ivan D. Trifunovich, David J. Kucera, Wen-Sen Li