Abstract: A monoclonal antibody is described characterized by its specificity to interferon-.alpha. (leukocyke interferon). Preferably the antibody has specificity to human interferon-.alpha.. The monoclonal antibody is secreted by a hybrid cell formed by the fusion of lymphocyte cells derived from an animal immunized with interferon-.alpha., with mycloma cells. The antibody has applications in the purification of interferon. It may be covalently attached to a solid support and used as an immunoadsorbent. Purifications of up to 5000 fold may be obtained in a single pass through an immunoadsorption column of this type. An immunoradiometric assay for interferon-.alpha. is also described.
Abstract: The present invention relates to a method for producing golden sintered alloys for ornamental purposes and suitable for use in watches. They are mainly composed of 10-40 percent by weight of titanium nitride, 10-30 percent by weight of nickel and valanced niobium carbide. Less than 40 percent by weight of the nickel may be substituted by at least one member from the group of chromium, molybdenum, tungsten and titanium. The alloys have a high degree of hardness (Rockwell A scale), excellent corrosion resistance and a beautiful gold color.
Abstract: A process is disclosed for producing steroid hormone receptor samples to be utilized as controls during assays of various human tissue for steroid hormones, especially estrogen. The process comprises collecting tissue known to include such receptors, adding a buffer solution to the tissue, homogenizing the tissue and buffer solution, centrifuging the homogenized mixture, and thereafter collecting the supernatant. The supernatant which contains the desired receptors is subdivided into suitable control sample size and preferably lyophilized to a flake.
Abstract: A foraminous body formed of a tin-containing atomized, compacted and sintered austenitic stainless steel powder, and process including the steps of sintering and cooling in a dissociated ammonia atmosphere.
Abstract: An essentially pyridine-free Karl Fischer reagent useful in the determination of water, comprises a dissolving agent containing sulfur dioxide and a pyridine substitute in a Karl Fischer solvent, and a titrating agent containing iodine in a Karl Fischer solvent, wherein the pyridine substitute is an alkali or alkaline earth metal benzoate or ammonia, and the reagent is essentially free of pyridine.
Type:
Grant
Filed:
December 21, 1981
Date of Patent:
November 22, 1983
Assignee:
Merck Patent Gesellschaft mit beschrankter Haftung
Abstract: Antibodies and antigens are disclosed which provide a method of detecting and a method of combating flukes. Fluke infections are screened by determining presence of fluke antigens defined by antibodies produced by hybridomas ATCC HB-8086 and HB-8087. Chronic and acute fluke infections are distinguished by determining presence of fluke spine protein. Fluke infections are combated by injecting warm-blooded animals with antibodies produced by hybridomas ATCC HB-8086, HB-8087 and HB-8088, or with proteins defined by those antibodies.
Abstract: A composition of material for use as a friction lining with a cast iron mating surface. The friction lining has an iron powder base that reacts with tin to alloy and hold substantially equal weight percentages of graphite and coke in a fixed position. The friction lining has a substantially constant wear rate up to 300.degree. C. and a linear wear rate between 300.degree.-500.degree. C.
Abstract: Dienes such as 1,3-butadiene, in relatively low concentration, are removed from mono-olefins, such as propylene and normal butenes, by passage over a catalyst of activated magnesium oxide while irradiated with ultraviolet light.
Abstract: A piston ring produced by a powder metallurgical method has a nearly triangular zone in cross section made of a low density sintered alloy metal powder. One edge of an outer peripheral surface or bottom surface of the piston ring forms a vertex of the triangular zone. The remainder of the piston ring is composed of a high density sintered alloy metal powder. This piston ring has a high abrasion resistance at the area thereof which slides on the cylinder wall and can be produced at low cost.
Abstract: A reference liquid system for use with a chemical analyzer that has a plurality of ion selective electrodes comprises a plurality of reference liquids, each of which has a first salt component such that ions of a first element to be measured are present in a predetermined concentration, a second salt component such that ions of a second element to be measured are present in a predetermined concentration, and an error compensation salt component present in a concentration effective to adjust(a) the activity coefficient factor and/or(b) the junction potential factorto reduce the error involved in use of the compensated reference liquid to less than fifty percent of the error involved in use of a corresponding uncompensated reference liquid.
Abstract: The present invention provides a stabilized thrombin preparation in solid or dissolved form, especially for analytical purposes, containing, as a stabilizer, serum albumin together with at least one protease inhibitor and at least one chelate former.
Abstract: An improved colorimetric reagent is disclosed, which is adapted to the determination of the iron content in blood serum. The formulation comprises only two aqueous solutions: one of these comprises a buffer, a soluble salt of an alkali metal or an alkaline earth metal, Chromazurol B, a cationic or nonionic surfactant, whereas the other solution comprises a complexing agent and possibly the same ingredients of the chromogenic reagent for hindering the formation of the disturbing complex between chromazurol B, the surfactant and the iron: the complexing agent is a polycarboxylic acid or a salt thereof.
Type:
Grant
Filed:
December 11, 1980
Date of Patent:
October 4, 1983
Assignee:
Istituto Sieroteropico E. Vaccinogeno Toscano "Sclavo" S.p.A.
Abstract: A urobilinogen control standard composition, control standard device and a method for preparing such composition are disclosed. The composition comprises a substituted indole:nonionic detergent solution which is reactive with p-diethylaminobenzaldehyde and hydrochloric acid. The composition is produced by dissolving the substituted indole in a selected nonionic detergent and diluting the solution to a predetermined level. The device is a carrier matrix impregnated with a solution of a substituted indole and a nonionic detergent.
Abstract: In accordance with the present invention, uranium values are extracted from materials containing uranium in valence states lower than its hexavalent state by contacting the materials containing uranium with an aqueous alkaline leach solution containing an alkaline chlorate in an amount sufficient to oxidize at least a portion of the uranium in valence states lower than its hexavalent state to its hexavalent state. In a further embodiment of the present invention, the alkaline leach solution is an aqueous solution of a carbonate selected from the group consisting of ammonium carbonate, ammonium bicarbonate and mixtures thereof. In yet another embodiment of the present invention, at least one catalytic compound of a metal selected from the group consisting of copper, cobalt, iron, nickel, chromium and mixtures thereof adapted to assure the presence of the ionic species Cu.sup.++, Co.sup.++, Fe.sup.+++, Ni.sup.++, Cr.sup.
Abstract: A method for diagnosis of rheumatoid arthritis and related diseases comprises determination of polyclonal lymphocyte activation in B-cells cultured in the presence of patient serum. A diagnostic kit is also provided.
Type:
Grant
Filed:
October 30, 1980
Date of Patent:
September 6, 1983
Inventors:
Marius C. Teodorescu, John L. Skosey, Jin-Lai Chang
Abstract: The present invention concerns a continuous process for the oxidizing attack of a uraniferous ore by means of an aqueous recycling liquor which contains in a dissolved state alkaline carbonate and bicarbonate and uranium at a concentration close to the limit of solubility thereof at the temperature of the attack operation. The uranium which is precipitated in the course of the attack operation is collected within the solid phase which remains after attack. By redissolution in a suitable aqueous liquor and separation from the sterile materials, a uraniferous liquor is obtained.
Abstract: The invention relates to a process for the determination of serum lipoproteins by an immuno-enzymatic method. The process of the invention consists in reacting a specific antibody of the apoprotein whose amount is to be measured, fixed on a support, with, on the one hand, the compound for coupling the corresponding lipoprotein with an enzyme and, on the other hand, the analyzed sample. The amount of enzyme fixed is then an inverse function of the apoprotein content of the sample. The support with the products which are fixed thereto are separated from the rest of the reagents and the activity of the enzyme of the support is measured which is compared with standard measurements.The process is useful for serum analyses, particularly for early detection of cardiovascular disease risks.
Abstract: In materials-testing involving comparative examination of the surface of a particular material specimen, specimen surfaces are irradiated with monochromatic light and the Raman spectra of the specimen surfaces are recorded only for certain predetermined spectral regions, the spectral regions having been predetermined through prior recording of the Raman spectra of comparison bodies of different surface character, from which prior recording lines of the spectra which depend on surface character have been selected and classified in accordance with their characteristic properties; characteristic line properties for the specimen recordings are compared to those for the comparison-body recordings in order to make a determination of whether the specimen surfaces are of the acceptable quality represented by the comparison-body surfaces.
Abstract: In a process for the production of microcapsules containing a liquid fill material, a dispersion-stabilizing species is produced in an aqueous acidic medium by interaction of a melamine formaldehyde precondensate and a water soluble polymer, neither of which alone is dispersion stabilizing with respect to the liquid fill material, and the precondensate is condensed by acid catalysis to produce a condensate which separates from solution and enwraps the liquid fill material to produce microcapsules.
Abstract: A radiation curable ink is provided which is convertible to a conductive coating when cured on the surface of a substrate. A particulated electrically conductive .[.metal containing.]. material is used in combination with an organic resin binder. Low temperature cure of the ink can be achieved with either actinic or ionizing radiation.
Type:
Grant
Filed:
June 7, 1978
Date of Patent:
October 11, 1983
Assignee:
General Electric Company
Inventors:
Donald A. Bolon, Gary M. Lucas, Ralph L. Bartholomew