Patents Examined by Benjamin R. Padgett
  • .alpha.-Keto aldehydes as enhancing agents of gastro-intestinal drug absorption
    Patent number: 4440740
    Abstract: A method and drug form enhancing the absorption of a rectally or orally administered drug from the rectal compartment into the blood stream of a warm blooded animal. The method includes the steps of preparing a drug form capable of being rectally and orally administered. The drug form comprises a therapeutically effective unit dosage amount of a selected drug of the type which is capable of being absorbed into the blood stream from the gastrointestinal area and an .alpha.-keto aldehyde or salts thereof being present in the drug form in a sufficient amount to be effective in enhancing the drug absorption rate, when administering the drug form to warm blooded animals.
    Type: Grant
    Filed: April 26, 1982
    Date of Patent: April 3, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Joseph A. Fix, Stefano A. Pogany
  • Heavy brine viscosifiers
    Patent number: 4439333
    Abstract: Polymeric compositions for, and methods of, increasing the viscosity of aqueous brine well servicing fluids comprising adding to the brine a composition containing hydroxyethyl cellulose, a solid organic activating agent for the hydroxyethyl cellulose, and a solvent for the activating agent which also functions as a suspending medium or carrier for the hydroxyethyl cellulose.
    Type: Grant
    Filed: May 8, 1981
    Date of Patent: March 27, 1984
    Assignee: NL Industries, Inc.
    Inventors: Roy F. House, Lonnie D. Hoover
  • Osmotic drug delivery system
    Patent number: 4439196
    Abstract: An osmotic drug (or other beneficial substance) delivery system comprises a multi-chamber compartment formed by an external shell and one or more chamber-dividing walls each with a small orifice, of a microporous material and overlayers of semipermeable membranes completely covering the outer shell of all but one chamber and substantially covering the outer shell of the remaining chamber. Osmotic agents, adjuvants, enzymes, drugs, pro-drugs, pesticides and the like are incorporated in the chambers covered by the semipermeable membrane, and external fluids that diffuse into those chambers form solutions and by osmotic pressure are forced through the orifice to the drug chamber to form a solution thereof and then through the exposed microporous shell to the exterior of the device at a rate controlled by the permeability of the semipermeable overlay and the osmotic pressure gradient across the shell.
    Type: Grant
    Filed: March 18, 1982
    Date of Patent: March 27, 1984
    Assignee: Merck & Co., Inc.
    Inventor: Takeru Higuchi
  • 1-.sup.11 C-D-Glucose and related compounds
    Patent number: 4439414
    Abstract: The novel compounds 1-.sup.11 C-D-glucose, 1-.sup.11 C-D-mannose, 1-.sup.11 C-D-galactose, 2-.sup.11 C-D-glucose, 2-.sup.11 C-D-mannose and 2-.sup.11 C-D-galactose which can be used in nuclear medicine to monitor the metabolism of glucose and galactose can be rapidly prepared by reaction of the appropriate aldose substrate with an alkali metal .sup.11 C-labeled cyanide followed by reduction with a Raney alloy in formic acid.
    Type: Grant
    Filed: January 26, 1982
    Date of Patent: March 27, 1984
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Chyng-Yann Shiue, Alfred P. Wolf
  • Stable, base serum compositions and preparation thereof
    Patent number: 4438202
    Abstract: A consistent, stable serum having good optical qualities and improved filterability suitable for control and calibration uses is disclosed as well as its method of preparation.
    Type: Grant
    Filed: November 30, 1981
    Date of Patent: March 20, 1984
    Assignee: Technicon Instruments Corporation
    Inventors: Philip V. Engler, Steven N. Buhl
  • Loose sintering of spherical ferritic-austenitic stainless steel powder and porous body
    Patent number: 4435483
    Abstract: A porous sintered body, preferably a filter or filter material, with good corrosion resistance and with a pore volume which can be predicted within specified comparatively narrow limits, is made by loose sintering of a preferably gas-atomized spherical powder a ferritic-austenitic stainless steel.
    Type: Grant
    Filed: February 8, 1982
    Date of Patent: March 6, 1984
    Assignee: Nyby Uddeholm Powder Aktiebolag
    Inventors: Christer Ahslund, Karl H. T. Andersson, Sven S. Bergh
  • Immunological reagents employing polymeric backbone possessing reactive functional groups
    Patent number: 4434150
    Abstract: An immunological substance detecting reagent is provided which, in the preferred embodiment, employs an immunological homolog specific for the immunological substance to be detected coupled to a water-soluble polymer having a net charge not greater than zero. The water-soluble polymer further has associated a plurality of marker substances such as fluorophore molecules thereby providing a reagent of increased sensitivity for the detection of an antigen-antibody immunological reaction.
    Type: Grant
    Filed: October 19, 1981
    Date of Patent: February 28, 1984
    Assignee: Ortho Diagnostic Systems, Inc.
    Inventors: A. R. M. Azad, Stefan J. Kirchanski, Michael C. Brown
  • Granulate-form powder agglomerates of pulverulent rubber chemicals and a process for production
    Patent number: 4434070
    Abstract: Granulate-form agglomerates of pulverulent rubber chemicals having a maximum primary grain size of 500 .mu.m , an active substance content of at least 90% by weight and an assessment (a) in the intermixing test of at the most 1.5, (b) in the dust proportion test of at the most 10, (c) in the fine material proportion test of at the most 5 and (d) in the falling test of at the most 70, as well as a process for its production characterized in that the pulverulent rubber chemicals of a maximum primary grain size of 500 .mu.m are mixed with a moistening agent and/or a lubricant and are supplied to a double shaft screw granulator with forced conveyance, in which the spacing between the nozzle plate and the vertically cut screw ends is between 0 and 1.6 mm, whereby the compression ratio K.sub.D is between 1:6 and 1:1.
    Type: Grant
    Filed: May 12, 1981
    Date of Patent: February 28, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Lindner, G/u/ nter Arend, Carl-Dieter Barnikel, G/u/ nter Frauenkron
  • Human leukocytic pyrogen test for the detection of exogenous fever-producing substances
    Patent number: 4434237
    Abstract: A method for determining the pyrogenicity of a substance, comprising the step of incubating said substance in the presence of a cell mixture for at least 46 hours at 35.degree. to 39.degree. C., wherein the cell mixture comprises human lymphocytes and human monocytes with a cell ratio of lymphocytes to monocytes of at least 2:1 and a composition with respect to the total of all cells present comprising at least 15% monocytes and no more than 10% granulocytes and wherein the cells have a contact ratio of from 0.0 to 0.75.
    Type: Grant
    Filed: March 31, 1982
    Date of Patent: February 28, 1984
    Inventor: Charles A. Dinarello
  • Monoclonal antibodies specific for the human transferrin receptor glycoprotein
    Patent number: 4434156
    Abstract: Monoclonal antibodies are produced specific for the cell surface transferrin receptor of human cells. Animals are inoculated with purified human transferrin receptor glycoprotein, human hematopoietic cells or fragments thereof, and spleen cells obtained from the animals are fused with myeloma cells to produce hybridomas. The hybridomas are cultured as clones, and antibodies obtained from the individual clones are tested for their specificty for human transferrin receptor. Clones which produce antibodies specific for the receptor and that interfere with or block transferrin binding are selected for further culturing to produce the antibody, and the antibody is obtained from the culture growth medium or from ascitic fluid of an animal bearing a tumor of the hybridoma. Monoclonal antibodies which block transferrin binding are useful in regulating cell growth and for other therapeutic uses.
    Type: Grant
    Filed: October 26, 1981
    Date of Patent: February 28, 1984
    Assignee: The Salk Institute for Biological Studies
    Inventor: Ian S. Trowbridge
  • Hypothyroid control serum
    Patent number: 4431741
    Abstract: A hypothyroid control serum for use in assay of thyroid function of serum with a reagent antiserum, said control comprising (a) serum from which triodothyronine and thyroxine have been stripped and (b) low-affinity antibody against triiodothyronine.
    Type: Grant
    Filed: December 17, 1981
    Date of Patent: February 14, 1984
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventors: Jerome Lewis, George H. Parsons, Jr.
  • Heated ion exchange process for the recovery of uranium
    Patent number: 4430308
    Abstract: The present invention relates to an improved method for the recovery of uranium values from a uranium-containing lixiviant by passing the lixiviant through a heated ion exchange resin to cause the resin to retain uranium values. The uranium values are subsequently recovered from the ion-exchange resin.
    Type: Grant
    Filed: December 13, 1982
    Date of Patent: February 7, 1984
    Assignee: Mobil Oil Corporation
    Inventor: Argell Fletcher
  • Radioactive diagnostic agent
    Patent number: 4430320
    Abstract: A radioactive diagnostic agent for renal cortex, adrenal cortex, myocardium, brain stem, spinal nerve, etc., which comprises as an essential component monoiodoacetic acid wherein the iodine atom is radioactive.
    Type: Grant
    Filed: October 8, 1981
    Date of Patent: February 7, 1984
    Assignee: Kabushiki Kaisha Seitai Kagaku Kenkyusho
    Inventors: Akiyo Shigematsu, Akira Tsuya, Michiaki Aihara, Akiko Suzuki, Michiko Matsuda
  • 6-Bromocholesterol derivatives
    Patent number: 4430321
    Abstract: Novel 6-bromo derivatives of cholesterol have the formula ##STR1## Such compounds are prepared from the known 6-iodocholesterol by treatment with cuprous bromide.These compounds, labelled with radioisotopes of Br-82 or Br-77, are localized in the adrenal, mammary and ovary tissue of female mammals and in the adrenal or prostate tissue of males when administered to such individuals. This provides a method for imaging adrenal, ovary or prostate tissue which is superior to use of the prior art 6-iodo-cholesterol.
    Type: Grant
    Filed: January 15, 1982
    Date of Patent: February 7, 1984
    Assignee: Merck Frosst Canada Inc.
    Inventors: Richard J. Flanagan, Leonard I. Wiebe
  • Aliphatic amine-containing Karl Fischer titration agent and method for using it
    Patent number: 4429048
    Abstract: For the titrimetric determination of small amounts of water, the Karl Fischer reagent is used which contains sulfur dioxide, iodine and pyridine as essential components. Replacement of pyridine by specific nitrogen bases is advantageous. Particularly suitable are selected aliphatic amines and nitrogen-containing heterocyclic compounds, especially imidazoles. The pyridine-free titration agent is distinguished by high storage stability; it can be used as bicomponent or monocomponent reagent.
    Type: Grant
    Filed: August 27, 1982
    Date of Patent: January 31, 1984
    Assignee: Riedel-de Haen Ag.
    Inventor: Eugen Scholz
  • Method and apparatus for making ozone
    Patent number: 4427636
    Abstract: An apparatus and method is disclosed for manufacturing ozone by treating oxygen or an oxygen bearing gas with UV radiation in the range of from about 130-170 nm. The method involves the use of cathode rays to bombard a UV emitting material which emits radiation substantially in the 130-170 nm range. The invention takes advantage of the fact that no radiation is generated substantially above 200 nm or below 130 nm which wavelengths tend to destroy ozone. Thus, unlike the prior art, the present invention does not both make and destroy ozone, but simply makes ozone.
    Type: Grant
    Filed: December 21, 1981
    Date of Patent: January 24, 1984
    Assignee: Westvaco Corporation
    Inventor: David N. Obenshain
  • Immunoassay of thymosin .alpha..sub.1
    Patent number: 4427783
    Abstract: An improved immunoassay for the polypeptide hormone thymosin .alpha..sub.1 is described. The assay employs an improved antibody which is elicited by an immunogen which has been prepared by coupling [Tyr.sup.1 ]-thymosin .alpha..sub.1 to an immunogenic carrier protein using a bifunctional diazonium coupling agent.
    Type: Grant
    Filed: December 14, 1981
    Date of Patent: January 24, 1984
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Edward Newman, A. Hirotoshi Nishikawa, Herbert E. Spiegel, Julia Symington
  • Foaming agents for use in drilling for oil and gas
    Patent number: 4425243
    Abstract: Foaming agents for use in oil and gas production comprising n-octyl dimethylamine oxide, n-decyl dimethylamine oxide, branched decyl dimethylamine oxide, and mixtures thereof, all of which generate copious quantities of stable foam even in the presence of brine and hydrocarbons.
    Type: Grant
    Filed: October 21, 1982
    Date of Patent: January 10, 1984
    Assignee: Millmaster Onyx Group, Inc.
    Inventors: Harold A. Green, Morris Weinstein, Kenneth W. Prodo
  • Phosphohemihydrate process for purification of gypsum
    Patent number: 4424196
    Abstract: A wet process for producing phosphoric acid and phosphohemihydrate by acidulation of phosphate rock. A strong phosphoric acid is obtained with concomitant production of an improved calcium sulfate that is extremely low in radioactivity by operation in Region II for shorter time so as to produce small sized hemihydrate particles, then hydration of a substantial proportion but less than all of the hemihydrate to coarse gypsum substantially free of radioactivity in a dilute acidic aqueous slurry at a temperature and P.sub.2 O.sub.5 concentration selected so as to be within Region I of FIG. 1 and having a substantial weight proportion of coarser gypsum particles that are substantially free of radioactivity.
    Type: Grant
    Filed: June 29, 1982
    Date of Patent: January 3, 1984
    Assignee: United States Gypsum Company
    Inventors: Jay W. Palmer, John C. Gaynor
  • Cancer detection procedure using an acyl carrier protein
    Patent number: 4424278
    Abstract: A method of detecting cancer in mammals which comprises admixing with a serum sample from said mammal detectably labelled acyl carrier protein and subsequently determining the amount of B-protein-acyl carrier protein complex which is formed.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: January 3, 1984
    Assignee: Research Corporation
    Inventors: Edsel T. Bucovaz, Walter D. Whybrew