Abstract: A method of producing a rotary dresser include forming a core piece of an iron-base powder and filling in tungsten or like metal powder between the core and an outer mold member containing diamond grit or the like. The construction is then heated to melt and infiltrate a metal alloy, such that a network structure is formed about the powdered metal particles. In a further embodiment, the metal materials may be arranged in concentric form about a metal bushing such that the bushing is included in the final structure.

Abstract: An improved competitive protein binding assay comprising; incubating an analyte in the presence of labeled analyte and a protein binder suitable for competitive binding activity by the analyte and the labeled analyte to provide a mixture having free analyte, free labeled analyte, bound analyte and bound labeled analyte, substantially separating the bound analyte and the bound labeled analyte from the free analyte and free labeled analyte to form a first fraction containing substantially the bound analyte and the bound labeled analyte and a second fraction containing substantially the free analyte and the free labeled analyte by causing a predetermined level of the mixture to flow through a bed of an organo-silane coupled to silica gel, and detecting the labeled analyte of at least one of the first and second fractions to determine the concentration of the analyte by comparison to a reference.

Abstract: Photochemical reactions are carried out by passing the fluid to be irradiated through a plurality of capillaries, each of which is surrounded by an actinic-radiation emitting plasma; the capillaries being transparent to the radiation. By banding the capillaries with a radiation-opaque material, the fluid being treated can repeatedly be subjected to brief periods of irradiation, alternating with periods of non-irradiation, during each pass through the capillaries.

Abstract: A new technique is disclosed for assaying for the presence of invasive cancer. While based on leukocyte adherence inhibition, it is improved by using relatively long lived radio-labeled leukocytes, fractionation of the leukocytes to separately treat T-cells and monocytes and by providing for human plasma or serum in the incubation medium.

Abstract: A process for determining the level of TAG in a sample of body fluid which comprises reacting the TAG in a sample of body fluid with an AG-binding lectin or L-fucose-binding lectin to form a TAG-lectin complex and measuring the amount of the TAG-lectin complex or an unreacted lectin is disclosed. The process shows low cross-reactivity with hepatic diseases and is useful for diagnosis of cancers.

Abstract: An osmotic device is disclosed for delivering two beneficial drugs to an environment of use. The device comprises a semipermeable wall surrounding a lumen divided into a first compartment containing a drug that is separated from a second compartment containing a different drug. An orifice through the wall communicates with the first compartment for delivering drug from the first compartment, and another orifice through the wall communicates with the second compartment for delivering drug from the second compartment. In operation, drug is dispensed separately from each compartment by fluid being imbibed through the wall into each compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall against the drug in each compartment thereby producing in each compartment a solution containing drug that is dispensed through their orifices at a controlled and continuous rate over a prolonged period of time.

Abstract: In the immunoassay of a particular protein in a biological fluid, there is frequently interference in the assay by other proteins present in the fluid, e.g. by complement factors or antibodies in human serum. The interference so caused can be avoided by subjecting the fluid to protein-digestion, using for example an enzyme such as pepsin, as a result of which the particular protein of interest, or a fragment thereof, can be assayed without interference by the other proteins. Also, radioallergosorbent tests for particular IgE antibodies can be improved in sensitivity and accuracy, by subjecting the absorbed IgE to enzymic digestion, and then assaying a fragment thereof.

Abstract: A method is disclosed for potentiating the immune response of an animal. The method consists in administering an antigen and an immunopotentiator in effective low dose, at a controlled rate, and continuously to produce the desired immune response.

Abstract: A device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space (2) a piston in the housing separating the space into an agent compartment and a power compartment, or a flexible container in the space, (3) an opening in the housing connecting the agent compartment or the container with the exterior of the housing, and (4) an osmotic device in the power compartment or beneath the container.

Abstract: Therapeutic and diagnostic methods employing metal chelate conjugated monoclonal antibodies are described. Metals employed in therapeutic conjugated antibodies include alpha particle, beta particle or Auger electron emitting isotopes. Diagnostic methods may be either in vivo or in vitro. Chelated metals employed in diagnostic techniques may include, inter alia, gamma or positron emitting metals as well as fluorogenic or paramagnetic metals.

Abstract: A new group of materials comprises intercalates of organometallic compounds in layered structures of water-insoluble salts comprised of a tetravalent metal cation and an acid phosphate, arsenate or vanadate anion. Related materials comprise intercalates of organometallic compounds in layered structures of uranyl and transuranyl phosphates, arsenates and vanadates. Intercalation hosts are represented either by the formula M(H.sub.1-y A.sub.y XO.sub.4).sub.2.nH.sub.2 O or by the formula H.sub.1-y A.sub.y TO.sub.2 XO.sub.4.nH.sub.

Abstract: A method for producing a machinable, high strength hot formed powdered ferrous base metal alloy is provided which comprises providing a particulate mixture consisting of, in weight percent, from about 1.0 to about 3.0 percent copper, from about 0.16 to about 0.35 percent sulfur, from about 0.4 to about 0.8 percent carbon, with the balance being iron plus from 0 to about 2 percent incidental impurities; forming this particulate mixture into a preformed article having a predetermined configuration; sintering the so-formed article at a temperature sufficient to produce the desired alloy; and subjecting the sintered article to a hot forming treatment to produce a hot formed, machinable, high strength ferrous base powdered metal alloy article having a density near theoretical.

Abstract: Disclosed is a continuously knitted tubular surgical mesh of monofilament threads free of water-leachable irritant impurities and physiologically inert even in the presence of infection, the threads being unattached at their points of crossing each other. Also disclosed are methods of using the surgical mesh in which the mesh is flattened thereby providing continuous knitted border edges on each side of the mesh, free of selvedge edges, which prevent unraveling or fraying of the border edges and at the same time avoid retaining any infection present by the border edges. Even though doubled, the tubular surgical mesh permits a greater porosity which allows substantially improved growth of tissues through it, it has greater stretch and flexibility than prior flat surgical meshes, and it avoids retaining infection or contamination by a selvedge edge. It also has increased tensile strength and improved flexural properties over prior flat meshes.

Abstract: A flexible, sheet-like, sustained release medicament device for orally administering a predetermined selective dose of a medicament and a method of preparing the device is disclosed. The device is of a multilayer composite construction comprising(a) at least one carrier film comprising at least one water-insoluble polymer and containing medicament, and(b) at least one barrier film overlaying said carrier film on at least one surface thereof and sealed to said carrier film along its periphery and in such a way as to entrap small quantities of air between said carrier and barrier films, said barrier film comprising at least one water-insoluble and water- and medicament-permeable polymer or copolymer,said multilayer composite construction having a bulk density of less than 1.0 g/cc, so as to render the sustained release medicament device buoyant in the gastric juices of the stomach, and being facilely divisible into any desired length.

Abstract: A salt block product and method of making and using same of a type suitable for use in forming a brine for regenerating and rejuvenating water conditioning ion exchange beds comprising integral block of salt having a stake hole extending inwardly of one surface thereof within which a mass of a water soluble rejuvenating agent is disposed at a position spaced inwardly of the surface of the block. The rejuvenating agent can comprise one or an admixture of additive agents which are adapted to dissolve in the water during the dissolution of the salt block forming a brine containing the additive agent uniformly distributed therethrough. In accordance with a preferred embodiment, a suitable closure is positioned in the stake hole outwardly of the additive agent to prevent deterioration thereof during shipment and storage which alternatively can be physically removed or is adapted to dissolve releasing the additive agent during the brine generating process.

Abstract: Vitamin B.sub.12 (cobalamin) and/or folate (folic acid) assay techniques can be simplified, by eliminating the step of heating or boiling the to-be-tested sample prior to its assay. This is accomplished by utilizing compositions and procedures:(1) which substantially completely liberate all vitamin B.sub.12 and/or folate from endogenous binding protein without heating or boiling;(2) which substantially completely destroy all endogenous binding protein which is present in the to-be-assayed sample, and which may bind natural and radioactive vitamin B.sub.12 or folate both due to its liberation from vitamin B.sub.12 or folate in the original sample or due to its unbound presence in the original sample;(3) which substantially completely inhibit or block any undestroyed endogenous binding protein; and(4) which substantially completely inhibit or destroy any intrinsic factor-blocking antibodies which may be present in the to-be-assayed sample.

Abstract: A process for recovering one or more non-radioactive transition metal compounds from an ore containing one or more compounds of said transition metal or metals and further containing at least one complex of a member selected from the group consisting of uranium, thorium, radium, titanium, and rare earth metals, which comprises decomposing said ore in crushed condition by means of an acid so that a portion of the ore is brought into solution in a liquid phase and another portion of the ore remains in a solid phase, said compound or compounds of the transition metal or metals to be recovered passing into only the liquid or into only the solid phase, the uranium in the crushed ore being treated so as to cause substantially all of said uranium to be present in an oxidation state in which it cannot, during the decomposition step, pass into the phase containing the transition metal compound or compounds.

Abstract: New alumina coated silica sols are produced by a method which comprises mixing a concentrated deionized silica sol with concentrated solutions of trivalent acid aluminum salts, heating this premix to at least 90.degree. C. for 1-15 minutes to form an alumina reacted silica sol solution, cooling this reacted silica sol solution to form a cooled alumina reacted silica sol solution, diluting with deionized water to about 10 weight percent solids, exposing this diluted alumina reacted silica sol to ultrafiltration through a membrane having a molecular weight cutoff of about 30,000, adding distilled or deionized water to the diluted alumina reacted silica sol during ultrafiltration to wash dissolved salts from this salt solution forming a diluted alumina-coated silica sol having a pH between about 4-5 and a conductivity between about 2,000-4,000 micromhos, concentrating this dilute alumina-coated silica sol to at least 30 weight percent solids, thereby obtaining a stable alumina-coated silica sol.

Abstract: An intra-vaginal device for supplying minerals, hormones or medicoments to an animal is formed as an injection moulded polymeric body having a skin in which adjacent at least part of the surface thereof at least one active ingredient is incorporated. The body is preferably separately moulded before the skin is applied and the skin is preferably of a two part silicone rubber or a polymer such as ethylene vinyl acetate or a polymer substance and the active ingredient is selected from one or more of progesterone oestrogen testosterone, mineral trace elements such as selenium cobalt copper and boron and anthelmintics.

Abstract: The invention provides a novel antioxidant obtained from rosemary and suitable for preventing oxidation of various organic materials or, in particular, oleaginous foodstuffs. The antioxidant is prepared by extracting rosemary with a non-polar organic solvent and further extracting the thus extracted material with an aqueous alkaline solution having a pH of at least 10.5 as a weakly acidic fraction soluble in such a strongly alkaline solution. The extraction with the non-polar organic solvent is preferably preceded or followed by steam distillation in order to remove any spicy volatile materials undesirable when the antioxidant is added to foodstuffs or the like. Column chromatographic separation of the above obtained weakly acidic fraction into components gives a novel compound 7.beta.,11,12-trihydroxy-6,10-(epoxymethano)abieta-8,11,13-trien-20-one as the effective ingredient of the antioxidant prepared from rosemary. Characterization of the above novel compound is given.