Abstract: A medicament delivery device comprises a housing and a syringe axially movable in the housing and the syringe having a barrel. The device further comprises a stopper axially movable in the barrel and which separates a first chamber and second chamber from one another. The stopper is axially movable in the barrel in response to a vapour pressure being received in the second chamber. The device also includes a biasing mechanism to axially move the syringe in the housing between a first syringe position and a second syringe position in response to a first reduction in the vapour pressure in the second chamber. In the first syringe position venting of the propellant from the second chamber through a first fluid pathway is permitted to enable the first reduction in the vapour pressure in the second chamber while venting of the propellant from the second chamber through a second fluid pathway is substantially prevented.

Abstract: A rectal medication administration device includes a tube, a balloon, a first valved port, and a second valved port. The tube includes a first lumen, a second lumen, and a plurality of holes extending from the first lumen therethrough. The balloon is proximal to the holes, is in communication with the second lumen, and is configured to be inflated to hold the tube in place within a patient's rectum. The first valved port is in communication with the first lumen and opens when connected to a first syringe or infusion set to provide medication transmission therethrough and closes when the first syringe or infusion set is withdrawn. The second valved port is in communication with the second lumen and opens when connected with a second syringe or infusion set to provide fluid to inflate the balloon and closes when the second syringe or infusion set is withdrawn.

Abstract: An injector includes an encapsulating portion configured to encapsulate a substance intended for injection, a first application portion configured to combust ignition charge and discharge a combustion product thereby applying a primary ejection energy to the substance intended for injection that is encapsulated in the encapsulating portion, an energy accumulation portion configured to accumulate an energy to be further applied to the substance intended for injection, the energy being different from the primary ejection energy applied by the first application portion. The injector also includes a second application portion configured to release the energy accumulated in the energy accumulation portion by using the discharged combustion product thereby applying, as a secondary ejection energy, the released energy to the substance intended for injection.

Abstract: A catheter assembly includes a catheter, a catheter hub, an inner needle, and an inner needle hub. The catheter assembly is disposed in a hollow portion axially extending in the interior of the inner needle, and includes a blunt needle having a distal end portion blunter than a needle tip and a movement mechanism for moving the blunt needle. The movement mechanism is configured separately from the catheter hub and causes the distal end of the blunt needle to protrude beyond the needle tip along with the movement of the catheter.

Abstract: The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.

Abstract: The invention relates to an electronic add-on module which is fitted releasably onto an automatic injection appliance before the start of injection. The add-on module comprises a force sensor for measuring a time-variable axial force component exerted on or transmitted to the attached add-on module by the injection appliance during an injection procedure. The add-on module also comprises a grip or a preferred grip position for gripping and holding the add-on module and the inserted injection appliance. The add-on module can additionally have a microphone for detection of acoustic signals. A state of the injection appliance can be determined by the add-on module solely on the basis of measurements of the axial force sensor, optionally supplemented by microphone measurements. The invention thus affords a straightforward and cost-effective way of monitoring or controlling the correct performance of an injection procedure carried out with an automatic injection appliance.

Abstract: A catheter is provided that includes a catheter body, a catheter hub, and a securing member disposed in the catheter hub to clamp the catheter between the securing member and the catheter hub. The securing member has an outer peripheral surface making contact with and stretching an inner peripheral surface of the catheter body. The catheter includes a recessed relief portion into which a thickness of the catheter body is inserted, the relief portion being partially provided circumferentially in an inner peripheral surface of the catheter hub.

Abstract: The present invention relates to a drive mechanism of a drug delivery device for setting and dispensing of a dose of a medicament, the mechanism comprising: a housing (20), a piston rod (120) to operably engage with a piston (14) of a cartridge (12) to displace the piston (14) in a distal direction (1), a rotatable member (80) arranged on an axially extending axis of rotation (4) in the housing (20), said rotatable member (80) being rotatable in a dose incrementing direction (5) against the action of a spring element (78) and being operably engageable with the piston rod (120) during dose dispensing, a clutch member (150) comprising at least one radially displaceable clutch element (153) to engage with a rim (82) of the rotatable member (80) with variably adjustable strength.

Abstract: A pressure jacket for use with a fluid injector may have a pressure jacket body having a proximal end, a distal end, and a circumferential sidewall extending between the proximal end and the distal end along a pressure jacket longitudinal axis. The pressure jacket may further have at least one resiliently deflectable retaining member having a first segment attached to the pressure jacket body and a second segment protruding from the first segment toward the distal end of the pressure jacket body and deflectable relative to the first segment. The pressure jacket may further have at least one actuation member associated with the at least one resiliently deflectable retaining member. The at least one actuation member may interact with a housing of the fluid injector when the pressure jacket is connected to the housing to deflect the at least one resiliently deflectable retaining member upon rotation of the pressure jacket.

Abstract: A mix and triggering assembly for a medicament delivery device, comprising: a housing structure having a proximal end and a distal end, a delivery member cover, a rotator sleeve, and a triggering member configured to be rotatably locked with the rotator sleeve and the delivery member cover, the triggering member being configured to move axially relative to the rotator sleeve, wherein the delivery member cover, the rotator sleeve and the triggering member are configured to be received by the housing structure, the delivery member cover being configured to extend from the proximal end of the housing structure, wherein the delivery member cover, the rotator sleeve and the triggering member are rotatably arranged relative to the housing structure, wherein the housing structure has a thread structure and the rotator sleeve and the triggering member are configured to be in a threaded connection with the thread structure in a ready to mix position of the triggering member, preventing irrotational axial movement of t

Abstract: The invention relates to an implantable device suitable for being fixed in a fixation position to a wall of a patient's stomach, the implantable device being accommodated in the stomach when the implantable device is in the fixation position, the implantable device being characterised in that it comprises a reserve of an active substance and an injector suitable for administering the active substance to the patient.

Abstract: An attachable needle assembly (2) is disclosed for use on a medication delivery pen (4). The needle assembly (2) includes a housing (8) enclosing a hub (12) that is configured to engage the medication delivery pen (4), a plurality of needles (18) configured to pierce a reservoir septum (6) of the medication delivery pen (4), a selection ring insert (30) that rotates and identifies which needle (24) of the plurality of needles (18) is to be selected, and a selection ring (36) that applies a force to expose the selected needle (24). When the housing (8) is in a first position, the plurality of needles (18) is not exposed, and when the housing (8) is in a second position, one of the plurality of needles (24) is exposed for medicament delivery.

Abstract: An apparatus includes a body, a cannula, a conduit, and a magnetic element. The cannula extends distally from the body. The cannula is flexible and has a distal end. The cannula defines a lumen distally terminating at the distal end. The cannula is sized and configured to pass between a sclera layer and a choroid layer in a human eye. The conduit is in fluid communication with the lumen. The magnetic element is positioned in the body.

Abstract: An electronic system (200) connectable to a medication delivery pen (4) and a needle assembly (2, 100), the electronic system (200) exchanging data regarding a medicament traveling from the medication delivery pen (4) to the needle assembly (2,100), the electronic system (200) comprising a hub (214) having a spike (216) that is configured to engage the medication delivery pen (4) and pierce a reservoir septum (6) of the medication delivery pen (4), a flow sensor (220) that is in fluid communication with the hub (214) to measure flow data of the medicament, one or more circuit boards (250, 260) electrically contacting the flow sensor (220) to process and transmit the flow data, the one or more circuit hoards (250, 260) include one or more fluid path holes (256, 264) to route a flow of medicament, and a septum (270, 284) that is configured to provide fluid communication between the flow sensor (220) and one of a plurality of needles (40, 124) of the needle assembly (2, 100) to administer the medicament to a pat

Abstract: Methods and systems for automatically pulsing different aspiration levels to an ocular probe are disclosed. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level, and applied to the probe in a pulsed manner.

Abstract: A patency checking system, may include a fluid path to be coupled to an intravenous (IV) device at a distal end of the fluid path; a patency port formed along a length of the fluid path; and a plunger fluidically coupled to the fluid path at the patency port to selectively draw blood into the fluid path to confirm patency of the fluid path.

Abstract: An active molecule delivery system whereby active molecules can be released on demand and/or a variety of different active molecules can be delivered from the same system and/or different concentrations of active molecules can be delivered from the same system. The active molecule delivery system includes a first electrode, a plurality of microcells, and a porous conductive layer. The microcells are filled with a medium including active molecules.

Abstract: A support catheter is used together with a guiding catheter in which a treatment catheter is inserted, the guiding catheter guiding the treatment catheter in a blood vessel, the support catheter being inserted in the guiding catheter from a proximal-side opening of the guiding catheter and having such a length that the support catheter protrudes from a distal-side opening of the guiding catheter, the support catheter guiding a distal end portion of the treatment catheter to a treatment site. The support catheter includes: a distal shaft forming a distal-side portion of the support catheter, the distal shaft having a tubular shape such that the treatment catheter is insertable in the distal shaft; and a proximal shaft forming a proximal-side portion of the support catheter. The proximal shaft is joined to a proximal-side portion of the distal shaft by a modified polyolefin-based adhesive.

Abstract: Multi-dose dispenser comprising: a product reservoir (14), on the X-axis, opening at a distal end through an outlet orifice and comprising a barrel (24); a piston (20) comprising a piston rod (38) having a rack and, at a distal end of the piston rod, a piston head (34) slidably mounted in the barrel (24) along the X-axis; a pawl mounted so as to be movable along the X-axis relative to the reservoir and configured to cooperate with the rack so as to drive the piston along the X-axis only in a forward direction of the piston in the barrel; a spring arranged to push the pawl back along the X-axis in a reverse direction; a case containing the pawl and at least a part of the piston; and a check valve arranged to seal the outlet orifice and allow only an outlet of product from the reservoir.

Abstract: A device for one-handed insertion of a guidewire into a vessel or cavity is provided. The device has a body, an actuator carriage, a guidewire feed, and a syringe. The body has a handle, a guideway, and a clip to retain the syringe. The syringe has a barrel and a plunger with a flange and a guidewire passage. The actuator carriage has a trigger and a clip to grasp the syringe plunger flange. The actuator carriage slides along the body guideway. The guidewire feed has a wire feed surface. The thumb engages wire at the wire feed surface to advance and retract the wire through the guidewire passage and a finger moves the trigger to move the syringe plunger rearwardly and/or forwardly, while the remaining fingers of the one hand grasp the handle. The device allows the user to sense resistance encountered by the tip of the wire.