Abstract: The present application provides for compositions comprising ?-galactosidase A in combination with an active site-specific chaperone for the ?-galactosidase A, and methods for treating Fabry disease in a subject in need thereof, that includes a method of administering to the subject such compositions. The present application also provides methods for increasing the in vitro and in vivo stability of an ?-galactosidase A enzyme formulation.

Abstract: Devices for the propagation or storage of microorganisms are provided including a first layer that has a first portion of a surface of the first layer, to which a first water-swellable gelling agent comprising a first clay is affixed. The devices further include a second layer that is separable from the first layer and has a first portion of a surface of the second layer, to which a second water-swellable gelling agent is affixed. Methods for detecting and enumerating at least one microorganism in a sample are provided. The methods include providing a device, separating the first layer from the second layer, adding an aliquot of a sample containing at least one microorganism onto the first or second water-swellable gelling agent to form an inoculated device, laminating the first layer back to the second layer, and incubating the inoculated device. Kits and methods of making the devices are also provided.

Abstract: The invention relates to a method for detecting Serpula lacrymans contamination in an internal environment, taking into account the absence and presence of VOCs produced by the metabolism of Serpula lacrymans, especially by means of the calculation of a contamination index.

Abstract: Reactor plant and process for culturing phototropic microorganisms with a reactor vessel and a photosynthetic module, which are connected with one another in a circulation circuit by a pump and can be controlled via a control unit, where in the circulation circuit or in the reactor vessel, a homogenizer is provided, where a light-intensity control of the photosynthetic module is provided, and where a bypass of the circulation circuit or of the reactor vessel with a filter device which is arranged externally of the reactor vessel for separating off extracellular products during the fermentation is provided.

Abstract: An object of the present invention is to provide a constitutive 1,4-dioxane-degrading bacteria offering excellent maximum relative rates of degradation of 1,4-dioxane. As a means for achieving the object, the present invention provides a constitutive 1,4-dioxane-degrading bacteria being strain N23 deposited as Accession No. NITE BP-02032.

Abstract: An improved method and related apparatus for detecting bacteria viability and drug effects using metabolic monitoring. A fluorescent material which is quenched by oxygen is co-localized with the target bacteria, and fluorescence signal is detected at the co-localized places. In some embodiments, the fluorescent material is a fluorescent nanoparticle mixed with the target bacteria in the sample, and co-localization is enhanced using centrifugation, electrophoresis, microflow path modified with antibodies, magnetic force, etc. In some other embodiments, the fluorescent material is a fluorescent film or 3-D matrix immobilized in the bacterial culture chamber, and bacteria in the sample is gathered into localized regions of the bacteria culture chamber where the fluorescent film or 3-D matrix is present by ways of centrifugation, electrophoresis or microflow path. Plasmonic nanoparticles with a metal core and plasmonic film with a metal film may be used as the fluorescent nanoparticles and fluorescent film.

Abstract: A fidaxomicin purification method, comprising: fermenting Actinoplanes sp. HS-16-20 to generate fermented liquid; conducting solid/liquid separation on the fermented liquid, soaking mycelium in an organic solvent, and filtering to obtain a solution containing fidaxomicin; treating the solution with nanofiltration concentrate, and separating to obtain fidaxomicin crude product; conducting preparative column chromatography on the fidaxomicin crude product, eluting with an acid aqueous solution containing an organic solvent, and separating to obtain the refined fidaxomicin product.

Abstract: The present invention provides dietary formulations comprising polyunsaturated fatty acids and vitamin E. The present invention further provides methods of treating various conditions, generally involving administering to an individual in need thereof an effective amount of a subject dietary formulation.

Abstract: To provide a method for simply measuring ethanolamine phosphate in a sample, and a reagent, kit, program and the like useful in the method. A measurement method of ethanolamine phosphate includes a first step of adding an enzyme, which can catalyze a reaction that forms acetaldehyde from ethanolamine phosphate, to a sample, and conducting a first enzymatic reaction to form acetaldehyde, phosphoric acid and ammonia; and a second step of quantifying at least one of the resultant acetaldehyde, phosphoric acid and ammonia to determine an amount of the ethanolamine phosphate in the measurement sample.

Abstract: The present invention has an object of providing a sugar derivative emitting blue fluorescence color which can be used for imaging of cells or intracellular molecules and a method for imaging cells using the derivative. Further, the present invention has an object of providing a method for detecting cancer cells at high accuracy by imaging, and an imaging agent used for this method. The present invention provides a fluorescently labeled sugar derivative having 3-carboxy-6,8-difluoro-7-hydroxycoumarin or 3-carboxymethyl-6,8-difluoro-7-hydroxy-4-methylcoumarin as a fluorescent molecular group in its molecule, and a cell imaging agent and an imaging method using the derivative. Further, the present invention provides an imaging agent and an imaging method for cancer cells using an L-glucose derivative having the above-described fluorescent molecular group in its molecule.

Abstract: Provided are surgical meshes embedded in a gelled, solubilized extracellular matrix (ECM) composition, methods of making the same, and methods of using the same to repair defects in a body. The surgical mesh may be a synthetic polymer such as polypropylene, and the ECM coating reduces the foreign body response and scarring at the site of implantation. The device is useful for repairing hernias, pelvic floor disorders, and in breast reconstructions.

Abstract: A method is provided to measure modulation of phosphatidylcholine export transport and/or formation activity in hepatocyte or stable cell-line preparations by test agents including but not limited to drugs, drug candidates, biologicals, food components, herb or plant components, amino acids, peptides, proteins, oligonucleotides, DNA, and RNA. Furthermore, the method is designed to determine modulation of phosphatidylcholine transport and/or formation activity not only by said test agents, but also their metabolites or biotransformation products formed in situ.

Abstract: Automated systems and methods for providing platelet concentrates and synthetic storage media with reduced residual plasma volumes are disclosed. The disclosed systems and methods reduce the residual volume of plasma in platelet concentrate to obtain a platelet product having a volume of plasma that is approximately 5% or less of the total platelet product volume. The disclosed systems and methods also reduce the residual volume of plasma in platelet concentrate to obtain a washed platelet product, wherein the volume of plasma in the washed platelet product is approximately 1% or less of the total washed platelet product volume. Storage media for platelets including less than approximately 10% plasma are also disclosed.

Abstract: The present invention is related to the field of tissue regeneration. It concerns more particularly new processes, tubes and devices for thrombin, platelet concentrate and wound healant preparations, alone or in combination with cell extracts, cell compositions and uses thereof.

Abstract: Described herein are methods of treating and preventing muscle wasting and muscle loss, using adherent stromal cells and conditioned medium produced thereby.

Abstract: Embodiments of a system and method for deforming a can include a substrate including an inlet module and an outlet module; a fluidic pathway coupled to the inlet module and the outlet module, and including a sample branch operable to transmit the sample fluid; one or more sheath fluid branches flanking the sample branch and operable to transmit sheath having a sheath fluid viscosity higher than a sample fluid viscosity of the sample fluid; a delivery region initiating at a junction between the sample branch and the one or more sheath fluid branches, and operable to transmit a co-flow comprising the sample fluid and the sheath fluid; and a deformation region located downstream of the delivery region and operable to deform the one or more particles of the sample fluid based upon a reduced velocity of the sheath fluid with respect to the sample fluid in the co-flow.

Abstract: The present disclosure relates to nutritional supplement including a peptide component. The nutritional supplement further includes a source of long-chain polyunsaturated fatty acids and Lactobacillus rhamnosus GG. The disclosure further relates to methods of protecting against obesity and its related metabolic disorders and inflammatory diseases in a target subject by providing the nutritional supplement(s) disclosed herein to a target subject, which includes a pediatric subject.

Abstract: This invention provides the use of a microorganism capable of improving both lipid metabolism and sugar metabolism. Specifically, the invention relates to: a lipid metabolism and/or sugar metabolism improver comprising, as an active ingredient, a bacterial cell selected from bacteria belonging to the genus Lactobacillus and the genus Bifidobacterium, a treated product of the bacterial cell, or a mixture thereof, having dual-agonistic activities to peroxisome proliferator activated receptor (PPAR)? and peroxisome proliferator activated receptor (PPAR)?; to a food or a beverage comprising the improver; and to a pharmaceutical composition comprising the improver.

Abstract: A detection system for determining alpha-methylacyl-CoA (AMACR) levels in a bodily sample includes at least one reaction solution for generating H2O2 upon combination with AMACR in the bodily sample and a biosensor for determining a level of generated H2O2. The reaction solution includes a (2R)-2-methylacyl-CoA epimer that can be chirally inverted by AMACR to a (2S)-2-methylacyl-CoA epimer and an enzyme that carries out beta oxidation with the (2S)-2-methylacyl-CoA epimer to generate hydrogen peroxide (H2O2).

Abstract: A method and assay for using carbonic anhydrase (CA), particularly CA-I or CA-II, as a biomarker of hemolysis. The method and assay detect hemolysis by determining a percentage erythrocyte hemolysis in a specimen or sample of blood based upon quantification of carbonic anhydrase present in the extracellular portion of the blood. The method and test serve to optimize therapeutic efficacy for treatments of hemolysis.