Patents Examined by Bin Shen
  • Birth tissue material and method of preparation
    Patent number: 10245349
    Abstract: A method of treating a soft tissue defect in or on the body of a patient is provided. A placental construct for treatment of a disease or condition is also provided. The placental construct includes a therapeutically effective amount of a birth tissue material.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: April 2, 2019
    Assignee: BioDlogics, LLC
    Inventor: Timothy R. Brahm
  • Capture, identification and use of a new biomarker of solid tumors in body fluids
    Patent number: 10247725
    Abstract: A new sensitive cell biomarker of solid tumors is identified in blood. This biomarker can be used to determine presence of carcinomas, rapid determination of treatment response, early detection of cancer, early detection of cancer recurrence, and may be used to determine therapy.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: April 2, 2019
    Assignee: CREATV MICROTECH INC.
    Inventors: Daniel Adams, Cha-Mei Tang
  • Process, tube and device for the preparation of wound healant composition
    Patent number: 10226516
    Abstract: The present invention is related to the field of tissue regeneration. It concerns more particularly new processes, tubes and devices for thrombin, platelet concentrate and wound healant preparations, alone or in combination with cell extracts, cell compositions and uses thereof.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: March 12, 2019
    Assignee: RegenLab USA LLC
    Inventor: Antoine Turzi
  • System and method for multiplexed affinity purification of proteins and cells
    Patent number: 10228313
    Abstract: In accordance with an embodiment of the invention, there is provided a method for: a) high-throughput, multiplexed, affinity-based separation of proteins—especially low abundance proteins—from complex biological mixtures such as serum; and b) high-throughput, multiplexed, affinity-based separation of cells—especially rare cells—from complex biological mixtures such as blood or blood fractions. The separation of proteins or cells is achieved based on differential binding to affinity-capture beads of different sizes and then sorting the protein-bound or cell-bound beads using the concept of centrifugal-induced Dean migration in a spiral microfluidic device. This method enables continuous-flow, high throughput affinity-separation of milligram-scale protein samples or millions of cells in minutes after binding.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: March 12, 2019
    Assignees: Massachusetts Institute of Technology, The Massachusetts General Hospital
    Inventors: Aniruddh Sarkar, Han Wei Hou, Jongyoon Han, Galit Alter
  • Method for assessment of hepatic function and portal blood flow
    Patent number: 10222366
    Abstract: A method for estimating portal blood flow and hepatic function in a subject is provided. In one example, the STAT test is an in vitro simplified, convenient test intended for screening purposes that can reasonably estimate the portal blood flow from a single blood sample taken 60 minutes after orally administered deuterated-cholate. The test can be administered to a patient having, or suspected of having, Chronic Hepatitis C, Primary Sclerosing Cholangitis (PSC), Non-Alcoholic Fatty Liver Disease (NAFLD), or any chronic liver disease.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: March 5, 2019
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Gregory Thomas Everson, Steve Mark Helmke
  • Methods and articles for delivering viable cells into solid tissue
    Patent number: 10220003
    Abstract: Embodiments provide swallowable devices, preparations and methods for delivering viable cells (VC) into the GI tract including GI wall tissue or other tissue site. Particular embodiments provide a swallowable device such as a capsule for delivering VC into an intestinal wall or other site. The VC can be contained within a tissue-penetrating shell disposed in the capsule that protects the VC as they pass through the GI tract until they are inserted into GI tract tissue or other location. The shell desirably has shape, size and material consistency to be contained in a swallowable capsule, delivered from the capsule into solid tissue by the application of force on the shell and biodegrade within the solid tissue to release the VC into the tissue. Within the shell or other structure the VC can be maintained in a viability-sustaining gel that preserves the viability of the VC for selected time periods.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: March 5, 2019
    Assignee: InCube Labs, LLC
    Inventors: Mir Imran, Joel Harris
  • Hollow microfiber
    Patent number: 10221382
    Abstract: The present invention relates to a hollow microfiber comprising (1) one or more cell-adhesive layers having a cell-adhesive hydrogel, (2) an outer shell layer having a high-strength hydrogel that covers the outer periphery of the cell-adhesive layer that is positioned farthest from the center axis among the one or more cell-adhesive layers, and (3) a cell layer that covers the inner periphery of the cell-adhesive layer that is positioned closest to the center axis among the one or more cell-adhesive layers. The present invention also relates to a method of manufacturing the hollow microfiber and a kit for carrying out the manufacturing method.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: March 5, 2019
    Assignee: THE UNIVERSITY OF TOKYO
    Inventors: Shoji Takeuchi, Hiroaki Onoe, Shigenori Miura
  • Pancreatic endocrine cells, method for producing same, and transdifferentiation agent
    Patent number: 10214728
    Abstract: A method for producing pancreatic endocrine cells, the method including introducing one or more genes of a GLIS family or one or more gene products thereof and a Neurogenin3 gene or one or more gene products thereof into somatic cells.
    Type: Grant
    Filed: July 3, 2015
    Date of Patent: February 26, 2019
    Assignee: Juntendo Educational Foundation
    Inventors: Masahito Matsumoto, Yasushi Okazaki, Izumi Sugahara
  • Biocompatible method of functionalising substrates with inert surfaces
    Patent number: 10215672
    Abstract: Biocompatible methods of functionalizing inert surfaces for use in biological applications are described. The methods employ the use of synthetic constructs of the generic structure F-S-L (where F is a functional moiety, S is a spacer selected to provide a construct that is dispersible in water, and L is a diacyl- or dialkyl-glycerophospholipid). An object of the invention is to localize or immobilize functional moieties to the inert surface of a substrate wherein the surface is comprised of glass, silver, polyamide, polycarbonate, polypropylene, polyethersulfone, polytetrafluoroethylene or polyvinylidene fluoride, and the substrate is comprised of a fiber, membrane, microsphere or nanosphere.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: February 26, 2019
    Assignee: KODE BIOTECH LIMITED
    Inventors: Stephen Micheal Henry, Stephen Robert Parker
  • Methods for diagnosis and intervention of hepatic disorders
    Patent number: 10215746
    Abstract: The disclosure provides a method for quantification of hepatic function in a subject comprising measuring the clearance of an orally administered isotopically labeled cholic acid in a subject with, or suspected of having or developing, a hepatic disorder, for example, chronic hepatitis C. The disclosure further provides methods and kits for assessment of hepatic function.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: February 26, 2019
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventor: Gregory Thomas Everson
  • Assessment of staining quality
    Patent number: 10209165
    Abstract: The quality of staining histological specimens has an impact on the histological assessment of the specimen. One of the causes for variability in the accuracy is the variations in the staining of the specimens to be tested in the working laboratories. The present invention provides a method for assessing the staining quality in a working laboratory and providing a quantitative quality measure for the staining quality. Thereby, it is possible for each working laboratory to evaluate their staining quality and to get feedback of how to improve the quality. The invention further relates to a system and a software program for carrying out the method.
    Type: Grant
    Filed: March 9, 2015
    Date of Patent: February 19, 2019
    Assignee: Visiopharm A/S
    Inventors: Michael Grunkin, Johan Doré Hansen
  • Methods and kits for measuring protease activity in feed
    Patent number: 10196670
    Abstract: Methods for measuring protease activity in feed and kits comprising components for measuring protease activity in feed.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: February 5, 2019
    Assignee: Novus International, Inc.
    Inventors: Drew L. Lichtenstein, Amie Lawhorn
  • Predictive method of characterizing the radiosensitivity and tissular reaction of a patient to therapeutic ionizing radiation
    Patent number: 10197578
    Abstract: A method for predicting cellular, tissular, and clinical radiosensitivity, based on the determination and correlation of several cellular and enzymatic parameters.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: February 5, 2019
    Assignees: UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE LEON BERARD, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Nicolas Foray, Adeline Granzotto, Clément Devic
  • Blood product from crocodylian species as a feed supplement for weanling pigs and poultry hatchlings
    Patent number: 10195230
    Abstract: The present invention is a feed supplement consisting of a blood product from at least one Crocodylian species such as the American alligator (Alligator mississippiensis). The blood product is whole blood, hemolyzed blood, serum or plasma. The feed supplement is a liquid or solid. The feed supplement may be combined with a high nutrient feed or starter diet. The feed composition may contain 0.1% or more by weight of the feed supplement. The feed supplement is fed to weanling pigs or poultry hatchlings to increase their weight and feed intake. It is also expected to promote gut health.
    Type: Grant
    Filed: December 14, 2006
    Date of Patent: February 5, 2019
    Assignee: McNeese State University
    Inventors: Mark E. Merchant, Frederick LeMieux, Jr.
  • Cellulase-producing novel strain and saccharification method using the same
    Patent number: 10196661
    Abstract: The present invention relates to the novel strain Pholiota adiposa SKU714, a method for producing cellulase from the strain and a method for saccharifying cellulose using the produced cellulase. Since the cellulase produced by the novel strain according to the present invention exhibits better saccharification yield than the existing saccharification enzymes, it can be used in various applications, including bioenergy production, textile industry, papermaking industry, detergent industry, feed industry, food industry, production of low-calorie foods, fermentation of food wastes, or the like.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: February 5, 2019
    Assignee: SK CHEMICALS CO., LTD.
    Inventors: Jung Kul Lee, Tae Su Kim, Sujit Sadashiv Jagtap, Min Ho Cha, Jong In Lee, Hang Duk Roh
  • Assay method for the detection of viable microbial cells in a sample
    Patent number: 10196671
    Abstract: The present invention discloses an assay method for the detection of viable microbial cells in a sample, the assay method comprising the steps of: i) adding an ATP degrading enzyme to a sample suspected of containing viable microbial cells to substantially degrade any extracellular ATP in the sample; ii) adding a phosphate containing compound to the sample to substantially halt action of the ATP degrading enzyme; and iii) subjecting the sample to a detection assay to establish the level of undegraded ATP in the sample to provide an indication of the level of viable microbial cells in the sample.
    Type: Grant
    Filed: January 9, 2013
    Date of Patent: February 5, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: Gerald J. Bugler, Catherine M. Ramsay, Wililam J. Simpson, Mark B. Driscoll
  • Methods and systems for processing exosomes
    Patent number: 10179149
    Abstract: Methods and systems of processing exosomes from a biologic sample, including providing a biological sample having a mixed population of exosomes, wherein the mixed population of exosomes includes two or more distinct subpopulations of exosomes; processing the biological sample to selectively remove one or more exosome subpopulations from the mixed population of exosomes thereby obtaining a sample enriched with a desired subpopulation of exosomes; and adding the enriched sample of exosomes to a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: January 15, 2019
    Inventor: Allan Yang Wu
  • Predictive method for determining tissual radiosensitivity
    Patent number: 10180437
    Abstract: A method for predicting cellular, tissue and clinical radiosensitivity, which is based on the determination and correlation of multiple parameters and cellular and enzymatic criteria.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: January 15, 2019
    Assignees: UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE LEON BERARD, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Nicolas Foray, Adeline Granzotto, Clément Devic
  • Stable NAD/NADH derivatives
    Patent number: 10167497
    Abstract: The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: January 1, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Dieter Heindl, Joachim Hoenes, Carina Horn, Claudia Gaessler-Dietsche
  • Sample holder for acoustic treatment
    Patent number: 10168258
    Abstract: A sample holder and method for separating components of a viscous sample, such as a sputum sample, in a vessel having a porous element. Liquid may be flowed through the vessel during acoustic energy treatment, which may disrupt the viscous sample. Smaller components of the sample may pass through the porous element with liquid introduced into the vessel. Larger components, such a microbes, may be captured by the porous element and may remain intact and viable for subsequent analysis. The porous element may be removable from the vessel to recover the microbes.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: January 1, 2019
    Assignee: Covaris, Inc.
    Inventor: James A. Laugharn, Jr.