Abstract: A production process of acetic acid comprises a reaction step for continuously allowing at least one member selected from the group consisting of methanol, dimethyl ether, and methyl acetate to react with carbon monoxide in a catalyst system comprising a rhodium catalyst, an iodide salt, and methyl iodide in the presence of acetic acid and water in a plant compromising a reactor 1; a flasher 2; and a distillation column 3; wherein part of the vaporized stream is introduced into a heat exchanger 7. The process achieves a production of acetic acid with a high purity in a resource-saving and energy-saving equipment by efficiently removing a reaction heat even in a large-sized plant.
Abstract: The invention relates to solid supports useful in medical applications that provide controlled release of drugs, such as peptides, nucleic acids and small molecules. The drugs are covalently coupled to the solid support through a linkage that releases the drug or a prodrug through controlled beta elimination.
Abstract: The present invention relates to a process for the preparation of polyether carbonate polyols from one or more H-functional starter substances, one or more alkylene oxides and carbon dioxide in the presence of at least one double metal cyanide catalyst, wherein the cyanide-free metal salt, the metal cyanide salt or both the mentioned salts used for the preparation of the double metal cyanide catalyst contain(s) from 0.3 to 1.8 mol base equivalents (based on 1 mol of the metal cyanide salt used for the synthesis of the catalyst) of alkaline metal hydroxide, metal carbonate and/or metal oxide.
Type:
Grant
Filed:
May 13, 2011
Date of Patent:
February 3, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Christoph Gürtler, Jörg Hofmann, Aurel Wolf, Stefan Grasser
Abstract: The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.
Type:
Grant
Filed:
October 7, 2011
Date of Patent:
February 3, 2015
Assignee:
Board of Regents, University of Texas System
Abstract: A compound represented by the following general formula (1), and a method for producing the compound represented by the general formula (1), the method comprising: reacting together a compound represented by the following general formula (2), a compound represented by the following general formula (3), and a compound represented by the following general formula (4): wherein R1 represents any of a protective group of a carboxyl group, and a hydrogen atom, R2 and R3 each independently represent any of a protective group of an amino group, and a hydrogen atom, and R4 represents any of a protective group of a carboxyl group, and a hydrogen atom.
Abstract: Provided are methods for producing fluorinated organic compounds, which preferably comprises converting at least one compound of formula (I) CH2XCHZCF3 to at least one compound of formula (II) CHX?CZCF3 where X and Z are independently H or F, with the proviso that X and Z are not the same. The converting step comprises catalytically reacting at least one compound of formula (I), preferably via dehydrogenation or oxidative dehydrogenation. In another aspect, the inventive method of preparing fluorinated organic compounds comprises converting a reaction stream comprising at least one pentafluoropropene to a product stream comprising at least one pentafluoropropane and at least one compound of formula (I), separating out the compound of formula (I) from the product stream, and converting the compound of formula (I) separated from the product stream to at least one compound of formula (II), wherein the conversion the compound of formula (I) to 3,3,3-trifluoropropyne is substantially limited.
Abstract: Disclosed are heterocyclylalkyl-substituted and heteroaralkyl-substituted pyridines, and pharmaceutically acceptable salts and prodrugs thereof, that are active against a range of mammalian therapeutic indications.
Type:
Grant
Filed:
June 24, 2011
Date of Patent:
January 20, 2015
Assignees:
Trustees of Tufts College, Arisaph Pharmaceuticals, Inc.
Inventors:
William W. Bachovchin, Hung-sen Lai, Daniel P. O'Connell, Wengen Wu, Christopher P. Kiritsy
Abstract: Compounds for UV-Vis detectable incorporation of a crosslinker a hapten into a protein or macromolecules are disclosed. The compounds comprise bis heterofunctional crosslinkers or haptens containing a chromophoric group that is incorporated into the linker that is positioned between a reactive linking moiety and a biotin molecule. The incorporation of the crosslinker or hapten into a protein or other macromolecules may be detected by UV-Vis spectroscopy.
Abstract: Methods and systems are provided for converting methane in a feed stream to acetylene. The method includes processing the acetylene to form a stream having acrylic acid. The hydrocarbon stream is introduced into a supersonic reactor and pyrolyzed to convert at least a portion of the methane to acetylene. The reactor effluent stream is to be treated to convert acetylene to acrylic acid. The method according to certain aspects includes controlling the level of carbon monoxide to prevent undesired reactions in downstream processing units.
Type:
Grant
Filed:
June 11, 2013
Date of Patent:
January 6, 2015
Assignee:
UOP LLC
Inventors:
Jeffery C. Bricker, John Q. Chen, Peter K. Coughlin
Abstract: The present invention provides acyloxy- and phosphoryloxy-butadiene-Fe(CO)3 complexes which can deliver carbon monoxide to a physiological target, wherein release of carbon monoxide can be enzymatically-triggered. The present invention also provides for methods of manufacturing the enzymatically-triggered carbon monoxide releasing molecules and methods for their use.
Type:
Grant
Filed:
February 4, 2011
Date of Patent:
January 6, 2015
Assignees:
Universitaet Zu Koeln, Universitaet Regensburg
Abstract: This invention relates to a novel crystalline polymorph of hexyl-5-aminolevulinate hydrochloride, referred to hereinafter as Form C, which is useful as precursor of a photo sensitizer in the photodynamic diagnosis and treatment of metabolically active cells related to diseases such as cancer of the uterus, cervix, vagina, rectum, colon, lower gastrointestinal tract; infection associated with cancer caused by human papilloma virus; non-cancerous lower gastrointestinal tract a human; inflammatory bowel disease; ulcerative colitis; Crohn's disease; inflammatory bowel syndrome; dysplasia of the female reproductive system; anus; penis; rosacea; and acne and which is suitable for use as the active ingredient of a commercial pharmaceutical product. The invention relates further to methods of preparing Form C and using it in the described pharmaceutical compositions.
Abstract: The present invention relates to colchicine derivatives expressed in chemical formula 1, or to pharmaceutically acceptable salts thereof, to a method for preparing said derivatives, and to a pharmaceutical composition comprising said derivatives. The colchicine derivatives according to the present invention exhibit superior immunomodulatory effects as compared with conventional immunomodulators or colchicines, and therefore can be valuably used as an immunomodulator for modulating an acute or chronic immune response in organ transplantation.
Type:
Grant
Filed:
February 18, 2011
Date of Patent:
January 6, 2015
Assignee:
The Asan Foundation
Inventors:
Duck Jong Han, Sung-eun Yoo, Jeehee Suh
Abstract: A production process for substituted phenylacetic acids or ester analogs thereof is disclosed. In this process toluene or toluene substituted with various substituents, an alcohol, an oxidant and carbon monoxide are used as raw materials to obtain compounds comprising structure of phenylacetic acid ester or analogs thereof by catalysis of the complex catalyst formed from transition metal and ligand, and such compounds are hydrolyzed to obtain various substituted phenylacetic acid based compounds. This type of compounds and their derivatives serve as important fine chemicals used widely in the industries of pharmaceuticals, pesticides, perfume and the like.
Type:
Grant
Filed:
December 20, 2012
Date of Patent:
December 30, 2014
Assignee:
Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences
Abstract: A process of producing oxalate by CO gas phase method includes the following steps: a) introducing nitrite salt, water and an inorganic acid first into a reactor I to produce a NO containing effluent I; and separating the resultant effluent to obtain the effluent II of NO; b) introducing the effluent II of NO, a C1-C4 alkanol and oxygen into a reactor II to be subjected to the reaction, and separating the resultant effluent to obtain the effluent IV of C1-C4 alkyl nitrites; c) introducing the effluent IV of C1-C4 alkyl nitrites and a CO gas stream into a coupling reactor where they are reacted to produce a NO containing effluent VI. The reactor I and/or the reactor II are preferably rotating supergravity reactors. Therefore, the process is applicable to the industrial production of oxalate by CO gas phase method.
Type:
Grant
Filed:
June 9, 2011
Date of Patent:
December 30, 2014
Assignees:
China Petroleum & Chemical Corporation, Shanghai Research Institute of Petrochemical Technology, SINOPEC
Inventors:
Weimin Yang, Juntao Liu, Wanmin Wang, Lei Li
Abstract: This disclosure describes methods of screening for compounds that disrupt the interaction between DNMT1 and the gamma-globin promoter or between LSD-1 and the gamma-globin promoter. This disclosure describes methods of screening for compounds that de-repress the gamma-globin gene.
Type:
Grant
Filed:
May 24, 2012
Date of Patent:
December 23, 2014
Assignee:
Regents of the University of Michigan
Inventors:
James Douglas Engel, Osamu Tanabe, Lihong Shi
Abstract: This invention provides a method of preventing or treating a dermatologic condition including, inter alia, psoriasis, contact dermatitis, and atopic dermatitis, in a subject, the method includes the step of administering to said subject a compound comprising a lipid or phospholipid moiety bound to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof, in an amount effective to treat the subject suffering from a dermatologic condition.
Type:
Grant
Filed:
September 21, 2006
Date of Patent:
December 23, 2014
Assignee:
Yissum Research Development Company of The Hebrew University of Jerusalem
Abstract: A regio-selective and consecutive Michael-Claisen process has been developed for substituted cyclohexane-1,3-dione synthesis started from unsubstituted or substituted acetone and ?,?-unsaturated esters. Substituted cyclohexane-1,3-diones are the basic unit found in several natural products, bioactive alkaloids and acridine dione type heterocycles, polyphenols, and unnatural amino acid synthesis. Most of the potent herbicidal and pesticidal active molecules contain cyclohexane-1,3-dione derivatives. Such an important intermediate synthesis using a facile, atom economy and one-pot process is a demandable area in organic synthesis.
Type:
Grant
Filed:
March 18, 2011
Date of Patent:
December 23, 2014
Assignee:
Council of Scientific & Industrial Research
Abstract: The present invention is directed toward a series of polyesters synthesized utilizing propane diol with tunable ascetics and performance in cosmetic formulation. These novel propane diol polyesters are designed to have great esthetics in cosmetic formulation. The physical properties and aesthetics of the current invention can be tuned rapidly by controlling the fatty groups, as well as the molecular weight of the polymer. The resulting propane diol polyesters have outstanding aesthetics and physical properties.
Abstract: The present application discloses a process for the preparation of a halofenate compound of the formula (III) or a salt thereof: wherein R, X and X? are as defined herein, the process comprising contacting a compound of formula (Ia) with a compound of formula (Ib) and N,N?-dicyclohexylcarbodiimide under conditions sufficient to form the compound of formula (III).
Abstract: The invention relates to a method for producing acyloxy benzoic acids of the formula (I), in which R1 is a linear or branched saturated alkyl group with 6 to 30 carbon atoms, a linear or branched mono- or polyunsaturated alkenyl group with 6 to 30 carbon atoms, or an aryl group with 6 to 30 carbon atoms. The acyloxy benzoic acids of the formula (I) are produced from para-hydroxy benzoic acid and a corresponding carboxylic acid halide in the presence of an alkali hydroxide.
Type:
Grant
Filed:
August 6, 2011
Date of Patent:
December 9, 2014
Assignee:
Clariant International Ltd.
Inventors:
Melanie Sajitz, Gerd Reinhardt, Isabel Scheffer, Werner Janitschek, Ina Herrgen