Patents Examined by Choon P. Koh
  • Patent number: 6322588
    Abstract: Medical devices are formed from metal/polymer composites that have improved characteristics. The metal/polymer composites have a relatively thick metal coating with an average metal thickness of greater than about 3 microns. The composite has mechanical properties, such as mechanical strength, durability and resiliency, contributed by the metal coating. The metal/polymer composites can be formed by solution based or vapor based approaches.
    Type: Grant
    Filed: August 17, 1999
    Date of Patent: November 27, 2001
    Assignee: St. Jude Medical, Inc.
    Inventors: Matthew F. Ogle, Matthew S. Reimink, Richard F. Schroeder
  • Patent number: 6315792
    Abstract: The invention creates a thin tubular multiple filament (film or fiber) structure that can hold high internal pressures. When desired, an extension of the filaments can be pulled in any direction to unfurl the structure. This device is useful for self expanding stent or stent graft delivery systems, balloon dilatation catheters, removable guide wire lumens for catheters, drug infusion or suction catheters, guide wire bundling casings, removable filters, removable wire insulation, removable packaging and other applications.
    Type: Grant
    Filed: November 9, 1999
    Date of Patent: November 13, 2001
    Assignee: Gore Enterprise Holdings, Inc.
    Inventors: Joseph Robert Armstrong, Michael Vonesh
  • Patent number: 6315791
    Abstract: An expandable prosthesis includes a self-expanding stent deployable between a substantially radially compressed configuration and a substantially radially expanded configuration. A biocompatible coating is attached to at least a portion of the outer surface of the self-expanding stent in the radially compressed configuration to inhibit radially expansion of the self-expanding stent to the radially expanded configuration. The biocompatible material is preferably integrally mounted to the self-expanding stent thus eliminating the need for a separate, independent delivery tube or sheath for maintaining the self-expanding stent in the radially compressed configuration during delivery of the self-expanding stent into a body vessel.
    Type: Grant
    Filed: December 23, 1998
    Date of Patent: November 13, 2001
    Assignee: Atrium Medical Corporation
    Inventors: Peter H. Gingras, Theodore Karwoski, Susan Hamelin, Jonathan Goodwin
  • Patent number: 6309423
    Abstract: A web of continuous filaments which are made of at least one semi-crystalline polymeric component covalently bonded as a linear block copolymer with or blended with one or more semi-crystalline or amorphous polymeric components. The filaments are intermingled together to form a porous web of filaments, the filaments having multiple contact points with each other within the web. The filaments are bonded at the contact points without requisite for added adhesive binders, adjuncts or post extrusion melt processing. The web may be bioresorbable. The web may also be provided in forms with relatively high cohesive shear strength. The polymeric components of the filaments exist, at least temporarily, in a homogenous substantially phase miscible uncrystallized state.
    Type: Grant
    Filed: December 5, 2000
    Date of Patent: October 30, 2001
    Assignee: Gore Enterprise Holdings, Inc.
    Inventor: Byron K. Hayes
  • Patent number: 6309420
    Abstract: An enhanced visibility composition for implantation from a remote source, so that the composition can be readily observed under fluoroscopy or other imaging techniques. The composition include a biocompatible matrix, such as a hard tissue implant material for example, and radiopaque particles mixed in the matrix. The radiopaque particles have a particle size between about 120&mgr; and 2200&mgr;, more preferably about 350&mgr; and 2200&mgr;, even more preferably between about 450&mgr; and 1600&mgr;, and most preferably between about 570&mgr; and 1150&mgr;. Preferably the hard tissue implant and the radiopaque particles are formed or prepared in a slurry. Optionally, the enhanced visibility composition may further include additional radiopaque particles or contrast particles mixed in with the composition, which have a particle size between about 120&mgr; and 350&mgr;, preferably between about 120&mgr; and 250&mgr;.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: October 30, 2001
    Assignee: Parallax Medical, Inc.
    Inventor: Howard Preissman
  • Patent number: 6305379
    Abstract: A process is disclosed for producing osteoinductive bone using a controlled-flow apparatus. The present apparatus allows for the controlled extraction of undesirable constituents from a body tissue. The present invention provides for the demineralization of ground bone particles or pieces of cancellous or cortical bone which permits the controlled and reproducible demineralization of bone to produce bone which is maximally osteoinductive. It has been demonstrated that ground cadaveric bone which is demineralized to a residual calcium level approximating 2% by dry weight of bone is optimally osteoinductive as assayed using in vivo and in vitro assays of osteoinductivity. The present controlled-flow apparatus includes one or more solution containers which supply solutions to be pumped into one or more vessels filled with tissue samples to be extracted. Solvent outflowing from the vessels can be monitored for pH, calcium ion concentration or conductivity as a basis for determining when extraction is complete.
    Type: Grant
    Filed: April 12, 2000
    Date of Patent: October 23, 2001
    Assignee: LifeNet
    Inventor: Lloyd Wolfinbarger, Jr.
  • Patent number: 6302905
    Abstract: Methods and apparatus for making an anastomotic connection between tubular fluid conduits in a patient. A connector may provided having an annular structure configured for placement partially within one of the tubular fluid conduits and for annular enlargement by expansion of an expandable structure positioned within an interior portion of the connector. The connector may be configured for plastic annular enlargement, and have members with free end portions that are configured to penetrate a wall of the tubular fluid conduits at locations that are annularly spaced around the connection. A portion of the connector may be selectively deflected radially out from a remainder of the connector in response to expansion of the expandable structure disposed inside the connector.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: October 16, 2001
    Assignee: St. Jude Medical Cardiovascular Group Inc.
    Inventors: David S. Goldsteen, Thomas J. Bachinski, Rudy Mazzocchi, Daniel J. Sullivan
  • Patent number: 6302913
    Abstract: This invention relates to a biomaterial useful in bone repair and replacement, and to implants for cranofacial, orthopaedic, and especially dental applications. The implants have a unique geometric configuration, their surfaces defining concavities having a shape and dimensions which induce or enhance the rate and/or amount of bone growth at the implant site. The biomaterial preferably has a specific porous configuration and the implant may be at least coated with such a biomaterial of hydroxyapatite, for example.
    Type: Grant
    Filed: November 22, 1996
    Date of Patent: October 16, 2001
    Assignee: Implico B.V.
    Inventors: Ugo Ripamonti, Anthony Nigel Kirkbride
  • Patent number: 6290723
    Abstract: A filler material for a surgically implantable prosthesis comprised of a synthetic triglyceride having a viscosity substantially greater than that of naturally occurring triglycerides is provided. The triglyceride composition is formed of saturated alkyl chains to reduce or limit the potential for oxidation of the alkyl chains to form peroxide groups which adversely affect the biocompatibility of the filler material and the implant. Preferably, the filler material has a viscosity substantially the equivalent of a normal human breast. The synthetic triglyceride filler material may also have a lower viscosity which is a liquid at room temperature for use in inflatable devices. Prostheses containing filler material having the desired viscosity and antioxidation characteristics are also provided as well as a method for preparing the filler material.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: September 18, 2001
    Inventors: Winston A. Andrews, Gloria R. Dumlao, Terry R. Knapp
  • Patent number: 6287330
    Abstract: An aortoiliac intraluminal grafting system incorporating novel structural features for enhancing the effective and efficient deployment of a tapered prosthesis having at least one attachment system, in the vessel of an animal body, the system including a balloon catheter assembly, an inferior capsule catheter assembly, a superior capsule assembly and means interacting therewith, and a capsule jacket assembly. The capsule assemblies include an inferior capsule and a superior capsule, wherein the attachment systems of the tapered prosthesis are disposed within the two capsules. The tapered prosthesis embodies a main tubular member and an inferior tubular portion, having attachment systems secured to the superior end of the main tubular member and the inferior end of the inferior tubular portion. An occlusive device and deployment catheter is also disclosed.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: September 11, 2001
    Assignee: Endovascular Technologies, Inc.
    Inventors: Peter K. Johansson, Dinah B. Quiachon, Victor M. Bernhard, Tammy L. Trayer, Richard S. Williams
  • Patent number: 6287340
    Abstract: The present invention provides a method for producing an anterior cruciate ligament ex vivo. The method comprises seeding pluripotent stem cells in a three dimensional matrix, anchoring the seeded matrix by attachment to two anchors, and culturing the cells within the matrix under conditions appropriate for cell growth and regeneration, while subjecting the matrix to one or more mechanical forces via movement of one or both of the attached anchors. Bone marrow stromal cells are preferably used as the pluripotent cells in the method. Suitable matrix materials are materials to which cells can adhere, such as a gel made from collagen type I. Suitable anchor materials are materials to which the matrix can attach, such as Goinopra coral and also demineralized bone. Optimally, the mechanical forces to which the matrix is subjected mimic mechanical stimuli experienced by an anterior cruciate ligament in vivo.
    Type: Grant
    Filed: May 14, 1999
    Date of Patent: September 11, 2001
    Assignees: Trustees of Tufts College, Massachusetts Institute of Technology
    Inventors: Gregory Altman, David Kaplan, Gordana Vunjak-Novakovic, Ivan Martin
  • Patent number: 6283997
    Abstract: A process for producing a ceramic composite having a porous network. The process includes providing a photocurable ceramic dispersion. The dispersion consists of a photocurable polymer and a ceramic composition. The surface of the dispersion is scanned with a laser to cure the photocurable polymer to produce a photocured polymer/ceramic composition. The photocured composition useful as a polymer/ceramic composite, or the polymer phase can be removed by heating to a first temperature that is sufficient to burn out the photocured polymer. It is then heated to a second temperature that is higher than the first temperature and is sufficient to sinter the ceramic composition to produce a purely ceramic composition having a porous network. Preferably and more specifically, the process uses a stereolithographic technique for laser scanning. The process can form a high quality orthopedic implant that dimensionally matches the bone structure of a patient.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: September 4, 2001
    Assignees: The Trustees of Princeton University, Ethicon, Inc.
    Inventors: Rajeev Garg, Robert K. Prud'Homme, Ilhan A. Aksay, Victor F. Janas, Kevor S. TenHuisen, Shawn T. Huxel
  • Patent number: 6273914
    Abstract: A spinal implant for rigid fixation of at least two vertebrae of a pine has at least one support member configured for attachment to the vertebrae and is comprised of a bio-compatible polymer composite. A plurality of fasteners attach the support members to the vertebrae. A predefined standard selection of such bio-compatible implant components Ore provided so as to define support members which conform to the specific anatomical structure of the patient's spine without being modified.
    Type: Grant
    Filed: December 2, 1997
    Date of Patent: August 14, 2001
    Assignee: Sparta, Inc.
    Inventor: Gary R. Papas
  • Patent number: 6269817
    Abstract: A cosmetic method for obtaining substantial cosmetic effects through simple massaging by ordinary people by first massaging in the direction of arterial blood flow and then in the direction of venous blood flow, or by massaging the surface of the skin with the use of a cosmetic comprising disintegrating particles while the pulse, dermal vasculature, skin temperature, or dermal blood flow is in a stimulated, dilated, elevated, or stimulated state as opposed to a resting state, and by washing the skin with a cleanser or a detergent, and then using a skincare cosmetic, wherein massaging is done using a massaging cosmetic comprising disintegrating particles before the skincare cosmetic is used after washing with a cleanser or detergent. This allows effective skincare to be achieved.
    Type: Grant
    Filed: September 21, 1998
    Date of Patent: August 7, 2001
    Assignee: Kao Corporation
    Inventors: Yoshinao Nagashima, Takahide Minami, Yukihiro Yada
  • Patent number: 6270523
    Abstract: A radially expandable support body is enveloped within a cocoon. In a preferred construction, the support is a stent, and a tube of polymeric material, e.g., polytetraeluoroethylene (PTFE), passes through the interior of the stent body and is turned back upon itself over the stent to form a cuff. The assembly is then heated and the outer layer contacts and coalesces with the inner layer, closely surrounding the stent body within a folded envelope having a continuous and seamless end. In one embodiment, an end portion of the tube is expanded before folding back over the-stent. The end portion, which becomes an exterior surface of the finished product, thus acquires a greater degree of porosity. Each end of the central tube may be so expanded, and folded back to seal all surfaces and both ends. The stent body itself may be a ring, or a short series of spaced-apart rings, or a wire or web, or a sheet possessing a number of apertures extending entirely through the sheet.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: August 7, 2001
    Assignee: Atrium Medical Corporation
    Inventors: Steve A. Herweck, Peter Gingras, Paul Martakos, Theodore Karwoski
  • Patent number: 6270530
    Abstract: A prosthetic repair fabric including a sheet of tissue infiltratable fabric and a second sheet, also preferably including tissue infiltratable fabric, which is united with the first sheet. The second sheet is fused to an adhesion resistant barrier, forming a laminate composite prosthesis without degrading the mechanical properties or tissue ingrowith capability of the first sheet.
    Type: Grant
    Filed: June 9, 2000
    Date of Patent: August 7, 2001
    Assignee: C.R. Bard, Inc.
    Inventors: Stephen N. Eldridge, Milo A. Titone
  • Patent number: 6270526
    Abstract: A method is disclosed for using tubular material to replace a semilunar heart valve (i.e., an aortic or pulmonary valve). To create such a replacement valve, the native valve cusps are removed from inside an aorta or pulmonary artery, and the inlet end of a tubular segment is sutured to the valve annulus. The outlet (distal) end of the tube is either “tacked” at three points distally, or sutured longitudinally along three lines; either method will allow the flaps of tissue between the suture lines to function as movable cusps. This approach generates flow patterns that reduce turbulence and closely duplicate the flow patterns of native semilunar valves. An article of manufacture is also disclosed, comprising a sterile biocompatible synthetic material which has been manufactured in tubular form, by methods such as extrusion or coating a cylindrical molding device, to avoid a need for a suture line or other seam to convert a flat sheet of material into a tubular shape.
    Type: Grant
    Filed: March 27, 2000
    Date of Patent: August 7, 2001
    Assignee: 3F Therapeutics, Inc.
    Inventor: James L. Cox
  • Patent number: 6267782
    Abstract: A variety of new ways can be used for associating antimicrobial elemental metal with a medical article. The associated antimicrobial metal reduces the risk of infection associated with the medical use of the medical article. New medical articles are produced by some of these new approaches. Some of the methods involve ways of adjusting the dissociation rate of associated elemental metal such that desired degrees of antimicrobial activity can be achieved over selected periods of time.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: July 31, 2001
    Assignee: St. Jude Medical, Inc.
    Inventors: Matthew F. Ogle, William R. Holmberg, Richard F. Schroeder, Donald S. Guzik, M. William Mirsch, II, Darrin J. Bergman, Hallie A. Finucane, Katherine S. Tweden
  • Patent number: 6263880
    Abstract: Method of enhancing blood flow in tissue wherein an implant is non-ablatively introduced into the tissue in order to stimulate production of angiogenic agents by the tissue, the agents produced by the tissue are absorbed into the implant, where they are stored, and the stored agents are released back into the tissue when the production of agents by the tissue subsides. The implant is fabricated of a bioresorbable material and is resorbed into the tissue after the agents are released. In some embodiments, an exogenous angiogenic agent in included in the implant and released into the tissue along with the agents which are produced by the tissue and absorbed by the implant.
    Type: Grant
    Filed: June 21, 1999
    Date of Patent: July 24, 2001
    Assignee: Neovasys, Inc.
    Inventors: Theodore L. Parker, Danforth Joslyn, Serjan D. Nikolic
  • Patent number: 6261255
    Abstract: The invention includes a composite tube for forming an arteriovenous fistula with at least two conjoined segments or sections. The first section includes an elongated tubing formed from PTFE or another catheter material that is similarly amenable for convenient arterioveneous access. The second section includes an elongated tubing formed from silicone or another suitable long term catheter material. An intermediate connection couples the first section to the second section. The diameter of the first segment is between 2 mm. to 10 mm. while the second segment is between 4 to 8 millimeters at the coupling site and tapers to approximately 3 to 4 mm. distally. The second segment includes outlet ports proximate a beveled tip permitting outward blood flow. Several intermediate connections may be employed including single composite tubing, flanged segments and male and female tabbed collars, as long as the connection allows uninterrupted laminar flow across the entire length of the arteriovenous fistula.
    Type: Grant
    Filed: November 6, 1998
    Date of Patent: July 17, 2001
    Inventors: Ronald Jay Mullis, William R. McNair