Patents Examined by Chris L Chin
  • Patent number: 9891149
    Abstract: A method for pretreatment of a sample of whole blood in a discrete fluid analyzing instrument comprises automated means for handling and analyzing the sample and means for performing a pretreatment step on the sample or a sub-sample of the sample. The means for pretreatment are used for immobilizing at least one substance or analyte from the sample or sub-sample wherein the substance or analyte is reversibly immobilized. Usually, the apparatus further comprises means for eluting the substance or analyte from the capture means prior to analysis.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: February 13, 2018
    Assignee: Thermo Fisher Scientific Oy
    Inventors: Sari Tikanoja, Annu Suoniemi-Kähärä, Johan Finell, Lili Arabshahi
  • Patent number: 9891233
    Abstract: The present disclosure relates to methods for predicting time-to-delivery in pregnant women. The methods include predicting that a pregnant woman will deliver within a predetermined time frame if PAMG-1 is determined to be present at a level above a predetermined detection threshold in a vaginal fluid sample obtained from the pregnant woman. Also provided are methods for determining a patient's risk of preterm labor and/or spontaneous rupture of the chorioamniotic membrane.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: February 13, 2018
    Assignee: N-Dia, Inc.
    Inventors: Anthony Ausiello, Ruben Salinas, Michael Thompson, Daniel J. Mackey, Kaitlyn Nardozzi, Michael Friedman
  • Patent number: 9885706
    Abstract: The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: February 6, 2018
    Assignee: Abbott Point of Care Inc.
    Inventors: Gary Vandersleen, Pierre Emeric, Paul Wasserman, Narendra Soman, Graham Davis, Cary Miller
  • Patent number: 9878323
    Abstract: We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: January 30, 2018
    Assignee: MESO SCALE TECHNOLOGIES, LLC
    Inventors: Eli N. Glezer, Bandele Jeffrey-Coker, Jeffery D. Debad, Sudeep M. Kumar, George B. Sigal, Gisbert Spieles, Michael Tsionsky, Michael Warnock
  • Patent number: 9874576
    Abstract: The present invention relates to novel lateral flow devices using two dimensional features, preferably, uniform two dimensional test and control features, and the methods for detecting an analyte using the lateral flow devices, and processes for making the lateral flow devices.
    Type: Grant
    Filed: April 12, 2013
    Date of Patent: January 23, 2018
    Assignee: SYMBOLICS, LLC
    Inventors: Brendan O'Farrell, Thomas C. Tisone
  • Patent number: 9874556
    Abstract: The present invention relates to novel lateral flow devices using two dimensional features, preferably, uniform two dimensional test and control features, to provide flow control information, to function as an internal control and/or to provide internal calibration information for the test device. The present invention also relates to methods for using the lateral flow devices to provide flow control information, to function as an internal control and/or to provide internal calibration information for the test device.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: January 23, 2018
    Assignee: Symbolics, LLC
    Inventors: Brendan O'Farrell, Thomas C. Tisone
  • Patent number: 9857364
    Abstract: The present invention relates to a method for detection of binding or interaction events between a binding agent and its corresponding analyte (such as an antibody and an antigen) in which a signal is detected which is substantially more amplified and thus easier to detect than in prior art systems. The method comprises simultaneous but separate addition of a first enhancement reagent having affinity for said analyte and a second enhancement reagent having affinity for the first enhancement reagent wherein the first enhancement reagent binds to the analyte and the second enhancement reagent binds to the first enhancement reagent, and, wherein the first and second enhancement reagents have more than one binding site so that they are able to bind to each other to thereby amplify a detectable signal from the binding event.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: January 2, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Tanja Jarhede, Anita Larsson
  • Patent number: 9851366
    Abstract: The present invention relates to novel lateral flow devices using two dimensional features, preferably, uniform two dimensional test and control features, and the methods for detecting an analyte using the lateral flow devices, and processes for making the lateral flow devices.
    Type: Grant
    Filed: April 12, 2013
    Date of Patent: December 26, 2017
    Assignee: SYMBOLICS, LLC
    Inventors: Brendan O'Farrell, Thomas C. Tisone
  • Patent number: 9851353
    Abstract: This invention relates to a system and methods including their manufacturing technologies for enhanced sensing capability of one or more bioagents covering from HIV, Pathogens, virus, to cells detection. More particularly, this invention is related to HIV and pathogen diagnosis system and methods which may increase its sensitivity and may reduce the diagnosis time. Furthermore, the diagnosis system and method may be applicable to all early stage patients with various age groups, where early and accuracy in diagnosis, are required.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 26, 2017
    Assignee: Banpil Photonics, Inc.
    Inventor: Achyut Dutta
  • Patent number: 9828577
    Abstract: A system and method for monitoring viscosity changes of a fluid stored in a volume are provided. The system includes a flexible chamber configured to receive and hold the fluid, a motion generator configured to induce a wave motion within the fluid, at least one sensor affixed at least in part to a portion of the flexible chamber and configured to measure at least a strain on a portion of the flexible chamber and generate an associated strain output. The strain output is effectuated by the wave motion of the fluid within the flexible chamber and correlates to a viscosity value of the fluid. A computer or controller is configured to receive the strain output from the sensor at a given time, compare the viscosity value associated with the strain output to a reference viscosity value, and determine whether to adjust the wave motion generated by the motion generator.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: November 28, 2017
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Gregory Heinz, Jimmie Beacham, Jr.
  • Patent number: 9823246
    Abstract: Disclosed are nanostructured gold films which may be produced by solution-phase depositions of gold ions onto a variety of surfaces. The resulting plasmonic gold films are used for enhanced spectroscopic-based immunoassays in multiplexed microarray format with detection mechanisms based on either surface-enhanced Raman scattering or near-infrared fluorescence enhancement. The preparation of the films and subsequent modifications of the gold film surfaces afford increased sensitivity for various microarrays. The films are discontinuous, forming gold “islands.” Sensitivity, size, shape, and density of the nanoscopic gold islands comprising the discontinuous nanostructured gold film are controlled to enhance the intensity of Raman scattering and fluorescence in the near-infrared, allowing for improved measurements in clinical diagnostic or biomedical research applications.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: November 21, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hongjie Dai, Scott M. Tabakman, Guosong Hong, Bo Zhang
  • Patent number: 9823240
    Abstract: Compositions, methods, and devices for the detection of multiple analytes with a single signal are provided.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: November 21, 2017
    Assignee: INVISIBLE SENTINEL, INC.
    Inventors: Nicholas Siciliano, Louis Leong, Martin Patrick Keough, Ashley Shaniece Brown
  • Patent number: 9816984
    Abstract: Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: November 14, 2017
    Assignee: INVISIBLE SENTINEL, INC.
    Inventors: Nicholas A. Siciliano, Martin Joseph Bouliane
  • Patent number: 9804155
    Abstract: Devices and methods incorporate mucolytic agents into a point-of-care testing device. The sample is loaded, and then the sample travels until it encounters one or more lysis agents and/or mucolytic agents. The mucolytic agent is preferably pre-loaded onto the collection device. In a preferred embodiment, the mucolytic agent is localized between the sample application zone and the conjugate zone. In embodiments with a sample compressor, one or more mucolytic agents may be pre-loaded and dried on the sample compressor, the sample collector, in various locations on the test strip, or in the running buffer.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: October 31, 2017
    Assignee: RAPID PATHOGEN SCREENING, INC.
    Inventors: Uma Mahesh Babu, Robert P. Sambursky
  • Patent number: 9797898
    Abstract: Devices and methods incorporate mucolytic agents into a point-of-care testing device. The sample is loaded, and then the sample travels until it encounters one or more lysis agents and/or mucolytic agents. The mucolytic agent is preferably pre-loaded onto the collection device. In a preferred embodiment, the mucolytic agent is localized between the sample application zone and the conjugate zone. In embodiments with a sample compressor, one or more mucolytic agents may be pre-loaded and dried on the sample compressor, the sample collector, in various locations on the test strip, or in the running buffer.
    Type: Grant
    Filed: May 3, 2012
    Date of Patent: October 24, 2017
    Assignee: RAPID PATHOGEN SCREENING, INC.
    Inventors: Uma Mahesh Babu, Robert P. Sambursky
  • Patent number: 9797817
    Abstract: Sandwich separation is based on forming a sandwich complex with a magnetic bead, buoyant bead, and a target. Once a sandwich formation is created, the sandwich can be separated using its dual physical properties, namely magnetism and buoyancy. Sandwich separation is highly specific, allows for removal of the beads that do not have any attached target, and reduces the number of background beads. Sandwich separation can also be used to allow for target detection in raw specimen. Also, improvement of detection capability is accomplished by performing AMBR measurements on a solid interface, where the rotational period speeds up and allows for dramatically reduced time-to-result.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: October 24, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Brandon H. McNaughton, Paivo Kinnunen, John G. Younger
  • Patent number: 9797019
    Abstract: The present invention relates generally to an assay for detecting and differentiating multiple analytes, if present, in a single fluid sample, including devices and methods therefore.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: October 24, 2017
    Assignee: Quidel Corporation
    Inventors: Paul Lambotte, Michael Cerrito, Cecille Ramirez
  • Patent number: 9791368
    Abstract: A label-free method for the spatio-temporal mapping of protein secretions from individual cells in real time by using a chip for localized surface plasmon resonance (LSPR) imaging. The chip is a glass coverslip compatible for use in a standard microscope having at least one array of functionalized plasmonic nanostructures patterned onto it. After placing a cell on the chip, the secretions from the cell are spatially and temporally mapped using LSPR imaging. Transmitted light imaging and/or fluorescence imaging may be done simultaneously with the LSPR imaging.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 17, 2017
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Marc P. Raphael, Joseph A. Christodoulides, Jeff M. Byers, James B. Delehanty
  • Patent number: 9784733
    Abstract: A rapid diagnostic test device uses driven flow technology to significantly expedite the testing time of a sample. The rapid diagnostic test device can be used to analyze liquids, such as some body fluids, by using labeled molecular affinity binding, such as immunochromatography. The test device can detect an analyte, such as an antibody or antigen, which may indicate a particular condition, the presence of a particular drug, or the like. The device includes an inner member that receives the body fluid. Dripping holes in the inner member, or a sloped surface, creates a stream force of the body fluid against the sample pad of the test strip. A portion of the stream force of the body fluid is directed upward toward the conjugate pad to push the antibody/body fluid sample onto the membrane of the test strip.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: October 10, 2017
    Assignee: DNT SCIENTIFIC RESEARCH, LLC
    Inventors: Naishu Wang, Michael Chang Chien
  • Patent number: 9778253
    Abstract: A bio-related substance assay tube 2 comprises a target substance capture bead 3 serving as a first microparticle, compensation bead 4 serving as a second microparticle on which a given amount of a bio-related substance has been immobilized, and a negative control bead 5 serving as a third microparticle for use as a negative control. A mount unit 12 comprises a nozzle communicating with a pump, and the bio-related substance assay tube 2 is mounted in the mount unit 12 to ensure communication with this nozzle. An analyte is introduced into the bio-related substance assay tube 2, followed by labeling the bio-related substance bound to each microparticle to cause light emission. Based on light emission from each microparticle, a calibration curve is prepared or the emission intensity of the first microparticle is compensated to quantify the bio-related substance.
    Type: Grant
    Filed: April 20, 2010
    Date of Patent: October 3, 2017
    Assignee: UNIVERSAL BIO RESEARCH CO., LTD.
    Inventor: Hideji Tajima