Patents Examined by D. W. Robinson
  • Patent number: 5968830
    Abstract: A method of transforming and regenerating soybean plants relies on selection of hypocotyl explants as the target material. Hypocotyl explants can be transformed either by microparticle bombardment with DNA-coated microparticles of inert metals, or by co-culturing with an Agrobacterium strain. The transformed explants can be successfully regenerated, using a protocol including culturing on a shoot induction medium, followed by transfer to a shoot elongation medium to form rooted plantlets, which are transplanted to soil.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: October 19, 1999
    Assignee: Mississippi State University
    Inventors: Yinghui Dan, Nancy A. Reichert
  • Patent number: 5071976
    Abstract: This invention provides a fermentation process which involves aerobically cultivating a strain of Methylophilus viscogenes under growth conditions to produce an accumulated quantity of a novel type of exopolysaccharide, such as heteropolysaccharide Poly 54.
    Type: Grant
    Filed: November 7, 1988
    Date of Patent: December 10, 1991
    Assignee: Celgene Corporation
    Inventor: David I. Stirling
  • Patent number: 4885289
    Abstract: The rate and character of androgen-stimulated beard hair growth in intact, sexually mature males is altered by the topical application out of a dermatologically acceptable carrier of an antiandrogen material. In a preferred practice of the invention, compositions containing both a steroid 5-alpha-reductase inhibitor and a cytoplasmic androgen receptor binding agent are employed.
    Type: Grant
    Filed: December 11, 1985
    Date of Patent: December 5, 1989
    Inventors: Miklos M. Breuer, Edwin G. Kaszynski, Douglas Shander, Vera R. Usdin, Hermes van der Lee
  • Patent number: 4212876
    Abstract: Certain substituted or unsubstituted 2-phenylbenzimidazoles, e.g., 1-methyl-2-phenylbenzimidazole, are useful as anti-obesity agents.
    Type: Grant
    Filed: June 21, 1978
    Date of Patent: July 15, 1980
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Patent number: 4173566
    Abstract: 1-benzhydryl-2-cyanoazetidine is a novel intermediate for the synthesis of N-diphenylalkyl-2-benzyl azacyclic compounds.
    Type: Grant
    Filed: August 23, 1978
    Date of Patent: November 6, 1979
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Daniel M. Solomon
  • Patent number: 4170655
    Abstract: Stable, aqueous or aqueous-alcoholic solutions of fat-soluble perfume oils or drugs, containing hydroxyalkyl ester- and/or N-(hydroxyalkyl)-amide-ethoxylates of the formula ##STR1## wherein R.sub.1 and/or R.sub.2 are an alkyl group having 1 to 18 carbon atoms or hydrogen, R.sub.3 is an alkyl group having 1 to 12 carbon atoms or an aryl group, X is an oxygen atom, the group >NH or the group >N--(C.sub.2 H.sub.4 O).sub.m H, and n and m are integers of from 0 to 40, with the proviso that the total of the carbon atoms of R.sub.1 +R.sub.2 is from 6 to 20 and the total of the numbers n+m is a value from 6 to 40.
    Type: Grant
    Filed: August 19, 1977
    Date of Patent: October 9, 1979
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Ulrich Zeidler, Fanny Scheuermann
  • Patent number: 4167581
    Abstract: 1-Aryloxy-3-aminoalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity and some of them additionally possess cardiac stimulant activity. Representative of the compounds disclosed is 1-(2-cyanophenoxy)-3-.beta.(4-hydroxyphenylacetamido)ethylamino-2-propanol .
    Type: Grant
    Filed: November 1, 1978
    Date of Patent: September 11, 1979
    Assignee: Imperial Chemical Industries Limited
    Inventor: Leslie H. Smith
  • Patent number: 4164570
    Abstract: An aqueous solution for treating glaucoma comprises 0.1-5.0% of a specially purified catecholamine e.g., epinephrine, 0.5-5.0% of a thiol, e.g., N-acetyl-L-cysteine, an acid compound unless the thiol is acid) to solubilize the catecholamine and a base e.g., NH.sub.4 OH to bring the pH to 6.0-7.5, the solution being free from borate ions. The acid compound, if used can be e.g., lactic acid, which may be buffered with ammonium lactate, or ammonium dihydrogen phosphate; preferably alkali metal ions are avoided. Guanethidine or like compounds which potentiate epinephrine can also be present.
    Type: Grant
    Filed: November 22, 1976
    Date of Patent: August 14, 1979
    Inventors: David Clough, Gary C. F. Ruder
  • Patent number: 4164582
    Abstract: A fungicide, especially for the dressing of cereal seeds, which contains: methylbenzimidazole-2-ylcarbamate and 1-[.beta.-(allyloxy)-2,4-dichlorophenethyl]imidazole, phenylcarbamoyl-1,4-oxatine or 1,2-di-(3-methoxycarbonyl-2) or methylbenzimidazole-2-ylcarbamate or 1-[.beta.-(allyloxy)-2,4-dichlorophenethyl]imidazole and at least two compounds selected from 2-pyridinethiol-1-oxide, zinc dimethyldithiocarbamate, 2,3-dihydro-6-methyl-5-phenylcarbamoyl-1,4-oxatine, 1,2-di-(3-methoxycarbonyl-2-thioureido)benzene, and the salts of the same.
    Type: Grant
    Filed: March 31, 1977
    Date of Patent: August 14, 1979
    Assignee: Kemira Oy
    Inventor: Pontus A. Harju-Jeanty
  • Patent number: 4164568
    Abstract: A veterinary composition comprising 40 to 80% of an actively absorbed monosaccharide, 7.5 to 30% of an actively absorbed naturally occurring amino acid, and 0.5 to 10% of an agent which is citric acid or a salt thereof; except that when the agent is a salt of citric acid, then the amino acid represents no more than 13% of the composition; are useful in the treatment of diarrhoea in animals such as calves.
    Type: Grant
    Filed: March 11, 1977
    Date of Patent: August 14, 1979
    Assignee: Beechamgroup Limited
    Inventor: Robert J. Bywater
  • Patent number: 4163790
    Abstract: Compounds of the following general formula are useful for increasing coronary blood flow in mammals: ##STR1## wherein R is hydrogen, acetyl, p-fluorobenzoylpropyl, carbamoyl, N-methylcarbamoyl, N,N-dimethylcarbamoyl, phenylcarbamoyl, or N-(.omega.-morpholinoethyl)carbamoyl; R.sup.1 is hydrogen; R.sup.2 is hydrogen or hydroxy; or R.sup.1 and R.sup.2 taken together form a second bond between the carbon atoms bearing R.sup.1 and R.sup.2 ; R.sup.3 is hydrogen or fluorine and pharmaceutically acceptable acid addition salts thereof.
    Type: Grant
    Filed: March 14, 1978
    Date of Patent: August 7, 1979
    Assignee: A. H. Robins Company, Inc.
    Inventors: Bernard V. Franko, Anthony G. Proakis
  • Patent number: 4161542
    Abstract: Amines of the formula I ##STR1## method of preparing the same and pharmaceutical compositions and methods for treating cardiovascular disorders by blocking the .beta.-receptors of the heart in combination with a peripheral vasodilating activity.
    Type: Grant
    Filed: December 27, 1977
    Date of Patent: July 17, 1979
    Assignee: Aktiebolaget Hassle
    Inventors: Enar I. Carlsson, Gustav B. R. Samuelsson, Bo T. Lundgren
  • Patent number: 4161526
    Abstract: Pyrithione, pyrithione salt or dipyrithione compositions containing the zinc salt of an organic or inorganic acid, zinc hydroxide or zinc oxide or a mixture thereof for prevention or removal of discoloration in said compositions, and the process of preventing such discoloration, are disclosed.
    Type: Grant
    Filed: July 20, 1978
    Date of Patent: July 17, 1979
    Assignee: Sterling Drug Inc.
    Inventor: William G. Gorman
  • Patent number: 4160821
    Abstract: A glycerine solution of zinc chloride or another pharmaceutically acceptable zinc salt that is soluble in glycerine provides effective therapy for gingivitis when applied to the gingivae and teeth.
    Type: Grant
    Filed: February 27, 1978
    Date of Patent: July 10, 1979
    Assignee: Johnson & Johnson
    Inventor: Tibor Sipos
  • Patent number: 4160835
    Abstract: Novel pharmaceutical compositions are disclosed. The compositions comprise an aryl substituted alanine and a substituted phenyl hydrazino propionic acid. The compositions are useful for treating hypertension.
    Type: Grant
    Filed: November 11, 1977
    Date of Patent: July 10, 1979
    Assignee: Merck & Co., Inc.
    Inventor: Clement A. Stone
  • Patent number: 4156734
    Abstract: Novel pharmaceutical compositions are disclosed. The compositions comprise an aryl substituted alanine and a substituted phenyl hydrazino propionic acid. The compositions are useful for treating hypertension.
    Type: Grant
    Filed: February 13, 1978
    Date of Patent: May 29, 1979
    Assignee: Merck & Co., Inc.
    Inventor: Clement A. Stone
  • Patent number: 4155995
    Abstract: A highly effective petroleum-based mosquito larvicide having dispersed therein minor amounts of a dialkyl polysiloxane and an ethoxylated mono-alkyl phenol.
    Type: Grant
    Filed: September 30, 1977
    Date of Patent: May 22, 1979
    Assignee: Witco Chemical Corporation
    Inventors: Heinz D. Heinz, Steven J. Escobar
  • Patent number: 4156001
    Abstract: Synergistic fungicidal compositions comprising ##STR1## in which R.sup.1 is optionally substituted phenyl,R.sup.2 is hydrogen, alkyl or phenyl,R.sup.3 is alkyl, cycloalkyl, phenyl or chlorophenyl, andY is a keto group or a functional derivative thereof, and at least one member selected from the group consisting of(a) dithiocarbamates,(b) N-polyhaloalkylthio-amines or -amides,(c) imidazole and benzimidazole derivatives,(d) optionally nitrated polyhalobenzenes,(e) N-sulphinyl-N'-aryl-hydrazines, and(f) sulphur or alkaline earth metal polysulphides.
    Type: Grant
    Filed: January 18, 1978
    Date of Patent: May 22, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wilhelm Brandes, Paul-Ernst Frohberger, Hans Scheinpflug, Wolfgang Kramer
  • Patent number: 4153715
    Abstract: A compound of the formula ##STR1## possesses antihypertensive activity. Also provided are methods for the preparation of the compounds as well as pharmaceutical formulations and methods for their use as antihypertensive agents.
    Type: Grant
    Filed: August 16, 1977
    Date of Patent: May 8, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Atkinson, Clarence S. Rooney, Yves Girard, Edward L. Engelhardt
  • Patent number: 4152461
    Abstract: Insecticidal and acaricidal compositions and methods of combating insects and acarid utilizing compounds of the formula ##STR1## wherein N REPRESENTS THE NUMBER 0, 1 OR 2,R.sub.1 represents hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.2 -alkoxy, C.sub.3 -C.sub.4 -alkenyloxy, C.sub.3 -C.sub.5 -alkynyloxy, halogen, C.sub.1 -C.sub.3 -alkylcarbonyl, formyl, C.sub.1 -C.sub.5 -alkoxycarbonyl or C.sub.1 -C.sub.2 -alkylthio,R.sub.2 represents hydrogen, C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.2 -alkoxy or chlorine, orR.sub.1 and R.sub.2 together represent the 3,4-methylenedioxy group,R.sub.3 represents hydrogen, methyl, ethyl or phenyl,R.sub.4 represents hydrogen or methyl.
    Type: Grant
    Filed: December 21, 1977
    Date of Patent: May 1, 1979
    Assignee: Ciba-Geigy Corporation
    Inventor: Friedrich Karrer