Abstract: A composition of matter is described herein which has insecticidal and miticidal activity and methods of use. The composition may be defined by the following generic formula: ##STR1## wherein R.sub.1 and R.sub.2 are independently methyl or halogen; R.sub.3 is selected from the following groups: ##STR2## R.sub.

Abstract: A method for the immuno-therapeutic control and treatment of acne by administering an effective amount for treatment of an immunological preparation comprising an immunogen and at least one anti-mitotic adjuvant agent together with a pharmaceutically acceptable carrier.

Abstract: The compound (bis-diethylamine)2,5-dihydroxybenzene-1,4-disulfonate is useful as a medicament against glaucoma. .

Abstract: A method of controlling the growth of microorganisms by applying to them or to their habitat an imidazoline represented by the formula ##STR1## where R can be hydrogen or methyl, R.sup.1 can be hydrogen, or alkyl of 1-3 carbon atoms, R.sup.2 can be hydrogen or methyl, R.sup.3 can be alkyl of 6-10 carbon atoms and x is 1 or 2.

Abstract: In accordance with the present invention, there is provided herein an in situ process for making stable PVP-iodine complex having a high level of iodine power. The process of this invention is carried out by adding a predetermined amount of free water to a PVP suspension, and admixing iodine therewith to form the desired solid complex. The PVP suspension may be obtained by suspension polymerization of N-vinylpyrrolidone (VP) in a suitable solvent, and used directly for succeeding steps of the process.

Abstract: An ophthalmic composition comprising a compound having the structural formula ##STR1## wherein X is selected from the group consisting of CH.sub.2 --CH.sub.2, CH.sub.2 and OCH.sub.2 ; and Y is selected from the group consisting of phenyl, P-methoxy phenyl and O-methoxy phenyl and a pharmaceutically acceptable salt thereof and a topically administrable ophthalmic pharmaceutical carrier. The foregoing composition is useful in lowering intraocular pressure in the eye. Reduction of intraocular pressure is of particular importance in the treatment of glaucoma, a disease characterized by elevated intraocular pressure.

Abstract: Tetrahydrodibenzopyrans having the structure ##STR1## in which R, R.sub.1, and R.sub.2 are alkyl having from 1 to 4 carbon atoms and ophthalmologically acceptable acid addition salts thereof are effective anti-glaucoma agents, free from all but a very small amount of CNS activity, when applied topically.

Abstract: An appetite curbing preparation comprising an alginate and diphosphonic acid or a nontoxic pharmacologically acceptable water-soluble salt thereof as an inhibitor of the precipitation of calcium salts. This preparation is useful for curbing the appetite of a warm-blooded animal.

Abstract: Preparation of iodophor granules of practically uniform particle size consisting of poly-N-vinyl-pyrrolidone, iodine and substance releasing iodide ions by combining with uniform thorough mixing(a) a solution and/or colloidal suspension of elementary iodine and a substance releasing iodide ions in a first solvent or solvent mixture, as well as(b) a solution and/or colloidal solution and/or suspension of PVP in a second solvent or solvent mixture which has a surface tension different from that of the first solvent or solvent mixture, and in which PVP is at least partially soluble or wettable, and in which the substances dissolved or suspended in the first solvent or solvent mixture are insoluble or only slightly soluble, and separating and drying the granules formed.

Abstract: A method of producing anorexia in warm-blooded animals which comprises administering racemic 2-(.beta.-phenyl-trans-vinyl)morpholine or the (2R) isomer thereof.

Abstract: The present invention relates to the use of salts of dichloroacetate which contain one or two molecules of dichloroacetate and one or two atoms of a mono- or divalent metallic cation, and particularly sodium dichloroacetate, for the treatment of hyperlipoproteinemia in humans.The method of this invention has utility in the treatment of conditions in a human patient-subject in which there is abnormal elevation of the blood levels of one or more of the major lipids (cholesterol and triglycerides) normally present in the body.

Abstract: A solid composition for making up a disinfectant or sterilizing preparation, which comprises a disinfecting or sterilizing amount of saturated dialdehyde having from 2 to 6 carbon atoms absorbed and/or adsorbed on an inorganic or organic particulate carrier material and, in some cases, an alkalinating agent.

Abstract: An ophthalmic solution is disclosed comprising an aqueous solution of polyvinyl alcohol, hydroxyethyl cellulose, polyvinylpyrrolidone, and, optionally, hydroxypropyl methylcellulose. The ophthalmic solution is used in treating dry eye syndrome due to insufficient tear production in humans and mammals, and as an ocular lubricant for inflamed eyes.

Abstract: Fungicidal compositions containing phosphorous acid, inorganic and organic salts thereof are disclosed, as well as a method of controlling fungus disease in plants by applying such compositions.

Abstract: There is described the stereoselective total synthesis of novel .DELTA..sup.2,3 -1,4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1## wherein X is amino, azido or acylamido and Z represents optionally substituted C.sub.1 -C.sub.6 alkyl, aryl, aralkyl or heterocyclic. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such antibacterial agents.

Abstract: Powdered aluminum aids in the treatment of, the alleviation of suffering during and the relief from conjunctivitis. When administered to the eye of an animal afflicted with croupous or membranous conjunctivitis, powdered aluminum assists in breaking down and removing the milky film associated with this malady. The powdered aluminum may be applied to a diseased eye by direct application, by spray or by an eye protector which may be tinted to further assist in the treatment of conjunctivitis by shutting out sun's and other light rays from the afflicted eye.The powdered aluminum is administered as such or in admixture with boric acid and/or antibiotic.

Abstract: There is described the stereoselective total synthesis by a variety of routes of novel suitably substituted .DELTA..sup.2,3 -1,4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1## wherein Q is hydrogen, alkyl, aralkyl or --CH.sub.2 COOZ where Z is hydrogen or the residue of an ester group and X is amino, azido or acylamino. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. Those compounds in which X is acylamino and their physiologically hydrolyzed esters and pharmaceutically acceptable salts are potent antibacterial agents.

Abstract: There is described the stereoselective total synthesis of novel .DELTA..sup.2,3 -1,4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1## wherein Z is halo, hydroxyl, etherified hydroxyl or hydroxyl esterified with a carboxylic acid residue or a sulfonic acid residue and X is amino, azido or acylamino. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such antibacterial agents.

Abstract: Mixtures of (a) bis-(2-X-phenyl)carbodiimides in which X is an alkyl or cycloalkyl group, which carbodiimide may be further substituted on each phenyl group by one or more halo, alkyl or cycloalkyl groups, and (b) quaternary ammonium compounds demonstrate superior ectoparasiticidal properties. Ectoparasiticidal compositions comprising these carbodiimides and quaternaries are described.

Abstract: Novel cephalosporin analogues, salts and esters thereof, their preparation, intermediates and antibacterial compositions containing them. The compositions are formulated for human use into unit dosage form containing 100-4,000 mg of antibacterial compound. The cephem analogues are characterized by having a ring O-heteroatom instead of a ring N-heteroatom and are designated as oxacephems.