Abstract: Compositions comprising, in combination, N'-aryl-N-methylformamidines and 3-phenoxybenzyl carboxylates exhibit synergistic insecticidal activity. The novel compositions are exemplified and their use for controlling insects is demonstrated.

Abstract: Trifluoromethylthiophenylethylamine derivatives, made from the corresponding acid chlorides by successive reduction, condensation with nitroethane, reduction, and condensation with an amine, possess anorexigenic properties, unaccompanied by central stimulant activity or cardiovascular effects.

Abstract: A new class of alkylthiophenoxyalkylamine derivatives and methods for preparation are described. The compounds have vasodilating and antispasmodic activity, inhibit blood platelet aggregation and are substantially free of beta-adrenergic blocking effects. They are particularly valuable in the treatment of disease states responsive to vasodilation such as obstructive peripheral vascular diseases and cerebral vascular deficiencies. Representative and preferred embodiments of the invention are N-[3-[4-(methylthio)phenoxy]propyl]octylamine and N-[3-[4-(1-methylethyl)thio]phenoxy]-propyl]octylamine.

Abstract: Bis-amides of formula ##STR1## and salts thereof, where R.sup.2 and R.sup.3 are hydrogen; alkyl of up to 9 carbon atoms, alkenyl or alkynyl of up to 4 carbon atoms, or aryl, groups optionally substituted by certain radicals; or cycloalkyl of 3-7 carbon atoms; and R.sup.1 and R.sup.4 are as R.sup.2 and R.sup.3 or amino groups optionally substituted by certain radicals, are fungicides, especially against soil borne fungal diseases of plants.

Abstract: The invention is concerned with micro granules for pesticides and their manufacture by wet grinding a suspension of the active compound together with adjuvants in a ball mill to a particle size of at most 0.01 mm and subsequent spray-drying of the suspension thus obtained under a pressure of from 5 to 8 atmospheres gauge and at 140.degree. to 300.degree. C.

Abstract: An ultra-pure, high molecular weight hyaluronic acid fraction which is characterized by the absence of significant cellular infiltration of the vitreous and anterior chamber, absence of significant flare in the aqueous humor, absence of significant haze or flare in the vitreous and absence of pathological changes to the cornea, lens, iris, retina, and choroid of the owl monkey eye when one milliliter of a 1% solution of the sodium salt thereof dissolved in physiological buffer is implanted in the vitreous replacing about one-half the existing liquid vitreous. This material is obtained from animal tissue containing hyaluronic acid by a process which comprises removing the blood from animal tissue containing hyaluronic acid, extracting hyaluronic acid therefrom, deproteinizing the hyaluronic acid extract, and removing any unidentified inflammation causing agents persent therein by treating the deproteinized hyaluronic acid extract at a pH of 6.0 - 7.

Abstract: N-diphenylalkyl-2-benzyl azacyclic compounds and pharmaceutical compositions thereof which are useful as antiobesity agents are disclosed herein. Some of these compounds also exhibit useful antimicrobial properties. Additionally, novel chemical intermediates for the synthesis of this series are provided.

Abstract: N-phenyl-N'-benzoyl-ureas of the formula ##STR1## in which R represents halogenoalkyl with 1 to 4 carbon atoms,R.sup.1 represents hydrogen or halogen,R.sup.2 represents halogen, nitro, alkyl with 1 to 3 carbon atoms or alkoxy with 1 to 3 carbon atoms,X represents an oxygen atom or sulfur atom, andn denotes 0, 1, 2, 3, 4 or 5;Which possess arthropodicidal properties.

Abstract: Antibacterial 1-oxadethiacephalosporins of the formula: ##STR1## [wherein Ar is ##STR2## (in which Acyl is organic or inorganic acyl); COB.sup.1 and COB.sup.2 each is carboxy or protected carboxy;Het is ##STR3## (in which COB.sup.3 is carboxy or protected carboxy); AND Y is hydrogen or methoxy;And when COB.sup.1, COB.sub.2, and/or COB.sup.3 is carboxy, pharmaceutically acceptable salts thereof are included,But with a proviso that when Y is methoxy, Het is ##STR4## a pharmaceutical or veterinary composition comprising the said 1-oxadethiacephalosporins and pharmaceutical carrier, and a method for treating or preventing human or veterinary infectious diseases comprising administering the said 1-oxadethiacephalosporin.

Abstract: In the digestive tract certain nerve endings regulate the release of certain hormones in response to the movement of a quantity of food through the digestive tract. This release of hormones controls the operation of the pancreas in supplying to the intestinal tract certain digestive enzymes which are used in breaking down fats, proteins, and certain complex carbohydrates in the food as the quantity of food passes through the small intestine. It is possible to anesthesize these nerve endings prior to the consumption of such a quantity of food so as to inhibit the release of these hormones. As a consequence of this, a quantity of food moving through the digestive tract past these anesthesized nerve endings will not be subject to the action of these enzymes and will move through the small intestine without such types of materials contributing food energy or calories to the body. This can be utilized to accomplish a reduction in weight or to control weight.

Abstract: Ophthalmic compositions are disclosed comprising an ophthalmic drug and locust bean gum.

Abstract: A method of reducing intra-ocular pressure in mammalian patients comprising administering to a glaucoma patient a therapeutically effective amount of a compound of the formula ##STR1## WHEREIN, IN THE C ring, X is CH.sub.2, S, ##STR2## or NR.sub.4 where R.sub.4 is H, loweralkyl, loweralkenyl, loweralkynyl or loweralkanoyl; n is an integer of 0 to 3; m is an integer of 0 to 3, or the C ring is a quinuclidine ring ##STR3## each R.sub.1 is loweralkyl, and when taken together, the substituents R.sub.1 R.sub.1 form oxygen; R.sub.2 is a C.sub.1 -C.sub.20 straight or branched chain alkyl, cycloalkyl, or wherein Y is a straight or branched chain alkylene group having from 1 to 10 carbon atoms, and each R.sub.5, R.sub.6 and R.sub.7 are the same or different members of the group consisting of H, halo or loweralkyl; R.sub.3 is H or ##STR4## WHEREIN Y' is a straight or branched chain alkylene group having 1 to 8 carbon atoms, a is an integer from 1 to 4, b is an integer from 1 to 4, Z is CH.sub.2, O, S or NR.sub.

Abstract: New compositions comprising xanthan gum, locust bean gum, and a pharmaceutical agent in a pharmaceutically acceptable liquid vehicle. More specifically these compositions are useful in drug delivery systems, particularly for ophthalmic drugs.

Abstract: Ophthalmic compositions are disclosed comprising an ophthalmic drug and xanthan gum.

Abstract: Pharmaceutical composition unit dosage forms adapted for enteral or topical administration are described, comprising a safe and effective amount of a pharmaceutically active medicament compound dissolved or uniformly dispersed in a flexible, water-soluble film carrier therefor. Admixtures of medicament and carrier are drawn into a film, which can be cut to desired unit dosage content.

Abstract: An improved method for the formation of naled-containing synthetic resin shaped bodies is disclosed. A mixture of a synthetic resin, naled, and a surface porosity control component is extruded in the presence of an acid-resistant material (e.g., nickel or nickel alloys or the like). Other insecticides (e.g., carbamates) may also be included in the naled-containing mixture, if desired. The resulting extrudates are useful as pet collars or the like and are formed without substantial degradation of the naled as has been found to occur in attempts to extrude in the presence of carbon steel.

Abstract: Compounds of the formula (I): ##STR1## and salts thereof wherein R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms or benzyl; R.sub.2 is hydrogen or alkyl of 1 to 4 carbon atoms or is joined to R.sub.1 so that the NR.sub.1 R.sub.2 moiety is a 5 -, 6- or 7-membered saturated heterocyclic ring; R.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms or acyl of 1 to 4 carbon atoms; R.sub.4 is an aromatic group; R.sub.5 is hydrogen or alkyl of 1 to 4 carbon atoms R.sub.6 is hydrogen or alkyl of 1 to 4 carbon atoms; X is --CH.sub.2 -- or an oxygen atom and the dotted line represents a single or double bond, are useful for inducing anorexia and for their mood-modifying effects.

Abstract: The invention relates to new N-substituted benzenesulphonamides of general formula ##STR1## in which N IS 2 OR 3,R.sub.1 and R.sub.2 are hydrogen atoms, methyl, ethyl groups, or jointly form with the nitrogen a nitrogenized heterocyclic ring having 5 or 6 members, in particular a piperidino, pyrrolidino or morpholino group,R.sub.3 is a hydrogen atom, an NO.sub.2 group, an NH.sub.2 group, or a halogen,R.sub.4 is a hydrogen, a halogen, an NH.sub.2 group or a sulphonamide group.These compounds are useful as active substances of medicaments, in particular as antiemetic.

Abstract: 1-Aryloxy-3-amidoalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity and some of them additionally possess cardiac stimulant activity. Representative of the compounds disclosed is 1-phenoxy-3-.beta.-isobutyramidoethylamino-2-propanol.

Abstract: Methods and compositions are provided for the treatment of dry eye and discontinuous tear films. The ophthalmic solution for maintaining a continuous tear film employs a combination of hydroxyalkylcellulose and polyvinyl alcohol in a predetermined ratio in an aqueous isotonic medium.