Patents Examined by Deborah D. Carr
  • Patent number: 12258537
    Abstract: PROBLEM To provide a composition comprising highly enriched PUFA or its alkyl esters while containing fatty acid esters of 3-MCPD at adequately low concentrations and to provide an efficient method for producing the composition. MEANS FOR SOLVING A composition that contains fatty acids or fatty acid alkyl esters as its major component, the composition containing highly unsaturated fatty acid or alkyl ester thereof, wherein the proportion of the highly unsaturated fatty acid in the constituent fatty acids of the composition is 50 area % or more and wherein the concentration of 3-MCPD as found upon analyzing the composition by American Oil Chemists' Society official method Cd 29b-13 assay A is less than 1.80 ppm.
    Type: Grant
    Filed: December 26, 2023
    Date of Patent: March 25, 2025
    Assignee: Nissui Corporation
    Inventors: Nobushige Doisaki, Kiyomi Furihata, Hideaki Yamaguchi
  • Patent number: 12257221
    Abstract: Described herein are nutritional compositions, such as ketogenic compositions, leucine-enriched amino acid mixtures, etc., useful, for example, for dietary management of intractable epilepsy. In some embodiments, the disclosure relates to methods of inhibiting epileptic seizures in a subject comprising administering to the subject a leucine-enriched amino acid mixture.
    Type: Grant
    Filed: March 24, 2021
    Date of Patent: March 25, 2025
    Assignee: AJINOMOTO CO., INC.
    Inventors: Susan Gingrich, Robert Reed, Kenji Nagao, Natsumi Nishikata
  • Patent number: 12258364
    Abstract: Provided is a method for purifying a phosphorus-containing olefin compound salt as a raw material or an intermediate that is useful to increase the purity of a target product in a method for producing an olefin compound and that can be applied to the production method, and a method for producing an olefin compound using a purified product obtained thereby.
    Type: Grant
    Filed: January 26, 2022
    Date of Patent: March 25, 2025
    Assignee: DAIKIN INDUSTRIES, LTD.
    Inventors: Yuuko Ito, Tsubasa Nakaue, Takehiro Chaki, Takashi Usui, Tomoyuki Iwamoto, Megumi Kushida
  • Patent number: 12252457
    Abstract: The present invention features novel peripherally-restricted isoguvacine analogs with reduced blood brain barrier permeability and methods of use thereof for reducing tactile dysfunction, social impairment, and anxiety in a subject diagnosed with Autism Spectrum Disorder, Rett syndrome, Phelan McDermid syndrome, or Fragile X syndrome.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: March 18, 2025
    Assignee: President and Fellows of Harvard College
    Inventors: David D. Ginty, Lauren L. Orefice, Jinbo Lee
  • Patent number: 12252477
    Abstract: The use of a medicament as a single agent, binary agent, or other combination comprising of substantially pure novel cannabinoids 1 and 2, optionally admixed with one or more known and novel cannabinoids and other known naturally occurring and synthetic tetracyclic 2A and tricyclic 1A cannabinoids for the prevention, treatment or cure of inflammatory mediated diseases or inflammatory mediated pathological conditions, anorexia, arthritis, cancer, pain, glaucoma, migraine, persistent muscle spasms, seizures (epileptic seizures), severe nausea, PTSD, autism spectrum disorder, drug abuse, insomnia, or any other chronic or persistent medical symptom.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: March 18, 2025
    Assignee: Bessor Pharma, LLC
    Inventors: Barry A. Berkowitz, Anthony G. Barrett, Daniel Elliott
  • Patent number: 12252455
    Abstract: The present invention relates to a process for the continuous synthesis of heavy alkyl acrylates by a transesterification reaction using hydrozincite as a heterogeneous catalyst.
    Type: Grant
    Filed: December 9, 2020
    Date of Patent: March 18, 2025
    Assignee: Arkema France
    Inventors: Clement Bellini, Sandra Maget, Patrice Defer
  • Patent number: 12220395
    Abstract: Agents containing either or both of aspartic acid and tyrosine are effective for improving intermittent endurance capacity.
    Type: Grant
    Filed: February 23, 2021
    Date of Patent: February 11, 2025
    Assignee: AJINOMOTO CO., INC.
    Inventors: Tomoko Ando, Sakiko Toyoda, Hiroyuki Kato, Yoshihito Nogusa
  • Patent number: 12213497
    Abstract: A method and system are disclosed for producing a protein and fiber feed product from a whole stillage byproduct produced in a corn dry milling process for making alcohol, such as ethanol, and/or other biofuels/biochemicals. In one embodiment, the method includes separating the whole stillage byproduct into an insoluble solids portion and a centrate (solubles) portion. Thereafter, a fine fiber and protein portion may be separated from the centrate (solubles) portion. The fine fiber and protein portion may be dewatered to provide a protein and fiber feed product. In one example, the protein and fiber feed product can include insoluble solids, such as wet or dry distiller's grains with or without solubles. The resulting protein and fiber feed product may be sold and/or used as rumen feed, swine feed, chicken feed, aqua feed, food uses, or have other uses, including pharmaceutical and/or chemical usage, for example.
    Type: Grant
    Filed: April 19, 2022
    Date of Patent: February 4, 2025
    Assignee: Fluid Quip Technologies, LLC
    Inventors: Neal Jakel, John Kwik
  • Patent number: 12209227
    Abstract: Docosahexaenoic acid-containing oil containing docosahexaenoic acid in a concentration of 40 wt. % or more of the total weight of fatty acids in the oil, and having an endothermic peak temperature determined by differential scanning calorimetry (DSC) of 15° C. or lower; a biomass including the same; and a method for producing docosahexaenoic acid-containing oil including obtaining a biomass by culturing microorganisms of the genus Aurantiochytrium capable of producing this docosahexaenoic acid-containing oil, recovering the biomass after culture, and extracting the oil from the biomass after recovery.
    Type: Grant
    Filed: November 10, 2022
    Date of Patent: January 28, 2025
    Assignee: NIPPON SUISAN KAISHA, LTD.
    Inventors: Takayoshi Sekiguchi, Yuji Okita, Yumiko Nishizawa
  • Patent number: 12208080
    Abstract: This disclosure relates to methods and compositions for inhibiting release of extracellular vesicles from a cell infected by a virus. One aspect of the disclosure relates to methods for treating viral diseases, reducing damage to a neuron from the central neural system (“CNS”) and/or treating neuroinflammation in a subject. In another aspect, provided herein are methods for inhibiting transcription of a viral RNA and/or release of extracellular vesicles from a cell infected by a virus.
    Type: Grant
    Filed: April 12, 2021
    Date of Patent: January 28, 2025
    Assignee: George Mason Research Foundation, Inc.
    Inventors: Fatah Kashanchi, Catherine DeMarino
  • Patent number: 12207673
    Abstract: A flavor composition comprising at least one compound that modulates, increases and/or enhances the activity of a GPR120 fatty acid receptor that can be used to enhance the fatty acid taste and/or palatability of pet food products is described herein. Also disclosed herein are methods for identifying said compounds.
    Type: Grant
    Filed: September 8, 2020
    Date of Patent: January 28, 2025
    Assignee: MARS, INCORPORATED
    Inventors: Scott Joseph McGrane, Matthew Ronald Gibbs, Richard Masten Fine, Jerry Wallace Skiles
  • Patent number: 12207670
    Abstract: Disclosed herein are embodiments for the isolation of fiber and protein from brewers' spent grain. In some embodiments, the protein has a reduced fat content. In some embodiments, the protein has an improved Protein Digestibility Corrected Amino Acid Score.
    Type: Grant
    Filed: December 20, 2023
    Date of Patent: January 28, 2025
    Assignee: Axiom Foods, Inc.
    Inventors: David J. Janow, Richard J. Ray
  • Patent number: 12186289
    Abstract: The present invention pertains to the field of maximizing performance of animals, particularly of pregnant animals and their offspring, particularly of pregnant sows and their offspring. Particularly the present invention is in the field of increasing the colostrum production of a sow, increasing average daily gain of the offspring, and/or improving neonatal survival of the offspring.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: January 7, 2025
    Assignee: Nutreco IP Assets B.V.
    Inventors: Pieter Langendijk, Theodorus Antonius Theresia Gerardus Van Kempen
  • Patent number: 12171727
    Abstract: Disclosed herein are compounds and ligands, and compositions formed therewith, that modulate insulin secretion and suppress appetite by activating ectopic olfactory receptors. Also disclosed herein are methods for using the compositions to treat endocrine diseases, such as type-2 diabetes, and disorders, such as abnormal insulin secretion.
    Type: Grant
    Filed: August 19, 2024
    Date of Patent: December 24, 2024
    Assignee: Olfactive Biosolutions, LLC
    Inventors: Christopher Hanson, William Harries
  • Patent number: 12173254
    Abstract: Embodiments of a method of purifying a lysophosphatidylcholine (e.g., LPC-DHA and/or LPC-EPA) from a composition containing the lysophosphatidylcholine and at least one impurity, e.g., from phospholipids, free fatty acids, triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), glycerol, sterols, tocopherols, vitamin A, flavonoids, and minerals can use a continuous simulated moving bed process, a batch column chromatography method, or a single column to provide a purified composition of the lysophosphatidylcholine. The purified lysophosphatidylcholine (e.g., LPC-DHA and/or LPC-EPA) products can be used in various pharmaceutical and nutraceutical applications, e.g., for treating and/or preventing a neurological disease or disorder.
    Type: Grant
    Filed: December 8, 2021
    Date of Patent: December 24, 2024
    Assignee: Orochem Technologies Inc.
    Inventors: Anil Rajaram Oroskar, Babu Siddegowda Antharavally, Asha Anil Oroskar
  • Patent number: 12161655
    Abstract: The present invention provides methods of treating mycobacterial infections or mycobacterial diseases by administering a tetracycline compound, e.g., omadacycline, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: December 10, 2024
    Assignees: Paratek Pharmaceuticals, Inc., The United States Government as represented by the Department of Veterans Affairs
    Inventors: Michael Henry Cynamon, Michael P. Draper, Judith N. Steenbergen, S. Ken Tanaka
  • Patent number: 12163106
    Abstract: A method of extracting Polyhydroxylated Fatty Alcohols is disclosed. The method may include: inserting crushed avocado seeds to one or more extraction chambers; flowing supercritical CO2 fluid through the crushed avocado seeds in one or more extraction chambers; and separating from the supercritical CO2 flown through the crushed avocado seeds the Polyhydroxylated Fatty Alcohols extracted and dissolved in the supercritical CO2. The supercritical CO2 fluid may be the only solvent used for dissolving and extracting the Polyhydroxylated Fatty Alcohols.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: December 10, 2024
    Assignee: AVOMED LTD.
    Inventors: Yael Dvori Levy, Oded Bashan, Ohad Bashan
  • Patent number: 12162819
    Abstract: Provided herein is a class of ionizable lipid compounds represented by formula (IV), or pharmaceutically acceptable salts, isotopic variants, tautomers or stereoisomers thereof. Also provided is a nanoparticle pharmaceutical composition comprising said compound, and the application of said compound and its composition in the delivery of nucleic acids.
    Type: Grant
    Filed: January 5, 2023
    Date of Patent: December 10, 2024
    Assignees: Beijing Jitai Pharmaceutical Technology Co., Ltd., Hangzhou Jitai Pharmaceutical Technology Co., Ltd.
    Inventors: Lin Zhang, Liu Yang, Andong Liu, Caida Lai, Wenshou Wang
  • Patent number: 12151232
    Abstract: The present invention relates to an isomerisation catalyst, in particular a zeolite catalyst. There is provided a method for making a particularly preferred zeolite catalyst by means of modifying catalytic zeolite materials. There is also provided a 5 process for isomerising fatty acids or alkyl esters thereof to produce branched fatty acids employing such an isomerisation catalyst, a composition comprising branched fatty acids, and also use of the isomerisation catalyst.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: November 26, 2024
    Assignee: CARGILL BIOINDUSTRIAL UK LIMITED
    Inventors: Bastiaan Wels, Sophie Claude Catherine Wiedemann, Tanja Van Bergen-Brenkman, Remco Benjamin Van Triet
  • Patent number: 12144795
    Abstract: The present disclosure relates to the preparation of a highly pure cannabidiol compound by a novel synthesis route. The cannabidiol compound can be prepared by an acid-catalyzed reaction of a di-halo olivetol with menthadienol, followed by two crystallization steps. The highly pure cannabidiol compound is produced in high yield, stereospecificity, or both, and shows exceedingly low levels of ?-9-tetrahydrocannabinol at the time of preparation and after storage.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: November 19, 2024
    Assignee: PURISYS LLC
    Inventors: Daniel M. Hallow, Jun He, Mark C. Dobish, Denis Petrovic, Gnel Mkrtchyan