Patents Examined by Douglas W. Robinson
  • Patent number: 5824864
    Abstract: Nucleotide sequences encoding a maize 5C9 polypeptide, the 5C9 polypeptide and structural and functional equivalents, and methods for controlling insect infestation in plants are provided.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: October 20, 1998
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Timothy W. Fox, Carl W. Garnaat, Terry EuClaire Meyer
  • Patent number: 5821398
    Abstract: An isolated DNA molecule comprising a nucleotide sequence encoding an inducible soft fruit promoter, particularly the alcohol dehydrogenase 2 promoter from tomato, is described. Isolated DNA molecules encoding the alcohol dehydrogenase 2 enzyme are also disclosed.
    Type: Grant
    Filed: July 26, 1995
    Date of Patent: October 13, 1998
    Assignee: Commonwealth Scientific & Industrial Research Org.
    Inventors: James Speirs, Colin John Brady, Elizabeth Lee, Richard Hinde, Terrence James Longhurst
  • Patent number: 5817483
    Abstract: The present invention is directed to a process for the production of a peptide, polypeptide, or protein having a predetermined property. In accordance with one embodiment, the process begins by producing by way of synthetic polynucleotide coupling, stochastically generated polynucleotide sequences. A library of expression vectors containing such stochastically generated polynucleotide sequences is formed. Next, host cells containing the vectors are cultured so as to produce peptides, polypeptides, or proteins encoded by the stochastically generated polynucleotide sequences. Screening or selection is carried out on such host cells to identify a peptide, polypeptide, or protein produced by the host cells which has the predetermined property. The stochastically generated polynucleotide sequence which encodes the identified peptide, polypeptide, or protein is then isolated and used to produce the peptide, polypeptide, or protein having the predetermined property.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: October 6, 1998
    Assignee: Stuart Kauffman
    Inventors: Stuart Alan Kauffman, Marc Ballivet
  • Patent number: 5814476
    Abstract: The present invention is directed to a process for the production of a peptide, polypeptide, or protein having a predetermined property. In accordance with one embodiment, the process begins by producing by way of synthetic polynucleotide coupling, stochastically generated polynucleotide sequences. A library of expression vectors containing such stochastically generated polynucleotide sequences is formed. Next, host cells containing the vectors are cultured so as to produce peptides, polypeptides, or proteins encoded by the stochastically generated polynucleotide sequences. Screening or selection is carried out on such host cells to identify a peptide, polypeptide, or protein produced by the host cells which has the predetermined property. The stochastically generated polynucleotide sequence which encodes the identified peptide, polypeptide, or protein is then isolated and used to produce the peptide, polypeptide, or protein having the predetermined property.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 29, 1998
    Assignee: Stuart Kauffman
    Inventors: Stuart Alan Kauffman, Marc Ballivet
  • Patent number: 5811640
    Abstract: The novel pepper variety of the genus and species Capsicum chinense Jacq. described here was the product of an organized breeding program using forms of this species collected by us during several years in South America and bred via a pedigree breeding program for adaptation to growth in the northeastern U.S. It is characterized by a spreading habit, small light green elliptic leaves, small regularly 5-merous flowers with white corolla having no corolla throat markings, purple anthers, a style that exceeds the anther, two or more flowers per leaf axil, self compatibility, a low level of capsaicin so it is not a hot pepper, green pendant fruits becoming red, yellow, or orange upon maturity and having a rounded base, a usually pointed apex, and thin carpels. Fruits are about 5 cm. long and 2.5 cm wide, weigh approximately 3 grams each, and have 2-4 locules. Pedicels are long, curved, and slender. Seeds are yellow, around 3 mm. in diameter, and 1000 seeds weigh about 3 grams.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: September 22, 1998
    Assignee: The Penn State Research Foundation
    Inventors: Paul Grun, Michael D. Orzolek
  • Patent number: 5811395
    Abstract: The present invention relates to a relaxin analogs and derivatives, and uses thereof. The present invention further relates to compositions comprising a relaxin analogs and derivatives, and relaxin wherein such composition exhibits an additive or synergistic effect.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 22, 1998
    Assignees: Medical University of South Carolina, Connetics Corporation
    Inventors: Christian Schwabe, Elaine Unemori
  • Patent number: 5808035
    Abstract: The present invention relates to a nucleoside having the formula: ##STR1## where R.sub.1 is a hydrogen or a protecting group;R.sub.2 is a hydrogen or a coupling group;R.sub.3 and R.sub.4 are each either a hydrogen or an alkyl group, where R.sub.3 and R.sub.4 can be connected in a ring;R.sub.5 is a hydrogen, an alkyl group, or a carboxylic ester group;R.sub.6 is a hydrogen, an alkyl group, or a carboxylic ester group;R.sub.7 is a hydrogen, a nitro group, a halogen, a cyano group, or an alkyl group, where R.sub.7 is attached at either position 4, 5 or 6; andBase is a protected heterocyclic base. Further, the present invention relates to a method of making the nucleoside and a method of oligomer synthesis utilizing the nucleoside.
    Type: Grant
    Filed: December 4, 1996
    Date of Patent: September 15, 1998
    Inventors: David A. Usher, Himanshu Rastogi
  • Patent number: 5808174
    Abstract: By selection for resistance to aryloxyphenoxyalkane-carboxylic acid herbicides, herbicide-tolerant maize cell lines, calli and plants regenerated therefrom can be obtained which pass this herbicide tolerance on to their progeny in a stable manner.
    Type: Grant
    Filed: January 14, 1997
    Date of Patent: September 15, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Gunter Donn
  • Patent number: 5808053
    Abstract: The invention generally relates to a process for modification of cationic starch at which the cationic starch is treated, in the presence of water, with an aluminium compound. The modified cationic starch is useful as a retention agent. The invention also relates to a method for improving retention and/or dewatering in papermaking at which cationic starch is modified by the process.
    Type: Grant
    Filed: January 17, 1997
    Date of Patent: September 15, 1998
    Assignee: Eka Chemicals AB
    Inventors: Hans Johansson, Tomas Lund, Ake Larsson
  • Patent number: 5804445
    Abstract: The present invention relates to inhibitors of the sequence specific transcription factor nuclear factor IL-6 (NF-IL6) and methods of use therefor. In particular, substitution mutants in the N-terminus of the NF-IL6 tryptic core domain are disclosed that have a higher binding affinity for the DNA binding site than does the wild-type sequence.
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: September 8, 1998
    Assignee: Board of Regents, The University of Texas System
    Inventor: Allan R. Brasier
  • Patent number: 5804694
    Abstract: A method for commercial production of GUS entails heterologous expression of the protein in plants, in native conformation, at an expression level such that avidin represents at least 0.1% of total extracted protein. A genetic map of the integration locus allows for the identification of the GUS-expressing plant. Genetic loci on a plant chromosome are revealed that support high levels of GUS expression and that can be used as a site of integration for high level expression of other genes of interest.
    Type: Grant
    Filed: November 6, 1995
    Date of Patent: September 8, 1998
    Assignee: ProdiGene, Inc.
    Inventors: Wesley B. Bruce, Elizabeth Hood, David J. Peterson, James C. Register, III, Derrick Witcher, John A. Howard
  • Patent number: 5801027
    Abstract: The invention discloses methods of controlling one or more genes in plants. The genes may be exogenous genes and produce a desired phenotypic trait in the plants produced. The genes are operatively linked to a heterologous upstream activating sequence (UAS) recognition site, which is activatable by a transactivating protein, such as GAL4. The genes linked to the UAS sequence, and nucleic acid encoding for the transactivating protein may originally be in separate transgenic plants, one of which fertilises the other to produce reproductive material, such as seed, which may be grown into plants expressing the desired phenotype. The desired phenotype may be herbicide resistance or the production of a polyhydroxyalkanoate, such as polyhydroxybutyrate.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: September 1, 1998
    Assignee: University of Warwick
    Inventors: Malcolm Bennett, Sean May, Nicola Ramsay
  • Patent number: 5801150
    Abstract: Synthetic compounds combining sulphur-containing or sulphur-free amino acids with aminopyrimidine and aminopyridine derivatives, as well as mineral or organic acid addition salts produced in the presence of an amino grouping, were synthesized. Non-sulphur amino acids such as glutamic acid, pyroglutamic acid, tyrosine, histidine and arginine, and sulphur amino acids such as methionine, cysteine, S-methyl-cysteine and cystine, were attached to minoxidil to give monosubstituted and disubstituted derivatives. The amides with a pyrimidine or pyridine structure coupled to an amide structure in which the carbonyl is from sulphur-containing or sulphur-free amino acid have the properties of; (1) excellent adhesion to the skin, particularly the epidermis; (2) capturing free radicals, in particular the superoxide anion and the hydroxyl radical; (3) selectively relaxing smooth muscle fibers; and (4) in vitro and in vivo keratinocyte growth, hair growth in humans, and fresh and accelerated fur growth in animals.
    Type: Grant
    Filed: July 2, 1996
    Date of Patent: September 1, 1998
    Inventors: Jean-Luc Caillot, Louis Jung, Minjie Zhao
  • Patent number: 5801028
    Abstract: Described are an isolated DNA fragment incorporating an osmotin gene promoter sequence, recombinant DNA incorporating a foreign structural gene under control of an osmotin gene promoter sequence, as well as methods and transformants involving the isolated DNA fragment and recombinant DNA. Also described are methods for the inhibition of fungal, insect, nematode, and viral pathogens in a plant using such recombinant DNA.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 1, 1998
    Assignee: Purdue Research Foundation
    Inventors: Ray Bressan, Paul M. Hasegawa
  • Patent number: 5792933
    Abstract: A cotton fiber-specific lipid transfer protein, its amino acid sequence, its protein-encoding DNA sequence, and its 5' flanking sequence are disclosed. In addition, the promoter and upstream sequences of two other lipid transfer proteins are disclosed. Finally, methods for utilizing these sequences to express genes of interest in Gossypium hirsutum L., in a fiber-specific fashion, are described.
    Type: Grant
    Filed: October 4, 1995
    Date of Patent: August 11, 1998
    Assignee: Mississippi State University
    Inventor: Din-Pow Ma
  • Patent number: 5792672
    Abstract: An improved method for removing a photoresist mask from an etched aluminum pattern after etching the pattern in a chlorine containing plasma has been created. The method is a two step process, in which a first stripping step is in a plasma containing O.sub.2 and H.sub.2 O and a second stripping step is in a plasma containing O.sub.2.
    Type: Grant
    Filed: March 20, 1996
    Date of Patent: August 11, 1998
    Assignee: Chartered Semiconductor Manufacturing Ltd.
    Inventors: Lap Chan, Simon Chooi Yen Meng, Tony Chan
  • Patent number: 5792921
    Abstract: Two nucleotide sequences encoding two different polypeptides found in yeast trehalose synthase have been isolated and cloned. A third polypeptide has been isolated from the enzyme and characterized, and a method is provided to isolate and clone the nucleotide sequence encoding this polypeptide. The coding sequences can be inserted into suitable vectors and used to transform host cells. The transformed cells will produce increased amounts of trehalose compared to the untransformed wild types and have increased tolerance to a variety of stresses, in particular to decreased availability of water. The invention may be used to improve the stress tolerance of organisms, to increase the storage life of foodstuffs and to produce trehalose economically on an industrial scale in an organism (e.g, baker's yeast) that is a traditional and safe foodstuff.
    Type: Grant
    Filed: August 15, 1994
    Date of Patent: August 11, 1998
    Inventors: John Londesborough, Outi Tunnela nee Vuorio, Tapio Palva, Kjell-Ove Holmstrom, Bjorn Welin, Abul Mandal
  • Patent number: 5792927
    Abstract: Rose plant cells are transformed by incubation with Agrobacterium cells carrying an exogenous DNA sequence. The callus cells may be obtained from various tissue sources, including stamen filaments, leaf explants, and the like, and whole rose plants may be regenerated from the transformed callus cells. The exogenous DNA will be stably incorporated into the chromosomes of the regenerated rose plant which will be able to express gene(s) encoded by the DNA sequence.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 11, 1998
    Assignee: Florigene Europe B.V.
    Inventors: Ebrahim Firoozabady, Karol Robinson
  • Patent number: 5792904
    Abstract: Methods are provided for selecting parental plants having disease resistance and for using these plants in breeding programs. In one method of the invention, lesion mimic mutants are screened for either resistance to a pathogen of interest or for the expression of systemic acquired resistance (SAR) genes. Such mutants having the desired traits or expressing the desired genes are then used in breeding programs. Parent plants can also be selected based on the constitutive expression of SAR genes. These mutants are phenotypically normal yet exhibit a significant level of disease resistance. Also disclosed are plant mutants that do not express systemic acquired resistance genes even when induced by a pathogen and methods of use for such mutants.
    Type: Grant
    Filed: May 16, 1996
    Date of Patent: August 11, 1998
    Assignee: Novartis Finance Corporation
    Inventors: John A. Ryals, Scott J. Uknes, Terrence Patrick Delaney, Eric R. Ward, Henry-York Steiner
  • Patent number: 5792928
    Abstract: This invention relates to plant cells, plants, and seeds expressing a polypeptide having larvicidal activity. In particular, the invention relates to plant cells, plants, and seeds expressing the N-terminal region of a polypeptide toxic against the larvae of Lepidoptera of the Noctuidae family, and preferably against S.littoralis.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 11, 1998
    Assignees: Institut Pasteur, Institut National de la Recherche Agronomique
    Inventors: Vincent Sanchis, Didier Lereclus, Ghislaine Menou, Marguerite-Marie Lecadet, Daniel Martouret, Raymond Dedonder