Patents Examined by Douglas W. Robinson
  • Patent number: 5792930
    Abstract: The present invention relates to a chimeric gene for conferring to plants an increased tolerance to a herbicide. This chimeric gene comprises, in the direction of transcription, a promoter region, a transit peptide region, a sequence encoding glyphosate tolerance and a polyadenylation signal region, wherein the promoter region consists of at least one promoter of a plant histone gene enabling the expression of the herbicide tolerance protein in the regions of glyphosate accumulation. The present invention further provides vectors containing the present chimeric genes, of glyphosate-tolerant plants.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 11, 1998
    Assignee: Rhone-Poulenc Agrochimie
    Inventors: Nicole Chaubet, Claude Gigot, Georges Freyssinet, Bernard Leroux
  • Patent number: 5792934
    Abstract: A transgenic plant into which a chimeric gene comprising a wound inducible promoter and a gene for an enzyme involved in cytokinin biosynthesis has been introduced shows enhanced resistance to insect infestation.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: August 11, 1998
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Ann C. Smigocki, John W. Neal, Jr.
  • Patent number: 5792932
    Abstract: The present invention relates to a plant promoter which comprises the sequence (B) ?SEQ ID NO: 4! below: ##STR1## or a sequence having a high degree of homology with the sequence (B).
    Type: Grant
    Filed: September 22, 1995
    Date of Patent: August 11, 1998
    Assignee: Rustica Prograin Genetique
    Inventors: Yves Marco, Dominique Roby, Michel Schneider, Alain Toppan
  • Patent number: 5789247
    Abstract: A plasmid vector designed for transforming lymphoblastoid cells, immortalized by Epstein Barr virus, for producing heterologous proteins, which comprises the bacterial DNA elements required for its amplification together with the following DNA fragments:the DNA elements which constitute an expression cassette allowing the insertion of a heterologous DNA to be expressed in the human lymphoblastoid cells,the Adenovirus 5 derived DNA sequence encoding the VA I and VA II RNA aimed at optimizing the messenger RNA translation,a gene engineered to be efficient as a selective marker in eukaryotic cells, andDNA segments selected for their property to promote plasmid DNA integration into the cell chromosome DNA.
    Type: Grant
    Filed: October 12, 1994
    Date of Patent: August 4, 1998
    Inventors: Annick Ballay, Georges Boffa, Jean-Pierre Cartron, Stany Chretien, Patrick Lambin, Claude Lopez, Sylvie Prigent, Charles Salmon
  • Patent number: 5789198
    Abstract: The present invention provides a polynucleotide which identifies and encodes a novel human leptin receptor-related protein (LRRP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding LRRP.
    Type: Grant
    Filed: August 1, 1996
    Date of Patent: August 4, 1998
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventor: Ingrid E. Akerblom
  • Patent number: 5786162
    Abstract: The invention relates to a fused gene containing: the promoter sequence of (a) gene(s) encoding the resistance to one or several metal(s) or encoding the catabolism of one or several xenobiotic compound(s), said promoter being inducible in the presence of said metal(s) or xenobiotic compound(s), or both, and downstream the promoter, a gene producing a detectable signal such as light emitting gene, said gene being under the control of said promoter, said gene producing a detectable signal being located at a position such that the induction of the promoter causes the transcription of the gene producing a detectable signal and such that there is no terminator between the promoter and the gene producing a detectable signal.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 28, 1998
    Assignee: Vito
    Inventors: Philippe Corbisier, Maximilien Mergeay, Ludovicus Diels
  • Patent number: 5786341
    Abstract: Methods are provided for controlling the synthesis of protein from the human gene for the pro.alpha.1(I) chain of type I procollagen in cells using mini-gene constructs which are injected into cells which synthesize the protein. Methods for controlling collagen deposition in tissue mini-gene constructs are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 28, 1998
    Assignee: Thomas Jefferson University
    Inventors: Darwin J. Prockop, Jaspal Khillan, Shi-Wu Li, Ruth Pereira
  • Patent number: 5783418
    Abstract: The present invention provides a nucleic acid sequence which identifies and encodes a G protein gamma subunit (gpg) which was isolated from human pituitary gland. The invention provides for genetically engineered expression vectors and host cells comprising nucleic acid sequence encoding GPG. The invention also provides for purified GPG.
    Type: Grant
    Filed: February 27, 1996
    Date of Patent: July 21, 1998
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Janice Au-Young, Susan G. Stuart, Lynn E. Murry, Karl J. Guegler, Jeffrey J. Seilhamer
  • Patent number: 5780593
    Abstract: A method of isolating a biomolecule from a medium containing biomolecules by ion exchange wherein the ion exchange material consists of a material having ion exchanging groups which can be transformed from a charged form to an uncharged form; the eluant comprises a charge neutralizing acid or base transforming the ion exchanging groups from the charged form to the uncharged form; and the charge neutralizing acid or base has a concentration in the eluant which is twice, preferably equal to or less than the concentration of the ion exchanging groups of the ion exchange material; the ion exchange material being in a packed, hydrated state. Preferably the method is for the isolation of phosphopeptides from a medium containing casein hydrolysates and the use of such isolated biomolecules is for the production of a food, a feed, a health care product, a cosmetic, or a pharmaceutical.
    Type: Grant
    Filed: July 12, 1995
    Date of Patent: July 14, 1998
    Assignees: Kem-En-Tec A/S, Md Foods AMBA
    Inventors: Allan Otto Fog Lihme, Margit Irene Aagesen, Claus Gammelg.ang.rd-Larsen, Katrine Hvid Elleg.ang.rd
  • Patent number: 5773702
    Abstract: Sugar beet plants which are resistant to imidazolinone herbicides are described. The sugar beet plants are derived from susceptible cells by selection for mutant imidazolinone resistant cells with the herbicide. The resistant plants derived from the cells can be grown in fields where imidazolinones have been used for weed control.
    Type: Grant
    Filed: July 17, 1996
    Date of Patent: June 30, 1998
    Assignee: Board of Trustees operating Michigan State University
    Inventors: Donald Penner, Terry R. Wright
  • Patent number: 5773680
    Abstract: The present invention relates to a wild rice seed, a wild rice plant, and a method for producing a wild rice hybrid seed. More specifically, the invention relates to a hybrid wild rice seed and plant produced using a cytoplasmic-genetic male sterility system. The F.sub.1 hybrid seed is produced by crossing male sterile wild rice plants with restorer wild rice plants.
    Type: Grant
    Filed: April 28, 1995
    Date of Patent: June 30, 1998
    Inventor: Ken Foster
  • Patent number: 5773681
    Abstract: The invention relates to plant embryos having an increased electrolyte content as compared to embryos germinated in tap water, as well as to a method of producing these plant embryos, wherein germinative seeds are germinated in an electrolyte solution.
    Type: Grant
    Filed: November 29, 1995
    Date of Patent: June 30, 1998
    Inventor: Norbert Fuchs
  • Patent number: 5773692
    Abstract: The initial steps in photosynthesis are the conversion of light energy into chemical energy. This conversion is performed by the multisubunit protein-pigment complexes of the thylakoid membranes. Oxygen-evolving photosystems contain photosystem I (PSI) and photosystem II (PSII), which act in tandem. In PSII, the majority of light-adsorbing chlorophylls are attached to LHCII, the light harvesting complex associated with this photosystem. LHCII is the most abundant member of the family of chlorophyll a/b binding (CAB) proteins. A gene encoding a type I chlorophyll a/b binding protein of LHCII (ICABPSII) has been cloned from Brassica napus L. An anti-sense RNA of this gene has been used to reduce the amount of chlorophyll a/b binding protein and thus reduce the amount of chlorophyll in the resulting transgenic plants. By using "site" specific promoters the reduction of chlorophyll can be targeted to specific organelles in the transgenic plant and thus can be used to reduce the green color at these sites.
    Type: Grant
    Filed: December 12, 1995
    Date of Patent: June 30, 1998
    Assignee: Her Majesty the Queen in right of Canada, as represented by Agriculture and Agri-Food Canada
    Inventors: Anne M. Johnson-Flanagan, Jas Singh, Laurian S. Robert, Janice Carole Politeski Morissette
  • Patent number: 5773696
    Abstract: An antifungal polypeptide, AlyAFP, that controls fungal damage to plants is provided. DNA encoding this polypeptide can be cloned into vectors for transformation of plant-colonizing microorganisms or plants, thereby providing a method of inhibiting fungal growth on plants. The polypeptide can be formulated into compositions that can be used to control undesired fungi on plants and elsewhere.
    Type: Grant
    Filed: March 29, 1996
    Date of Patent: June 30, 1998
    Assignee: Monsanto Company
    Inventors: Jihong Liang, Dilip Maganlal Shah, Yonnie Shun Wu, Cindy Annette Rosenberger
  • Patent number: 5773697
    Abstract: The invention discloses a transgenic method for producing fruit with diminished or very little seeds or fruits with reduced seed number. It involves the temporal expression of a cytotoxic gene or combination of genes targeted toward arresting seed development at a time sufficiently after pollination that fruit development and maturation is normal while early enough in seed development that seed maturation per se is minimized. The invention also includes transgenic constructs, vectors, and methods for production of the fruit with diminished or very little seed bearing plants.
    Type: Grant
    Filed: April 23, 1996
    Date of Patent: June 30, 1998
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Dwight T. Tomes, Bin Huang, Paul D. Miller
  • Patent number: 5773688
    Abstract: cDNA derived from the ARF gene that is actively expressed in barley seeds, roots and callus, but is highly suppressed or almost not expressed at all in leaves, was cloned. Next, the upstream region of the ARF gene was cloned, its promoter activity was verified, and a gene expression vector using the expression region of this gene was produced.
    Type: Grant
    Filed: April 7, 1995
    Date of Patent: June 30, 1998
    Assignee: Sapporo Breweries Limited
    Inventors: Hisao Kuroda, Naohiko Hirota, Kazutoshi Ito
  • Patent number: 5773703
    Abstract: Novel herbicide resistance has been introduced into rice plants, making the plants resistant to herbicides which normally interfere with a plant's acetohydroxyacid synthase. For the first time it is possible to selectively control the weed called "red rice" in commercial rice fields by planting rice varieties incorporating the novel herbicide resistance, and treating the field with herbicide.
    Type: Grant
    Filed: April 4, 1996
    Date of Patent: June 30, 1998
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Timothy P. Croughan
  • Patent number: 5770576
    Abstract: Methods of treatment of subjects with systemic toxicity by administering an R'-Glu-Trp-R" pharmaceutical preparation.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: June 23, 1998
    Assignee: Cytran, Inc.
    Inventors: Vyacheslav G. Morozov, Vladimir Kh. Khavinson
  • Patent number: 5770788
    Abstract: Fertile corn plants are produced by culturing anthers or pollen in the presence colchicine which is added to an otherwise ordinary anther culture medium after a pre-culture phase in the absence of the colchicine. The colchicine induces doubling of the chromosome numbers in regenerated plants which would otherwise be infertile haploids. Haploid doubling provides a rapid route to homozygous parental plant lines.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 23, 1998
    Inventor: Xu Jia
  • Patent number: 5770720
    Abstract: A human ubiquitin conjugating enzyme, designated hUBC-9, its full amino acid sequence, and nucleic acid polymers which encode hUBC-9 are disclosed. In addition to having functional ubiquitin conjugating activity, this enzyme has transcriptional repressor activity which is independent of the conjugating activity. The conjugating activity of hUBC-9 enhances transcription through degradation of transcription suppressor proteins such as WT1, and possibly, of hUBC-9 itself. The repressor activity of hUBC-9 suppress gene transcription, probably by disrupting the transcriptional initiation complex through specific interactions with the DNA binding region of the TATA binding protein (TBP). In use, hUBC-9, yUBC-9 and other ubiquitin conjugating enzymes having repressor activity can be fused to proteins having a DNA binding domain, such as Gal4, or used in conjunction with reppressors such as Wilm's tumor suppressor gene product, WT1.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: June 23, 1998
    Assignee: Barnes-Jewish Hospital
    Inventors: Thomas F. Deuel, Zhao-Yi Wang, Thomas E. Shenk