Abstract: The invention comprises a method and apparatus for sampling optical pathways having a common tissue depth, such as a maximum mean depth of penetration in the dermis, with a common sample position of a person for analysis in a noninvasive analyte property determination system, comprising the steps of: probing skin with a range of illumination zone-to-detection zone distances with at least two wavelength ranges and detecting, using a set of detectors, illumination zone-to-detection zone distances having mean optical pathways probing the common tissue layer, such as without the mean optical pathways entering the subcutaneous fat layer of the person. Optionally, the skin tissue layers are modulated and/or treated via tissue displacement before and/or during data collection. Optionally, given illumination zone-to-detection zone distances are dynamically selected based upon a measure of state of the skin of the person.

Abstract: The present disclosure describes example systems, methods, apparatuses, and medical devices for obtaining physiological parameter data from a wearable patient monitoring device. An example patient monitoring device can include an emitter and a detector. The emitter can emit light through tissue of a patient. The detector can sense the light after it passes through and is attenuated by the tissue and can generate a signal indicative of the sensed light. When the patient monitoring device is attached to or worn by the patient, the emitter and detector are aligned such that the light from the emitter travels through an opening between a first bone and a second bone of the patient prior to being sensed by the detector.

Abstract: A system (100) and a method for analyzing a physiological condition of a user. The system (100) comprises one or more sensors (102a, 102b) to measure one or more parameters including temperature and relative humidity from the user's skin and/or a corresponding temperature and relative humidity from the user's environment via an air gap. A signal representative of the measured parameters is generated. The system (100) also includes at least one transceiver (108) communicably connectable to the sensing unit (102) via one or more communication interfaces, wherein the transceiver (108) is configurable to analyze one or more received signals to initiate one or more events based on the analyzed parameters of the user. The system (100) further includes a processing unit (110) to receive one or more signals from the transceiver (108) and uses artificial intelligence and machine learning techniques to alert users of an impending physiological condition.

Abstract: A compliance and effectiveness tracking engine system including a sensor system to obtain sensed sleep data for a sleep session for a user, and a user interface implementing a user data acquisition system to obtain perceived sleep data from the user after the sleep session. The system further includes a server system implementing a predictive engine to predicted sleep data for the user, based on user background data and transactional data reflecting one or more medical interventions for the user. The server implementing a compliance and effectiveness tracking engine (CETE) to compare the sensed sleep data, the perceived sleep data, and the predicted sleep data, and to determine effectiveness of the one or more medical interventions for the user, and compliance with a protocol associated with the one or more medical interventions.

Abstract: Devices, systems, and methods for eliminating noise in non-invasive biological interrogation techniques may be described herein. A method may include taking a first set of measurements over a time period. The first set of measurements may be indicated by an electronic signal. The first set of measurements may correspond to a physiological characteristic of a subject. A change in the physiological characteristic of the subject may correspond to a change in a blood constituent of the subject. The method may include: taking a second set of measurements over the time period; correlating the first and second sets of measurements, wherein the correlating removes noise from the electronic signal; sectioning out the electronic signal; calculating an amplitude difference between two or more sections of the electronic signal; and determining a change in the amount of the blood constituent based on the difference.

Abstract: In some examples, a system includes processing circuitry configured to generate a laser speckle contrast signal based on a received signal indicative of detected light, wherein the detected light is scatted by tissue from a coherent light source. The processing circuitry may also determine, from the laser speckle contrast signal, a flow value and determine, from the laser speckle contrast signal, a waveform metric. Based on the flow value and the waveform metric, the processing circuitry may determine a blood flow metric for the tissue and output a representation of the blood flow metric.

Abstract: An implantable extravascular pressure sensing system includes a cuff including a first brace portion affixed to a second brace portion and defining a longitudinal axis therebetween. The first brace portion defines a fluid chamber, the fluid chamber defining a recessed aperture. A first lateral restraint and a second lateral restraint are disposed between the first brace and the second brace, the first lateral restraint and the second lateral restraint being configured to be displaceable in a direction orthogonal to the longitudinal axis. A diaphragm is coupled to the fluid chamber and sealing the recessed aperture. A fluid is disposed within the fluid chamber for exhibiting a hydraulic pressure in communication with the diaphragm. A pressure sensor is coupled to the first brace portion, the pressure sensor being configured to measure a change in the hydraulic pressure when a force is imparted on the diaphragm.

Abstract: A noninvasive glucometer and a blood glucose detection method are provided. The noninvasive glucometer includes a light source, a spectrometer and detecting space into which an object to be detected intervenes; the detecting space is connected with the light source and the spectrometer respectively, so that a spectrum emitted by the light source can generate incident light entering the spectrometer after passing through the object to be detected. The spectrometer includes: an optical modulation layer configured to perform light modulation on the incident light to obtain a modulated spectrum; a photoelectric detection layer located below the optical modulation layer, and configured to receive the modulated spectrum and provide differential responses with respect to the modulated spectrum; and a signal processing circuit layer located below the photoelectric detection layer and configured to reconstruct the differential responses to obtain an original spectrum.

Abstract: In some examples, a medical system includes a medical device. The medical device may include a housing configured to be implanted in a target site of a patient, a light emitter configured to emit a signal configured to cause a fluorescent marker to emit a fluoresced signal into the target site, and a light detector that may be configured to detect the fluoresced signal. The medical system may include processing circuitry configured to determine a characteristic of the fluorescent marker based on the emitted signal and the fluoresced signal. The characteristic of the fluorescent marker may be indicative of a presence of a compound in the patient, and the processing circuitry may be configured to track the presence of the compound of the patient based on the characteristic of the fluorescent marker.

Abstract: Systems and methods directed to the assessment of circulatory complications due to advancement of diabetes. Embodiments include an optical measurement device having a light source with one or more wavelengths and configured to illuminate an area of tissue, a detector configured to capture the light reflecting from one or more layers of the tissue at the one or more illumination wavelengths, a processor configured to compute, based on the detected signal of layer extracted circulatory data, one or more estimates of tissue vascular health, and a display or communication device (e.g., electronic data transfer) configured to store or report the tissue vascular health. In exemplary embodiments, the distribution of chromophores such as hemoglobin in different layers of skin is extracted using a combination of structured light in the visible and near-infrared regime.

Abstract: A device, having a housing; a power source configured to supply electrical power to a conductive percutaneous implant in a circuit including the conductive percutaneous implant and tissue of a patient adjacent to the conductive percutaneous implant; an electrical sensor configured to generate a signal indicative of at least one electrical parameter of the circuit; and at least one data processing system having one or more processors configured to receive the signal and analyze the signal to determine at least one of a presence or change of infection of the tissue, and pass a control signal to the power source to vary the electrical power responsive to determining at least one of the presence or change of infection of the tissue.

Abstract: The technology relates to medical devices for monitoring and assessing vascular health. In one embodiment, the technology is an apparatus that attaches to a subject's finger comprising a heating and cooling component, a coherent source, a temperature sensor, an image detector, and/or a component for data control and management. In another embodiment, there is a component that alters local blood flow in the subject, and laser speckle contrast and photoplethysmography (PPG) signals from the altered blood flow in the subject are compared to monitor the vascular health of the subject.

Abstract: A blood pressure measurement device may include one or more piezoelectric sensors (e.g., differential piezoelectric sensors) for detecting blood flow through a limb of a user as part of determining blood pressure measurements. The piezoelectric sensor(s) may additionally or alternatively be used to determine one or more biological parameters of users (e.g., a ballistocardiogram, a heart rate, a heart rate variability, and a pulse wave velocity). The blood pressure measurement device may additionally or alternatively include a capacitive sensor for determining a pressure applied to the limb of the user by the blood pressure measurement device and/or operational states of the blood pressure measurement devices (off-arm, on-arm, inflating, deflating, tightness, and the like).

Abstract: A system for use in monitoring application is described. The system comprises a light detection unit and an illumination arrangement. The detection unit is configured for collecting light returning from a selected inspection region for determining variations in collected light intensity. The illumination arrangement comprises one or more light sources configured for providing illumination of a selected wavelength range directed toward said inspection region. Wherein the illumination arrangement is arranged around the detection unit to provide symmetrical illumination conditions with respect to an axis connecting said detection unit and said inspection region.

Abstract: A physiological signal monitoring device includes a sensing member and a transmitter connected to the sensing member and including a circuit board that has electrical contacts, and a connecting port, which includes a socket communicated to the circuit board and a plurality of steel balls. The sensing member is removably inserted into the socket. The steel balls are electrically connected to the electrical contacts and the sensing member for enabling electric connection therebetween. Each of the steel balls is frictionally rotated by the sensing member during insertion of the sensing member into the socket and removal of the sensing member from the socket.

Abstract: A sensor for evaluating tissue of a subject is provided. The sensor includes a flexible spine disposable on the subject, a flexible member that includes first and second flexible member portions accommodated within the flexible spine, a light source, a detector and a rigid member. The light source is attached to the first flexible member portion and is configured to emit light toward the tissue. The detector is attached to the second flexible member portion and is configured to receive the light having reflected off the tissue. The rigid member is coupled with the first and second flexible member portions. In response to a curvature of the flexible spine, the rigid member moves the first and second flexible member portions along the flexible spine to adjust a distance between the light source and the detector.

Abstract: An electronic device according to various embodiments may comprise: a memory storing instructions; at least one biometric sensor; a display; and at least one processor, wherein the at least one processor is configured to execute the stored instructions in order to: obtain biometric information of a user related with the electronic device by using the at least one biometric sensor; obtain first data indicating a cardiovascular state of the user from the biometric information; obtain second data indicating a relative difference between the first data and reference data indicating a cardiovascular state in a resting state of the user; and display, by using the display, an indication for indicating a health status of the user, on the basis at least of the second data.

Abstract: A sensor device includes a housing defining a cavity, an inlet to receive fluid pumped from an instrument device, an outlet to return the fluid to a fluid reservoir, and a fluid channel defined inside the cavity between the inlet and the outlet. A heat pump is mounted inside the cavity, and has a side surface thermally coupled to the fluid channel and an opposite side surface thermally coupled to a plate. The heat pump is configured to induce a temperature change. A sensor unit is aligned with an aperture in the plate and includes an optical component and a thermal component. The optical component configured to measure a vascular endothelial response from the induced temperature change.

Abstract: A measurement engine of a wearable electronic device may compensate for wavelength variations of light emitted as part of blood-oxygen saturation measurements. In some cases, determining an estimated blood-oxygen saturation value is based at least partially on temperature data that may be used to compensate for temperature-based wavelength variations of the emitted light, drive current data that may be used to compensate for drive-current-based wavelength variations of the emitted light, and/or calibration information that may be used to compensate for manufacturing variability across different light emitters. In various embodiments, the measurement engine may use temperature data, the drive current data, and/or calibration information in a variety of ways to determine estimated blood-oxygen saturation values, including using lookup tables or calibration curves, applying functions, and the like.

Abstract: An optical sensing device includes a device casing and an optical sensor on the device casing. In an embodiment, the optical sensing device further includes an image-capturing device on the device casing. The sensing direction of the optical sensor and the capturing direction of the image-capturing device point in the same direction. The image-capturing device can capture an image of an object to be sensed by the optical sensor. In another embodiment, the optical sensing device further includes a flexible shielding cover on the device casing and enclosing the optical sensor for shielding the optical sensor from external light.