Abstract: A skin-adorned physiological or biochemical sensing device is disclosed herein. The device preferably comprises a first substrate and a second substrate. The first substrate comprises an array of solid microneedles designed to penetrate a biological interface to access a physiological fluid or tissue. Each microneedle is capable of electrical interface with the physiological fluid or tissue. The second substrate comprises integrated circuitry designed to transduce at least one signal produced by an electrophysiological or electrochemical reaction. A sensing device is formed that is capable of interpreting the signal arising from the electrophysiological or electrochemical reaction to ascertain the level of some physiological or biochemical entity.

Abstract: Catheter-based devices and methods for continuously monitoring vascular lumen dimensions, in particular in the inferior vena cava (IVC) for determining heart failure and/or fluid status of a patient. Related therapy systems and methods for integrated monitoring and therapy are also disclosed.

Abstract: In some examples, a device includes processing circuitry configured to receive first and second signals indicative of first and second physiological parameters, respectively, of a patient. The processing circuitry is also configured to determine a first estimate of a limit of autoregulation of the patient based on the first and second signals. The processing circuitry is further configured to determine a difference between the first estimate of the limit of autoregulation and one or more other estimates of the limit of autoregulation. The processing circuitry is configured to determine a weighted average of the first estimate and a previous value of the limit of autoregulation based on the difference between the first estimate and the one or more other estimates. The processing circuitry is configured to determine an autoregulation status based on the weighted average and output, for display via the display, an indication of the autoregulation status.

Abstract: This disclosure provides a dielectric sensor configured to detect a physiological variable within a subject. The dielectric sensor having at least one split-ring resonator configured to be positioned within an oral cavity of the subject and to be bioresponsive to at least one physiological variable. The split-ring resonator having a first resonator loop, a second resonator loop, and a dielectric interlayer interposed between and contacting the first resonator and the second resonator.

Abstract: A method and a device for detecting OSAHS provided that the method comprises: acquiring a vibration signal of a subject during sleep, and determining a breathing signal of the subject (S1), wherein the breathing signal comprises an inspiration signal generated upon inspiration and an expiration signal generated upon expiration; acquiring strength of a first vibration signal within a specified frequency range and superimposed on the inspiration signal, and strength of a second vibration signal within a specified frequency range and superimposed on the expiration signal adjacent to the inspiration signal (S2); and comparing, according to a preset method, the strength of the first vibration signal with the strength of the second vibration signal, and determining, according to a comparison result, whether the subject is snoring (S3).

Abstract: A motor response of a muscle to neural stimulation is assessed. Electrical stimuli are applied from a first electrode to a selected neural pathway to evoke an efferent neural response. A slow neural response upon the neural pathway evoked by the electrical stimuli is observed. Based on the slow neural response, a motor response of at least one muscle to the stimuli is assessed.

Abstract: Technologies for emotion prediction based on breathing patterns include a wearable device. The wearable device includes a breathing sensor to generate breathing data, one or more processors, and one or more memory devices having stored therein a plurality of instructions that, when executed, cause the wearable device to calibrate a personalized emotion predictive model associated with the user, collect breathing data of the user of the wearable device, analyze the breathing data to determine a breathing pattern, predict, in response to an analysis of the breathing data, the emotional state of the user using the personalized emotion predictive model, and output the emotional state of the user.

Abstract: A novel and useful pressure sensor array incorporating sensor elements constructed from electrically conductive film as a substrate. Examples of commercially available electrically conductive (i.e. piezoresistive) film include Velostat and Linqstat. A wearable device is described incorporating an array of pressure sensors with flexible properties and a biocompatible material interface between the sensor elements and a user's skin. The pressure sensor array uses the electrically conductive film as a substrate and places a pair of conductors in a suitable configuration to form individual sensor elements. The sensor elements detect the change in resistance of the electrically conductive film when pressure is applied thereto. The sensor elements may be implemented in an interdigitated or opposing configuration. The sensor array also comprises a mechanical interface on top of the sensor elements for transferring or focusing the applied pressure to the electrically conductive film.

Abstract: System and methods are disclosed for adjusting behavior of a medical device. An exemplary method includes monitoring physiological data of a patient and determining whether the medical device is stationary or in motion based on detection by a proximity sensor or a motion sensor. The method further includes displaying the monitored physiological data in a first display mode in response to determining that the medical device is stationary and displaying the monitored physiological data in a second display mode in response to determining that the medical device is in motion. The second display mode is simplified comparing to the first display mode.

Abstract: A wearable respiration monitoring system having a transmitter coil that is adapted to generate and transmit multi-frequency AC magnetic fields and a plurality of receiving coils adapted to detect variable strengths in the AC magnetic fields and generate AC magnetic field strength signals representing anatomical displacements of a monitored subject. The wearable monitoring system further having an electronics module that is adapted to receive the AC magnetic field strength signals and determine at least one respiratory disorder associated with the monitored subject as a function of the AC magnetic field strength signals.

Abstract: Embodiments relate to multi-focal intravascular pressure catheters and related systems and methods. In an embodiment, a catheter comprises a plurality of pressure sensors spaced apart along at least a portion of the catheter. Each of the plurality of pressure sensors can comprise a pressure membrane arranged over an aperture in the catheter. In an embodiment, the pressure membrane can comprise carbon nanotubes, silver or gold nanoparticles, or another suitable material that can provide a signal in response to a mechanical change (e.g., deformation or flexing of the pressure membrane) to indicate a pressure or change in pressure. Signals from the plurality of pressure sensors can be communicated to an electrical interface which can calibrate or convert the signals into a visual indication of the pressure at any one of the plurality of pressure sensors as well as pressure gradients between various ones of the plurality of pressure sensors.

Abstract: A method and apparatus monitors chronic disease state of a patient. The method may include extracting, in a processor, for each of a plurality of monitoring sessions, a respiratory feature from a respiratory signal indicative of the patient's respiration during the monitoring session, the respiratory signal derived from at least one sensor; and computing, in a processor, a stability measure of the patient for a monitoring session, the stability measure representing an indication of a change point having occurred at the monitoring session in a statistical distribution of the respiratory feature.

Abstract: A sensor of an implantable medical device senses electrical activity of the brain. A data analyzer of the device monitors an electrographic signal corresponding to the electrical activity of the sensed brain signal, and processes the brain signal to obtain a measure of phase-amplitude coupling. For a selected portion of the electrographic signal, the data analyzer detects first features and second features of the electrographic signal. The first features represent oscillations in a low frequency range, while the second features represent oscillations in a frequency range higher than the low frequency range. For example, the low frequency range may correspond to theta frequency and the higher frequency range may correspond to gamma frequency. The data analyzer determines a measure of phase-amplitude coupling between oscillations in the low frequency range and oscillations in the higher frequency range based on occurrences of second features which coincide with first features.

Abstract: Herein is disclosed a sensor for noninvasive measurement of the partial pressure of CO2 (pCO2) in the skin of a human. The sensor comprises a housing, a gas measuring chamber for measuring gases, at least one chimney for communication of gases diffusing through the skin to the gas measuring chamber, a broad band light source transmitting light into the gas measuring chamber and a detector system comprising a first and a second photodetector. The first photodetector detects light at a wavelength wherein CO2 absorbs light and the second photodetector acts as a zero reference detector by measuring light in a freeband where no gases absorb light.

Abstract: Systems and methods are provided for identifying, monitoring, and treating migraines and migraineurs. An electroencephalogram (EEG) of a patient is obtained. The EEG comprises a plurality of EEG signals. At least two features are extracted of a network feature across at least one pair of the plurality of EEG signals in the alpha frequency band, a feature derived from a signal decomposition of at least one EEG signal, and a feature representing the power spectrum density of at least one EEG signal. The patient is classified into one of a plurality of classes, each representing one of the presence of migraine symptoms, a response to migraine treatment, a type of migraineur, a current stage of a migraine, and a likelihood that the patient is a migraineur, according to the extracted at least two features.

Abstract: Examples of invasive biosensor alignment and retention features and methods are described. One example biosensor includes a housing comprising: a first surface defining a first opening, and a second surface opposite the first surface, the second surface defining a second opening, the first and second openings defining a substantially unobstructed pathway through the housing; a biosensor wire partially disposed within the housing and having an exterior portion extending through the first opening; a hollow insertion needle positioned within the pathway and extending through the first opening, the hollow insertion needle at least partially encircling the biosensor wire; and a biosensor retention feature collapsible against the first surface of the housing, the biosensor retention feature encircling and contacting the hollow insertion needle.

Abstract: A method and apparatus is proposed to estimate the aortic pulse transit time (PTT) from only time intervals measured between fiducial points of the longitudinal ballistocardiogram (BCG) without the need to apply any sensor to the area where the arrival of the arterial pulse waveform is to be detected. From the longitudinal BCG of a subject, which can be obtained by means of sensors integrated in a single element with which the subject's body comes into contact, two fiducial points of the BCG waveform are detected in which one of the points is associated with the arrival of the arterial pulse wave to a zone proximal to the heart and the other is associated with the arrival of said arterial pulse wave to a distal zone, respectively. From the time interval between the two points, an estimate of the aortic (carotid-femoral) PTT is provided either directly or through a process of previous calibration.

Abstract: Provided is a formula and method for monitoring individual metabolic response that involve calculation of the lag/latency time (LT) for the peak levels of measured a variety of glucose values by HATR-FTIR (horizontally attenuated total reflection Fourier transform infrared) spectroscopy and the LT for the peak level of capillary blood glucose (CBG), with subsequent calculation of the LT changes between them. Obtained meaningful time-dependent and dose-dependent glucose values and their LT changes characterize glycemic variability (GV) in a qualified subject, that can be used to predict the patient's risk of hyperglycemia, to stage Type II diabetes and, in general, to be considered as a new metrics of assessing the quality of metabolic control.

Abstract: Devices that sense sweat and are capable of providing chronological assurance are described. The device uses at least one sensor to measure sweat or its components and to determine a sweat sampling rate. The chronological assurance is determined, at least in part, using the sweat sampling rate. The sweat sampling rate may be determined, at least in part, using a sweat volume and/or a sweat generation rate, both of which may be measured or predetermined.

Abstract: The present invention relates to a wound volume measuring method and device, wherein the method comprises the steps of: disposing a foam dressing on a wound site; hermetically sealing the wound site by attaching a film dressing on skin adjacent to the wound site; supplying a negative pressure to the hermetically sealed space formed between the film dressing and the wound site, and thereby discharging fluid into the hermetically sealed space; measuring the flow of the fluid discharged from the hermetically sealed space; and calculating the volume of the wound site on the basis of the measured fluid flow.