Patents Examined by Erin M Bowers
  • Method for detection of (PA) using volatile biomarkers
    Patent number: 10329597
    Abstract: A method of determining the presence of Pseudomonas involves establishing a gaseous headspace over a surface suspected of containing at least one Pseudomonas strain and contacting at least a portion of the gaseous headspace with a capillary microextraction of volatiles (CMV) sampling device to absorb at least one component of the headspace by the CMV sampling device. The component loaded CMV sampling device is coupled to an injection port of an analytical device where the components are desorbed into the analytical device, where components are separated, detected, and identified to determine if one or more of the identified components is a biomarker for at least one Pseudomonas strain.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: June 25, 2019
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: Jose Almirall, Wen Fan, Kalai Mathee
  • Hypoxia-cultured mesenchymal stem cells for treating atherosclerotic lesions
    Patent number: 10314862
    Abstract: A method and a pharmaceutical composition for treating an atherosclerotic lesion are provided, including administering a subject in need thereof a therapeutically effective amount of a composition comprising hypoxia-cultured MSCs obtained by culturing auto- or allo-MSCs under low oxygen conditions.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: June 11, 2019
    Assignee: National Yang-Ming University
    Inventor: Shih-Chieh Hung
  • Method for the diagnosis of Niemann-Pick disease
    Patent number: 10302664
    Abstract: The present invention is related to a method for diagnosing Niemann-Pick disease in a subject comprising a step a), wherein the step a) comprises detecting a biomarker in a sample from the subject, wherein the biomarker is compound 509.
    Type: Grant
    Filed: May 14, 2014
    Date of Patent: May 28, 2019
    Assignee: Centogene AG
    Inventors: Arndt Rolfs, Hermann Mascher
  • Process and system for predicting responders and non-responders to mesalamine treatment of ulcerative colitis
    Patent number: 10295527
    Abstract: A process and system directed to a more effective, individual based treatment regimen which is built on clinical identified target biomarkers associated with gender differential responses to mesalamine, and includes one or more panels of target biomarkers that distinguishes mesalamine response differences between genders and determines the efficacy of mesalamine for patients being treated for various UC conditions and effectively identifies and validates novel drug targets for new UC therapeutics, new diagnostics and diagnostics standards for UC therapeutic strategies.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: May 21, 2019
    Inventors: Bruce Yacyshyn, Mary E. Yacyshyn
  • Probiotic bacterial strains and symbiotic composition containing the same intended for infant food
    Patent number: 10286017
    Abstract: Selection of probiotic strains belonging to the genus Bifidobacterium and to a symbiotic composition containing the same for use of feeding infants, is described.
    Type: Grant
    Filed: May 9, 2012
    Date of Patent: May 14, 2019
    Assignee: PROBIOTICAL S.P.A.
    Inventors: Giovanni Mogna, Gian Paolo Strozzi, Luca Mogna
  • Robust, easy to use immobilized enzyme reactors
    Patent number: 10266819
    Abstract: The disclosure provides an innovative immobilized enzyme reactor working system that includes improved reactor formats, heating element, optimum buffers, filtration apparatus and collection componentry for easy to use sample preparation. The system provides enhanced recovery, improved reproducibility and parallel processing capabilities capable of quantitatively processing hundreds of difficult to digest samples simultaneously in a shortened period of time.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: April 23, 2019
    Assignee: PERFINITY BIOSCIENCES, INC.
    Inventors: Kevin Wayne Meyer, John Patrick O'Grady, Robert Harold Ellis, Nicholas Brian Herold, Derrick Nathaniel Poe
  • Method for isolating urea while removing objectionable CO2
    Patent number: 10266872
    Abstract: A method for isolating urea and removing CO2 from plasma samples, comprising the following steps: a) providing a plasma sample; b) adding an acid so as to partially remove CO2; c) lyophilizing the sample so as to further remove CO2 and obtain a dried sample; and d) redissolving the dried sample and neutralizing to a pH value of 4 to 7 using a buffer solution, wherein optionally a filtration step is carried out before adding the acid.
    Type: Grant
    Filed: July 30, 2011
    Date of Patent: April 23, 2019
    Assignee: Cytonet GmbH & Co. KG
    Inventor: Sitke Aygen
  • Blood biomarker for early blood brain barrier disruption in ischemic stroke
    Patent number: 10254295
    Abstract: Methods and apparatus for determining blood brain barrier (BBB) damage and treating patients who may have suffered from BBB damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood. According to some embodiments, the method further provides determining the degree of BBB damage based on the concentration of occludin fragments in the sample. In further embodiments the present disclosure provides kits for detecting the presence of occludin fragments in a blood sample.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: April 9, 2019
    Assignee: STC.UNM
    Inventors: Ke Jian Liu, Wenlan Liu, Graham Timmins, Rong Pan
  • Method for producing astaxanthin by fermentation
    Patent number: 10240215
    Abstract: An object of the present invention is to provide a method for microbioiogically producing astaxanthin of high concentration at low cost while suppressing production of canthaxanthin. Specifically, the present invention relates to a method for producing carotenoids including astaxanthin comprising culturing a bacterium that concurrently produces astaxanthin and canthaxanthin in a medium containing biotin, wherein a ratio of concentration of produced canthaxanthin to concentration of produced astaxanthin in a culture product after the end of culture in the medium is lower than that in a culture product alter the end of culture in a biotin-free medium.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: March 26, 2019
    Assignee: JX Nippon Oil & Energy Corporation
    Inventors: Kazuaki Hirasawa, Hiroshi Satoh, Hisashi Yoneda, Tetsuhisa Yata, Mitsutoshi Azuma
  • Methods of recellularizing a tissue or organ for improved transplantability
    Patent number: 10233420
    Abstract: Described herein are methods of recellularizing an organ or tissue matrix.
    Type: Grant
    Filed: September 1, 2011
    Date of Patent: March 19, 2019
    Assignee: Regents of the University of Minnesota
    Inventors: Doris Taylor, Stefan M. Kren
  • Method and apparatus for producing astaxanthin
    Patent number: 10227557
    Abstract: A method for producing astaxanthin incorporates a method for producing astaxanthin-rich algae cells and a method for extracting astaxanthin therefrom. An initial feedstock comprises healthy algae, water, and nutrients. During a growth phase, carbon dioxide and light from a light source are supplied to the feedstock, thereby amplifying the algae. At least a portion of the nutrients remaining after amplification of the algae are separated from the amplified algae. During a stress phase, carbon dioxide and light are supplied to the amplified algae, thereby promoting production of astaxanthin by the amplified algae. The amplified algae and a cover are placed within an interior of an attrition mill having interior surfaces and media which are substantially non-reactive to astaxanthin and milled to release the astaxanthin from the algae. The cover limits oxidation of the released astaxanthin.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: March 12, 2019
    Assignee: Sustainable Nutrition, Inc.
    Inventors: John Carberry, Matthew John Carberry, Dennis Steven Tagrin
  • Synergistic antimicrobial effect
    Patent number: 10226491
    Abstract: The present invention is related to the field of bioprotection, in particular to an antimicrobial composition comprising a Lactobacillus rhamnosus strain and/or a Lactobacillus paracasei strain. Furthermore, the present invention concerns uses for such an antimicrobial composition, food, feed and pharmaceutical products comprising such an antimicrobial composition, a method of manufacturing such food, feed and pharmaceutical products and a method for reducing the content of unwanted microorganisms of such food, feed and pharmaceutical products.
    Type: Grant
    Filed: April 9, 2012
    Date of Patent: March 12, 2019
    Assignee: Chr. Hansen A/S
    Inventors: Tina Hornbaek, Maike Lisberg, Silja Kej Diemer
  • Methods and compositions for somatic cell proliferation and viability
    Patent number: 10214725
    Abstract: Methods and compositions for somatic cell proliferation as well as increasing viability of somatic cells are provided. The compositions include heparin binding protein isolated from a medium conditioned by growth of pluripotent stem cells, such as, human embryonic stem cells, human embryonic carcinoma cells. The methods include contacting a somatic cell with a heparin binding protein composition for a sufficient period of time to provide for enhanced proliferation and/or viability of the somatic cell as compared to the absence of the heparin binding protein composition.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: February 26, 2019
    Assignee: The Regents of The University of California
    Inventors: Irina M. Conboy, Michael J. Conboy, Hanadie Yousef, David V. Schaffer
  • Wound debridement compositions containing seaprose and methods of wound treatment using same
    Patent number: 10206982
    Abstract: Wound debridement compositions containing the proteolytic enzyme Seaprose and use of such compositions in wound treatment for the enzymatic debridement of wounds.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: February 19, 2019
    Assignee: SMITH & NEPHEW ORTHOPAEDICS AG
    Inventors: Lei Shi, Aleksa Jovanovic, Dennis Carson
  • Enzymatic wound debriding compositions with enhanced enzymatic activity
    Patent number: 10155061
    Abstract: The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: December 18, 2018
    Assignee: Smith & Nephew, Inc.
    Inventors: Lei Shi, Aleksa Jovanovic, Duncan Aust
  • Pathways to generate hair cells
    Patent number: 10143711
    Abstract: This disclosure relates to methods and compositions for modulating (e.g., increasing) Atoh1 activity (e.g., biological activity) and/or expression (e.g., transcription and/or translation) in vivo and/or in vitro, e.g., in a biological cell and/or in a subject. The methods and compositions described herein can be used in the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression in a biological cell.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: December 4, 2018
    Assignee: Massachusetts Eye & Ear Infirmary
    Inventors: Albert Edge, Fuxin Shi
  • Systems, apparatuses and methods for reading an amino acid sequence
    Patent number: 10139417
    Abstract: Embodiments of the present disclosure relate to amino acid, modified amino acid, peptide and protein identification and sequencing, by means of, for example, electronic detection of individual amino acids or small peptides.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: November 27, 2018
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Stuart Lindsay, Peiming Zhang, Yanan Zhao
  • Process for fermenting co-containing gaseous substrates
    Patent number: 10131872
    Abstract: A process is provided for fermenting CO-containing gaseous substrates. Bacteria are sporulated and then germinated in the presence of a CO-containing gaseous substrate to provide an inoculum. The resulting inoculum is effective for providing a fermentation with an ethanol productivity having a specific STY of 1 or greater.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: November 20, 2018
    Inventor: Ryan Senaratne
  • Method for recycling plastic products
    Patent number: 10124512
    Abstract: The invention relates to a method for recycling at least one plastic product, the method comprising degrading at least one polymer of the plastic product to monomers using an enzyme and recovering the resulting monomers. The method of the invention may be used for degrading, simultaneously or sequentially, at least two different polymers of the plastic product, and/or for recycling at least two plastic products.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: November 13, 2018
    Assignee: CARBIOS
    Inventors: Cédric Boisart, Emmanuel Maille
  • Isolated renal cells and uses thereof
    Patent number: 10105392
    Abstract: The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: October 23, 2018
    Assignee: INREGEN
    Inventors: Sharon C. Presnell, Andrew Bruce, Shay M. Wallace, Sumana Choudhury, Russell W. Kelley, Manuel J. Jayo, Jessica J. Reinsch, Patricia D. Tatsumi, Timothy A. Bertram, Eric S. Werdin, Oluwatoyin A. Knight, H. Scott Rapoport, Roger M. Ilagan