Patents Examined by Golam M M Shameem
  • Valomaciclovir polymorphs
    Patent number: 9492456
    Abstract: The present invention relates to crystalline forms of valomaciclovir, processes for preparing crystalline forms of valomaciclovir, pharmaceutical compositions thereof and methods of using thereof.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: November 15, 2016
    Assignee: EPIPHANY BIOSCIENCES, INC.
    Inventors: Mike H. O'Neill, Gregory P. Butke
  • Macrocyclic compounds as trk kinase inhibitors
    Patent number: 9493476
    Abstract: Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: November 15, 2016
    Assignee: Array BioPharma, Inc.
    Inventors: Steven W. Andrews, Kevin Ronald Condroski, Julia Haas, Yutong Jiang, Gabrielle R. Kolakowski, Jeongbeob Seo, Hong-Woon Yang, Qian Zhao
  • Wee1 degradation inhibitors
    Patent number: 9493464
    Abstract: The invention provides compounds that inhibit the degradation of Wee1. The compounds of the present invention are generally N-((1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amines. Compounds of the invention can be used for treatment of malconditions in patients for which inhibition of Wee1 is medically indicated, for example cancer, Alzheimer's, neurological disorders, psychiatric disorders, or inflammation-related disorders.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: November 15, 2016
    Assignee: The Scripps Research Institute
    Inventors: William R. Roush, Ronald Rahaim, Mathieu Bibian
  • Solid forms of tenofovir
    Patent number: 9487546
    Abstract: The present invention relates to solid forms of tenofovir and methods for preparation, use and isolation of such forms.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: November 8, 2016
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Paul Bernard Hurley, Olga Viktorovna Lapina, Bing Shi, Fang Wang, Zhi Xian Wang, Jacqueline Ching-See Woo
  • Process for preparing ceftaroline fosamil
    Patent number: 9481698
    Abstract: The present invention relates to a novel process for preparing ceftaroline fosamil as well as to intermediates of this process.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: November 1, 2016
    Assignee: Sandoz AG
    Inventors: Hubert Sturm, Josef Wieser
  • ?-lactam compounds
    Patent number: 9469610
    Abstract: Novel methods for the production of enantiomerically pure (EP) ?-lactams by decomposition of ?-diazo-?-ketoamides.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: October 18, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Yvette S. Vaske, Maximillian E. Mahoney, Joseph P. Konopelski
  • Method for eradicating weeds with derivatives of 3-acetyl-5-sec-butyl-4-hydroxy-3-pyrrolin-2-one
    Patent number: 9468209
    Abstract: A compound represented by formula (I), or (II), or a salt thereof, for eradicating weeds.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: October 18, 2016
    Assignee: NANJING AGRICULTURAL UNIVERSITY
    Inventors: Sheng Qiang, Shiguo Chen, Chunlong Yang, Xinbin Dai, Yunfa Dong
  • Process for forming a primary, a secondary or a tertiary amine via a direct amination reaction
    Patent number: 9469620
    Abstract: The present invention concerns a process to obtain primary, secondary or tertiary amines, via a direct amination reaction of alcohols in presence of bis(perfluoroalkylsulfonimide) acid or salts thereof catalysts, and derivatives.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: October 18, 2016
    Assignees: RHODIA OPERATIONS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Floryan Decampo, Damien Cartigny, Mohamad Ousmane, Marc Pera Titus
  • Method for producing specific oximes and oximethers
    Patent number: 9464038
    Abstract: Method for preparing certain oximes and oxime O-methyl ethers by reacting poorly water-soluble carbonyl compounds with salts of hydroxylamine or hydroxylamine O-methyl ether or the free base of hydroxylamine in the presence of certain phosphoric esters or salts thereof of the formula (I) wherein R1, R2 and X are defined as specified in the description.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: October 11, 2016
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Albert Schnatterer, Dieter Heinz, Martin Littmann, Ulrich Philipp, Juergen Ludwig, Constantin Frerick, Michael Barz
  • Spirocyclic sulfones as gamma secretase inhibitors
    Patent number: 9464103
    Abstract: Disclosed herein are compounds of Formula (I), wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containing the compound of Formula (I) and use of the compound in the treatment of neurodegenerative diseases or conditions such as Alzheimer's disease.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: October 11, 2016
    Assignee: MERCK SHARP & DOHME CORP.
    Inventors: Dmitri Pissarnitski, Zhiqiang Zhao
  • Difluoromethylation of unsaturated compounds
    Patent number: 9464087
    Abstract: A reagent for carrying out a difluoromethylation reaction of unsaturated compounds and ring-nitrogen-containing aromatic compounds, a zinc difluoro-methanesulfinate, as well as a method for making the reagent and a method for its use are disclosed.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: October 11, 2016
    Inventors: Phil S. Baran, Janice Akemi Dixon, Ryan Baxter, Yuta Fujiwara
  • Method for late introduction of the () hydroxyl group carbapenem ?-lactam antibiotic synthesis
    Patent number: 9458479
    Abstract: The presently disclosed subject matter demonstrates that ThnG and ThnQ enzymes encoded by the thienamycin gene cluster in Streptomyces cattleya oxidize the C-2 and C-6 moieties of carbapenems, respectively. ThnQ stereospecifically hydroxylates PS-5 giving N-acetyl thienamycin. ThnG catalyzes sequential desaturation and sulfoxidation of PS-5, giving PS-7 and its sulfoxide. The ThnG and ThnQ enzymes are relatively substrate selective, but give rise to the oxidative diversity of carbapenems produced by S. cattleya, and orthologues likely function similarly in allied streptomyces.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: October 4, 2016
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Craig Arthur Townsend, Micah Jeffrey Bodner, Ryan Martin Phelan, Michael Francis Freeman
  • Process for purifying crude furan 2,5-dicarboxylic acid using hydrogenation
    Patent number: 9458122
    Abstract: A process to produce a dry purified furan-2,5-dicarboxylic acid (FDCA) is described. After oxidation of 5-(hydroxymethyl)furfural (5-HMF), a crude FDCA stream is produced that is fed to a crystallization zone followed by a solid-liquid displacement zone to form a low impurity slurry stream. The solids in the low impurity slurry stream are dissolved in a dissolution zone to produce a hydrogenation feed that is hydrogenated in a hydrogenation reactor to generate a hydrogenated FDCA composition. The hydrogenated FDCA composition is routed to a crystallization zone to form a crystallized produce stream that is separated from liquid in a solid-liquid separation zone to generate a purified wet cake stream containing FDCA that can be dried in a drying zone to generate a dry purified FDCA product stream.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: October 4, 2016
    Assignee: Eastman Chemical Company
    Inventors: Ashfaq Shahanawaz Shaikh, Kenny Randolph Parker, Mesfin Ejerssa Janka, Lee Reynolds Partin
  • Cleaning, surfactant, and personal care compositions
    Patent number: 9458414
    Abstract: A cleaning or personal care composition containing at least one of 1,4-pentanediol and a ketal alcohol of formula (1) wherein R2 is hydrogen or C1-3 alkyl, each R3, R4, and R5 is independently hydrogen or C1-6 alkyl, R6 and R7 are each independently hydrogen or C1-6 alkyl, a=0-3, and b=0-1. R2 is hydrogen or C1-3 alkyl, each R3, R4, and R5 is independently hydrogen or C1-6 alkyl, each R6 and R7 is independently hydrogen, C1-6 alkyl optionally substituted with at least one hydroxyl groups, a=1-6, and b=0-2.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: October 4, 2016
    Assignee: GFBIOCHEMICALS LIMITED
    Inventors: Lee R. Rieth, Satyanarayana Majeti, Erich J. Molitor
  • Method of preparing intermediate of salmeterol
    Patent number: 9447067
    Abstract: A method of preparing an intermediate of salmeterol (Compound 1, 2-amino-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol) includes: reacting compound 2 with 2-methoxypropene in a first organic solvent to produce a reaction solution including compound 3, compound 2 including a 2-bromo precursor of Compound 1; reacting compound 3 with a nitrogen source to produce compound 4; reacting compound 4 with sodium borohydride in a second organic solvent to produce compound 5; and debenzylating compound 5 by ammonium formate/palladium-carbon catalytic transfer hydrogenation in a third organic solvent to produce Compound 1. A method of preparing salmeterol includes preparing Compound 1, and reacting Compound 1 to prepare salmeterol.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: September 20, 2016
    Assignee: Amphastar Pahmaceuticals, Inc.
    Inventors: Yinhua Qiu, Zhengyuan Wu, Song Chen, Haoning Zhang
  • Methods of producing cancer compounds
    Patent number: 9446141
    Abstract: Provided herein are methods of making the compound of Formula I: and certain intermediates involved in such process.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 20, 2016
    Assignee: GenSpera, Inc.
    Inventors: John K Lynch, Jeff Hutchison, Xiong Fu, Kevin Kunnen
  • Quinone based nitric oxide donating compounds for ophthalmic use
    Patent number: 9446015
    Abstract: The present invention relates to novel nitric oxide donor compounds for the use in the treatment and/or prophylaxis of hypertensive glaucoma, normotensive glaucoma and ocular hypertension.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: September 20, 2016
    Assignee: NICOX SCIENCE IRELAND
    Inventors: Ennio Ongini, Nicoletta Almirante, Laura Storoni
  • Composition containing isosorbide monoester and isosorbide diester
    Patent number: 9445595
    Abstract: What are described are compositions comprising one or more compounds of the formula (I) and one or more compounds of the formula (II) in which R, Ra and Rb each independently of one another are straight-chain or branched saturated alkyl groups having 5 to 11 carbon atoms or straight-chain or branched mono- or polyunsaturated alkenyl groups having 5 to 11 carbon atoms, wherein the total amount of the compounds of the formulae (I) and (II), based on the total weight of the compositions, is at least 60% by weight. In an advantageous manner, the compositions are suitable for producing cosmetic, dermatological or pharmaceutical compositions, crop protection formulations, washing or cleaning compositions or paints or coatings.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: September 20, 2016
    Assignee: Clariant International Ltd.
    Inventors: Maurice Frederic Pilz, Peter Klug, Franz-Xaver Scherl, Joerg Grohmann
  • Method for treating glioblastomas and other tumors
    Patent number: 9440914
    Abstract: Methods of treating an astrocytoma with agents effective to inhibit microglia function are provided, as well as methods of enhancing the efficacy of brain tumor radiation therapy on an astrocytoma in a subject. Also provided are methods of treating other solid tumor types, and tumor cell invasion, with guanylhydrazone compounds.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 13, 2016
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Yousef Al-Abed, Marc Symons
  • Substituted prolines/piperidines as orexin receptor antagonists
    Patent number: 9440982
    Abstract: The present invention is directed to compounds that modulate the bioactivity of an orexin receptor such as OX1 or OX2, or both; to pharmaceutical compositions and combinations comprising a compound of the invention; to methods of treatment of malconditions in patients wherein modulation of an orexin receptor is medically indicated; and to methods of preparation of compounds of the invention.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: September 13, 2016
    Assignee: Eolas Therapeutics, Inc.
    Inventors: Theodore M. Kamenecka, Yuanjun He, Rong Jiang, William Nguyen, Xinyi Song, Robert Jason Herr, Qin Jiang