Patents Examined by Golam M M Shameem
  • 2,3-Fluorinated glycosides as neuraminidase inhibitors and their use as anti-virals
    Patent number: 9604954
    Abstract: Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for treatment or prophylaxis of viral infection. In particular, compounds and compositions may be for use in the treatment or prophylaxis of viral influenza.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: March 28, 2017
    Assignee: The University of British Columbia
    Inventors: Stephen Withers, Andrew Graham Watts, Jin Hyo Kim, Tom Wennekes
  • Bioderived based plasticizers
    Patent number: 9605132
    Abstract: A bioderived based plasticizer is produced by reacting a bioderived diol (and/or a bioderived alcohol) and a bioderived carboxylic acid in the presence of N,N?-dicyclohexylcarbodiimide (DCC), wherein the bioderived carboxylic acid includes a hydrolyzed oil. The bioderived carboxylic acid (e.g., linoleic acid, ?-linolenic acid, oleic acid, and mixtures thereof) may be produced by hydrolyzing a triglyceride, such as canola oil, linseed oil, soybean oil, and mixtures thereof. In one embodiment of the present invention, a bioderived based plasticizer is produced by reacting 2,5-bis-(hydroxymethyl)furan and ?-linolenic acid in the presence of DCC. In some embodiments of the present invention, the bioderived based plasticizer is blended into one or more polymers.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: March 28, 2017
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Joseph Kuczynski, Jason T. Wertz, Jing Zhang
  • Resist composition, method for forming resist pattern, polyphenolic compound for use in the composition, and alcoholic compound that can be derived therefrom
    Patent number: 9598392
    Abstract: A resist composition containing a compound represented by the general formula (1) or (2), a method for forming a resist pattern using the composition, a polyphenolic compound for use in the composition, and an alcoholic compound that can be derived therefrom are described.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: March 21, 2017
    Assignee: MITSUBISHI GAS CHEMICAL COMPANY, INC.
    Inventors: Masatoshi Echigo, Masako Yamakawa
  • Method of isolating blue anthocyanin fractions
    Patent number: 9598581
    Abstract: The present invention is directed to a method of isolating fractions of anthocyanin molecules from anthocyanin-containing vegetable and fruit juices and extracts, or combinations thereof, at a select pH based on differences in polarity of the anthocyanin molecules in the anthocyanin-containing vegetable and fruit juices and extracts.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 21, 2017
    Assignees: MARS, INCORPORATED, THE OHIO STATE UNIVERSITY
    Inventors: Rebecca J. Robbins, J. Christopher Johnson, Thomas M. Collins, Neda Ahmadiani, M. Monica Giusti
  • Process for the preparation of dipeptidylpeptidase inhibitors
    Patent number: 9593119
    Abstract: The present invention provides a process for the preparation of linagliptin, a compound of Formula I, the process comprising deprotecting a compound of Formula II wherein R1 and R2 together with the nitrogen to which they are attached form a phthalimido group, wherein the aromatic ring of the phthalimido group is substituted with one or more R3 substituents selected from the group consisting of halogen, alkyl, nitro and amino; or R1 is H and R2 is selected from the group consisting of trialkylsilyl, 2-trialkylsilylethoxycarbamates, acetyl, trihaloacetyl, 9-fluorenylmethoxycarbonyl, trityl, alkylsulfonyl, arylsulfonyl, diphenylphosphine and sulfonylethoxycarbonyl.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: March 14, 2017
    Assignee: GLENMARK PHARMACEUTICALS LIMITED
    Inventors: Sunil Kumar Singh, Sachin Srivastava, Shekhar Bhaskar Bhirud
  • Guanine analogs as telomerase substrates and telomere length affectors
    Patent number: 9593137
    Abstract: This invention relates to compounds useful for inhibiting telomere elongation. More specifically, the invention provides nucleotide analogs that are incorporated into telomeres by telomerase thereby inhibiting elongation of telomeres. The compounds are useful in treating cancer and other cell proliferative diseases.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: March 14, 2017
    Assignee: Geron Corporation
    Inventors: Sergei M. Gryaznov, Ronald A. Pruzan, Krisztina Pongracz
  • DNA-PK inhibitors
    Patent number: 9592232
    Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: March 14, 2017
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Paul S. Charifson, Kevin Michael Cottrell, Hongbo Deng, John P. Duffy, Huai Gao, Simon Giroux, Jeremy Green, Katrina Lee Jackson, Joseph M. Kennedy, David J. Lauffer, Mark Willem Ledeboer, Pan Li, John Patrick Maxwell, Mark A. Morris, Albert Charles Pierce, Nathan D. Waal, Jinwang Xu
  • Methods for purifying 5-(halomethyl)furfural
    Patent number: 9586922
    Abstract: The present disclosure provides methods for purifying a 5-(halomethyl)furfural composition, including 5-(chloromethyl)furfural, at operating conditions that decrease or minimize the decomposition or degradation of 5-(chloromethyl)furfural during the process. The methods may employ certain solvents, operating conditions, and/or techniques (e.g., gas stripping). The gaseous 5-(halomethyl)furfural produced from the process can be condensed or deposited to yield 5-(halomethyl)furfural in liquid or solid form. The solid 5-(halomethyl)furfural may be amorphous or crystalline.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: March 7, 2017
    Assignee: MICROMIDAS, INC.
    Inventors: Alex B. Wood, Shawn M. Browning, Makoto N. Masuno, Ryan L. Smith, John Bissell, II
  • Nitrogen-containing bicyclic aromatic heterocyclic compound
    Patent number: 9585889
    Abstract: On the basis of a cathepsin S inhibitory effect, an excellent agent for treating or preventing autoimmune disease, allergic disease, graft rejection of an organ, bone marrow or tissue, systemic lupus erythematosus, or the like is provided. It was found that a nitrogen-containing bicyclic heterocyclic compound has an excellent cathepsin S inhibitory effect, thereby completing the invention. The compound of the present invention has an cathepsin S inhibitory effect, and can be used as an agent for preventing and/or treating autoimmune disease, allergic disease, graft rejection of an organ, bone marrow or tissue, systemic lupus erythematosus, or the like.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: March 7, 2017
    Assignee: Astellas Pharma Inc.
    Inventors: Yutaka Nakajima, Sunao Imada, Yuji Takasuna, Naohiro Aoyama, Takahiro Nigawara, Shohei Shirakami, Fumiyuki Shirai, Junji Sato, Keita Nakanishi, Kaori Kubo
  • Macrocyclic salt-inducible kinase inhibitors
    Patent number: 9586975
    Abstract: The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of SIK kinase, more in particular SIK1, SIK2 and/or SIK3 and/or mutants thereof, for use in the diagnosis, prevention and/or treatment of SIK-kinase associated diseases. Moreover, the present invention provides methods of using said compounds, for instance as a medicine or diagnostic agent.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 7, 2017
    Assignee: ONCODESIGN S.A.
    Inventors: Petra Marcella Francoise Blom, Jan Marie Cyriel Jozef Hoflack, Pascal Andre Rene Benderitter
  • Unsaturated fatty acid ester-based compositions useful as plastic additives
    Patent number: 9586918
    Abstract: Compositions useful as plastic additives may be prepared from renewable resources such as vegetable oils by functionalizing an unsaturated fatty acid ester with epoxy, acyloxy, and optionally alkoxy groups.
    Type: Grant
    Filed: February 17, 2014
    Date of Patent: March 7, 2017
    Assignee: Arkema Inc.
    Inventors: Mohammad R. Kazemizadeh, David E. Maixner
  • Boron ester fused thiophene monomers
    Patent number: 9580448
    Abstract: A compound of formula (I), formula (II), or a combination thereof, and salts thereof is described. Each A may be independently an optionally substituted conjugated species or an optionally substituted aromatic species. Each R may be independently an optionally substituted C1-C40 linear alkyl chain, an optionally substituted branched alkyl chain, an optionally substituted alkyl chain containing heteroatoms, substituted alkyl chains, or H. Each R2 may be independently an optionally substituted C1-C40 linear alkyl chain, an optionally substituted branched alkyl chain, an optionally substituted alkyl chain containing heteroatoms, substituted alkyl chains, H, or part of a cyclic boronate ester with an other R2. Each n may be independently less than or equal to 3 and greater than or equal to 1. Each x may be independently less than or equal to 3.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: February 28, 2017
    Assignee: Corning Incorporated
    Inventors: Mingqian He, James Robert Matthews, Weijun Niu, Arthur Lawrence Wallace
  • Compositions and methods for the production of pyrimidine and pyridine compounds with BTK inhibitory activity
    Patent number: 9580449
    Abstract: The present invention provides novel pyrimidine and pyridine compounds according to Formula (I), Formula (II), Formula (III), Formula (IV) and Formula (V) their manufacture and use for the treatment of hyperproliferative diseases including, but not limited to, cancer, lupus, allergic disorders, Sjogren's disease and rheumatoid arthritis. In preferred embodiments, the present invention describes irreversible kinase inhibitors including, but not limited to, inhibitors of Bruton's tyrosine kinase.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: February 28, 2017
    Assignee: Merck Patent GmbH
    Inventors: Brian L. Hodous, Lesley Liu-Bujalski, Reinaldo Jones, Donald Bankston, Theresa L. Johnson, Igor Mochalkin, Ngan Nguyen, Hui Qiu, Andreas Goutopoulos, Nadia Brugger
  • Compounds that expand hematopoietic stem cells
    Patent number: 9580426
    Abstract: The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.
    Type: Grant
    Filed: April 5, 2013
    Date of Patent: February 28, 2017
    Assignees: Novartis AG, The Scripps Research Institute
    Inventors: Anthony E. Boitano, Michael Cooke, Shifeng Pan, Peter G. Schultz, John Tellew, Yongqin Wan, Xing Wang
  • Polymorphic forms of nilotinib hydrochloride
    Patent number: 9580408
    Abstract: Crystalline Forms R5, R5a, R5b and R6 of nilotinib hydrochloride and processes for their preparation.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: February 28, 2017
    Assignee: DR. REDDY'S LABORATORIES LIMITED
    Inventors: Vishweshwar Peddy, Ramanaiah Chennuru, Srividya Ramakrishnan
  • Carbondisulfide derived zwitterions
    Patent number: 9580385
    Abstract: Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: February 28, 2017
    Inventor: Thomas P. Daly
  • Methods for preparing SGLT2 inhibitors
    Patent number: 9573959
    Abstract: This invention relates to methods for preparing a sodium-glucose transporter 2 (SGLT2) inhibitor, a cocrytalline SGLT2 and (S)-5-oxopyrrolidine-2-carboxylic acid (L-PGA) complex, and intermediates useful in the preparation of the said SGLT2 inhibitor.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: February 21, 2017
    Assignee: MSD International GMBH
    Inventors: Steven J. Brenek, Stephane Caron, Jade D. Nelson, Mark E. Webster, Rodney Matthew Weekly
  • Stereo controlled synthesis of ()-dienals via tandem Rh(I) catalyzed propargyl claisen rearrangement
    Patent number: 9573871
    Abstract: A novel Rh(I)-catalyzed approach to synthesizing functionalized (E,Z) dienal compounds has been developed via tandem transformation where a stereoselective hydrogen transfer follows a propargyl Claisen rearrangement. Z-Stereochemistry of the first double bond suggests the involvement of a six-membered cyclic intermediate whereas the E-stereochemistry of the second double bond stems from the subsequent protodemetallation step giving an (E,Z)-dienal. The reaction may be represented by the following sequence.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: February 21, 2017
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Dinesh V. Vidhani, Marie E. Krafft, Igor Alabugin
  • Heterocyclyl compounds
    Patent number: 9573944
    Abstract: The present invention is related to heteroaryl compounds as MEK inhibitors. The invention includes heteroaryl compounds of formula I, their tautomers and pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present invention also includes process of preparation of the said compounds and intended use in therapy of them.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: February 21, 2017
    Assignee: Lupin Limited
    Inventors: Bhavesh Dave, Rakesh Kumar Banerjee, Samiron Phukan, Abhijit Datta Khoje, Rajkumar Hangarge, Jitendra Sambhaji Jadhav, Venkata P. Palle, Rajender Kumar Kamboj
  • Organic electroluminescent materials and devices
    Patent number: 9577200
    Abstract: Triphenylene containing benzo-fused thiophene compounds are provided. Additionally, triphenylene containing benzo-fused furan compounds are provided. The compounds may be useful in organic light emitting devices, particularly as hosts in the emissive layer of such devices, or as materials for enhancement layers in such devices, or both.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: February 21, 2017
    Assignee: UNIVERSAL DISPLAY CORPORATION
    Inventors: Bin Ma, Yonggang Wu, Chun Lin, Raymond Kwong