Abstract: A method of predicting successful treatment of disorders of bodily tissue includes obtaining, with a device, energy signal data from the bodily tissue of a patient. The obtained energy signal data is analyzed in a controller to determine an activity score value associated with the bodily tissue. The activity score value is compared, in the controller, to a threshold value, with the threshold value being based on energy signal data from the same bodily tissue of normal, disease free patients. Based on the comparison, a probability of success of a particular therapy in treating the bodily tissue is determined. A system for performing the method is also disclosed.

Abstract: An apparatus for patient's lung function testing using forced oscillation technique is described. The apparatus includes a sub-woofer configured to generate a pressure wave. The apparatus further includes a waveguide configured to direct the generated pressure wave to be introduced into airflow towards the patient's lung. The apparatus includes a pressure transducer configured to measure a change in pressure of the airflow and one or more flow transducers configured to measure a change in flowrate of the airflow, in response to the pressure wave introduced into the airflow. The apparatus includes a computing unit configured to determine a mechanical impedance of the patient's lung based on the measured change in pressure and flowrate of the airflow.

Abstract: A kit for intravascular implantation of an implantable medical device (IMD) within a patient includes the IMD, an elongated shaft, and a locking mandrel. The IMD comprises a fixation assembly comprising a loop and defines at least one longitudinal lumen and a port in fluid communication with the lumen. The shaft is sized to traverse a vasculature of the patient. The port is sized to receive at least a portion of the loop. The locking mandrel is configured to be positioned within the at least one lumen of the shaft and to pass through the loop within the lumen at the port. A reduced profile portion of the shaft defines a reduced profile with respect to at least one other portion of the shaft. At least a portion of the reduced profile portion is configured to be adjacent to the IMD when the IMD is positioned on the shaft.

Abstract: In an embodiment, PhotoPlethysmoGraphy (PPG) signals are processed by detecting peaks and valleys in the PPG signal, segmenting the PPG signal to provide a time series of PPG waveforms located between two subsequent valleys in the PPG signal, applying to the waveforms in the time series pattern recognition with respect to a reference PPG waveform pattern produced based on a mathematical model of the PPG signal by assigning to the waveforms in the time series a recognition score. A resulting PPG signal is produced by retaining the waveforms in the time series having an assigned recognition score reaching a recognition threshold, and discarding the waveforms in the time series having an assigned recognition score failing to reach the recognition threshold.

Abstract: An electronic device and method are disclosed herein. The electronic device includes a sensor and a processor. The processor implements the method, including measuring infrared light corresponding to a user using the sensor, and detecting biometric information of the user if the infrared information satisfies a predetermined condition.

Abstract: A catheter, such as a fractional flow reserve catheter, includes an elongate shaft having a proximal end optionally coupled to a handle or luer fitting and a distal end having a distal opening. A pressure sensing wire extends to the distal portion of the elongate shaft to be coupled to a pressure sensor mounted on the distal end for measuring a pressure of a fluid within lumen of vessel. The pressure sensor wire is disposed within a pocket formed adjacent to the pressure sensor thereby minimizing the profile of the catheter. Bending or flexing stress or strain experienced by a pressure sensor mounted to a fractional flow reserve catheter when tracking the catheter through the vasculature creates a distortion of the sensor resulting in an incorrect pressure reading or bend error. In order to isolate the sensor from bending or flexing stress and strain, the sensor is mounted so that the sensor is spaced apart from the elongate shaft of the catheter.

Abstract: A system and method for determining cardiovascular parameters can include: receiving a plethymogram (PG) dataset, removing noise from the PG dataset, segmenting the PG dataset, extracting a set of fiducials from the PG dataset, and transforming the set of fiducials to determine the cardiovascular parameters.

Abstract: Systems, processes and devices for real-time brain monitoring for epileptic spasms and hypsarrhythmia or electrodecremental events to generate and control an interface of a display device with a visual representation of a Brain Value Index for epileptic spasms and hypsarrhythmia or electrodecremental events, a connectivity map and treatment guidance. Systems, processes and devices for real-time brain monitoring capture sensor data, process the data and dynamically update the interface in real-time.

Abstract: The present invention refers to a blood pressure measuring system (10) configured to surround a patient's body part (E), comprising pressurization means (12, 14) for applying pressure to the body part (E), and comprising a kinking-proof shell (20; 30), wherein the kinking-proof shell (20; 30) is arranged so as to be located between the pressurization means (12, 14) and the body part (E), when the blood pressure measuring system (10) surrounds the body part (E). The present invention further refers to a method of applying a blood pressure measuring system (10).

Abstract: A portable sampling device (1) for collecting particles in a stream of exhaled breath comprising a housing (10) with an inlet (11) and an outlet (12) arranged to guide the stream of exhaled breath therethrough, a collecting device holder (20) arranged at least partially inside the housing and comprising at least one flow path (21) in fluid connection with the inlet in which a collecting device (30) is arranged, the collecting device being adapted to collect the particles in the exhaled breath, wherein the collecting device has a diameter smaller than the flow path diameter and is movably arranged in the collecting device holder.

Abstract: A computer-implemented method for determining lung pathology from an audio respiratory signal comprises inputting a plurality of audio files comprising a training set into an artificial neural network (ANN), wherein the plurality of audio files comprise sessions with patients with known pathologies of known degrees of severity. The method further comprises annotating the plurality of audio files with metadata relevant to the patients and the known pathologies and analyzing the plurality of audio files, wherein the analyzing comprises extracting spectrograms for each of the plurality of audio files and a plurality of descriptors associated with wheeze and crackle from the plurality of audio files. Additionally, the method comprises training the ANN using the plurality of audio files, the spectrograms, the metadata and the plurality of descriptors. The method finally comprises determining a lung pathology associated with a new sound recording inputted into the ANN.

Abstract: A method for analyzing an audio respiratory signal comprises capturing the audio respiratory signal from a subject using a microphone and partitioning the audio respiratory signal into a plurality of overlapping frames. The method further comprises calculating a fourier transform for each frame and determining a magnitude spectrum using the fourier transform of the plurality of overlapping frames. Additionally, the method comprises extracting a spectrogram using the magnitude spectrum and analyzing the spectrogram to determine characteristics pertaining to wheeze sounds in the audio respiratory signal.

Abstract: Disclosed are a heart rate detection system and a wearable device using the same. The heart rate detection system includes a light emitting unit, a light sensor and a processor. The light emitting unit emits a light to a human body. The light sensor senses a reflected light of the light and accordingly generates a first electric signal. The processor calculates the low-frequency noise signal and the high-frequency noise signal of the first electric signal, and removes them. After that, the processor executes a peak detection with respect to the first electric signal to calculate peak values of the first electric signal, and calculate a heart rate based on the time intervals among the peak values.

Abstract: A measurement system is disclosed that includes features for detecting the presence of nitric oxide from a gas sample, such as exhaled breath. The measurement system includes an assembly that introduces one or more reducing gases into a reactor-sensor assembly to help stabilize the sensor signal response and improve the performance of the assembly over time. Suitable reducing gases include hydrogen gas (H2), carbon dioxide (CO), benzaldehyde, bisphenol A, and other similar compounds. The reducing gas may be introduced directly from one or more surrounding gases or through tubing or inline piping. The reducing gas may be generated from the liquid or solid forms.

Abstract: The current invention pertains to an apparatus and method for the determination of excess post-exercise oxygen consumption (EPOC) and the estimation of blood lactate levels. While these exercise parameters are traditionally determined using indirect calorimetry and blood sampling, this invention provides a method for the determination of these parameters using heart rate data. A wearable photoplethysmography device for measuring heart rate is included as an exemplary embodiment, however, the method of the current inventions can also be used with heart rate data from any heart rate monitor. In an embodiment of the present invention a supply demand differential equation is used to continuously monitor EPOC in real-time. Furthermore, blood lactate levels can also be estimated as a function of EPOC.

Abstract: A blood pressure estimating apparatus includes: a detecting unit that detects a first parameter representing a period length being a length of a period of a heartbeat of a living body; a processing unit that determines, using the detected first parameter, a change of a volume of at least one vessel among a plurality of vessels that resiliently deform in a mathematical model with respect to time, the mathematical model expressing blood flowing in a circulatory system of the living body with fluid flowing through a flow path formed by annularly coupling the plurality of vessels, and estimates blood pressure of the blood using the determined change and the mathematical model.

Abstract: A method includes receiving acoustic inputs; generating signal channels from the acoustic inputs; pre-processing data in the signal channels; extracting S1-S2 peaks from the pre-processed data; removing artifacts and outliers from the S1-S2 peaks; generating S1-S2 signal channels based on the S1-S2 peaks in the pre-processed signal channels; selecting two or more of the S1-S2 signal channels; and combining the selected two or more S1-S2 signal channels to produce an acoustic uterine monitoring signal.

Abstract: The present disclosure provides systems and methods for predicting fluid responsiveness. Embodiments include sensors configured to obtain a high-resolution electrocardiogram signal and a computer system connected to the sensors, the computer system including a memory, a processor, and a display device. Computer system may be configured to receive the electrocardiogram signal from the sensors. Processor may be configured to detect and process changes in at least one of length, amplitude, slope, area, depth, and height of at least one of P, Q, R, S, T, and U complex of the electrocardiogram signal caused by the influence of physiological variables on each other to create a prognostic index. Processor may be further configured to analyze, quantify, and combine the prognostic index of the changes in the electrocardiogram signal and generate a fluid responsiveness prediction. Display device may display the results of the fluid responsiveness prediction.

Abstract: The pulse wave detecting device includes a sensor section in which two element rows consisting of a plurality of pressure detecting elements arranged in a direction B are arranged in a direction A perpendicular to the direction B, and an air bag pressing the sensor section to a body surface in a state that the direction B intersects a direction in which an artery below the body surface of a living body. An arrangement interval between the two element rows in the direction A is 5 mm or more and 15 mm or less.

Abstract: Systems and methods of leveraging high-fidelity continuous respiratory volume monitoring for rapid patient assessment are disclosed herein.