Abstract: A process is provided for the production of m-benzoyl-hydratropic acid which comprises heating the reaction mixture obtained from the condensation of 2-benzoyl-cyclohexanone and pyruvic acid, its esters or salts, at a temperature of 200.degree. to 230.degree. and in the presence of an acid catalyst.

Abstract: 2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, anti-pyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.

Abstract: A process for the synthesis of Ibuprofen, p - isobutyl hydrotropic acid is described based upon the aromatization reaction which takes place when a dialkyl .alpha.-acetyl-.alpha.-[(5-methyl-3-oxo)-hexyl]-.alpha.'-methyl-succinate (II) is heated at temperatures of about 200.degree. with a strong acid, or a salt of a strong acid with an organic base.

Abstract: Terephthalic acid is esterified with an alkylene glycol by heating in a first stage one mole of the acid with at least about 1.2 moles of the glycol and 0.01 to 1.0% based on the weight of the acid of a volatile organic base at a temperature between 240.degree. and 320.degree. C and at a pressure above the vapor pressure of the glycol at the reaction temperature until about 75-85% of the acid groups initially present in the terephthalic acid have been esterified, and then maintaining the reaction mixtures from the first stage in a second stage at a temperature between 240.degree. to 320.degree. at a pressure less than that of the said first stage until at least about 95% of the acid groups initially present in the terephthalic acid have been esterified.

Abstract: In the process for preparing dimethyl terephthalate by oxydizing p-xylene and/or methyl p-toluate with molecular oxygen or a molecular oxygen-containing gas in the presence of a heavy metal catalyst, esterifying the resulting oxidation reaction mixture with methanol, followed by submitting the resulting esterification reaction mixture to distillation to separate dimethyl terephthalate and fractions of lower boiling point than dimethyl terephthalate, and thereafter recycling to said oxidation step (A) the distillation residue containing said heavy metal catalyst and/or (B) the extract portion containing said heavy metal catalyst obtained by further extraction treatment of said distillation residue (A), the improvement which comprises contact-treating said distillation residue (A) or said extract portion (B) with methanol prior to recycling same.

Abstract: Certain carboxylic acid esters in which the alcohol portion contains an alpha-thioamide group are useful as pesticides.

Abstract: Diacyloxyolefins are isomerized by mixing one or more diacyloxyolefins with at least one alkali metal, alkaline earth metal or ammonium salt of a carboxylic acid and a polar diluent.

Abstract: 2-Hydroxy-3-alkylsulfoxypropyl-1 esters of arene polycarboxylic acids.

Abstract: Compounds having the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or acyl, and R.sub.4 is lower alkyl have utility in the treatment of coronary diseases.

Abstract: New N-arylcarbamic acid esters of the formula ##STR1## in which R is lower aliphatic hydrocarbyl, optionally substituted,R.sup.1, r.sup.2 and R.sup.3, which may be identical or different, are each hydrogen, alkyl, cycloalkyl, alkoxy, haloalkyl or halogen,R.sup.4 is alkyl, alkenyl, alkynyl, cycloalkenyl, haloalkyl, haloalkenyl, haloalkynyl, alkoxyalkyl or alkylthioalkyl, acylalkyl (i.e., alkanoyloxyalkyl), alkoxycarbonylalkyl, carbalkoxyalkyl, carbalkoxyalkenyl, or an optionally substituted cycloalkyl, aryl, aralkyl, aryloxyalkyl or arylthioalkyl radical, or the grouping ##STR2## wherein R.sup.4' is hydrogen or is defined as R.sup.4 is defined above, andY and Y' are oxygen or sulfur.Are outstanding effective in regulating the growth of plants, i.e., to inhibit, stimulate or alter the growth of plants.

Abstract: A process for the production of dimethyl terephthalate and intermediate products of the dimethyl terephthalate manufacture from the high-boiling by-products obtained during the air oxidation of p-xylene and methyl p-toluate in the liquid phase, subsequent esterification of the thus-formed acids, and separation of the thus-produced esters, which comprises treating said high-boiling by-products with methanol at an elevated temperature and then separating the resultant product rich in dimethyl terephthalate by distillation with the addition of a carrier gas or a carrier vapor.

Abstract: A novel substituted-arylacetic acid ester of the formula, ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen or a halogen atom, a C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, C.sub.1 -C.sub.4 alkoxy, cyano, nitro, methylthio, C.sub.1 -C.sub.4 alkanoyl, C.sub.1 -C.sub.4 alkanoyloxy, or C.sub.1 -C.sub.4 alkoxycarbonyl group, or R.sub.1 and R.sub.2, taken together, may form methylenedioxy, a C.sub.3 -C.sub.5 alkylene or butadienylene (--CH.dbd.CH--CH.dbd.CH--) ring; R.sub.3 is a C.sub.2 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, propargyl, C.sub.3 -C.sub.6 cycloalkyl or cyclopropylmethyl group; R.sub.4 is hydrogen or a halogen atom, methyl or ethyl group; R.sub.5 is allyl, propargyl, 3-butenyl, 3-butynyl, phenyl or benzyl group; and A is oxygen or sulfur atom or --CH.dbd.CH-- group, which possesses various useful insecticidal and acaricidal activities and can be prepared by reacting a substituted-arylacetic acid of the formula; ##STR2## wherein R.sub.1, R.sub.2, R.sub.

Abstract: Compounds of the formula: ##STR1## wherein R represents a member selected from the group consisting of a straight or branched alkyl group of from one to twenty carbon atoms (C.sub.1 -C.sub.5 being preferred), an ethoxycarbonyl group, a benzyloxycarbonyl group, a phenyl group, an ##STR2## WHEREIN R is as defined above and R.sub.3 is a member selected from the group consisting of a hydrogen atom, a methyl group and a phenyl group, and a 2-, 3-, or 4-pyridyl group, or the HX salts thereof, wherein X represents a pharmaceutically acceptable acid addition salt anion, are extremely valuable in the treatment of conditions responsive to sympathomimetic agents.The compounds of this invention find therapeutic application to warm-blooded animals (e.g., humans) in the management of asthma, nasal congestion and as decongestants, vasoconstrictors, mydriatic agents, and anti-glaucomatous agents in the practice of opthalmology.

Abstract: Olefins may be esterified by reaction with esters of saturated alcohols containing at least two carbon atoms in the presence of a catalytic amount of a tin halide catalyst, the reaction being effected at temperatures ranging from about 0.degree. to about 150.degree. C.

Abstract: Antioxidants such as the reaction product of p-amino-diphenylamine and glycidyl methacrylate [3-N-(4'-anilinophenyl) amino-2-hydroxypropyl methacrylate], and the reaction product of n-hexyl-N'-phenyl-p-phenylenediamine and glycidyl methacrylate [3-[N-(4'-anilinophenyl)-N-(1,3-dimethylbutyl)]amino-2-hydroxy-propyl methacrylate], age resistant polymers having monomeric age resisters physically combined therewith and oxidation resistant polymeric compositions prepared by free radical polymerization techniques involving the use of said antioxidants as monomers.

Abstract: This invention relates to an improvement in the process for preparation of 2-(amylbenzoyl)benzoic acid containing a high percentage of 2-(t-amylbenzoyl)benzoic acid. More particularly it relates to a process for preparation of 2-(amylbenozyl)benzoic acid wherein said 2-(amylbenzoyl)benzoic acid is prepared by reacting t-amylbenzene with phthalic anhydride in the presence of Lewis acid, characterized by that 2-(amylbenzoyl)benzoic acid containing a high percentage of 2-(t-amylbenzoyl)benzoic acid is produced by suppressing the undesirable isomerization reaction of the amyl radical by applying one of the means selected from the group consisting of the means of introducing an inert gas into the reaction system and the means of reducing the pressure of the reaction system. 2-(Amylbenzoyl)benzoic acid is a compound useful as the starting material of preparation of 2-amylanthraquinone which is an effective organic catalyst in the manufacture of hydrogen peroxide.

Abstract: A process for making terephthalic acid of high purity by feeding an aqueous equilibrium hydrolysis solution of terephthalonitrile to a reactive distillation column operated at a temperature of from about 200.degree. C to about 260.degree. C at autogenous pressure where the equilibrium solution is subjected simultaneously to further hydrolysis and distillation of ammonia while maintaining the concentration of aromatic materials in the aqueous liquid in said column sufficiently high to effect precipitation of dissolved terephthalic acid, removing the water vapor and ammonia from the top of the column, subjecting bottoms product in said column to further hydrolysis and distillation in a reboiler, returning vapor from the reboiler to the distillation column, removing an aqueous slurry of terephthalic acid from the reboiler and separating terephthalic acid product.

Abstract: The invention concerns dehydrogenation of carboxylic acids, lactones, esters, nitriles, the carbon skeleton of the feed material being characterized as containing mono-unsaturation or alternatively functional groups such as hydroxyl which convert under process conditions to unsaturation, the dehydrogenation reaction being conducted in the presence of a contact catalyst comprising a carbonaceous layer effective for the dehydrogenation of mono-unsaturated reactants to di-unsaturated products. Another aspect of the invention involves production of the mono-unsaturated reactants. In particular, the invention provides a route to sorbic acid, for example by dehydrogenation of hexenoic acids or esters thereof.

Abstract: Novel 2'-(carboxymethoxy)-chalcones of the formula ##STR1## wherein one or two of X.sup.1, X.sup.2 and X.sup.3 are 3-methyl-2-butenyloxy and the other or others are hydrogen, possess excellent antigastric and anti-duodenal ulcer activities, together with a high absorptive ratio in the living body and low acute and chronic toxicity.

Abstract: Phenylacetic acid is produced by reacting chlorotoluene with sodium to form tolylsodium, rearranging the product to benzyl sodium and then reacting the benzyl sodium with a carboxylating agent.