Patents Examined by Jean F Vollano
  • Method for making dimethyl sulfone from dimethyl sulfoxide and hydrogen peroxide
    Patent number: 6552231
    Abstract: The present invention provides a process for synthesizing dimethyl sulfone by the oxidation of dimethyl sulfoxide with hydrogen peroxide.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: April 22, 2003
    Assignee: Sloss Industries Corporation
    Inventors: Charles A. Jones, Joyce D. Friedrich, John C. Paschall, Wima K. Alwis
  • Preparation of biphosphine ligands for incorporation into catalytic complexes
    Patent number: 6548708
    Abstract: This invention relates to processes for making phosphorus compounds R2P—X—PR2, R2P—M, R2P—L and R3P, and the novel cation R2P+(L)—X—P+(L)R2, where R represents an optionally substituted hydrocarbyl group, X represents a bridging group, L represents a leaving group and M represents an alkali metal atom. The invention relates further to a process for making a compound R2P—L from a compound R—H via a new process for making the compound R—Li followed by its reaction with a compound Hal2P—L. The compound R2P—X—PR2 is a ligand suitable for making catalysts for copolymerizing carbon monoxide and a olefinically unsaturated compound.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: April 15, 2003
    Assignee: SRI International
    Inventors: Roelof Van Ginkel, Alexander Van Der Made, Jan De With, Wolf Eilenberg
  • Method for the production of arylsulfides and compositions made therefrom
    Patent number: 6548709
    Abstract: The present invention relates to methods for production of arylsulfides wherein an aromatic compound is reacted with elemental sulfur in the presence of solid acid catalyst. The solid acid catalyst can be a zeolite. The methods are useful for producing alkylated diphenylsulfides from aromatic compounds and elemental sulfur.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: April 15, 2003
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Margaret M. Wu, Philip Trotto, Shifang Luo, Jose G. Santiesteban, Hye Kyung C. Timken, Sandeep S. Dhingra, Simon C. Weston, Richard T. Spissell
  • Bis-phosphonate compounds
    Patent number: 6548042
    Abstract: The present invention provides a pharmaceutical compound, or pharmaceutically acceptable salt thereof, for use in medicine, wherein said compound is of formula I wherein R is a pharmaceutically active moiety; Ar is an aromatic moiety; X is a linker group; and Y is a moiety comprising two phosphonate groups. Further aspects of the invention relate to a method for palliative and curative treatment of bone disorders and cancer related disorders, such as breast cancer.
    Type: Grant
    Filed: July 9, 2001
    Date of Patent: April 15, 2003
    Inventors: Erik {haeck over (A)}rstad, Lars Skattebøl
  • Styryl sulfone anticancer agents
    Patent number: 6548553
    Abstract: Styryl sulfone compounds of the invention selectively inhibit proliferation of tumor cells, and induce apoptosis of tumor cells, while sparing normal cells.
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: April 15, 2003
    Assignee: Temple University-of the Commonwealth System of Higher Education
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy
  • Manufacture of polysulfones
    Patent number: 6548622
    Abstract: Polysulfones are manufactured by reacting a sulfuric acid or sulfur trioxide with a bireactive aromatic compound, using as a “promoter” a carboxylic acid anhydride. The product polymers are useful as molding resins.
    Type: Grant
    Filed: September 27, 2001
    Date of Patent: April 15, 2003
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Marc Bruce Goldfinger
  • Transfer hydrogenation process and catalyst
    Patent number: 6545188
    Abstract: A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal cyclopentadienyl complex which is coordinated to defined bidentate ligands. Preferred metals include rhodium, ruthenium and iridium. Preferred bidentate ligands are diamines and aminoalcohols, particularly those comprising chiral centers. The hydrogen donor is advantageously a secondary alcohol or a mixture of triethylamine and formic acid. The process can be employed to transfer hydrogenate ketones and imines, which are preferably prochiral. Catalysts for use in such a process are also provided.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: April 8, 2003
    Assignee: Avecia Limited
    Inventors: Andrew John Blacker, Ben James Mellor
  • Process for preparing cyclic phosphines
    Patent number: 6545183
    Abstract: The present invention concerns the preparation of a cyclic phosphine from the corresponding primary phosphine and a bifunctional alkylating agent, wherein alkylation, and displacement of each functional group, occurs in the presence of a strong base, is modified by adding the strong base, in an amount sufficient for cyclisation, to a preformed mixture or reaction product of the primary phosphine and the alkylating agent.
    Type: Grant
    Filed: July 6, 2000
    Date of Patent: April 8, 2003
    Assignee: Chirotech Technology Limited
    Inventor: Ulrich Berens
  • Method of preparing magnesium alcoholates
    Patent number: 6544446
    Abstract: A method of preparing magnesium alcoholates Mg(OR)2 (where R=alkyl residue having 2 to 10 carbon atoms) is described. Addition products of 1,3-dienes to magnesium metal in a polar, aprotic solvent are reached with an alcohol R—OH.
    Type: Grant
    Filed: November 20, 2001
    Date of Patent: April 8, 2003
    Assignee: Chemetall GmbH
    Inventors: Ulrich Wietelmann, Dieter Hauk, Peter Rittmeyer
  • Methods and compositions for modulating alpha adrenergic receptor activity
    Patent number: 6545182
    Abstract: Methods and compositions for the treatment of pain using thiourea derivatives. Particularly disclosed are new compositions for the treatment of chronic pain, and methods for their use.
    Type: Grant
    Filed: February 5, 2001
    Date of Patent: April 8, 2003
    Assignee: Allergan Sales, Inc.
    Inventors: Ken Chow, Daniel W. Gil, Wenkui Fang, Michael E. Garst, Wheeler A. Larry
  • HIV integrase inhibitors
    Patent number: 6541515
    Abstract: Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines are described. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. The culture Cytospora sp. MF 6608 (ATCC PTA-1691) is also disclosed, as well as processes for making a compound of the present invention employing the culture.
    Type: Grant
    Filed: August 9, 2001
    Date of Patent: April 1, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Sheo Bux Singh, Hiranthi Jayasuriya, Ziqiang Guan, Keith C. Silverman, Russell B. Lingham, Anne W. Dombrowski, Daria J. Hazuda, Jon D. Polishook
  • Synthesis of 2H- and 13C-substituted dithanes
    Patent number: 6541671
    Abstract: The present invention is directed to labeled compounds, [2-13C]dithiane wherein the 13C atom is directly bonded to one or two deuterium atoms. The present invention is also directed to processes of preparing [2-13C]dithiane wherein the 13C atom is directly bonded to one or two deuterium atoms. The present invention is also directed to labeled compounds, e.g., [2H1−2, 13C]methanol (arylthio)-, acetates wherein the 13C atom is directly bonded to exactly one or two deuterium atoms.
    Type: Grant
    Filed: February 13, 2002
    Date of Patent: April 1, 2003
    Assignee: The Regents of the University of California
    Inventors: Rodolfo A. Martinez, Marc A. Alvarez, Louis A. Silks, III, Clifford J. Unkefer
  • Mixture for use as wound dressing
    Patent number: 6541040
    Abstract: The invention relates to a mixture for use as wound dressing, which comprises: a) paraffins complying with DAB and/or synthetic waxes selected from the group consisting of montan waxes, petroleum waxes, Fischer-Tropsch waxes, polyolefin waxes, petrolatum, wax alcohols, and oxidates of the aforementioned substances; b) at least one metal hydroxide. The mixture is stable on prolonged storage at room temperature and promotes collagen regeneration in vivo in cases of bone trauma.
    Type: Grant
    Filed: October 9, 1998
    Date of Patent: April 1, 2003
    Assignee: Ernst Milbauer KG
    Inventor: Wolfgang Mühlbauer
  • Preparation of alkenylphosphonic acid derivatives
    Patent number: 6534669
    Abstract: Alkenylphosphonic acid derivatives are prepared by reacting phosphonic acid derivatives with alkynes in the presence of a metal complex catalyst system comprising (a) nickel and (b) a phosphine having at least two trivalent phosphorus atoms.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: March 18, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Jochem Henkelmann, Katrin Klass, Jan-Dirk Arndt
  • Process for preparing salts of dialkylphosphinic acids
    Patent number: 6534673
    Abstract: The invention relates to a process for preparing salts of dialkylphosphinic acids, which comprises a) reacting alkylphosphonous and/or hypo- phosphorous acid and/or alkali metal salts thereof with olefins in the presence of a free-radical initiator to give dialkylphosphinic acids and/or alkali metal salts thereof and b) reacting the dialkylphosphinic acids and/or alkali metal salts thereof obtained according to a) with metal compounds of Mg, Ca, Al, Sb, Sn, Ge, Ti, Zn, Fe, Zr, Ce, Bi, Sr, Mn, Li, Na and/or K to give the metal dialkyl20 phosphinate salts.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: March 18, 2003
    Assignee: Clariant GmbH
    Inventors: Norbert Weferling, Hans-Peter Schmitz, Günter Kolbe
  • Process for the preparation of zinc dithiocarbamates
    Patent number: 6534675
    Abstract: Zinc dithiocarbamates are obtained in especially readily filterable form and high purity when zinc salts are first added, in aqueous solution, to the secondary amines underlying the zinc carbamates, so that a zinc salt complex of the amines is formed, and carbon disulfide and then sodium hydroxide solution are then introduced, with stirring, into the aqueous suspension so obtained, the temperatures being maintained in the range from room temperature to the boiling temperature of carbon disulfide until the reaction has completely finished.
    Type: Grant
    Filed: April 2, 2001
    Date of Patent: March 18, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rüdiger Schubart, Hans-Wilhelm Engels
  • Triarylphosphine oxide derivatives containing fluorine substituent and preparing method thereof
    Patent number: 6531633
    Abstract: The present invention relates to fluorine-containing triarylphosphine oxide derivatives and preparing method thereof. Particularly, the present invention relates to both fluorine- and phosphine oxide-containing triarylphosphine oxide derivatives which can be utilized in preparing polyimides having excellent adhesion, fire retardancy and low dielectric constant as well as superior thermal stability and mechanical properties, and preparing method thereof.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: March 11, 2003
    Assignee: Kwangju Institute of Science and Technology
    Inventors: Tae-Ho Yoon, Kwang Un Jeong, Young-Jun Jo
  • Substantive water-soluble 2-hydroxy sulfobetaines of cinnamidoalkylamines
    Patent number: 6531628
    Abstract: Substantive UV-absorbing water-soluble 2-hydroxy sulfobetaine of cinnamidoalkylamines of Formula I. Hair, skin and fabric care compositions containing the compounds of Formula I. wherein, R1 is a substituent, selected from H, halo, —OH, —NH2, —NO2, —OCH3, —N(CH3)2, alkyl groups containing from 1 to 6 carbon atoms, alkoxy groups containing from 1 to 6 carbon atoms, alkylamino or N,N-dialkylamino groups containing from 1 to 6 carbon atoms; R2 is selected from hydrogen, alkyl group containing from 1 to 12 carbon atoms; R3 and R4 are independently selected from benzyl, alkyl group containing from 1 to 12 carbon atoms, n is an integer from 1 to 6.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: March 11, 2003
    Assignee: Galaxy Surfactants Ltd.
    Inventors: Nirmal Madhukar Koshti, Arun Harchandra Jawale, Bharat Bhikaji Parab, Shubhangi Dattaram Naik, Manasi Dattatraya Moghe, Tanaji Shamrao Jadhav, Subhash Shivling Nashte
  • Method for the production of phosphonomethylglycine
    Patent number: 6528680
    Abstract: The present invention relates to a process for the preparation of phosphonomethylglycine in which N-phosphonomethyliminodiacetic acid N-oxide is brought into contact with a catalytically active quantity of at least one catalyst, selected from amongst a thionyl halide, ammonium dithionite or an alkali metal dithionite, a dialkyl sulfite, sulfur dichloride, sulfur dioxide and sulfurous acid, in a reaction chamber by metering the N-phosphonomethyliminodiacetic acid N-oxide into the reaction chamber in such a way that always at least 50% of the N-oxide metered into the reaction chamber are converted.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: March 4, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Nicola Christiane Aust, Thomas Butz, Martin Fischer
  • Process for preparing diketone compounds and precursors thereto
    Patent number: 6525225
    Abstract: A process for preparing compounds of the formula: wherein R2 is lower alkyl; or phenyl optionally substituted by from one to five groups, the same or different, which are lower alkyl, lower haloalkyl, halogen or —SR4; R3 is halogen, lower alkyl, lower haloalkyl, lower alkoxy, lower haloalkoxy, —S-alkyl, cycloalkyl having from 3 to 7 carbon atoms in the ring, alkenyl or alkynyl having from 3 to 7 carbon atoms, or —(CR5R6)—SR2 wherein q is one or two; R4 is lower alkyl; R5 and R6 independently represent hydrogen, lower alkyl or lower haloalkyl; and n is zero or an integer from one to three; intermediate compounds of the formula: and processes for preparing them.
    Type: Grant
    Filed: November 23, 2001
    Date of Patent: February 25, 2003
    Assignee: Rhone Poulenc Agrochimie
    Inventors: Virginie Pevere, Alain Gadras, Susan Mary Cramp, Charles Walter Ellwood