Patent number: 6423752
Abstract: Indane dimer compounds of general formula 5 or 6 are pharmaceutically useful, particularly to achieve smooth muscle relaxing activity and/or mast cell stabilizing activity and/or inflammatory activity. In formula 5 R1, R2 and R3to R15 and in formula 6 R1, R2 and R4 to R15, are selected from one or more of the same of different of: H, halo, hydroxy, alkoxy, aryloxy, acetoxy, carboxy, alkyl carbonyl, hydro carbonyl, amino, amido, alkylamino, hydroxylamino, sulphonic acid groups, sulphoxide groups, sulphone groups, C1-C10 alkyl or C3-C8 cycloalkyl groups. In formulae 5 and 6, X is O or NR, and the R in NR may be hydrogen, acyl, alkyl or sulphonate groups. In formulae 5 and 6 any one or more of R1, 1R1; R1, 1R2; R9, 1R9; R10, 1R10 and R14, 1R10 may together represent oxo.
Type:
Grant
Filed:
June 8, 1998
Date of Patent:
July 23, 2002
Assignee:
Venantius Limited
Inventors:
John Walsh, Neil Frankish, Helen Sheridan, William Byrne