Patents Examined by Jean F Vollano
  • Patent number: 6492557
    Abstract: A bis(aminostyryl)naphthalene compound represented by the general formula [I] or the like below. (where R2 and R3 each denotes an unsubstituted aryl group; R1 and R4 each denotes an aryl group having a specific substituent such as methoxy group; and R5 and R6 each denotes a cyano group or the like.) A process for producing a bis(aminostyryl)naphthalene compound represented by the general formula [I] by condensation of, for example, 4-(N,N-diarylamino)benzaldehyde with diphosphonic ester or diphosphonium The bis(aminostyryl)naphthalene compound emits intense yellow or red light. The process permits efficient production of the bis(aminostyryl)naphthalene compound.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: December 10, 2002
    Assignee: Sony Corporation
    Inventors: Mari Ichimura, Tadashi Ishibashi, Shinichiro Tamura
  • Patent number: 6489513
    Abstract: The invention relates to the preparation of enantiomerically pure bis-diphenylphosphine oxides in a particularly advantageous manner by (1) reacting an aromatic bromine compound with a diphenylphosphinic chloride in a mixture of tetrahydrofuran and an aromatic hydrocarbon to give a diphenylphosphine oxide, which is isolated from a solution in an aromatic hydrocarbon by adding a saturated aliphatic hydrocarbon; (2) metalating the resulting diphenylphosphine oxide in the 6-position and reacting the metalated diphenylphosphine oxide with iodine at temperatures not less than −25° C.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: December 3, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Torsten Pohl, Thomas Prinz, Guido Giffels, Wolfram Sirges
  • Patent number: 6486356
    Abstract: A process for preparing a compound of the formula: which comprises reacting a compound of the formula: wherein R1 is C1-6 straight- or branched-chain alkyl, with a compound of the formula: in an aprotic solvent in the presence of base.
    Type: Grant
    Filed: March 28, 2000
    Date of Patent: November 26, 2002
    Assignee: Rhone-Poulenc Agro
    Inventors: Didier Bernard, Michel Casado, Virginie Pevere, Alain Truchon
  • Patent number: 6486210
    Abstract: Styryl benzylsulfones of formula I are useful as antiproliferative agents, including, for example, anticancer agents: wherein (a) (i) at least three of R1, R2, R3, R4 and R5 are independently selected from the group consisting of halogen, C1-C6 alkyl, C1-C6 alkoxy, nitro, cyano, carboxyl, hydroxyl, phosphonato, amino, sulfamyl, acetoxy, dimethylamino(C2-C6 alkoxy) and trifluoromethyl, and the balance of said R1, R2, R3, R4 and R5 are independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, nitro, cyano, carboxyl, hydroxyl, phosphonato, amino, sulfamyl, acetoxy, dimethylamino(C2-C6 alkoxy) and trifluoromethyl; and (ii) R6, R7, R8, R9 and R10 are independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, nitro, cyano, carboxyl, hydroxyl, phosphonato, amino, sulfamyl, acetoxy, dimethylamino(C2-C6 alkoxy) and trifluoromethyl; or (b) (i) at least three of R6, R7, R8, R9 and R10 are independently selected from the
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: November 26, 2002
    Assignee: Temple University—Of the Commonwealth System of Higher Education
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy
  • Patent number: 6482970
    Abstract: The invention is drawn to compounds of formula (I) which is HOO—C(R1)(R2)—OO—(R1)(R2)—OO—(C═O)—(O)nR3 wherein n is 0 or 1, R1 and R2 are independently selected from the group consisting of H, C1-C20 alkyl, C3-C20 cycloalkyl, C6-C20 aryl, C7-C20 aralkyl, C7-C20 alkaryl which may be optionally substituted or R1 and R2 can form a C3-C12 cycloalkyl group and R3 is selected from C1-C20 alkyl, C3-C20 cycloalkyl, C6-C20 aryl, C7-C20 aralkyl, and C7-C20 alkaryl which can be optionally substituted; a process for the preparation of the peroxy esters or peroxy carbonates of formula (I); and the method of using the compounds as polymer initiators or curing agents.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: November 19, 2002
    Assignee: Akzo Nobel NV
    Inventors: Anna Gerdine Van De Bovenkamp-Bouwman, Joachim Willem J. Van Gendt, John Meijer, Bart Fischer, Andreas Herman Hogt
  • Patent number: 6482982
    Abstract: Halogenated derivatives of two synthetic anti-tuberculosis agents, thioacetazone and p-aminosalicylic acid, have been synthesized. In general, the halogenated compound has the structure of Structure I: wherein X1 is a halogen and X2 is a second halogen or hydrogen, and Y is sulfur or oxygen; or, has the structure of Structure IV: wherein X1 is a halogen and X2 is a second halogen or hydrogen. Alternatively, the halogenated compounds may be pharmaceutically acceptable salts of these compounds. These halogenated derivatives possess anti-mycobacterial activity and are particularly useful for the treatment of Mycobacterium tuberculosis infections. In particular, fluorinated analogs of thioacetazone and p-amino-salicylic acid have been synthesized for use as anti-tuberculosis therapeutic agents either alone or in combination with other conventional anti-tuberculosis therapeutic agents.
    Type: Grant
    Filed: March 8, 2001
    Date of Patent: November 19, 2002
    Assignee: University of Sciences of Philadelphia
    Inventors: Farzad Kobarfard, Joel M. Kauffman
  • Patent number: 6482988
    Abstract: A liquid crystalline sulfur compound exhibiting high anisotropic factor of dipolemoment is provided. A terphenyl skeleton sulfur compound expressed by the general formula (I) is provided. A compound is preferred wherein, in the general formula (I), m is 1, n is 5 to 18, and R3 is an alkyl group wherein the number of carbon atoms is n or fewer than n. A method of synthesisng the terphenyl skeleton sulfur compound wherein, after implementing the synthesizing processes for a methoxy terphenyl derivative, a hydroxy terphenyl derivative, and terphenyl alkyloxy bromide derivative, that bromide derivative and thiourea are caused to react, etc. A self-assembled monolayer made using the terphenyl skeleton sulfur compound noted above is also provided.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: November 19, 2002
    Assignees: Seiko Epson Corporation, National Institute of Advanced Industrial Science and Technology
    Inventors: Hitoshi Fukushima, Takashi Tamaki
  • Patent number: 6476273
    Abstract: A process for preparing phosphonium phenolate is disclosed. The process entails a reaction of phosphonium halide with phenol in an aqueous alkaline solution at a temperature of 0 to 55° C. The molar ratio of phenol to phosphonium halide is between 2:1 to 10:1 and the pH of the solution is 9.5 to 11. An optional embodiment entails carrying out the reaction in the further presence of alcohol.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: November 5, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Annett König, Lothar Bunzel, Uwe Hucks
  • Patent number: 6476246
    Abstract: Chiral, unsymmetrical bidentate organophosphorus ligands of the formula (I) are reacted with transition metal centers to form complexes with catalytic activity. The compounds contain chiral bicycloaliphatic skeletons. Synthesis of the bidentate ligands proceeds from norbornyl derivatives.
    Type: Grant
    Filed: October 24, 2001
    Date of Patent: November 5, 2002
    Assignee: Degussa AG
    Inventors: Axel Monsees, Uwe Dingerdissen, Sabine Laschat, Thorsten Sell
  • Patent number: 6476276
    Abstract: A process for preparing hydroperoxides which comprises oxidizing hydrocarbon by a gas containing oxygen in the presence of a specific compound and converting them selectively to corresponding hydroperoxides. The specific compound is the compound that can capture radicals. The preferable example may be a compound selected from radicals of oxygen, nitrogen, phosphorus, sulfur, carbon or silicon or a compound that forms radicals of these in the reaction system. The present invention can be applied to oxidation of hydrocarbons including arylalkylhydrocarbons such as cumene, m-diisopropylbenzene, p-diisopropylbenzene, 1,3,5-triisopropylbenzene, isopropylnaphthalene, diisopropylnaphthalene, isopropylbiphenyl, diisopropylbiphenyl, etc.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: November 5, 2002
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Shigekazu Matsui, Hiroshi Kuroda, Nobuya Hirokane, Haruyuki Makio, Toshihiro Takai, Koji Kato, Terunori Fujita, Makoto Kamimura
  • Patent number: 6476256
    Abstract: A process for the preparation of an oxyacid of phosphorus comprising contacting elemental phosphorus with water in the presence of a catalyst effective to promote oxidation of phosphorus by reaction with water. The use of a noble metal catalyst such as Pd under moderate agitation and low severity conditions is effective for the preparation of P(III) oxyacid in high selectivity. Other suitable catalysts may comprise, for example, other Group VIII metals (particularly other platinum metals); oxides, salts, phosphides, and/or coordination compounds of Group VIII metals; Group IB metals; and/or oxides, salts, phosphides, and/or coordination is compounds of Group IB metals. Various apparatus and process schemes for the preparation of phosphoric and phosphorous acid are also disclosed.
    Type: Grant
    Filed: May 29, 2001
    Date of Patent: November 5, 2002
    Assignee: Monsanto Company
    Inventors: Jerald D. Heise, Erik D. Sall, Martin P. McGrath
  • Patent number: 6476271
    Abstract: A method is provided for making substantially ether-free alkali metal tetrakis(pentafluorophenyl) borate salts from tetrakis(pentafluorophenyl) borate magnesium bromide and converting the alkali metal tetrakis(pentafluorophenyl) borate salts to essentially ether-free trityl tetrakis(pentafluorophenyl) borate.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: November 5, 2002
    Assignee: Honeywell International, Inc.
    Inventor: Michael Van Der Puy
  • Patent number: 6476272
    Abstract: Organophosphines of the formula (R)aP(H)3−a( where R is C1-C20 alkyl, alkenyl, alkaryl or styryl and a is 1, 2, or 3) are produced by (i) reacting a tris(hydroxyorgano)phosphine (THP) with an organic halogen containing compound; (ii) reacting the product of (i) with a base; (iii) removing aldehydes from the product of (ii) and adding an organic phase, followed by distillation or phase-separation to obtain the desired product.
    Type: Grant
    Filed: June 18, 2001
    Date of Patent: November 5, 2002
    Assignee: Rhodia Consumer Specialties Limited
    Inventors: Gary Woodward, Ranbir Singh Padda, Christian Thomas Regius
  • Patent number: 6472560
    Abstract: The present invention relates to a novel process for preparing hydrazodicarbonamide (HDC) that is, after oxidation to azodicarbonamide (ADC), used industrially as a polymer auxiliary.
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: October 29, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Manfred Jautelat, Walter Leidinger
  • Patent number: 6472386
    Abstract: A compound of formula (1): wherein A is a single bond, C≡C, CONH or NHCO; W is a carbon atom or a nitrogen atom; X is CH, a nitrogen atom, an oxygen atom or a sulfur atom; Y is CH, CHR1, in which R1 is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy-lower-alkyl, aryl, aryl-lower-alkyl or heteroaryl-lower-alkyl group, a nitrogen atom, an oxygen atom, a sulfur atom or NR2, in which R2 is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy-lower-alkyl, aryl, aryl-lower-alkyl or heteroaryl-lower-alkyl group; Z is a nitrogen atom, an oxygen atom, a sulfur atom, CH or NR3, in which R3 is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy-lower-alkyl, aryl, aryl-lower-alkyl or heteroaryl-lower-alkyl group; m is 1 or 2; and n is a number of 1 to 5, with the proviso that one or two of W, X, Y and Z are heteroatoms; an acid-addition salt thereof, or a hydrate thereof.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: October 29, 2002
    Assignee: Kowa Co., Ltd.
    Inventors: Tatsuhiko Kodama, Masahiro Tamura, Toshiaki Oda, Yukiyoshi Yamazaki, Masahiro Nishikawa, Takeshi Doi, Yoshinori Kyotani
  • Patent number: 6465695
    Abstract: A method for manufacturing cumene hydroperoxide comprises reacting cumene and oxygen in the presence of a water phase comprising aqueous ammonia, and in the absence of an additive comprising an alkali or alkaline earth metal, to form cumene hydroperoxide. A system for producing cumene hydroperoxide comprises a cumene feed in fluid communication with a reactor having a cumene hydroperoxide oxidate outlet; an oxygen feed in fluid communication with the reactor; and an ammonia feed in fluid communication with the cumene feed and/or the reactor, wherein the cumene feed, the oxygen feed, the ammonia feed, and the reactor are free of an additive comprising an alkali or alkaline earth metal.
    Type: Grant
    Filed: July 27, 2001
    Date of Patent: October 15, 2002
    Assignee: General Electric Company
    Inventors: John William Fulmer, Eugene Edward Scott, William Dale Kight
  • Patent number: 6465444
    Abstract: The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: October 15, 2002
    Assignees: Merck Frosst Canada & Co., Banyu Pharmaceutical Co., Ltd.
    Inventors: Christopher Bayly, Mitsuru Ohkubo
  • Patent number: 6462215
    Abstract: A process that can be used for sulfonating, sulfating, or sulfamating an organic compound is disclosed. The process can comprise, consist essentially of, or consist of, contacting the organic compound with sulfur trioxide under a condition sufficient to effect the sulfonation, sulfation, or sulfamation of the organic compound. The organic compound can be an aromatic compound, alcohol, carbohydrate, amine, amide, protein, or combinations of two or more thereof. The sulfur trioxide can be present in a complex comprising an inorganic support such as zeolite, silicalite, silica, titanosilicate, borosilicate, clay, aluminophosphate, and combinations of two or more thereof.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: October 8, 2002
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Stephen Ernest Jacobson, David Richard Corbin
  • Patent number: 6462200
    Abstract: The invention relates to the preparation and use as catalysts of diphosphines of the formula (I) in which R is C6-C14-aryl or C4-C13-heteroaryl containing 1 to 3 heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, wherein the aryl and heteroaryl radicals may optionally be substituted by halogen, C1-C6-alkyl, C1-C6-alkoxy, and/or trimethylsilyl, and R1 to R4, independently of one another, are each hydrogen, C1-C10-alkyl, C1-C10-alkoxy, F, Cl, or Br.
    Type: Grant
    Filed: September 7, 2001
    Date of Patent: October 8, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Birgit Driessen-Hölscher, Joachim Kralik, Inga Ritzkopf, Christian Steffens, Guido Giffels, Claus Dreisbach, Thomas Prinz, Walter Lange
  • Patent number: 6462216
    Abstract: The present invention provides a process for producing phosphorohalidate characterized in that a crude reaction product obtained by reacting a phosphorus oxyhalide with an aromatic hydroxy compound in the presence of a Lewis acid catalyst is purified by distillation in the presence of an alkali metal salt. The process of the invention produces a high-purity phosphorohalidate in high yield which contains no impurities such as the phosphorus oxihalidate and aromatic hydroxy compound used as starting materials and the catalyst.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: October 8, 2002
    Assignee: Daihachi Chemical Industry Co., Ltd.
    Inventor: Yasunori Fujita