Patents Examined by John W. Rollins, Jr.
  • Patent number: 4729999
    Abstract: The invention involves a method for treating symptoms secondary to estrogen deficiency without using estrogen. Weakly estrogenic antiestrogens are administered to estrogen deficient women in the absence of estrogen administration. Maximum estrogenic activity is therby obtained and the harmful side effects of estrogen therapy are avoided.
    Type: Grant
    Filed: October 12, 1984
    Date of Patent: March 8, 1988
    Assignee: BCM Technologies
    Inventor: Ronald L. Young
  • Patent number: 4728510
    Abstract: A bath preparations comprise a cyclodextrin clathrate compound of a component of milk. The bath preparations may further comprise egg white and/or at least one vitamin selected from the goup consisting of vitamin A, vitamins B, vitamin C, Vitamin D, vitamin E, vitamin F and vitamin P. The bath preparations may be used together with a saccharifying enzyme, which is mixed with the bath preparations or which is insulated from the bath preparations.A method for producing the bath preparations comprises contacting milk, which is selected from the group consisting of cow's milk, components of cow's milk, powdered milk, evaporated milk, components of evaporated milk, raw cream and components of raw cream, with cyclodextrin to form a cyclodextrin clathrate compound of the component of milk, and mixing the cyclodextrin clathrate compound of the component of milk with other raw materials of baths.
    Type: Grant
    Filed: February 24, 1986
    Date of Patent: March 1, 1988
    Assignee: Japan Liquid Crystal Co., Ltd.
    Inventors: Ichiro Shibanai, Kenji Nakamura
  • Patent number: 4728511
    Abstract: A composition useful for the treatment of cancer comprises a colloidal or semi-colloidal suspension of DNA-repressor proteins derived from a finely divided mammal nerve tissue, particularly brain tissue.A method of treating cancer comprises administering to the patient a suitable daily dosage of the above composition, accompanied by the administration of suitable doses of immuno globulin (gamma-globulin), during a period of from 45 to 60 days.
    Type: Grant
    Filed: May 12, 1986
    Date of Patent: March 1, 1988
    Inventor: Daniel M. de la Torre
  • Patent number: 4726948
    Abstract: An anti-bacterial composition capable of being activated in the gastro-intestinal tract of mammals is provided. Said composition comprises an effective amount of lactoferrin and lactoperoxidase, and an activating system present in sufficient amounts to activate said lactoperoxidase in the gastro-intestinal tract. In accordance with another aspect of the present invention, the anti-bacterial composition is introduced into the gastro-intestinal tract of mammals as a component of foodstuff and/or animal feedstuff. In accordance with yet another aspect of the present invention, a method for treating gastro-intestinal infections is disclosed. This method for treating gastro-intestinal infections in mammals comprises introducing the above anti-bacterial composition into the intestinal tract of mammals.
    Type: Grant
    Filed: July 19, 1985
    Date of Patent: February 23, 1988
    Assignee: Oleofina, S.A.
    Inventors: Jean-Paul H. P. Prieels, Jean-Paul Perraudin
  • Patent number: 4725591
    Abstract: Compounds having one or two substituents at the 3-position, represented by the general formula ##STR1## wherein R.sub.1 is an optionally acylated or protected amino group and X is hydrogen atom or methoxy group, or a pharmaceutically acceptable salt thereof; when used either alone or in combination with a .beta.-lactam antibiotic, show excellent .beta.-lactamase inhibitory activity and can be used as drugs for use in humans and domestic animals.
    Type: Grant
    Filed: February 3, 1984
    Date of Patent: February 16, 1988
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Taisuke Matsuo, Mitsuzo Kuno, Kenji Okonogi
  • Patent number: 4724234
    Abstract: A method of producing oncolysis and regression of malignant tumors and other malignant conditions without adverse effects on normal body cells is described. A calorically and compositionally defined nutritional regimen providing a minimum of amino acids and fatty acids and a maximum of carbohydrates is administered concurrently with a drug regimen of an agent or agents that uncouple oxidative phosphorylation, most preferably 2,4-dinitrophenol.
    Type: Grant
    Filed: October 28, 1985
    Date of Patent: February 9, 1988
    Assignee: Therapeutical Systems Corp.
    Inventor: Clarence D. Cone, Jr.
  • Patent number: 4722843
    Abstract: A skin moisturizing, nutritive, and healing cream is produced by blending a predominant quantity of juices from an avocado, cucumber, lady's mantle or burdock, red clover, and white willow and the remainder being lemon juice and anhydrous lanolin wherein the lanolin being the major portion of the remainder. The ingredients are blended to a creamy texture and the cream is massaged into the skin by hand.
    Type: Grant
    Filed: January 7, 1985
    Date of Patent: February 2, 1988
    Inventor: William L. Vinson
  • Patent number: 4722842
    Abstract: A purified growth inhibitory factor comprising a lipid-like compound derived from or substantially similar to the factor present in lymphocyte or liver cell plasma membranes is capable of inhibiting cytolytic T-lymphocyte killing response and mitogen-induced B cell, T cell, or lymphoid tumor cell proliferation.
    Type: Grant
    Filed: October 11, 1985
    Date of Patent: February 2, 1988
    Assignee: President and Fellows of Harvard College
    Inventors: Kathryn C. Stallcup, Matthew F. Mescher, Steven J. Burakoff
  • Patent number: 4720379
    Abstract: Use of 2,3-dimercaptopropane-1-sulfonic acid and/or 2,3-dimercaptosuccinic acid as well as their salts for combatting radiation injuries and poisonings effected by alkylating agents.
    Type: Grant
    Filed: December 5, 1984
    Date of Patent: January 19, 1988
    Assignee: Hey Chem. Pharm. Fabrik GmbH & Co. KG
    Inventors: Eduard Heyl, Wolfgang Parr
  • Patent number: 4720487
    Abstract: This invention relates to bornane derivatives of the formula: ##STR1## wherein Z stands for: ##STR2## and Y stands for an arabinose, xylose or ribose rest, the acetylated form of the same, with either a pyrane or furane configuration and bound to the R rest to lead either to the .alpha. or to the .beta. anomer, to a process for the preparation of these compounds and to therapeutic compositions comprising one of them as an essential ingredient.
    Type: Grant
    Filed: April 1, 1985
    Date of Patent: January 19, 1988
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventor: Andre Esanu
  • Patent number: 4719235
    Abstract: Methods and compositions are provided for treating selected viral infections wherein the anti-virally active ingredient is a compound of the following formula: ##STR1## wherein R' and R" are each independently a straight chain or branched chain alkyl group having from 5 to 8 carbon atoms, M is NH.sub.4, Na, K or Ca, and x is 1 when M is NH.sub.4, Na or K, and x is 2 when M is Ca.
    Type: Grant
    Filed: May 8, 1985
    Date of Patent: January 12, 1988
    Assignee: Gerald N. Kern
    Inventor: Gerald N. Kern
  • Patent number: 4719239
    Abstract: The invention relates to liquid, transparent, multicomponent systems for use in pharmaceutical products for cutaneous, peroral, vaginal and parenteral administration of pharmaceutical active agents. The multicomponent systems according to the invention contain the active agents in a solution of an oily and optionally an aqueous component in the presence of certain physiologically acceptable surfactants and cosurfactants. Under certain conditions, the cosurfactants can serve as oil components or the latter can optionally take over the cosurfactant function. The biological availability of the active agents applied in the form of the multicomponent systems according to the invention is much better than that of active agents applied in the form of known multicomponent systems.
    Type: Grant
    Filed: February 22, 1985
    Date of Patent: January 12, 1988
    Inventors: Bernd W. W. Muller, Hans-Jurgen Franzky, Claus-Jurgen Kolln
  • Patent number: 4719111
    Abstract: A composition for treatment of decubitus ulcers comprising an admixture of from about 10 to about 50 parts lecithin, from about 10 to about 50 parts goldenseal root or rhizome, and from about 10 to about 50 parts myrrh gum.
    Type: Grant
    Filed: June 14, 1985
    Date of Patent: January 12, 1988
    Inventor: Lynn M. Wilson
  • Patent number: 4717719
    Abstract: Pharmaceutical compositions are described which have antithrombotic activity suitable for the prevention and for the therapy of cardiac infarcts, cerebral infarcts and venous thrombosis. They contain as the active component a fraction of heparin which has been modified by nitrogen desulfatation and succinylation, which fraction contains less than 10% of the N-sulfate groups of the heparin starting material and more than 0.6 succinyl radicals per disaccharide unit. The method of treatment is described.
    Type: Grant
    Filed: January 20, 1984
    Date of Patent: January 5, 1988
    Assignee: Italfarmaco S.p.A.
    Inventors: Giancarlo Sportoletti, Piergiuseppe Pagella, Pietro Cremonesi
  • Patent number: 4717727
    Abstract: Esters of pyridine-2,4- and -2,5-dicarboxylic acid act as inhibitors of proline hydroxylase and lysine hydroxylase and are suitable as fibrosuppressants and immunosuppressants, in particular for the treatment of disturbances of the metabolism of collagen and collagen-like substances and of the biosynthesis of Cl.sub.q.
    Type: Grant
    Filed: August 29, 1985
    Date of Patent: January 5, 1988
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Volkmar Gunzler, Hartmut Hanauske-Abel, Jurgen Mohr, Georg Tschank, Kari Kivirikko, Kari Majamaa, Dietrich Brocks
  • Patent number: 4716173
    Abstract: A composition adapted to prolong the residence time of sulfa and cinchona alkaloid drugs in the circulating plasma of mammals including humans comprising hexanoic acid, potassium hydrogen tartrate, tannic acid, pectin and riboflavin, with the further presence of glutamic acid in the case of sulfa drugs and L-tyrosine in the case of the cinchona alkaloids.
    Type: Grant
    Filed: February 6, 1985
    Date of Patent: December 29, 1987
    Inventor: Aida Salatinjants
  • Patent number: 4711902
    Abstract: A medicament formulation of intravenous injection comprising a medicinally active compound, a lipid phase, an emulsifier and water, the lipid phase being present in up to about 30% by weight, the emulsifier being present in about 0.1 to 10% by weight, and water being present up to 100%, the lipid phase containing up to about 50% by weight of a sparingly soluble medicinally active compound, and consisting essentially of(a) at least one ester principally of at least one medium chain-length fatty acid, or(b) a mixture of at least one ester principally of at least one medium chain-length fatty acid with at least one vegetable or animal oil, the mixture containing at least 10% by weight of the ester principally of the medium chain-length fatty acid, or(c) at least one ester principally of at least one medium chain-length fatty acid, at least one vegetable or animal oil, or a mixture thereof, in combination with 0.3 to 200% by weight of benzyl alcohol based on the content of lipid or oil.
    Type: Grant
    Filed: October 18, 1984
    Date of Patent: December 8, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventor: Peter Serno
  • Patent number: 4710492
    Abstract: This invention relates to 3'-azido-2',3'-dideoxy-5-halouridine, particularly, 3'-azido-2', 3'-dideoxy-5-bromouridine and 3'-azido-2',3'-dideoxy-5-iodouridine, and its use in treating patients infected with a retrovirus.
    Type: Grant
    Filed: June 23, 1986
    Date of Patent: December 1, 1987
    Assignee: Yale University
    Inventors: Tai-Shun Lin, William H. Prusoff
  • Patent number: 4710490
    Abstract: Compositions which contain lipid containing molecules possessing angiogenic activity are disclosed. The lipid containing molecules have been found in mammalian tissue, particularly the omentum, of various animals. Additionally, known lipids, such as gangliosides, are unexpectedly found to possess angiogenic activity. A method for obtaining the omentum-derived lipids, and for use of these and known lipids, are disclosed as well.
    Type: Grant
    Filed: October 1, 1985
    Date of Patent: December 1, 1987
    Assignees: Angio Medical Corporation, Trustees of Boston University
    Inventors: Nicholas Catsimpoolas, Robert McCluer, Robert S. Sinn, James Evans
  • Patent number: 4708949
    Abstract: Therapeutic compositions are composed of four plant extracts: ginsenoside, tetramethyl pyrazine, astragalan and atractylol. Pharmaceutical dosage units are prepared by conventional means with specific weight ranges and proportions of each of the four ingredients. The pharmaceutical dosage units are highly effective in treating cerebral vascular disease and the sequelae thereof. The dosage units are also useful for bolstering immunofunction in healthy and diseased patients.
    Type: Grant
    Filed: September 24, 1985
    Date of Patent: November 24, 1987
    Inventor: Yaguang Liu