Patents Examined by John W. Rollins, Jr.
  • Patent number: 4708873
    Abstract: Debridement of ulcerated necrotic tissue of the skin or mucous membrane is promoted by applying thereto an aqueous solution of biphenamine and aloe vera, the former preferably being dissolved in the latter, thereby promoting healing of the lesion.
    Type: Grant
    Filed: January 29, 1986
    Date of Patent: November 24, 1987
    Inventor: Thomas L. Schulte
  • Patent number: 4707478
    Abstract: This invention relates to methods for the prophylactic and curative treatment of gastrointestinal and cardiovascular disorders and parasitic infections in humans and animals, using a class of hetrocyclic amidino substituted urea and thiourea compounds, a novel class of heterocyclic amidino substituted urea and thiourea compounds and pharmaceutical compositions and animal feed additives including the same.
    Type: Grant
    Filed: September 16, 1982
    Date of Patent: November 17, 1987
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: William L. Studt, Harry K. Zimmerman, Stuart A. Dodson
  • Patent number: 4707360
    Abstract: Pharmaceutical compositions having vasculoprotecting activity, containing an ubiquinone compound together with one or more compounds of flavanoid, heparinoid, terpenic or glycosidic structure, such as escin, troxerutin, asiaticoside, heparin, delphinidin, tribenoside.
    Type: Grant
    Filed: April 29, 1986
    Date of Patent: November 17, 1987
    Assignee: Seuref A.G.
    Inventor: Pierre-Noel Brasey
  • Patent number: 4705687
    Abstract: Method of treating autoimmune diseases such as rheumatoid arthritis by administration of a suppressor factor obtained in the supernatant of a human cell line. A particular human cell line is CEM which has survived treatment with 6-thioguanine.
    Type: Grant
    Filed: June 17, 1985
    Date of Patent: November 10, 1987
    Assignee: Ortho Pharmaceutical (Canada) Ltd.
    Inventor: Catherine Y. Lau
  • Patent number: 4705780
    Abstract: Pichia or extracts of Pichia may be used in the treatment of human beings and animals for the purpose of non-specific immunostimulation, potentiation of the action of antibiotics and increasing vaccine activity.
    Type: Grant
    Filed: July 24, 1986
    Date of Patent: November 10, 1987
    Assignee: Univablot
    Inventors: Jacqueline O. Massot, Jaques N. Astoin
  • Patent number: 4705779
    Abstract: The present invention relates to pharmaceutical compositions comprising 3-dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotria zine and at least one of a factor of Vitamine P and/or (+)-2-(3,4-dihydroxyphenyl)-3,5,7-cromanetriole as active ingredients, a process for preparing the same and a method for treating pancreatic inflammations with the said composition.The pharmaceutical compositions according to the invention are useful for the treatment of pancreatic inflammations.
    Type: Grant
    Filed: November 8, 1984
    Date of Patent: November 10, 1987
    Assignee: Biogal Gyogyszergyar of Debrecen and Alkaloida Vegyeszeti Gyar of Tiszavasvari
    Inventors: Laszlo Madi-Szabo, Margit Morvai, Eva Horvath nee Feher, Sandor Jansco, Piroska Tamasi, Kovacs, Istvan, Kiss nee Loss, Ilona Maria, Gyorgy Bacsa, Maria Kubala nee Papp, Magdolna Bene nee Horvath
  • Patent number: 4704381
    Abstract: The present invention is concerned with the use of adenosine derivatives for the treatment of allergic diseases, as well as for bronchosphatic and broncho-constrictive reactions brought about by inflammation. The above adenosine derivatives can be used alone or together with xanthine derivatives. The invention is further concerned with compositions containing compounds of adenosine derivatives and optionally compounds of xanthine derivatives together with appropriate pharmaceutical carriers.
    Type: Grant
    Filed: February 13, 1985
    Date of Patent: November 3, 1987
    Assignee: Boehringer Mannheim GmbH
    Inventors: Wolfgang Schaumann, Otto-Henning Wilhelms, Androniki Roesch, Wolfgang Kampe
  • Patent number: 4704281
    Abstract: The medicinal vegetable composition for treating some hepatobiliary diseases, according to the invention, contains an association of the plants Epilobium hirsutum L., Chamaenerion palustre Schreb. and Chamaenerion angustifolium (L.)Scop., their ratio being 15 to 40: 20 to 50: 35 to 80, respectively, the ratio being calculated based on 100 g of vegetable material.
    Type: Grant
    Filed: November 18, 1985
    Date of Patent: November 3, 1987
    Assignee: Directia Sanitara a Judetului Neamt Laboratoarele Plantavorel
    Inventors: Ludovic L. Elthes, Aristina Elthes
  • Patent number: 4702914
    Abstract: In a preferred embodiment there is provided for application to ordinary pet food for dogs, cats, puppies and kittens, a dietary ketchup sauce inclusive of garlic as a prophylactic against flea infestation and of diethyl-carbamazine as a prophylactic against mosquito heart-worm, and further inclusive of vitamins and minerals of dietary nature, dietary seed, salt, and honey.
    Type: Grant
    Filed: April 30, 1984
    Date of Patent: October 27, 1987
    Inventor: Hillary A. Ryan
  • Patent number: 4703062
    Abstract: Medium chain triglyceride containing lipid emulsions for the nutrition of liver diseased or septicemic patients are improved by the inclusion in the emulsions of long chain triglycerides. The emulsions may also contain amino acids in proportions desirable for the nutrition of liver diseased patients, as well as carbohydrates, drugs, vitamins and electrolytes.
    Type: Grant
    Filed: September 9, 1985
    Date of Patent: October 27, 1987
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventors: George L. Blackburn, Vigen K. Babayan, Bruce Bistrian, Lyle L. Moldawer, Richard Cotter
  • Patent number: 4702915
    Abstract: The invention is concerned with a skin regenerating cosmetic composition which contains as active ingredient the extract of the pod and/or grain of green peas.
    Type: Grant
    Filed: July 1, 1986
    Date of Patent: October 27, 1987
    Assignee: Innofinance Altalanos Innovacios Penzintezet
    Inventors: Tibor Keri, Janosne Kristof
  • Patent number: 4703060
    Abstract: The oil of pips of fruits of the Ribes genus is an abundant, cheap source of .gamma.-linolenic acid.It is extracted using solvents from dried and ground residues from the production of juices, preserves and jellies or brandies, liqueurs and schnapps of fruits, such as blackcurrant, redcurrant or gooseberry. According to a preferred embodiment, the residues are treated with ethanol before being extracted with hexane in order to free the oil from most of the free fatty acids, waxes, colorings and odorous compounds.The refined oil is a valuable ingredient in cosmetic, dermatological, dietetic and pharmaceutical compositions.
    Type: Grant
    Filed: October 14, 1983
    Date of Patent: October 27, 1987
    Assignee: Nestec S.A.
    Inventors: Helmut Traitler, Heike Winter
  • Patent number: 4702918
    Abstract: A sustained-release composition, which comprises (a) a substance which forms a gel in water, (b) a fat and/or oil which is solid at room temperature and (c) a pharmaceutical, said composition having a specific gravity of not more than about 1.
    Type: Grant
    Filed: August 2, 1985
    Date of Patent: October 27, 1987
    Assignee: Nippon Shinyaku Co. Ltd.
    Inventors: Koichi Ushimaru, Koichi Nakamichi, Hitoshi Saito
  • Patent number: 4703042
    Abstract: The invention provides novel orally active salts of the formula ##STR1## in which .circle. is the skeleton of a polyol, n is the number of OH's in the polyol (3 to 24); p is .gtoreq.3 and .ltoreq.n; r is the available valence of the heparin unit and .gtoreq.3 and .ltoreq.7; sr is equal to pv; and R.sup.+ is ##STR2## in which R.sup.iv is C.sub.1 -C.sub.3 alkyl; R' and R" are C.sub.1 -C.sub.7 alkyl, the same or different, or combined so that --NR'R" represents the residue of a saturated monocyclic secondary amine; R"' is identical to the corresponding portion of a natural amino acid; the alkylene groups contain 1 to 3 carbon atoms; and R.sup.v is H, --CONH.sub.2 or --COO(C.sub.1 -C.sub.7 alkyl). The salts are stable lipoidal "ion pairs" or complexes which can be absorbed through the gastrointestional wall and which slowly release heparinic acid to achieve long-lasting anticoagulant activity. Novel quaternary salts which are intermediates to the heparin salts of the invention are also disclosed.
    Type: Grant
    Filed: December 17, 1985
    Date of Patent: October 27, 1987
    Inventor: Nicholas S. Bodor
  • Patent number: 4701458
    Abstract: Substantially nontoxic materials such as cysteamine constituting a source of sulfhydryl groups are useful in inhibiting diarrhea induced by Escherichia coli heat-stable enterotoxin. Such materials block ST-induced secretion prior to the formation of cyclic GMP without interference with normal basal activity or metabolism and may inactivate ST itself by breaking disulfide bridges. Combinations of a substantially nontoxic material constituting a source of sulfhydryl groups and an alpha-2 adrenergic receptor, such as naphazoline, or berberine are also useful in inhibiting such diarrhea.
    Type: Grant
    Filed: February 7, 1985
    Date of Patent: October 20, 1987
    Assignee: St. Louis University
    Inventor: Richard N. Greenberg
  • Patent number: 4699791
    Abstract: The antiseptic product consists essentially of extracts of wine vinegar and honey. It may in addition advantageously contain extract of propolis. By the addition of specific natural ingredients one obtains antiseptic lotions, antiseptic tinctures, antiseptic handkerchiefs, and antiseptic shampoos or liquid soap and creams.
    Type: Grant
    Filed: September 5, 1985
    Date of Patent: October 13, 1987
    Inventor: Jacques-Ami Tabord
  • Patent number: 4698360
    Abstract: The invention provides a method for preventing and fighting the harmful biological effects of free radicals in the organism of warm blooded animals and more especially human beings, namely cerebral involution, hypoxia following atherosclerosis, cardiac or cerebral infarction, tumour promotion, inflammation, ischaemia, alterations of the synovial liquid, collagen degradation, among others. The method consists in administering to said animals and especially to human beings an amount, efficient against said effects, of a plant extract with a proanthocyanidins content which has a radical scavenger effect, the extract being in the form of a medicament and coming more especially from the bark of conifers.
    Type: Grant
    Filed: April 9, 1985
    Date of Patent: October 6, 1987
    Assignees: Societe Civile d'Investigations Pharmacologiques d'Aquitaine, Horphag Overseas Ltd.
    Inventor: Jack Masquelier
  • Patent number: 4696812
    Abstract: Thrombin solutions can be rendered storage stable using stabilizing quantities of an anti-autolytic buffer in combination with low levels of saline and glycerol to prevent denaturation.
    Type: Grant
    Filed: October 28, 1985
    Date of Patent: September 29, 1987
    Assignee: Warner-Lambert Company
    Inventors: Steven B. Silbering, Russell U. Nesbitt, Mahdi B. Fawzi
  • Patent number: 4696819
    Abstract: A naturally occurring anorexic composition of matter that does not alter locomotor function comprising the water soluble constituents of the coca leaf (Erythroxylon coca). Anorexic compositions consisting of the foregoing described product prepared from coca leaves in admixture with a non-toxic, pharmaceutically acceptable carrier. A method of suppressing appetite levels in animals comprising administering a therapeutically effective concentration of the inventive product in a pharmaceutically suitable carrier intravenously, orally, intraperitioneally and intramuscularly. The method of preparing an anorexically active product from coca leaves.
    Type: Grant
    Filed: April 30, 1982
    Date of Patent: September 29, 1987
    Assignee: University of Mississippi
    Inventors: John A. Bedford, Hala N. Elsohly, Marvin C. Wilson, Carlton E. Turner
  • Patent number: 4695458
    Abstract: Use of a solution of alpha-chymotrypsin in a physiological solution medium, especially of a physiological saline solution or of a solution of glutathion-bicarbonate according to Edelhauser in a dilution of 1:20,000 to 1:30,000, preferably 1:25,000, corresponding to a ratio of amounts of 1 milligram of alpha-chymotrypsin to 20 to 30 milliliters, preferably 25 milliliters of the solution medium, for the treatment and cleaning of the posterior lens capsule left behind in an extracapsular cataract operation.
    Type: Grant
    Filed: February 5, 1986
    Date of Patent: September 22, 1987
    Inventor: Jorg H. Krumeich