Abstract: There is disclosed a process for the isolation of the hypolipaemic active substance lovastatin from a sample, e.g. fermentation broth, mycelium or filtrate of Aspergillus terreus (ATCC 20542) or Aspergillus oryzae (ATCC 74135) by extraction with butyl acetate. Simultaneously with the concentration of the extract, lactonisation takes place. There follows a direct crystallization of lovastatin in the lactone form from butyl acetate.
Type:
Grant
Filed:
December 5, 1995
Date of Patent:
January 27, 1998
Assignee:
KRKA tovarna zdravil, p.o
Inventors:
Pavica Hajko, Tanja Vesel, Ivan Radez, Miroslav Pokorny
Abstract: A biological is used as a therapeutic agent or booster to produce sustained responses in the immune cells against tumors. The biological of the present invention is derived from the pleuroperitoneal organs of a neotenic amphibian, e.g., axolotl, or from the notochord and surrounding tissues of an Agnathan, e.g., Lamprey eel, or from mesenteries and visceral organs from the pleuroperitoneal cavity of older fetuses or baby vertebrates from fish to humans, or from tadpoles of frogs at the stage when both the tail and the four legs are present, i.e., just before completion of the metamorphosis period.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
January 20, 1998
Inventors:
Clifford R. Bryan, deceased, by Marguerite Bryan, administratrix
Abstract: A composition containing an emulsion comprising a mixture of fatty acids or derivatives thereof and a compound of vegetal origin that has an attractive effect on cats. This composition can be utilized in a process for preventing cats from urinating a marked spot or to prevent anxiety in cats or to familiarize cats placed in a new environment.
Abstract: The present invention relates to a cosmetic or a pharmaceutical composition, in particular a dermatological composition. The composition is characterized in that it comprises a cosmetically or pharmaceutically, and in particular dermatologically, effective quantity of an extract of a plant of genus Tephrosia, in particular an extract of the species Tephrosia purpurea. According to the invention, it has been discovered that the extract of the plant of genus Tephrosia is useful in preparing a cosmetic, pharmaceutical, and in particular dermatological composition, presenting body-slimming, pigmenting, anti-aging, or anti-inflammatory activity.
Abstract: A therapeutic herbal composition including Trigonella foenum-graecum seed, Syzygium aromaticum fruit, Allilum sativum bulb, Cinnamonmum zyelanicum bark, Saussurea costus root and Euphorbia lathyris bud which includes an effective amount of sodium chloride to promote the digestibility and storage stability of the compositions, have been shown effective in reducing cholesterol, and triglycerides. This herbal composition has use in lowering cholesterol and treating arthritis, blood pressure and Alzheimer's disease. It is also effective as a bitters tonic.
Abstract: The present invention is directed to an herbal compound which aids in the relief of symptoms caused by female hormonal imbalances. The herbal compound of the present invention preferably comprises red raspberry, bayberry, blue cohosh, capsicum, cascara sagrada, damiana, ginger, valerian and a binding agent. The ratio of red raspberry to the other herbal constituents is preferably two to one. The herbal compound preferably further comprises a binding agent which comprises cellulose, to hold the herbal components together, as well as vegetable powder, used as a food carrier so that the herbal compound can be safely and effectively taken on an empty stomach. The binding agent preferably also comprises ingredients to allow the herbal compound to dissolve in the stomach. In the preferred embodiment, the herbal compound and binding agents are formed as a tablet, with the exterior surface thereof coated with a food glaze.
Abstract: Delivery of fuel and cofactors augments ATP production in cells, and mitigates damages in ischemic or metabolically impaired tissues. The processes may be particularly effective in acute or chronic ischemic conditions, for reversing anesthesia, for treating diabetes, for producing or preventing coma due to lack of fuel or ATP, for reversing processes of aging, as dietary supplements, as performance enhancers, for example, in sports, for tissue transplantation and other surgery, and for cold storage or cryopreservation of tissues such as organs.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
January 13, 1998
Assignees:
Life Resuscitation Technologies, Inc., Organ, Inc.
Abstract: Lactic acid bacteria of the genus Lactobacillus do not exhibit deconjugation of bile acids and inhibition of nutrient absorption, and exhibit lowering of cholesterol in blood and liver. The particular species of the genus Lactobacillus exhibiting these characteristics is Lactobacillus acidophilus. Furthermore, the strain Lactobacillus acidophilus CL-0062 has been internationally deposited under accession number FERM BP-4980.
Abstract: Inha enzyme crystals and methods of growing said crystals are presented. Three crystal forms of the Inha enzyme with discrete unit cell parameters were obtained. The crystals of the Inha enzyme are of sufficient size and quality for x-ray crystallographic determination of the three dimensional structure of the Inha enzyme in concert with heavy atom derivatives of said crystals. With the three dimensional structure of the Inha enzyme, compounds which inhibit the biochemical activity of the Inha enzyme may be developed.
Type:
Grant
Filed:
April 28, 1994
Date of Patent:
December 30, 1997
Assignee:
Albert Einstein College of Medicine of Yeshiva University, a Division of Yeshiva University
Inventors:
James Sacchettini, John Blanchard, William R. Jacobs, Jr.
Abstract: Small particles and fines included along with larger subdivided solids are treated with liquid to extract soluble solids therein in a process using milli-screens with milli-sized openings of less than about 0.095 inches across. The milli-screen openings may be kept open for the passage of liquids with specially-designed wipers and/or back-flushing from a liquid compartment and/or rotation of the milli-screen past the matrix of subdivided solids, the subdivided solids themselves acting as a screen cleaner. The invention is useful in batch or continuous diffusers for extracting soluble solids from subdivided solids containing small particles and fines.
Abstract: The present invention provides a lipolysis acceleration method which comprises orally administering a thistle-series or pepper-family plant, or an extract thereof; or dermatologically applying it by local administration or as a bath medicine composition. According to the method of the present invention, marked lipolysis acceleration effects can be obtained. It exhibits excellent effects for the control, prevention and improvement of obesity.
Abstract: An agent for promoting the proliferation of Bifidobacterium which comprises an indigestible substance which is prepared by heating a starch in the presence of a mineral acid and a small amount of water to prepare a pyrodextrin and hydrolyzing the pyrodextrin in the presence of an acid; and use of the indigestible substance for promoting the proliferation of Bifidobacterium in the intestine. Foods containing the indigestible substance promote the proliferation of Bifidobacterium in the intestine and can be very excellent health foods.
Abstract: The present invention provides an artificial organ system comprising an endothelial cell layer, an epithelial cell layer and an artificial microporous membrane disposed between and indirect contact with the endothelial cell layer and epithelial cell layer such that the membrane has an endothelial side and an epithelial side.
Type:
Grant
Filed:
September 23, 1994
Date of Patent:
December 9, 1997
Assignee:
The United States of America as represented by the Department of Health and Human Services
Inventors:
Frederick D. Quinn, Kristin A. Birkness
Abstract: Cosmetic products available in the form of frozen cakes obtained by rehydration of a lyophilizate with water or physiological serum, characterized in that the lyophilizate contains extracts of plant substances.
Abstract: An enzyme preparation that exhibits cephalosporin chloroperoxidase activity is isolatable from a microorganism species of the Rathayibacter genus. This enzyme preparation can convert cephalexin to cefaclor in a single step. A particular, unique microorganism that can provide the cephalosporin chloroperoxidase enzyme preparation is Rathayibacter biopuresis.
Type:
Grant
Filed:
December 20, 1994
Date of Patent:
December 9, 1997
Assignee:
Biopure Corporation
Inventors:
Bing L. Wong, Yong-Qiang Shen, Yung-Pin Chen
Abstract: Lactic acid bacteria of the genus Lactobacillus having the following specific properties: (1) an increased amount of acidity of lactic acid when storing a product cultured by the bacteria at 10.degree. C. for two weeks being 0.5% or less; (2) an activity of cell membrane bound adenosine triphosphatase-being 5 .mu.mol.Pi/min/mg protein or less; and (3) the bacteria having neomycin resistance. Furthermore, a fermented milk product containing the lactic acid bacteria is disclosed.
Abstract: A method of controlling soil borne pests and pathogens, e.g., nematodes in which a predisposition material is incorporated in the soil which predisposes the pests or pathogens by weakening their resistance to attack by soil microbes. The predisposing material may be a lignosulfonate or other organic material which penetrates the cuticle of the pests or pathogens and renders them more amenable to attack by soil microbes. Preferably the predisposition material is accompanied by nutrient material such as a sugar, which may be a natural accompaniment of the predisposition material as in the case with lignosulfonates and/or which may be added. Preferably also the predisposition material is accompanied by macronutrients such as nitrogen and phosphorus macronutrients, also micronutrients and vitamin/co-factor.
Abstract: The present invention provide a method for the industrial production of L-isoleucine which is useful as pharmaceuticals, foods, feed additives and the like. The method comprises cultivating in a nutrient medium a microorganism belonging to the genus Escherichia which is capable of rapidly growing in a medium containing L-homoserine as the single nitrogen source and has an ability to produce L-isoleucine in the medium, producing and accumulate L-isoleucine in a culture and recovering L-isoleucine therefrom.
Type:
Grant
Filed:
May 24, 1996
Date of Patent:
December 9, 1997
Assignee:
Kyowa Hakko Kogyo Co., Ltd.
Inventors:
Yasuichiro Suga, Masato Ikeda, Kuniki Kino
Abstract: The present invention provides a new ice nucleus-forming bacterium strain, Xanthomonas campestris INXC-1 (FERM BP-4191), a process for the cultivation of the new ice nucleus-forming bacterium, an ice nucleus-forming substance containing the ice nucleus-forming bacterium, and the uses of the ice nucleus-forming substance.
Abstract: The present invention relates to the preparation and use of compositions for the treatment of skin disorders such as psoriasis, eczema and lichen planus, as well as for the promotion of good health and the alleviation of stress. The compositions are based on extracts from the plants Melia azadirachta and/or Centratherum anthelminthicum. A variety of other herbal extracts may be included, and the compositions may take the form of a cream or ointment based on ghee, or they may be in a powdered form of suitable for preparing decoctions in hot water.