Patents Examined by John W. Rollins
  • Method of treating damaged tissue with semi-occlusive salicylic acid ointment
    Patent number: 5645826
    Abstract: A method of treating damaged tissue by applying a composition to the damaged tissue in an amount effective to treat the damaged tissue. The composition includes a semi-occlusive ointment base and salicylic acid in an amount effective to produce keratoplasticity.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: July 8, 1997
    Assignee: Abbe Cosmetic Group International, Inc.
    Inventor: Robert M. Posner
  • Treatment of viral infections
    Patent number: 5643891
    Abstract: Treatment of animals or humans carrying or infected with HTLV-I, HTLV-I (including HTLV-I-associated leukemias or lymphomas), non-A, non-B hepatitis virus, hepatitis B virus, EBV, equine infectious anaemia or other lentiviruses or having antibodies to said viruses is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof. Also disclosed is the use of the 5'-mono-, di- and triphosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof for the same purpose.
    Type: Grant
    Filed: February 26, 1993
    Date of Patent: July 1, 1997
    Assignee: Glaxo Wellcome Inc.
    Inventors: Janet Litster Rideout, David Walter Barry, Sandra Nusinoff Lehrman, Martha Heider St. Clair, Phillip Allen Furman
  • Method for treating patients with precancerous lesions by administering substituted sulfonyl indenyl acetic and propionic acids and esters thereof
    Patent number: 5643959
    Abstract: Substituted indenyl sulfonyl acetic acids are useful to inhibit growth of precancerous lesions.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: July 1, 1997
    Assignees: Cell Pathways, Inc., University of Arizona
    Inventors: Rifat Pamukcu, Klaus Brendel
  • Stable 2-chloro-2'-deoxyadenosine formulations
    Patent number: 5641757
    Abstract: Shelf stable formulations of 2-CdA in water are disclosed which contain benzyl alcohol, m-cresol, a buffer and sodium chloride or a solubilizing agent such as propylene glycol or polyethylene glycol.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: June 24, 1997
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Michael Bornstein, Rosemary Rozman, Kevin Francis Long, Hsiao Yung Guh
  • Plant medium-chain thioesterases
    Patent number: 5639790
    Abstract: By this invention, further properties and uses of plant medium-chain thioesterases are provided. In a first embodiment, this invention relates to plant seed and oil derived from that seed, which normally do not contain laurate, but now are found to contain laurate. In yet a different embodiment, this invention relates to a particular medium-chain thioesterase sequence, the Bay medium-chain thioesterase DNA sequence and to DNA constructs for the expression of this enzyme in a host cell. Other aspects of this invention relate to methods for using a plant medium-chain thioesterase. Expression of a plant medium-chain thioesterase in a bacterial cell to produce medium-chain fatty acids is provided. Methods to produce an unsaturated medium-chain thioesterase by the use of a plant medium-chain thioesterase are also described herein.
    Type: Grant
    Filed: November 18, 1993
    Date of Patent: June 17, 1997
    Assignee: Calgene, Inc.
    Inventors: Toni Alols Voelker, Huw Maelor Davies
  • Aqueous plant extract having antiviral activity
    Patent number: 5639460
    Abstract: An aqueous extract of Oenothera caespitosa having antiviral activity. Compositions containing such an extract are especially effective in topically treating herpes simplex lesions. Methods of making and using the extract are also disclosed. Topically applied compositions relieve pain and promote healing of lesions caused by the herpes simplex virus, varicella virus, and Epstein-Barr virus. The composition may also reduce the recurrence of herpes simplex lesions and act as a prophylactic agent by interrupting the spread of the virus and subsequent vesicle and lesion formation.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 17, 1997
    Inventor: Hal C. Raymond
  • Use of saponin in methods and compositions for pathogen control
    Patent number: 5639794
    Abstract: Methods and compositions employing saponin as synergist in combination with a natural product, such as an aromatic aldehyde, are provided for controlling the colonization and/or growth of plant and animal pathogens, such as fungi, insects, arachnids and non-aquatic mollusks, on materials such as plants, plant parts and agricultural products before, during, after and/or processing. The invention finds use in treating agricultural crops for pathogenic organisms which colonize the surfaces of plant parts and tissues and controlling the level of toxic metabolites present in consumable products derived from plant materials, as well as reducing the health risk associated with their consumption. A method of employing saponin to kill nematodes is also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 17, 1997
    Assignee: Proguard, Inc.
    Inventors: Ralph W. Emerson, Bradford G. Crandall, Jr.
  • Method for the therapeutic treatment of a mammalian eye using an admixed composition containing free molecular iodine
    Patent number: 5639481
    Abstract: The present invention relates generally to an enzymatically generated iodine microbicide and more specifically to the use of such a microbiocide for the inactivation of pathogenic organisms that are contaminants in or on sensitive biological materials such as the human eye or tissue culture cells. The biocidal agent from the enzymatic reaction is free molecular iodine generated so as to establish a minimum level of 5 ppm in a fashion such that free molecular iodine comprises at least 25% of the total iodine species present on a molar basis.
    Type: Grant
    Filed: November 1, 1995
    Date of Patent: June 17, 1997
    Assignee: Symbollon Corporation
    Inventors: Jack H. Kessler, James C. Richards
  • Compositions for treatment of the hair
    Patent number: 5639459
    Abstract: The invention provides a composition for the treatment for the hair, scalp and skin to improve condition and to assist in hair regrowth which comprises a pharmaceutically acceptable oxalate of a group Ia or Ia or ammonium oxalate metal disposed in a pharmaceutically acceptable carrier of diluent therefor. Preferably, the group IIa metal is calcium and the pharmaceutically acceptable carrier or diluent is an ointment.
    Type: Grant
    Filed: July 6, 1995
    Date of Patent: June 17, 1997
    Inventor: Elias Bouras
  • Mistletoe extract and method
    Patent number: 5637563
    Abstract: A method for making and identifying mistletoe extracts as being of a pharmaceutical grade which is useful in treating AIDS, cancers and other diseases where the immune system is suppressed. The method is based on the discovery of five marker proteins which selectively bind with different sugars. Pharmaceutical grade extracts in accordance with the invention require certain concentration levels of each protein. An additional further requirement is that each protein fraction must meet specific bioactivity levels with respect to preventing malignant cell proliferation. Fingerprint markers with respect to viscotoxins and alkaloids present in the extract are also provided. Methods of treatment using the pharmaceutical grade mistletoe are disclosed.
    Type: Grant
    Filed: April 14, 1995
    Date of Patent: June 10, 1997
    Assignee: University of Southern California
    Inventor: Tasneem A. Khwaja
  • Obtention of ice nucleating agent from sea buckthorn
    Patent number: 5637301
    Abstract: Sea buckthorn berry juice and aqueous extracts obtained from sea buckthorn berry and leaf tissue provide an ice nucleating agent and thereby operate, upon addition of the juice and/or extract to a freezeable food product, to increase the freezing temperature of the food product. A protein and a protein-lipid aggregate having the ice-nucleating activity may be isolated from the juice and/or extract. The extracts may be obtained by extracting the tissue with an aqueous solution containing a saccharide, particularly pectin alone or in combination with another saccharide.
    Type: Grant
    Filed: November 23, 1994
    Date of Patent: June 10, 1997
    Inventors: Alfred Jann, Rolv Lundheim, Peter Niederberger, Michel Richard
  • Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
    Patent number: 5635187
    Abstract: The present invention is directed to methods of obtaining plant-derived delipidated extracts that inhibit apoptosis, the extracts obtained, compositions containing said extracts and methods of using said compositions. FIG. 11 is a bar graph which illustrates a lower incidence of diarrhea in rats treated with methotrexate and fed a diet of compositions of the claimed invention as compared to controls.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 3, 1997
    Assignee: LXR Biotechnology Inc.
    Inventors: Ian C. Bathurst, John D. Bradley, L. David Tomei, Philip J. Barr
  • Extracts of Piliostigma thonningii, the use thereof and formulations containing them
    Patent number: 5635185
    Abstract: The present invention relates to novel extracts of Piliostigma thonningii Schum. having antiviral action, the process for the preparation thereof, the therapeutical use thereof and formulations containing said extracts. These novel extracts are used in the treatment of pathologies of viral origin, such as herpetic, influenza and broncho-pulmonary diseases and they also proved to be active on HIV virus.
    Type: Grant
    Filed: July 13, 1994
    Date of Patent: June 3, 1997
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Paolo Morazzoni, Giuseppe Mustich
  • Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
    Patent number: 5635186
    Abstract: The present invention is to methods of obtaining plant-derived compositions that inhibit apoptosis, the compositions obtained thereby, compositions comprising the composition, and methods of use thereof.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: June 3, 1997
    Assignee: LXR Biotechnology Inc.
    Inventors: Ian C. Bathurst, John D. Bradley, L. David Tomei, Philip J. Barr
  • Essential oil composition with bactericide activity
    Patent number: 5635184
    Abstract: The present invention relates with a bacterial composition comprising an effective amount of an essential oil distilled from a resinous tree preferably Schinus Molle L. Pseudomonas aeruginosa and Staphylococcus aureus are killed by the composition.
    Type: Grant
    Filed: June 3, 1994
    Date of Patent: June 3, 1997
    Assignees: Eduardo Haim Pinto, Teodoro Poradosu Haidenvurcel
    Inventor: Ricardo M. Camano
  • Chocolate with improved and enriched aroma, and a process of its production
    Patent number: 5635183
    Abstract: A raw material cacao for chocolate may be improved and enriched in its aroma, thereby providing a chocolate whose consumption results in increased mental concentration, and which has an improved cacao aroma and reduced sweetness. The chocolate of the invention is produced by using the improved and enriched cacao nibs produced by an alkali-treatment of cacao beans. The process for producing the chocolate using cacao nibs of improved and enriched aroma comprises removing shells and germs from raw or semi-roasted cacao beans to prepare cacao nibs, adding an alkali thereto and stirring for reaction thereof with the alkali, subsequently drying and roasting the same and finally grinding and pulverizing the alkali-treated cacao nibs to prepare a cacao mass to be used for producing the chocolate in the conventional way. The alkali is preferably calcium hydroxide.
    Type: Grant
    Filed: March 30, 1994
    Date of Patent: June 3, 1997
    Assignee: Lotte Company Limited
    Inventors: Toshio Takemori, Toshinobu Tsurumi, Masanori Ito, Tatsuya Kamiwaki
  • Stability of azadirachtin-containing solid
    Patent number: 5635193
    Abstract: The stability of an azadirachtin-containing solid preparation is increased if the preparation contains about 5% or less volatile polar solvents and 1% or less water. Reduction of the percentage of volatile polar solvents present in preparations of azadirachtin-containing solids to such levels improves the storage-stability of the solids without significantly degrading the azadirachtin in the solid. Solvents are preferably removed by drying the preparation at a suitable temperature for a time sufficient to reduce the level of water and volatile polar solvents to acceptable levels.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 3, 1997
    Assignee: Thermo Trilogy Corporation
    Inventors: James F. Walter, Michael T. Roland
  • Chemically-defined non-polymeric valency platform molecules and conjugates thereof
    Patent number: 5633395
    Abstract: Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide duplexes of at least 20 base pairs that have significant binding activity for human lupus anti-dsDNA autoantibodies.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: May 27, 1997
    Assignee: La Jolla Pharmaceutical Company
    Inventors: Stephen M. Coutts, David S. Jones, Douglas A. Livingston, Lin Yu
  • Method for culturing Chinese hamster ovary cells
    Patent number: 5633162
    Abstract: A biochemically defined culture medium for culturing engineered Chinese hamster ovary (CHO) cell lines, which is essentially free from protein, lipid and carbohydrate isolated from an animal source, having water, an osmolality regulator, a buffer, an energy source, amino acids including L-glutamine, an inorganic or recombinant iron source, and a synthetic or recombinant growth factor, and optionally non-ferrous metal ions vitamins and cofactors. Also cells adapted to grow in such a culture medium.
    Type: Grant
    Filed: March 4, 1994
    Date of Patent: May 27, 1997
    Assignee: Glaxo Wellcome Inc.
    Inventors: Michael J. Keen, Nicholas T. Rapson
  • Lipid-modified serum free media
    Patent number: 5631159
    Abstract: Methods are provided for producing serum-free, animal cell culture media which have enhanced cell culture properties, such as cell growth, cell viability and protein production properties. The cell culture properties of standard serum-free media formulations, which include compositions such as inorganic salts, glucose, fatty acids, amino acids and vitamins, can be enhanced according to the methods of the invention, by providing the media with an additive. The additive in one embodiment can be produced by the acid or base catalyzed hydrolysis of a phosphoglyceride.
    Type: Grant
    Filed: September 22, 1993
    Date of Patent: May 20, 1997
    Assignee: Creative BioMolecules, Inc.
    Inventors: Paul G. Marshall, Patrick M. Guertin