Patents Examined by John W. Rollins
  • Patent number: 5693676
    Abstract: A pharmaceutical composition contains a nitric oxide donor and advantageously an optional corticosteroid and/or topical anesthetic. The composition is useful in a method for treating anal disorders such as anal fissure, anal ulcer, hemorrhoidal disease, levator spasm, and so forth, by topical application to or proximate the affected area.
    Type: Grant
    Filed: June 20, 1996
    Date of Patent: December 2, 1997
    Assignee: Neptune Pharmaceutical Corporation
    Inventor: Stephen R. Gorfine
  • Patent number: 5693327
    Abstract: The present invention relates to the preparation and use of compositions for the treatment of skin disorders such as psoriasis, eczema and lichen planus, as well as for the promotion of good health and the alleviation of stress. The compositions are based on extracts from the plants Melia azadirachta and/or Centratherum anthelminthicum. A variety of other herbal extracts may be included, and the compositions may take the form of a cream or ointment based on ghee, or they may be in a powdered form of suitable for preparing decoctions in hot water.
    Type: Grant
    Filed: July 12, 1995
    Date of Patent: December 2, 1997
    Inventor: Eladevi Shah
  • Patent number: 5693523
    Abstract: The present invention provides a new ice nucleus-forming bacterium strain, Xanthomonas campestris INXC-1 (FERM BP-4191), a process for the cultivation of the new ice nucleus-forming bacterium, an ice nucleus-forming substance containing the ice nucleus-forming bacterium, and the uses of the ice nucleus-forming substance.
    Type: Grant
    Filed: January 7, 1997
    Date of Patent: December 2, 1997
    Assignee: Q. P. Corporation
    Inventors: Michiko Watanabe, Takahiro Makino, Kazuo Honma
  • Patent number: 5691201
    Abstract: The present invention is concerned with the use of sabeluzole for the manufacture of a medicament for the treatment of patients suffering from chronic neuro-degenerative diseases such as dementia of the Alzheimer type (DAT) or Alzheimer's disease, amyotrophic lateral sclerosis (ALS), dementia associated with Parkinson's disease and related diseases which are characterized by progressive dementia.
    Type: Grant
    Filed: October 11, 1995
    Date of Patent: November 25, 1997
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Gilbert Henri Camiel Clincke, Luc Remi Mathilde Tritsmans, Hugo Alfons Gabriel Geerts
  • Patent number: 5691319
    Abstract: Compounds of formula (I): ##STR1## wherein: R.sup.1, R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen atoms, optionally substituted alkanoyl groups and alkenylcarbonyl groups, PROVIDED THAT at least one of R.sup.1, R.sup.2 and R.sup.3 represents an unsubstituted alkanoyl group having from 5 to 24 carbon atoms, said substituted alkanoyl group or said alkenylcarbonyl group; and one of R.sup.4 and R.sup.5 represents a hydrogen atom and the other represents a cyano group; have valuable anti-tumor activity.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 25, 1997
    Assignee: Sankyo Company, Limited
    Inventors: Masakatsu Kaneko, Hitoshi Hotoda, Tomoyuki Shibata, Tomowo Kobayashi, Yoshihiro Mitsuhashi, Akira Matsuda, Takuma Sasaki
  • Patent number: 5688772
    Abstract: Novel Quinoa saponin pharmaceutical compositions are disclosed. The compositions are useful for enhancing mucosal absorption of a drug administered therewith.
    Type: Grant
    Filed: July 27, 1995
    Date of Patent: November 18, 1997
    Assignee: University of Saskatchewan
    Inventors: Alberto Estrada, Mark J. Redmond, Bernard Laarveld
  • Patent number: 5688508
    Abstract: The present invention is drawn to feed compositions including purslane leaves harvested at bloom. The present invention is further drawn to methods of reducing serum cholesterol and triglycerides with the present feed compositions of purslane leaves, as well as methods of preventing and treating coronary heart disease with the feed compositions.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: November 18, 1997
    Assignee: Virginia State University
    Inventors: Michael O. Ezekwe, Thomas R. Omara-Alwala, Tadesse Mebrahtu
  • Patent number: 5688509
    Abstract: The present invention provides a controlled-release insect repellent device and a method for repelling insects from food, tobacco, or other consumable items. The controlled-release insect repellent device comprises an insect repellent composition contacting a substrate. The controlled-release insect repellent device is prepared by a method comprising applying the insect repellent composition to the substrate wherein the repellent compound used is present in the controlled-release insect repellent device in an amount such that when it is released it is non-toxic to humans and animals. The method for repelling insects comprises placing the controlled-release insect repellent device in an area where insects may be present. The insect repellent composition comprises a repellent compound and a controlled-release agent, the controlled-release agent which comprises a compound which may be synthetic and/or natural, and, optionally, a solvent.
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: November 18, 1997
    Assignee: Tenneco Packaging
    Inventors: M. Nabil Radwan, Gaylord Powers Allin
  • Patent number: 5688510
    Abstract: A process for producing a pharmaceutical composition is disclosed. In the process, 1 part by weight of a physiologically inert powdery additive, 0.001-1 part by weight of a macromolecular additive per part by weight of said insert powdery additive, and at least one drug substance are used as ingredients and processed en bloc by means of a multi-screw extruder. The drug substance used in the process can be selected from the following group: subliminable drug, volatile drug, drug hydrolyzable in the presence of water, drug which develops whiskers, and hygroscopic or deliquescent drug. The process confers increased physicochemical stability to the pharmaceutical composition and the drug substance contained therein.
    Type: Grant
    Filed: May 17, 1996
    Date of Patent: November 18, 1997
    Assignee: Nippon Shinyaku CO. LTD.
    Inventors: Kouichi Nakamichi, Shougo Izumi, Hiroyuki Yasuura
  • Patent number: 5688500
    Abstract: Disclosed is a process for growing the microflora Thraustochytrium, Schizochytrium, and mixtures thereof, which includes the growing of the microflora in fermentation medium containing non-chloride containing sodium salts, in particular sodium sulfate. In a preferred embodiment of the present invention, the process produces microflora having a cell aggregate size useful for the production of food products for use in aquaculture. Further disclosed is a food product which includes Thraustochytrium, Schizochytrium, and mixtures thereof, and a component selected from flaxseed, rapeseed, soybean and avocado meal. Such a food product includes a balance of long chain and short chain omega-3 highly unsaturated fatty acids.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 18, 1997
    Assignee: OmegaTech Inc.
    Inventor: William R. Barclay
  • Patent number: 5688781
    Abstract: A novel method for preventing, stabilizing or causing regression of vascular leak syndrome is disclosed. The method comprises administering to a patient in need thereof a compound selected from the group consisting of a corticosteroid, a non-steroidal anti-inflammatory agent, 15-deoxyspergualin and related compounds, and phospholipase A.sub.2 inhibitors.
    Type: Grant
    Filed: August 19, 1994
    Date of Patent: November 18, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Clay Siegall, Dana Chace
  • Patent number: 5688674
    Abstract: A metabolite, e.g., ethanol, is continuously produced from low cost carbohydrate substrates by a process which comprises pulverizing the carbohydrate substrate; liquefying and saccharifying the pulverized substrate; continuously fermenting the lique-saccharified substrate in a fermentor equipped with a moving filter, in the presence of flocculent biological cells maintained at a concentration ranging from 90 to 160 g/l by using the moving filter and a culture medium to produce a fermentation product mixture; and recovering the desired metabolite from the fermentation product mixture.
    Type: Grant
    Filed: February 27, 1996
    Date of Patent: November 18, 1997
    Assignee: Cha-Yong Choi
    Inventors: Cha-Yong Choi, Young-Lyeol Yang
  • Patent number: 5686296
    Abstract: The present invention provides a coloring agent and process for preparing yeast cell ghosts having a light color and less flavor. The yeast cell ghosts are to be contained as a component of the coloring agent. Further, the yeast cell ghosts contain a proportion of intact yeast cell walls and one color source. The color source is selected based upon the desired color in the coloring agent and in any product in which the coloring agent is used, such as a pigment or dye. Also uses for the coloring agent are disclosed, such as their use in foodstuffs, pharmaceuticals and cosmetics. The coloring agents must be acceptable for food and pharmaceutical use. The steps for making the yeast cell ghosts are sequential and involve extracting yeast debris having a solids content not exceeding 20% by weight. An acid is used to perform the extraction and further treatment of the extracted debris with an alkali to obtain whole cells and cells having disrupted cell walls.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 11, 1997
    Assignee: CPC International Inc.
    Inventors: John Charles Hobson, Roderick Norman Greenshields
  • Patent number: 5679351
    Abstract: A clove oil formulation which inhibits soil-borne fungal diseases is disclosed. The formulation includes about 70-90% by weight rectified clove oil, and about 2-30% by weight surfactant. The surfactant includes about 15-95% by weight nonionic compounds such as ethoxylated monoglycerides, ethoxylated diglycerides, ethoxylated alcohols, silicone glycol copolymers, sorbitan fatty acid esters, ethoxylated alkyl phenols, ethylene oxide block copolymers, and propylene oxide block copolymers. The surfactant further includes about 5-85% by weight anionic compounds such as amine alkylaryl sulfonate, calcium alkylaryl sulfonate and phosphate esters. The formulation may also include up to about 30% by weight of a solvent such as alcohol, esters, glycol ethers, mineral oil, methyl esters and hydrocarbon solvents.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 21, 1997
    Assignee: Thermo Trilogy Corporation
    Inventors: James Frederic Walter, James Charles Locke, Michele Carter Normoyle
  • Patent number: 5679393
    Abstract: A process for preparation of a fat fraction of vegetable origin enriched with unsaponifiable materials. A fat of vegetable origin is treated with a hot polar solvent of the ketone type to obtain a first fraction insoluble in the hot ketone solvent which is rich in unsaponifiable materials, and a second fraction which is a solution of hot soluble materials. The first fraction is then separated from the second fraction, and the second fraction is subjected to a crystallization in a crystallization solvent at a temperature below 0.degree. C., followed by filtering to obtain a filtrate. The crystallization solvent is then evaporated from the filtrate to obtain a further fraction rich and unsaponifiable materials.
    Type: Grant
    Filed: October 25, 1995
    Date of Patent: October 21, 1997
    Assignee: Deslog
    Inventors: Joel Laur, Anne Castera, Fran.cedilla.ois Mordret, Xavier Pages-Xatart-Pares, Jean-Michel Guichard
  • Patent number: 5679567
    Abstract: An isolated pure culture of a strain of Phaffia rhodozyma which produces astaxanthin in an mount of at least 600 .mu.g per g Phaffia rhodozyma dry matter, as determined by HPLC analysis.
    Type: Grant
    Filed: October 13, 1994
    Date of Patent: October 21, 1997
    Assignee: Gist-brocades, B.V.
    Inventors: Bent Flen.o slashed., Ib Christensen, Robert Larsen, Steffen Radich Johansen, Eric A. Johnson
  • Patent number: 5677174
    Abstract: Isolated porcine pancreatic cells, isolated populations of such cells and methods for isolating and using the cells to treat subjects with diseases characterized by insufficient insulin activity are described. The porcine pancreatic cells are preferably non-insulin-secreting porcine pancreatic cell having the ability to differentiate into an insulin-secreting cell upon introduction into a xenogeneic subject, such as a human subject. Such cells include embryonic porcine pancreatic cells obtained from embryonic pigs between about day 31 and day 35 of gestation. The porcine pancreatic cells can be modified to be suitable for transplantation into a xenogeneic subject, for example, by altering an antigen (e.g., an MHC class I antigen) on the cell surface which is capable of stimulating an immune response against the cell in the subject (e.g., by contact with an anti-MHC class I antibody, or a fragment or derivative thereof).
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: October 14, 1997
    Assignee: Diacrin Incorporated
    Inventor: Jonathan Dinsmore
  • Patent number: 5677442
    Abstract: Disclosed are novel non-reducing saccharide-forming enzyme, and its preparation and uses. The enzyme is obtainable from the culture of microorganisms such as Rhizobium sp. M-11 (FERM BP 4130) and Arthrobacter sp. Q36 (FERM BP-4316), and capable of forming non-reducing saccharides having a trehalose structure when allowed to act on reducing partial starch hydrolysates. Glucoamylase and .alpha.-glucosidase readily yield trehalose when allowed to act on the non-reducing saccharides. These non-reducing saccharides and trehalose are extensively useful in food products, cosmetics and pharmaceuticals. Also disclosed is a method of crystallizing trehalose from a 65 to 90% aqueous solution in the absence of organic solvent.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 14, 1997
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Kazuhiko Maruta, Michio Kubota, Toshiyuki Sugimoto, Toshio Miyake
  • Patent number: 5677346
    Abstract: A method for treating urinary incontinence while avoiding concomitant liability of adverse effects associated with racemic oxybutynin is disclosed. The method comprises administering a therapeutically effective amount of (S)-oxybutynin, (S)-desethyloxybutynin or a pharmaceutically acceptable salt thereof, substantially free of the corresponding R enantiomer. Pharmaceutical compositions in the form of tablets and transdermal devices comprising (S)-oxybutynin or (S)-desethyloxybutynin and an acceptable carrier are also disclosed, as is a synthesis of desethyloxybutynin.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 14, 1997
    Assignee: Sepracor, Inc.
    Inventors: Gunnar Aberg, John R. McCullough, Yue Fang
  • Patent number: 5674498
    Abstract: In a blood-lipid depressant for depressing a blood-lipid level, an effective component of the depressant is an extract extracted with an extracting solvent from a senna species (Cassia mimosoides L. var. nomame Makino). An effective component of the depressant is an extract obtained by fractionating via chromatographic methods an extract extracted with an extracting solvent from a senna species (Cassia mimosoides L. var. nomame Makino).
    Type: Grant
    Filed: June 23, 1995
    Date of Patent: October 7, 1997
    Assignee: Lotte Co., Ltd.
    Inventors: Shuji Inoue, Masato Egawa, Susumu Shimura, Yoshio Itoh