Abstract: A physiological signal monitoring device is adapted for monitoring a physiological signal of a biofluid, and includes: a biosensor strip that has at least one signal output end adapted for outputting the physiological signal; a strip reciprocating module that includes a strip seat for receiving the biosensor strip, a guide seat mounted to the strip seat, and a rotating plate mounted rotatably to the strip seat for triggering reciprocating movement of the biosensor strip and the guide seat relative to the strip seat; and a contact module that includes an electronic module, and at least one extending piece connected electrically with the at least one signal output end to transmit the physiological signal to the electronic module.

Abstract: Provided is an ex vivo system allowing for assessment of tumor and other cell responses to pluralities of agents or agent combinations using a microdose delivery microdevice implanted into an ex vivo tissue sample. The microdevice permits localized intra-tissue sample agent delivery and provides the ability to predict the drug efficacy within days after application. Systems for maintaining tissue samples ex vivo over hours to weeks are provided, which can be used to house tissue samples during exposure of the tissue to microdoses of agents applied using the delivery microdevices. Also provided are biomarkers (galectin and/or neuropilin) useful in evaluating the efficacy of agents.

Abstract: A fluidic handling unit includes a baseplate, a fluidic inlet block, a fluidic outlet block, a pump in fluidic communication with the fluidic inlet block and the fluidic outlet block, a carrier control board in electrical communication with the pump, and a flow cell carrier comprising a microfluidic flow cell receiving area, wherein the flow cell carrier is configured to receive and retain the fluidic handling unit. A bottom surface of the fluidic handling unit is configured to complementary mate with a top surface of the flow cell carrier, or wherein a bottom surface of the flow cell carrier is configured to complementarily mate with a top surface of the fluidic handling unit.

Abstract: Exemplary embodiments of the inventive concept are directed to devices for facilitating the creation of pathology cell blocks and to methods for creating such cell blocks using said devices. Various cell block preparation devices are described, which cell blocks may be comprised of various media and may be provided with one or multiple wells for receiving and retaining tissue/cell specimens, such as cytology specimens. The tissue/cell specimen laden cell block preparation devices are treated with fixative to produce cell block specimens that are highly amenable to sectioning and subsequent analysis according to known methods. A marker may be integrated into any of the cell block preparation devices to guide a technologist during sectioning and subsequent application of cell block sections to slides for proper orientation of the cell block sections.

Abstract: A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.

Abstract: The present invention relates to an apparatus (1) and method (2) for automatically preparing liquid-based cytology (LBC) slides (107) by means of filtration comprising of at least one substrate (101) for holding a vial (103) containing specimen, a filter (105) and a slide (107) wherein said substrate (101) is located at a first station (FS); at least one working station (WS) comprises of a working platform (109) connected to said first station (FS) wherein said first station (FS) includes a vertical rotary conveyor system (121) which is flexible, user friendly and capable of providing uniformity of the cell distribution in the homogenous thin-layer LBC slides (107) as well as increase system throughput.

Abstract: A smear staining machine and a smearing control method and device thereof. The viscosity of the test sample is used for guiding the configuration of at least on smearing parameter. Since the viscosity of the test sample presents multiple influences of many effecting parameters, it is more suitable for presenting the characteristics of the test sample. Therefore, better smearing effect could be acquired by referring the viscosity of the test sample to get the smearing parameter.

Abstract: A method includes: obtaining relevant information of the bone marrow smear; generating a global image; generating a to-be-digitized region, an amount of nucleated cells to be collected, and an amount of megakaryocytes to be classified; digitally labeling the bone marrow smear; scanning the to-be-digitized region by low magnification, labeling and identifying a target observation object; generating a switched image of the scanned region; scanning megakaryocytes by low magnification, and labeling and identifying the scanned megakaryocytes, the amount of the scanned megakaryocytes being the same as the amount of megakaryocytes to be classified; generating images of the scanned megakaryocytes; scanning nucleated cells by oil mirror scanning, and labeling and identifying the scanned nucleated cells, the amount of the scanned nucleated cells being the same as the amount of nucleated cells to be collected; generating images of the scanned nucleated cells; and generating a digital smear of the bone marrow smear.

Abstract: An article comprising: a planar base having a first surface and an opposing second surface and an outer peripheral edge, wherein the second surface includes an area comprising a plurality of protuberances and configured to attach and maintain orientation of a frozen tissue specimen block; and a removable lid having a first side and a second side, wherein the first side defines a continuous planar surface and the second side defines a recessed portion configured to cover a frozen tissue specimen block and an outer rim configured to engage with the outer peripheral edge of the base, wherein the outer rim does not form part of the recessed portion, wherein the area of the base and the recessed portion of the lid are aligned.

Abstract: The present invention provides devices, systems, and methods, for performing biological and chemical assays.

Abstract: The present inventive concept provides non-toxic compositions including ethanol, a polymer, and a polar aprotic solvent and methods of using the same in the field of preservation of plant, human and non-human animal tissue and anatomic pathology disciplines (e.g., surgical pathology, histopathology, cytopathology, forensic pathology). In particular, the compositions provide a safer alternative to aldehyde-based compositions.

Abstract: A histologic tissue sample support device includes a tissue cassette a frame, and a lid. The tissue cassette has a recess including a body with at least one side wall and a bottom wall and is formed of material that can be successfully sectioned in a microtome and is resistant to degradation from solvents and chemicals used to fix, process and stain tissue. The tissue cassette is movably coupled to the frame. The lid is separably coupled to a peripheral portion of the frame. When the lid is separated from the peripheral portion, the lid and the tissue cassette are capable of moving from a first position to a second position with respect to the frame, and in the second position the bottom wall and at least a portion of the side wall extend beyond a bottom edge of the frame for sectioning in the microtome.

Abstract: A system having a first automatic machine (1) for processing or investigating biological samples and a second automatic machine (16) for processing or investigating biological samples. The first machine (1) and the second machine (16) are electrically connected to an electrical power grid in order to be supplied with electrical energy as an electrical load. The first machine (1) has a first control apparatus (13) and the second machine (16) has a second control apparatus (19), which detect disruptions in the supply of electrical energy from the power grid and, in the event of a disruption, switch over to a withdrawal of electrical energy from a first energy reservoir (12) or a second energy reservoir (18). The first machine (1) and the second machine (16) are also electrically connected to each other, such that the electrical energy is transferrable from an energy store of one of the automatic machines to the other automatic machine.

Abstract: The subject disclosure provides systems, computer-implemented methods, and clinical workflows for meso-dissection of biological specimens and tissue slides by incorporating annotation and inter-marker registration modules within digital pathology imaging and meso-dissection (or milling) systems. Images of a reference slide a milling slide may be acquired using the same imaging system, with the annotations on the image associated with the milling slide being based on the inter-marker registration. Each image along with its respective annotations and meta-data may be associated with a project or a case, and stored in an image management system. A same-marker registration may be used to map annotations from the annotated image of the milling slide to a live image of the milling slide. The milling slide may be milled based on the annotations, with milled tissue output into a contained that is labeled in association with the labeled input slides.

Abstract: A device used to cut lanes and bands from an agarose gel is provided. The instrument uses cutting edges to separate DNA in lanes as well as in bands to allow for easier processing of separated DNA. This device also allows for standardization of the sizes of cut bands so that less is wasted.

Abstract: In one embodiment, a cartridge includes at least one compartment and a reagent in the at least one compartment. The reagent is a chemical composition for testing at least one of soil and vegetation for a chemical contained in the soil or vegetation. The reagent can be used in a soil and/or vegetation analysis test. The cartridge can contain an authentication chip to ensure that the reagent is the correct reagent for the analysis test.

Abstract: The present invention provides an apparatus for detecting an analyte in a fluid sample, comprising a fluid sample collection element, comprising a fluid sample collection element that comprises an absorbing element; a carrier for accommodating a testing element; and a chamber for accommodating a testing element carrier, wherein the testing element carrier is located in the chamber, and the carrier further comprises an extrusion structure that is in contact with the absorbing element and extrudes the absorbing element.

Abstract: Compositions and methods for the simultaneous capture and release using micropattern surfaces for tissue and cell microdissection. In one example, a patterned thermoplastic film has a first surface and a plurality of projections attached to and extending outwardly from the first surface. The projections form a pattern on the thermoplastic film.

Abstract: Filter (45) for a pathology assembly (10) comprising a first side (41) that is configured to facilitate the outflow of a fixating, conserving and/or nurturing liquid and/or gas, the first side (41) being configured to withhold at least one specimen, the first side (41) being configured to facilitate recognition and analysis of the specimen, a ridge (46) comprising a filter closing element (26) and a second side (39) opposing the first side (41) comprising a supporting structure (44) and a first member for a first seal (48).

Abstract: Handheld forceps comprising: a body comprising trunk and a first arm and a second arm extending from a base of the trunk coupled at one end and separated from one another at a second end; a rod disposed in the body, the rod comprising a first end positioned in the first arm and a second end positioned in the second arm and forming an apex in the trunk; a compression spring disposed around the apex of the rod in the trunk; and a button coupled to the apex of the rod and protruding through an opening in the trunk. Also a method of using the handheld forceps.