Patents Examined by Jyoti Nagpaul
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Patent number: 11493411Abstract: The present invention relates to a fluid transport system for an automated slide treatment apparatus for treating one or more tissue samples disposed on slides, whereby the slide treatment apparatus includes a plurality of slide treatment modules arranged to receive ones of the slides, and the fluid transport system includes a fluid dispensing robot configured by a controller to dispense a plurality of reagents to said ones of the slides received in the slide treatment modules to treat said one or more tissue samples respectively.Type: GrantFiled: December 19, 2018Date of Patent: November 8, 2022Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Zbigniew Mioduszewski, Aaron Ridgway, Matthew King, Blake Hellard
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Patent number: 11480502Abstract: Disclosed are compositions, methods, and kits for clearing tissue that preserve cellular morphology, reporter fluorescence, and epitope labeling which allow for quantitative phenotypic analysis of intact organs. The compositions include, for example, a compound of formula R1—C(X)—NR2R3, wherein R1 is alkyl, haloalkyl, hydroxyalkyl, amino, or alkylamino, X is O or S, and R2 and R3 are independently H, alkyl, or hydroxyalkyl, a salt thereof, or a combination thereof, and at least one non-ionic density gradient medium. Also disclosed are methods for clearing tissue comprising positioning a tissue in a tissue clearing composition and allowing a tissue clearing composition to permeate the tissue. Further disclosed are methods for visualizing tissue characteristics which involve fixing a tissue, staining the tissue, positioning the tissue in the tissue clearing composition and allowing the tissue clearing composition to permeate the tissue, and imaging the tissue utilizing a microscope or tissue scanning device.Type: GrantFiled: August 29, 2017Date of Patent: October 25, 2022Assignee: United States of America, as represented by the Secretary, Department of Heatlth and Human ServiceInventors: Ronald N. Germain, Weizhe Li, Michael Y. Gerner
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Patent number: 11471879Abstract: A system and method for ejecting one or more fluids from a digital dispense device. The method includes a) inputting to a memory a volume per unit area for each of the one or more fluids to be ejected from the digital dispense device; b) matching the volume per unit area to a device resolution for the digital dispense device; c) formatting fluid ejectors for the digital dispense device for the device resolution; and d) ejecting fluid from the digital dispense device to provide the volume per area for each of the one or more fluids.Type: GrantFiled: October 30, 2019Date of Patent: October 18, 2022Inventors: Bruce A Deboard, Brian T. Jones, Michael A. Marra, III
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Patent number: 11474007Abstract: A digital dispense system and methods for preparing samples for analysis. The digital dispense system includes a fluid droplet ejection system housed in a housing unit. The fluid droplet ejection system contains a fluid droplet ejection head and fluid cartridge containing one or more fluids to be dispensed. A cartridge translation mechanism is provided for moving the fluid droplet ejection head and fluid cartridge back and forth over a sample holder in an x direction. A sample tray translation mechanism moves a sample tray back and forth beneath the fluid droplet ejection head and fluid cartridge in a y direction orthogonal to the x direction.Type: GrantFiled: September 1, 2019Date of Patent: October 18, 2022Inventors: James D. Anderson, Jr., John Glenn Edelen, Manish Giri, Michael A. Marra, III, Sam Norasak
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Patent number: 11474121Abstract: The present invention provides a device and a method for automated liquid exchange in a horizontally rotating container that may be applied in automated sample treatment by using chemical solutions, in sequential order. Such applications include biomolecule staining on solid support or fixed samples such as western blot or tissue slice processing. Such sequential chemical reactions are usually performed on flat surfaces. Alternatively, these reactions can be completed with much less volume of reagents in horizontally rotating containers. Yet, it is difficult to automate these processes in rotating containers since the required tubing would twist due to the continuous rotation of the container. The present invention solves the problem of twisting of tubing by leading them through a stationary tubing carrier that passes through the rotating container.Type: GrantFiled: May 20, 2019Date of Patent: October 18, 2022Assignee: SMARTRESEARCH DOO BEOGRAD-ZVEZDARAInventor: Marko Panic
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Patent number: 11465151Abstract: The present disclosure provides apparatus and methods for handling slides. The apparatus includes a carrier comprising a retention hole and a cartridge having a case coupled to one or more separators that together define a plurality of compartments each configured to accept the carrier. At least one of the separators comprises a guide hole, with all guide holes are disposed on a first axis. The retention hole of the carrier is aligned with the first axis when the carrier is disposed in a seated position within one of the compartments. The cartridge also comprises a plurality of spacers each partially disposed within at least one of the guide holes.Type: GrantFiled: February 7, 2020Date of Patent: October 11, 2022Inventors: Jeffrey Ross Gray, James Clail Crowe
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Patent number: 11467070Abstract: The present invention relates to a porous material for inclusion of cytological preparations such as for example the material taken from procedures of fine needle aspiration with high effectiveness level. The effectiveness consists in quantitative and qualitative advantages: the proposed porous material has a high affinity for the cellular material which is captured and kept in the meshes by forming a kind of tissue without losing cellular elements thus with a quantitative advantage with respect to the traditional methods. Moreover, the material proposed in the patent is provided with wide cells delimited by thin meshes, this allows a wide diffusion of the fixative by optimizing the morphology preservation of the cytological sample; such qualitative advantage translates into optimum yield of the ancillary methods for studying the pathology.Type: GrantFiled: November 2, 2017Date of Patent: October 11, 2022Assignees: UCS DIAGNOSTIC S.R.L., UNIVERSITÀ CAMPUS BIO-MEDICO DI ROMAInventors: Marcella Trombetta, Alberto Rainer, Anna Crescenzi, Chiara Taffon, Pamela Mozetic, Marco Costantini, Antonio Santoro
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Patent number: 11458478Abstract: An integrated stage for holding rapid test reagent cards includes two U-shaped sidewalls opposite to each other, a first receiving space, a second receiving space, and an elastic sheet. The U-shaped sidewalls cooperatively define the first receiving space. The second receiving space is formed in the first receiving space and is lower than the first receiving space. The elastic sheet is arranged on a short side of the first receiving space. The first receiving space is used for allowing the integrated stage to hold a first rapid test reagent card. The second receiving space is used for allowing the integrated stage to hold a second rapid test reagent card. The integrated stage utilizes the elastic sheet to hold and fix the first rapid test reagent card or the second rapid test reagent card.Type: GrantFiled: November 18, 2020Date of Patent: October 4, 2022Assignee: NATIONAL CHENG KUNG UNIVERSITYInventors: Yu-Cheng Lin, Wei-Chien Weng, Kai-Wen Lin
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Patent number: 11460381Abstract: A bead beater homogenizer includes a shaft having a main body extending along a main axis and a distal connection body extending along a connection axis that is acutely angled with respect to the main axis, a motor configured to rotate the shaft about the main axis, a head rotatably connected to the distal connection body of the shaft, and a clamp secured to the head and configured to secure a sample vial holder configured to hold one or more sample vials therein, wherein rotational motion of the shaft about the main axis is translated into motion of the head in directions normal to the main axis. A sample vial holder having an internal network of channels defined within the housing through which a coolant can be passed to control a temperature of a vial disposed therein is also provided.Type: GrantFiled: November 13, 2019Date of Patent: October 4, 2022Assignee: SPEX SAMPLEPREP, LLCInventors: Warren Stephen Slutter, Greg King, Eric Smith, Lea Anderson-Smith, Jim Distabile, Geoff Cohen, Andrew Beck
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Patent number: 11454576Abstract: Assay apparatus for use with a handheld specimen collection tool having an elongated specimen collection tip for bearing bodily specimen therealong. The assay apparatus includes a drum having a transparent, generally cylindrical, hollow drum body with a horizontal longitudinal drum body centerline, an internal drum body surface and an external drum body surface and a backlight illuminator for backlighting the drum body. The assay apparatus includes an elongated specimen collection tube for snug sliding insertion of the elongated specimen collection tip thereinto for depositing bodily specimen on the drum body and an elongated scanner for scanning the backlighted drum body for acquiring a bodily specimen scan.Type: GrantFiled: June 11, 2020Date of Patent: September 27, 2022Assignee: GYNTOOLS LTDInventors: Menachem Lev-Sagie, Nimrod Lev
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Patent number: 11446671Abstract: Systems and methods for processing biological specimens are provided. The biological specimen processing system generally includes a flow cell carrier for holding a microfluidic flow cell and a fluidic handling unit attachable to the flow cell carrier. The fluidic handling unit interfaces with the microfluidic flow cell and can include fluidic pumps, fluidic connections, integrated electronics, and processing software to facilitate processing of a biological specimen contained in the microfluidic flow cell.Type: GrantFiled: March 14, 2017Date of Patent: September 20, 2022Assignee: LEICA MICROSYSTEMS CMS GMBHInventors: Meret Vollenweider, Stephen Eric Zingelewicz, Alex David Corwin, Kashan Ali Shaikh, Jessica Godin Karp, Michael Steven Lazare, David Andrew Shoudy, Christine Lynne Surrette
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Patent number: 11439225Abstract: A make-up brush system includes a mandrel having a first end and a second end. The first end includes a gripping surface for engagement with a hand of a make-up artist and the second end being shaped and dimensioned for selective engagement with a plurality of make-up brushes. A plurality of make-up brushes is provided. Each of the plurality of make-up brushes includes a first end and a second end, the first end including a functional component of the make-up brush and the second end including a coupling member shaped and dimensioned for selective engagement with the second end of the mandrel. The system also includes a case both supporting and sanitizing the various components of the present invention. The case includes a tray supporting the plurality of make-up brushes in accessible positions within the case.Type: GrantFiled: September 4, 2020Date of Patent: September 13, 2022Inventors: Darren Levy, Frank Levy
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Patent number: 11441976Abstract: A system, methods, and apparatus are described to collect and prepare single cells, nuclei, subcellular components, and biomolecules from specimens including tissues. The system can perform enzymatic and/or physical disruption of the tissue to dissociate it into single-cells or nuclei in suspension or subcellular components including nucleic acids. In some embodiments, the titer of dissociated cells is monitored at intervals and the viability determined. In some embodiments, the processing is adjusted according to the measurements of the titer and viability. In some embodiments, the single-cells or nuclei in suspension are washed and resuspended in the buffer or media of choice. In some embodiments, the conditions are chosen to produce nuclei. In other embodiments, the single-cells or nuclei are purified by affinity paramagnetic bead processing. In some embodiments, matched bulk nucleic acid to the single-cells is produced.Type: GrantFiled: October 28, 2021Date of Patent: September 13, 2022Assignee: S2 GENOMICS, INC.Inventors: Stevan Bogdan Jovanovich, Frank Zaugg, Kaiwan Chear, Roger McIntosh, Nathan Pereira
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Patent number: 11441112Abstract: An incubation device has multiple rocking platforms with each platform pivotally mounted about a respective axis. Each rocking platform has a respective receiving device for mechanically reversibly receiving a respective incubation channel. The device also has a common drive unit for common respective rocking movements of each platform from a zero position through with a specific angle range as a result of movement of the drive unit. Each rocking platform is coupled to the drive unit via a respective coupling mechanism, and each coupling mechanism elastically and resiliently couples the respective rocking platform to the drive unit, such that when the rocking platform is restrained, despite continuation of the drive movement, the rocking platform remains motionless in a fixed position. After release of the restraint on the rocking platform, the rocking platform resumes the rocking movement with the specific angle range.Type: GrantFiled: June 3, 2019Date of Patent: September 13, 2022Assignee: EUROIMMUN Medizinische Labordiagnostika AGInventors: Christian Kaffka, Martin Rateike, Winfried Stöcker
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Patent number: 11435369Abstract: In one embodiment, a biological sample analyzer has a housing having at least one outer wall that defines a cavity therein. A receptacle, which can support a consumable holder containing a biological sample, is disposed within the internal cavity. At least one heater applies heat to the receptacle when the consumable holder is supported by the receptacle. At least one heater sensor detect temperatures of the receptacle over time. A controller detects whether the consumable holder is below an ambient temperature based on a decrease in temperature of the receptacle when the consumable holder is inserted into the receptacle. The controller also increases an amount of thermal energy transferred from the at least one heater to the consumable holder when the controller detects that the consumable holder is below the ambient temperature so as to heat the consumable holder to a target temperature.Type: GrantFiled: March 16, 2020Date of Patent: September 6, 2022Assignee: Siemens Healthcare Diagnostics Inc.Inventors: George Zantos, George Yeung
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Patent number: 11435268Abstract: The present disclosure relates to systems and methods for tracking and printing within a histology system. In some embodiments, a system is provided that includes an information reader configured to read identifying data associated with a tissue block, a microtome configured to cut one or more tissue sections from the tissue block, one or more slides for receiving the one or more tissue sections, and a printer configured to receive the identifying data and print, after the one or more tissue sections are cut from the tissue block, one or more labels for the one or more slides, the one or more labels comprising information associating the one more tissue sections on the one or more slides with the tissue block.Type: GrantFiled: October 21, 2021Date of Patent: September 6, 2022Assignee: Clarapath, Inc.Inventors: Partha P. Mitra, Janak Sewkarran, Baris Yagci, Jerry R. Pinto
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Patent number: 11422072Abstract: Disclosed is a specimen smearing apparatus including: a slide supplying section configured to supply a glass slide yet to be processed; a first processing section configured to perform a first process on the glass slide, the first processing section being disposed in a first direction with respect to the slide supplying section, the first direction being a far direction of an apparatus body of the specimen smearing apparatus; a second processing section configured to perform on the glass slide a second process which is different from the first process, the second processing section being disposed in a second direction with respect to the first processing section, the second direction being a left-right direction of the apparatus body and orthogonal to the first direction; and a first drying processing section disposed in a third direction with respect to the second processing section, the third direction being a near direction of the apparatus body and opposite to the first direction, the first drying processType: GrantFiled: July 21, 2020Date of Patent: August 23, 2022Assignee: SYSMEX CORPORATIONInventors: Shogo Kubota, Seiya Shinabe, Hiroyuki Koga, Noriyuki Nakanishi, Yuichiro Ohmae, Toshihisa Tanaka, Tetsuya Oda
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Patent number: 11415487Abstract: A collection device for collecting a sample dissected or ablated from an object includes a collection container configured to collect the dissected or ablated sample. An electrode pair is arranged on a side of a base of the collection container facing away from the object or on or in the base itself. The electrodes of the electrode pair are arranged concentrically. A voltage supply is configured to apply a voltage to the electrodes of the electrode pair such that a divergent electric field is generated at least in a region of the collection container.Type: GrantFiled: September 14, 2018Date of Patent: August 16, 2022Assignee: LEICA MICROSYSTEMS CMS GMBHInventor: Christian Siemensen
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Patent number: 11401558Abstract: Provided herein are kits, devices and methods for rapid analysis of biological samples. In particular, kits, devices and methods described herein can be applied to rapid nucleic acid analysis of solid tissue samples.Type: GrantFiled: December 16, 2016Date of Patent: August 2, 2022Assignee: CLEAR GENE, INC.Inventor: Brandon Steelman
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Patent number: 11402305Abstract: A smear staining apparatus may include: a chamber part in which glass slides can be placed and that is configured to contain a staining solution for staining a smear on each of the glass slides; a cover part that covers the chamber part from above and comprises an insertion hole through which the glass slides are transported to the chamber part; and a transport part that transports the glass slides to the chamber part through the insertion hole.Type: GrantFiled: July 27, 2018Date of Patent: August 2, 2022Assignee: SYSMEX CORPORATIONInventors: Takaaki Nagai, Noriyuki Nakanishi, Seiya Shinabe, Tetsuya Oda, Mitsuo Yamasaki, Hiroyuki Koga