Patents Examined by Karl Puttlitz
  • Patent number: 7723382
    Abstract: The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer from 0 to 6, and p is 0 or 1, and X is O, S, SO, SO2, NR13 or PR13 or an aryl, heteroaryl group, said process comprising reacting a compound of formula (B) R—COOZ (B) wherein R is as defined above and Z is hydrogen or a cation selected from: Li+, Na+, K+, Ca++, Mg++, tetralkylammonium, tetralkylphosphonium, with a compound of formula (C), as reported in the description, wherein R1-R12 and m, n, o, p, q, r, s are as defined above and Y is a suitable leaving group.
    Type: Grant
    Filed: August 6, 2003
    Date of Patent: May 25, 2010
    Assignee: Nicox S.A.
    Inventors: Piero del Soldato, Giancarlo Santus, Francesca Benedini
  • Patent number: 7622606
    Abstract: The present invention relates to compositions of peroxycarboxylic acid that have reduced odor compared to conventional peroxycarboxylic acid compositions, methods employing these reduced-odor compositions, and methods of making these compositions. Typically, the reduced-odor compositions include an amine oxide surfactant.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: November 24, 2009
    Assignee: Ecolab Inc.
    Inventors: Kim R. Smith, Robert D. P. Hei
  • Patent number: 7423177
    Abstract: This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, ?-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.
    Type: Grant
    Filed: March 5, 2002
    Date of Patent: September 9, 2008
    Assignee: TransTech Pharma, Inc.
    Inventors: Adnan M. M. Mjalli, Robert C. Andrews, Ramesh Gopalaswamy, Chris Wysong
  • Patent number: 7414150
    Abstract: A method for purifying a crude (meth)acrylic acid obtained by a vapor phase catalytic oxidation method, characterized in that the crude (meth)acrylic acid having most parts of water and acetic acid removed therefrom, is fed to and distilled in a first distillation column of a purification system comprising first to third three distillation columns, the top fraction from the first distillation column is fed to and distilled in the second distillation column, the resulting top fraction is recovered as a high purity (meth)acrylic acid product, the bottoms from the first and second distillation columns are fed to and distilled in the third distillation column, and the resulting top fraction is fed to the first distillation column.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: August 19, 2008
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Shuhei Yada, Yasushi Ogawa, Yoshiro Suzuki, Kenji Takasaki
  • Patent number: 7414128
    Abstract: The present invention relates to crystalline R-guanidines of (2S)-2-Ethoxy-3-{4-[2-(10H-phenoxazin-10-yl)ethoxy]phenyl}propanoate, its preparations and its use as therapeutic agents. More specifically the present invention relates to crystalline Arginine (2S)-2-Ethoxy-3-{4-[2-(10H-phenoxazin-10-yl)ethoxy]phenyl}propanoate, preferably (L)-Arginine (2S)-2-Ethoxy-3-{4-[2-(10H-phenoxazin-10-yl)ethoxy]phenyl}propanoate, its preparation and its use as therapeutic agent.
    Type: Grant
    Filed: March 14, 2005
    Date of Patent: August 19, 2008
    Assignees: Dr. Reddy's Laboratories, Limited, Dr. Reddy's Laboratories, Inc.
    Inventors: Søren Ebdrup, Petra Christine Lugstein
  • Patent number: 7411089
    Abstract: New nateglinide crystals, i.e. nateglinide A-type crystals (main peaks in powder X-ray diffraction: 4.4°, 5.2°, 15.7°, 18.5°(2?)), M-type crystals (main peaks in powder X-ray diffraction: 6.0°, 14.2°, 15.2°, 18.8°(2?)) and P-type crystals (main peaks in powder X-ray diffraction: 4.8°, 5.3°, 14.3°, 15.2°(2?)), can be produced by dissolving nateglinide in a solvent in which nateglinide is highly soluble and then adding a solvent in which nateglinide is difficultly soluble or, alternatively, by dissolving nateglinide in a mixed solvent composed of a solvent in which nateglinide is highly soluble and another solvent in which it is difficultly soluble, cooling the nateglinide solution to form crystals, filtering the mixture and drying the crystals at a specified temperature.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: August 12, 2008
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yoshihito Koguchi, Tomoko Nakao, Michito Sumikawa
  • Patent number: 7399881
    Abstract: A transesterification process of methyl acetate is provided. The process comprises: (a) performing a first reactive distillation of a methyl acetate solution and a first alcohol to generate a first ester and a first mixture; (b) performing a first distillation of a first part of the first mixture to generate a second mixture; and (c) performing a second reactive distillation of a first part of the second mixture and a second alcohol to generate a second ester; wherein the respective one of the first and second alcohols is a limiting reagent. The transesterification process provided in the present invention could highly reduce the investing production cost of the transesterification of the by-product, methyl acetate, in the conventional polyvinyl alcohol plants.
    Type: Grant
    Filed: March 8, 2007
    Date of Patent: July 15, 2008
    Assignee: National Taiwan University
    Inventors: Hsiao-Ping Huang, Cheng-Ching Yu, Ming-Jer Lee, Jyun-Hong Chen, Jian-Kai Cheng
  • Patent number: 7396952
    Abstract: An improved process for preparing carbamic ester derivatives of the general formula (1) by reaction with carbon monoxide and water in the presence of a palladium catalyst is provided.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: July 8, 2008
    Assignee: LANXESS Deutschland GmbH
    Inventors: Bettina Hölzer, Herbert Diehl
  • Patent number: 7396953
    Abstract: Novel derivatives of fumagalone have the general formula (I): and are useful angiogenes is inhibitors; these can be formulated into pharmaceutical compositions suited for human or veterinary medicine, or can be formulated into cosmetic compositions.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: July 8, 2008
    Assignees: Galderma Research & Development, CNRS
    Inventors: Jacques Eustache, Pierre Van De Weghe, Vincent Rodeschini, Celine Tarnus
  • Patent number: 7396898
    Abstract: The present invention relates to a novel diamine, a novel acid dianhydride, and a novel composition containing a polyimide produced from such diamine and acid dianhydride. Specifically, the present invention relates to an acid dianhydride that has a photosensitive group bonded through the mediation of an alkylene group or a fluoroalkylene group, a diamine that has a reactive group bonded through the mediation of an alkylene group or a fluoroalkylene group, and a polyimide composition that contains a novel polyimide having at least one of such acid dianhydride residue and diamine residue in a molecule thereof.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: July 8, 2008
    Assignee: Kaneka Corporation
    Inventor: Koji Okada
  • Patent number: 7393976
    Abstract: A method is provided herein for purifying (meth)acrylic acid to provide a purified (meth)acrylic acid product having a low aldehyde concentration and not more than 0.2 wt % water. One embodiment of the method includes distilling (meth)acrylic acid in the presence of an aldehyde treating compound. Another embodiment of the method includes also distilling crude (meth)acrylic acid in the presence of a reactive drying agent. (Meth)acrylic acid produced in this manner is especially suitable for use in specialty (meth)acrylic acid polymers, such as for example superabsorbent polymers, binders, and ethylene-(M)AA copolymers.
    Type: Grant
    Filed: November 1, 2004
    Date of Patent: July 1, 2008
    Assignee: Rohm and Haas Company
    Inventors: Abraham Benderly, Michael Stanley DeCourcy, Alan Sopchik
  • Patent number: 7393973
    Abstract: Disclosed is an optimized system for more efficiently and economically producing terephthalic acid. The system includes an oxidative digestion reactor/zone configured to provide optimized residence time distribution for the solid and liquid phases of the reaction medium processed therein.
    Type: Grant
    Filed: March 1, 2006
    Date of Patent: July 1, 2008
    Assignee: Eastman Chemical Company
    Inventors: Robert Lin, Ruairi Seosamh O'Meadhra, Alan George Wonders, Thomas Michael Pell, Jr.
  • Patent number: 7390918
    Abstract: An integrated process for the production of an alkenyl carboxylate, such as vinyl acetate which process comprises the steps of (a) contacting in an oxidation reaction zone a C2 to C4 alkane, such as ethane, a molecular oxygen-containing gas, optionally the corresponding alkene and optionally water, in the presence of a catalyst to produce a stream comprising alkene, carboxylic acid and water; (b) separating at least a portion of the stream from step (a) into a fraction comprising the alkene and a fraction comprising the carboxylic acid and water; (c) contacting in a second reaction zone at least a portion of said alkene fraction produced in step (b), a carboxylic acid and a molecular oxygen-containing gas, in the presence of a catalyst to produce a product stream comprising an alkenyl carboxylate, water and carboxylic acid; (d) separating at least a portion of the product stream from step (c) and at least a portion of the carboxylic acid and water fraction produced in step (b) by azeotropic distillation into
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: June 24, 2008
    Assignee: BB Chemicals Limited
    Inventors: Robert William Clarke, Mark Stephen Roberts
  • Patent number: 7385075
    Abstract: A process is described for preparing esters of an acid component selected from among polybasic C4-C10 carboxylic acids and an alcohol component selected from among C3-C12 alkanols or from among C3-C12 alkanediols, the alkyl chain of which may have interruption by from 1 to 3 oxygen atoms, by a) heating at boiling point, in a reaction zone and in the presence of an esterification catalyst, a mixture essentially consisting of the acid component or of an anhydride thereof and of the alcohol component, b) using rectification to separate the vapor comprising alcohol and water into an alcohol-rich fraction and a water-rich fraction, and c) returning the alcohol-rich fraction into the reaction zone and conducting the water-rich fraction out of the process. The process is simple to carry out and permits rapid achievement of essentially quantitative conversion.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: June 10, 2008
    Assignee: BASF Aktiengesellschaft
    Inventors: Walter Disteldorf, Günther Golfier, Bernd Morsbach, Kurt Schwirten
  • Patent number: 7384789
    Abstract: Diamino polyacetate benzene compounds are used as a selective fluorescence probe, sensor, or binders for divalent metal ions. The compounds provide for uses as divalent metal ion sensors in diagnostic applications and binders for environmental and medical treatments.
    Type: Grant
    Filed: January 30, 2007
    Date of Patent: June 10, 2008
    Assignee: The University of North Dakota
    Inventors: Anamitro Banerjee, Julius N. Ngwendson
  • Patent number: 7385078
    Abstract: An energy-curable polymer-forming composition for making a pressure sensitive adhesive includes an unsaturated oligomer resin and an adhesive promoter which increases the peel strength of the adhesive without reducing its tack. The composition also includes a tackifier and various other optional components such as photoinitiator, chain extender, reactive diluent and the like.
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: June 10, 2008
    Assignee: Cognis Corporation
    Inventors: Ulrike Varlemann, Ning Chen, Arifin Marzuki, Ramesh Narayan
  • Patent number: 7381837
    Abstract: A method comprises continuously supplying an alcohol to a pressurized reaction system, pressurizing carbon monoxide with a compressor 8 attached to a first feed line 22, for continuously supplying carbon monoxide to the reaction system via a second feed line 23 with a reference flow rate F, and converging excess carbon monoxide in the reaction system in the first feed line via a branched circulation line 24 for allowing to react alcohol with carbon monoxide. The reference flow rate F in the second feed line 23 is a total rate of a reference consumption flow rate Fcs in the reaction and a flow rate F1 in excess rate over a fluctuation consumption flow rate ?Fcv in the reaction system (F=Fcs+F1, F1>?Fcv).
    Type: Grant
    Filed: February 26, 2003
    Date of Patent: June 3, 2008
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Hidehiko Nakajima, Yoshiyuki Harano, Manabu Yamada
  • Patent number: 7381838
    Abstract: Process for carrying out catalytic multiphase reactions in a tubular reactor, in which at least three reactants are present in three different phases, wherein the process is carried out in at least one tubular reactor, and the catalyst is present in a continuous phase, at least one reactant is present in this continuous phase, and at least two reactants are present dispersed in the continuous phase and the loading factor B of the tubular reactor is equal to or greater than 0.2. In particular, the multiphase reaction is a hydrocarboxylation of at least one olefin to a carboxylic acid.
    Type: Grant
    Filed: March 4, 2005
    Date of Patent: June 3, 2008
    Assignee: OXENO Olefinchemie GmbH
    Inventors: Klaus-Diether Wiese, Wilfried Bueschken
  • Patent number: 7381827
    Abstract: The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: June 3, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Minzhang Chen, Andrew D. Jones, Philip L. Nyce, Martin Trudeau, David J. Guerin, John R. Snoonian
  • Patent number: 7381849
    Abstract: This invention relates to the compositions and processes for preparing 2,3,3?,4?-tetramethylbenzophenone and asymmetrical dianhydrides such as 2,3,3?,4? benzophenone dianhydride (a-BTDA), and 3,4?-(hexafluoroisopropylidene)diphthalic anhydride (a-6FDA). a-BTDA is prepared by Suzuki coupling with catalysts from a mixed anhydride of 3,4-dimethylbenzoic acid and 2,3-dimethylbenzoic acid with a respective 2,3-dimethylphenylboronic acid and 3,4-dimethyl phenylboronic acid to form 2,3,3?,4?-tetramethylbenzophenone which is oxidized to 2,3,3?,4?-benzophenonetetracarboxylic acid followed by cyclodehydration to obtain a-BTDA. The a-6FDA was prepared by nucleophilic trifluoromethylation of 2,3,3?,4?-tetramethylbenzophenone with trifluoromethyltrimethylsilane to form 3,4?-(trifluoromethylmethanol) bis(o-xylene) which is converted to 3,4?-(hexafluoroisopropylidene-bis(o-xylene). The 3,4?-(hexafluoroisopropylidene)-bis(o-xylene) is oxidized to the corresponding tetraacid followed by cyclodehydration to yield a-6FDA.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: June 3, 2008
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: Chun-Hua Chuang