Patents Examined by Karl Puttlitz
  • 5-azido-laevulinic acid, method for the production thereof and its use
    Patent number: 7319164
    Abstract: The present invention relates to 5-azido levulinic acid, a process for its preparation, its use. Using 5-azido levulinic acid as starting material for the synthesis of 5-amino levulinic acid hydrochloride it is possible to obtain the latter in good yield an in pharmaceutical acceptable quality. 5-Azido levuliniv acid is synthesized in that methyl 5-bromo levulinate and/or methyl 5-chloro levulinate is converted with aqueous hydrochloric acid and as a result of an incomplete bromine/chlorine exchange at the C-5-postion a mixture of 5-chloro levulinic acid and 5-bromo levulinic acid is obtained, and the obtained 5-chloro levulinic acid, a mixture of 5-chloro levulinic acid and 5-bromo levulinic acid and the pure 5-bromo levulinic acid is transferred into 5-azido levulinic acid by conversion with a nucleophilic azide.
    Type: Grant
    Filed: January 8, 2002
    Date of Patent: January 15, 2008
    Inventor: Sven Aldenkortt
  • Process for producing aliphatic carboxylic acid
    Patent number: 7319168
    Abstract: It is an object of the present invention to provide a process for producing aliphatic carboxylic acid, which can stabilize operation of a distillation column upon production of aliphatic carboxylic acid by reducing a water content in an aqueous aliphatic carboxylic acid solution by a distillation column, and can shorten a time during the non-steady state such as at starting up of distillation column operation.
    Type: Grant
    Filed: May 13, 2004
    Date of Patent: January 15, 2008
    Assignee: Nippon Shokubai Co., Ltd.
    Inventor: Kenji Sanada
  • Catalyst synthesis of halogenated compounds with catalyst regeneration with elemental halogen
    Patent number: 7319175
    Abstract: Catalysts such as antimony halides, which are useful in fluorination reactions involving hydrogen fluoride, may be reduced during the reaction and require regeneration. Regenerative oxidation is usually carried out by introducing elemental halogen, preferably fluorine or chlorine, into the reaction mixture. In accordance with the invention elemental halogen is prevented from coming into contact with starting materials or intermediate products which are reactive therewith. This is preferably achieved by withdrawing part of the reaction mixture from the reactor, mixing the withdrawn part with chlorine or fluorine in order to regenerate the catalyst, and thereafter returning the withdrawn part to the reactor.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: January 15, 2008
    Assignee: Solvay Fluor und Derivate GmbH
    Inventors: Max Braun, Carsten Brosch
  • Method of decomposing by-product during the production of (meth)acrylic ester
    Patent number: 7319162
    Abstract: A method of decomposing a Michael addition reaction product formed as a by-product in the production step of a(meth)acrylic ester and recovering (meth)acrylic acid, a (meth)acrylic ester and an alcohol, in which the formation of an olefin as a by-product can be suppressed. A method of thermally decomposing a by-product at the time of production of a (meth)acrylic ester using an alcohol bearing a branched chain and having 3 or more carbon atoms, wherein the decomposition reaction is carried out in the absence of a catalyst.
    Type: Grant
    Filed: June 21, 2004
    Date of Patent: January 15, 2008
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Shuhei Yada, Kenji Takasaki, Yasushi Ogawa, Yoshiro Suzuki
  • Method for producing (meth) acrylic acid
    Patent number: 7319169
    Abstract: The present invention relates to a method for producing (meth)acrylic acid comprising a process of recovering (meth)acrylic acid as an aqueous (meth)acrylic acid from a (meth) acrylic acid-containing gas mixture produced by the catalytic gas phase oxidation of at least one reactant selected from the group consisting of propane, propylene, isobutylene and (meth) acrolein, and a system usable for the method.
    Type: Grant
    Filed: February 18, 2005
    Date of Patent: January 15, 2008
    Assignee: LG Chem, Ltd.
    Inventors: Seong Pil Kang, Seok Hwan Choi, Kyoung Su Ha, Geon Yong Kim, Boo Gon Woo, Sang Youn Lee, Young Bae Kim, Koo Hyun Kang
  • Aminopolycarboxylic acid aqueous solution composition and stabilization method of aminopolycarboxlic acid
    Patent number: 7319165
    Abstract: The present invention is to provide a stabilized aqueous aminopolycarboxylate solution composition and a method of stabilizing the aminopolycarboxylate through preventing the same from caking. An aqueous aminopolycarboxylate solution composition containing an aminopolycarboxylate represented by the following general formula (1): in the formula, X may be the same or different and represents a hydrogen atom, an alkali metal atom, or an ammonium group, which has a D-form/L-form molar ratio of an aspartic acid skeleton of the aminopolycarboxylate of 1/0 to 0.7/0.3 or 0.3/0.7 to 0/1, has a solid concentration of 25 to 60 mass %, and has a pH value of not more than 11.
    Type: Grant
    Filed: June 11, 2003
    Date of Patent: January 15, 2008
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Yasutaka Sumida, Mitsuhiro Kitajima
  • Process for preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation
    Patent number: 7317123
    Abstract: The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra? and Rc? are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XVI wherein Ra? and Rc? are each independently of the other hydrogen or a hydroxy-protecting group, R* and R** are each independently of the other hydrogen or an amide-protecting group, and Rb is a carboxy-protecting group; which methods proceed to further new intermediates and methods for their preparation
    Type: Grant
    Filed: July 2, 2002
    Date of Patent: January 8, 2008
    Assignee: Teva Pharmaceutical Industries, Ltd
    Inventors: Reinhold Öhrlein, Gabriele Baisch, Hans Jörg Kirner, Stephan Burkhardt, Martin Studer, Frank Bienewald
  • Method of preparing fatty acid monoesters
    Patent number: 7312355
    Abstract: The invention relates to a method of producing fatty acid monoesters and polyhydroxylic alcohols by means of transesterification between a polyhydroxylic alcohol and a compound that is selected from a fat of animal origin, a fat of vegetable origin, and a fatty acid methyl ester. The invention is characterised in that the transesterification reaction is performed in the presence of basic solid catalysts, said basic solids being oxides that are selected from mixed oxides of one or more monovalent metals and one or more trivalent metals, mixed oxides of one or more divalent metals and one or more trivalent metals, and mixtures of same.
    Type: Grant
    Filed: April 12, 2006
    Date of Patent: December 25, 2007
    Assignees: Consejo Superior de Investigaciones Cientificas, Universidad Politecnica de Valencia, Universiti Malaya
    Inventors: Avelino Corma Canòs, Sara Iborra Chornet, Alexandra Isabelle Velty, Sharifah Bee Abd Hamid
  • Methods for the synthesis of milnacipran and congeners thereof
    Patent number: 7309799
    Abstract: One aspect of the present invention relates to methods for synthesizing milnacipran or congeners thereof. Another aspect of the present invention relates to asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof. The present invention also relates to methods for synthesizing intermediates useful in the non-asymmetric or asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: December 18, 2007
    Assignee: Collegium Pharmaceutical, Inc.
    Inventors: Stephen L. Buchwald, Timothy M. Swager, Roman V. Rariy
  • Method for discontinuous purification of crude acrylic acid by means of crystallization
    Patent number: 7307189
    Abstract: Crude acrylic acid is purified batchwise by crystallization by a process which comprises at least one purification stage and at least one stripping stage and in which at least the first stripping stage is carried out in a different crystallizer from the first purification stage.
    Type: Grant
    Filed: May 16, 2001
    Date of Patent: December 11, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Eck, Dieter Baumann, Joerg Heilek, Klaus Joachim Mueller-Engel
  • Process for producing allyl-containing compounds
    Patent number: 7304184
    Abstract: An allyl-containing compound represented by following Formula (3): wherein R2, R3, R4, R5 and R6 may be the same as or different from one another and each represent hydrogen atom or an organic group; R7 represents an organic group; and Y represents oxygen atom or sulfur atom, is produced by reacting an allyl ester compound represented by following Formula (1): wherein R1 represents hydrogen atom or an organic group; and R2, R3, R4, R5 and R6 are as defined above, with a compound represented by following Formula (2): R7—Y—H??(2) wherein R7 is an organic group; and Y is as defined above, in the presence of at least one transition element compound.
    Type: Grant
    Filed: February 26, 2004
    Date of Patent: December 4, 2007
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Yasutaka Ishii, Takahiro Iwahama, Tatsuya Nakano
  • Process for the synthesis of fluoroorganic compounds
    Patent number: 7304191
    Abstract: The present invention relates to a fluorination method for the synthesis of halofluoroorganic compounds which can be used, inter alia, as precursors in the synthesis of 2,3-unsaturated fluoroorganic carbonyl compounds comprising a fluorine substituent in the 2 position.
    Type: Grant
    Filed: August 6, 2001
    Date of Patent: December 4, 2007
    Assignee: Solvay (Societe Anonyme)
    Inventors: Véronique Mathieu, Francine Janssens, James Franklin
  • CaSR antagonist
    Patent number: 7304174
    Abstract: A compound represented by the following formula (1), a pharmaceutically acceptable salt thereof or an optically active form thereof: wherein each symbol is as defined in the specification. A compound having a calcium-sensing receptor antagonistic action, a pharmaceutical composition comprising the compound, particularly a calcium receptor antagonist and a therapeutic drug for osteoporosis are provided.
    Type: Grant
    Filed: April 23, 2004
    Date of Patent: December 4, 2007
    Assignee: Japan Tobacco Inc.
    Inventors: Yuko Shinagawa, Teruhiko Inoue, Toshihiro Kiguchi, Taku Ikenogami, Naoki Ogawa, Kenji Fukuda, Takashi Nakagawa, Masanori Shindo, Yuki Soejima
  • Copolymerizable photoinitiators for UV-crosslinkable adhesives
    Patent number: 7304119
    Abstract: The invention relates to radically copolymerizable acetophenone or benzophenone derivatives, which may be obtained by reacting a) acrylic or methacrylic compounds, which contain at least one isocyanate-reactive group [compounds a)], with b) compounds, which contain at least two isocyanate groups [compounds b)] and c) acetophenone or benzophenone derivatives, which contain at least one isocyanate-reactive group [compounds c)]. Said invention also relates to copolymers, which contain said copolymerizable photoinitiators, as well as to the use of said copolymers in UV-crosslinkable substances, in particular hot-melt pressure-sensitive adhesives.
    Type: Grant
    Filed: October 4, 2002
    Date of Patent: December 4, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Wolf-Dieter Balzer, Ulrich Erhardt, Volker Ladenberger, Harald Meyer, Bernd Bruchmann, Karl-Heinz Schumacher
  • Method for improving spreading properties of cosmetic ingredients
    Patent number: 7304177
    Abstract: Described is a method for improving the spreading properties of fatty alcohol containing cosmetic ingredients by providing a fatty alcohol containing starting material and adding an effective amount of acylating source [e.g., R1C)?O)OC(?O)R2, where R1 is an alkyl substituent of the acyl group having between 1 and 5 carbons; where R2 is a long chain fatty alkyl subsistent (non-limiting examples are unsaturated substituents such as CH3—(CH2)7—CH?CH—CH2—(CH2)x—, and saturated substituents such as CH3—(CH2)y—, wherein x ranges from 4 to 12, and y ranges from 14 to 22, and the like)], wherein the spreading properties of the starting material are increased over the spreading properties originally exhibited.
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: December 4, 2007
    Assignee: International Flora Technologies, Ltd.
    Inventors: Robert Kleiman, Sambasivarao Koritala, John C. Hill
  • Process for producing perfluorodiacyl fluorinated compounds
    Patent number: 7301052
    Abstract: The present invention provides a process for producing compounds useful as raw materials for various fluororesins in high yields in few steps from inexpensive and readily available starting materials. The following compound (1) and the following compound (2) are reacted to form the following compound (3), then the compound (3) is fluorinated in a liquid phase to form the following compound (4), and the ester bonds in the compound (4) are dissociated to form the compound (5), or the compound (5) and the compound (6). HOCH2-Q-O—(CH2)3—OH,??(1) CRBCOX,??(2) RBCOOCH2-Q-O—(CH2)3—OCORB,??(3) RBFCOOCF2-QF-O—(CF2)3—OCORBF,??(4) FCO-QF-O—(CF2)2—COF,??(5) RBFCOF.
    Type: Grant
    Filed: August 19, 2005
    Date of Patent: November 27, 2007
    Assignee: Asahi Glass Company, Linited
    Inventors: Shu-zhong Wang, Takashi Okazoe, Eisuke Murotani, Kunio Watanabe, Daisuke Shirakawa, Kazuya Oharu
  • Boronate esters
    Patent number: 7301046
    Abstract: The present invention relates to optically active boronate derivatives which are useful as intermediates for the synthesis of HMG-CoA enzyme inhibitors such as atorvastatin, cerivastatin rosuvastatin, pitavastatin, and fluvastatin.
    Type: Grant
    Filed: February 25, 2002
    Date of Patent: November 27, 2007
    Assignee: Biocon Limited
    Inventors: Tom Thomas Puthiaparampil, Sumithra Srinath, Madhavan Sridharan, Sambasivam Ganesh
  • Process for preparing unsaturated, cyclic orthoesters
    Patent number: 7297812
    Abstract: An unsaturated, cyclic orthoester is prepared by reacting an unsaturated carboxylic acid with glycidol, thereby obtaining a reaction mixture; and adding an orthoester to the reaction mixture, thereby obtaining said unsaturated, cyclic orthoester.
    Type: Grant
    Filed: April 21, 2006
    Date of Patent: November 20, 2007
    Assignee: Degussa AG
    Inventors: Johannes Ruwwe, Jutta Hessing, Kerstin Bodmann
  • Method for catalytic dimerization of isocyanates
    Patent number: 7297752
    Abstract: The invention concerns a method for preparing polyisocyanates by cyclodimerization of isocyanate functions borne by initial monomer isocyanates. The invention is characterised in that it comprises steps which consist in: a) providing a reaction medium comprising initial monomer isocyanates, optionally in the presence of a solvent; b) adding to said reaction mixture a (cyclo)dimerization catalyst comprising a compound of the family of super acids; c) heating the reaction medium to a temperature ranging between 0° C. and 300° C., advantageously between 20° C. and 200° C. until the desired rate of transformation is obtained; d) optionally inactivating or eliminating the reaction catalyst; and e) optionally eliminating the unreacted monomer.
    Type: Grant
    Filed: November 20, 2001
    Date of Patent: November 20, 2007
    Assignee: Rhodia Chimie
    Inventor: Jean-Marie Bernard
  • Method for dehydrogenofluorination of an aromatic carbamoyl fluoride
    Patent number: 7291750
    Abstract: A method for dehydrogenofluorination for transforming an aromatic carbamoyl fluoride into a corresponding isocyanate, is provided. The method includes subjecting a carbamoyl fluoride to a temperature not less than 80° C. in a solvent wherein the carbamoyl fluoride is in a dissolved or finely dispersed state in the solvent. The method is applicable to organic synthesis.
    Type: Grant
    Filed: July 4, 2000
    Date of Patent: November 6, 2007
    Assignee: Rhodia Chimie
    Inventors: Gilbert Guidot, Christophe Rochin, Laurent Saint-Jalmes