Patents Examined by Kathleen K. Fonda
  • Cationic biopolymers
    Patent number: 5962663
    Abstract: The invention relates to new cationic biopolymers with an average molecular weight of 800,000 to 1,200,000 Dalton, a Brookfield viscosity (1% by weight in glycolic acid) below 5,000 mPas, a degree of deacetylation of 80 to 88% and an ash content of less than 0.3% by weight which are obtained by repeatedly subjecting crustacean shells to alternate acidic and alkaline degradation under defined conditions. Compared with known cationic biopolymers of the chitosan type, the new biopolymers form clear solutions and, at the same time, show excellent film-forming properties, despite their high molecular weight.
    Type: Grant
    Filed: March 10, 1997
    Date of Patent: October 5, 1999
    Assignees: Henkel Kommanditgesellschaft auf Aktien, Norwegian Institute of Fisheries and Aquaculture Ltd.
    Inventors: Rolf Wachter, Holger Tesmann, Ronald Svenning, Ragnar Olsen, Even Stenberg
  • Seco compounds from the class of tylosins
    Patent number: 5962661
    Abstract: Seco compounds from a class of tylosins represented by the formula I whereinR stands for H or CH.sub.3,R.sup.1 stands for H, CH.sub.3, C.sub.1 -C.sub.3 acyl or aryl sulfonyl,R.sup.2 stands for H and R.sup.3 stands for NH.sub.2 or OH, or R.sup.2 and R.sup.3 together stand for .dbd.O or .dbd.NOH,R.sup.4 stands for H or C.sub.1 -C.sub.3 acyl,and the line - - - stands for a double or a single bond,and to a process for their preparation are provided.Oximation of 4'-demicarosyl-8a-aza-8a-homorelymycin causes breaking of the lactam to obtain a seco compound. The seco compound can be subjected to reductive N-alkylation or to conversion of the hydroxyimino group into a keto group and then optionally to N- or N,O-acylation, a catalytical hydrogenation of the double bond or a reduction of the ketone or a reduction of the hydroxyimino group into an amino group.
    Type: Grant
    Filed: July 14, 1998
    Date of Patent: October 5, 1999
    Assignee: Pliva, Farmaceutska, Kemijska, Prehrambena i Kozmeticka Industrija, Dionicko Drustvo
    Inventors: Nevenka Lopotar, Amalija Narandja, Zoran Mandic
  • Inhibition of selectin binding
    Patent number: 5962422
    Abstract: This invention provides a system for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently crosslinked lipid composition is prepared having saccharides and acidic group on separate lipids. The composition is then interposed between the cells so as to inhibit binding. Inhibition can be achieved at an effective oligosaccharide concentration as low as 10.sup.6 fold below that of the free saccharide. Since selectins are involved in recruiting cells to sites of injury, this system can be used to palliate certain inflammatory and immunological conditions.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: October 5, 1999
    Assignee: The Regents of the University of California
    Inventors: Jon O. Nagy, Wayne R. Spevak, Falguni Dasgupta, Carolyn Bertozzi
  • Compounds for stimulating nerve growth
    Patent number: 5962434
    Abstract: Compounds which can stimulate neuronal growth by inhibiting the neuronal inhibitory activity of myelin-associated glycoprotein (MAG), and a method of using the compounds for stimulating neuronal growth are provided. The invention further provides a method of identifying compounds which inhibit myelin-associated glycoprotein inhibition of axonal outgrowth of injured nerve cells. The method involves contacting the compound with myelin-associated glycoprotein under conditions which allow myelin-associated glycoprotein and the compound to bind and detecting the binding.
    Type: Grant
    Filed: August 23, 1996
    Date of Patent: October 5, 1999
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Ronald L. Schnaar, Lynda J. S. Yang, Akira Hasegawa
  • Cosmetic or pharmaceutical composition containing an andiroba extract
    Patent number: 5958421
    Abstract: The subject of the invention is the use of a lipid extract of Andiroba for the inhibition of glucose-6-phosphate dehydrogenase and its application to the inhibition of adipocyte differentiation.
    Type: Grant
    Filed: April 14, 1998
    Date of Patent: September 28, 1999
    Assignee: Laboratoires de Biologie Vegetale Yves Rocher
    Inventors: Fran.cedilla.oise Rouillard, Juliette Crepin, Gaelle Saintigny
  • Polysaccharides having a high iduronic acid content
    Patent number: 5958899
    Abstract: Process for the preparation of polysaccharides having a high iduronic acid content comprising:a) N-deacetylation of the polysaccharide K5 from E. coli or of the heparan sulfate or O-desulfation of heparin or heparan sulfate;b) N-sulfation of the product obtained from the stage a);c) epimerization in presence of the C5 epimerase enzyme;d) sulfation of at least some free hydroxy groups, wherein the stage c) is carried out in a reaction medium constituted by a classical buffer solution formed by HEPES, potassium chloride, EDTA and TRITON X-100 to which a suitable additive is added.
    Type: Grant
    Filed: April 12, 1996
    Date of Patent: September 28, 1999
    Assignee: Inalco S.p.A.
    Inventors: Giorgio Zoppetti, Pasqua Oreste, Giovanni Cipolletti
  • Non-thrombogenic coating composition and methods for using same
    Patent number: 5955588
    Abstract: The present invention provides an anti-thrombogenic coating composition for blood-contacting surfaces. The coating comprises a covalent complex of from 1 to 30 hydrophobic silyl moieties of Formula I: ##STR1## wherein R.sub.1 is a C.sub.1-8 alkyl or C.sub.6-32 aryl group, each R.sub.2 is independently selected from the group consisting of C.sub.1-8 alkyl and C.sub.6-32 aryl, R.sub.3 is N or O, and n is a number from 1 to 10, directly bound to a heparin molecule via covalent bonding.
    Type: Grant
    Filed: September 22, 1998
    Date of Patent: September 21, 1999
    Assignee: Innerdyne, Inc.
    Inventors: Ray Tsang, Shigemasa Osaki
  • Oregano for the treatment of internal parasites and protozoa
    Patent number: 5955086
    Abstract: The use of oregano and its essential oil in the treatment of, and prophylactic use for, parasitic infections is described.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: September 21, 1999
    Assignee: Biotics Research Corporation
    Inventors: Daryl L. DeLuca, William S. Sparks, Robert A. Ronzio, Denis R. DeLuca
  • Method for treating alcoholic liver disease
    Patent number: 5952309
    Abstract: A method for the inhibition and amelioration of alcholic liver disease in a mammal in need of such treatment by administering novel analogs of Lipid A which act as endotoxin antagonists. These antagonists compounds are found to inhibit the swift increase in alcohol metabolism which typically accompanies ingestion of alcohol and which may lead to the pathophysiological abnormalities associated with alcoholic liver disease.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: September 14, 1999
    Assignee: Eisai Company, Ltd.
    Inventors: Daniel P. Rossignol, Ronald G. Thurman, William J. Christ, Michael D. Lewis
  • Stable mixture for the detection of alkaline phosphatase containing a salt of o-cresolphthalein monophosphoric acid
    Patent number: 5948631
    Abstract: The subject matter of the invention is a stable mixture for the detection of alkaline phosphatase, wherein it contains the N-methylglucamine salt of o-cresolphthalein monophosphoric acid and N-methylglucamine as well as an analytical element for the detection of alkaline phosphatase with a matrix that carries this mixture. In addition the invention concerns a method for the determination of alkaline phosphatase using a salt of o-cresolphthalein monophosphoric acid, wherein the sample is brought into contact with a mixture according to the invention or an analytical element according to the invention and a change in color is observed in the presence of alkaline phosphatase.A subject matter of the invention is also a salt of o-cresolphthalein monophosphoric acid with N-methylglucamine as well as a process for producing such a salt.
    Type: Grant
    Filed: August 7, 1997
    Date of Patent: September 7, 1999
    Assignee: Roche Diagnostics GmbH
    Inventors: Rolf Nagel, Steffen Bossert-Reuther, Thomas Zeibig
  • Method of producing in water-containing celluose solutions in water-containing tertiary amine N-oxides
    Patent number: 5948905
    Abstract: Process for preparing a solution of cellulose in water-containing tertiary amine N-oxides via preparation of a mixture containing cellulose, tertiary amine N-oxides and water and subsequent reduction of the water content of this mixture, whereby in a first step heat is supplied to the mixture which is subjected to a pressure higher than the partial pressure of the water contained in the mixture, and in a second step the mixture is subjected to flash evaporation, whereby water is evaporated under reduced pressure.
    Type: Grant
    Filed: October 29, 1997
    Date of Patent: September 7, 1999
    Assignee: Akzo Nobel NV
    Inventors: Hans-Georg Connor, Ulrich W. Wachsmann, Richard A. G. Kruger
  • Process for screening candidate agents that modulate the hemostatic system
    Patent number: 5945297
    Abstract: The present invention provides a method for screening candidate agents to identify compounds that modulate the hemostatic system. The method of the invention involves a screening medium comprised of stored whole blood, preferably diluted with buffer, to which unrefrigerated platelets have been added. Candidate agents that may inhibit or activate clot formation or clot lysis are added to the screening medium and suitable compounds are identified. The assay provided is physiologically relevant, rapid, inexpensive and allows for large scale screening of candidate agents.
    Type: Grant
    Filed: April 29, 1998
    Date of Patent: August 31, 1999
    Assignee: MetaXen LLC
    Inventor: Albert P. Gadbut
  • Method of promoting bone growth with hyaluronic acid and growth factors
    Patent number: 5942499
    Abstract: A bone growth-promoting composition is provided comprising hyaluronic acid and a growth factor. The composition has a viscosity and biodegradability sufficient to persist at the site of desired bone growth for a period of time sufficient to promote the bone growth. Preferably hyaluronic acid is used in a composition range of 0.1-4% by weight and preferred growth factor is bFGF, present in a concentration range of about 10.sup.-6 to 100 mg/ml.
    Type: Grant
    Filed: March 5, 1997
    Date of Patent: August 24, 1999
    Assignee: Orquest, Inc.
    Inventor: Michael Radomsky
  • Process for producing pharmaceutical preparations having a higher content of active plant ingredients
    Patent number: 5939071
    Abstract: The present invention relates to a process for preparing dry plant extracts and pharmaceutical preparations containing such extracts having a high content of active plant ingredients such as essential oils and phenols wherein a fluid extract or a tincture of drugs is typically fed into the drying system Inox Maurer or Inox Glatt.RTM., e.g. IUT 20, IUT 50, IUT 100 or IUT 2000, and dried at a starting and return temperature between 120 and 5.degree. C., a preferred interior temperature between 10 and 80.degree. C., especially preferably between 25 and 70.degree. C., and a pressure between 0.5 and 1000 mbar, preferably between 5 and 100 mbar and especially preferably between 30 and 70 mbar, said drying being effected while the stirrer runs between 0 and 10 rpm, preferably between 2 and 5 rpm, and at a rotational speed of the chopper between 200 and 800 rpm.
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: August 17, 1999
    Inventor: Heinz Walter Joseph
  • .alpha.galactosylceramide derivatives
    Patent number: 5936076
    Abstract: The present invention relates to the novel .alpha.-galactosylceramide represented by the formula (A): ##STR1## wherein R represents ##STR2## where R.sub.2 represents H or OH and X denotes an integer of 0-26, or R represents --(CH.sub.2).sub.7 CH.dbd.CH(CH.sub.2).sub.7 CH.sub.3 and R.sub.1 represents any one of the substituents defined by the following (a)-(e):(a) --CH.sub.2 (CH.sub.2).sub.Y CH.sub.3,(b) --CH(OH)(CH.sub.2).sub.Y CH.sub.3,(c) --CH(OH)(CH.sub.2).sub.Y CH(CH.sub.3).sub.2,(d) --CH.dbd.CH(CH.sub.2).sub.Y CH.sub.3, and(e) --CH(OH)(CH.sub.2).sub.Y CH(CH.sub.3)CH.sub.2 CH.sub.3,wherein Y denotes an integer of 5-17.The present invention also relates to an anti-tumor agent and an immunostimulator comprising one or more of the aforementioned compounds as effective ingredients.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: August 10, 1999
    Assignee: Kirin Beer Kabushiki Kaisha
    Inventors: Tatsuo Higa, Koji Akimoto, Yasuhiko Koezuka, Teruyuki Sakai, Masahiro Morita, Takenori Natori
  • Amino-deoxy-disaccharides and amino-deoxy-oligosaccharides
    Patent number: 5936075
    Abstract: Synthesis of an amino-disaccharide, amino-oligosaccharide or a derivative thereof, characterized in that a monosaccharide, a disaccharide, an oligosaccharide, a glycoside or a derivative thereof, in the presence of a glycosidase as catalyst, is reacted with an amino-deoxy-saccharide or a derivative thereof, and that the amino-saccharide is isolated from the product mixture directly or after chemical/enzymatic modification.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 10, 1999
    Assignee: Bioflexin AB
    Inventor: Kurt G. I. Nilsson
  • Formulation for I.V. administration of the boron delivery drug, boronophenylalanine (BPA)
    Patent number: 5935944
    Abstract: A process and product formulated by complexing boronophenylalanine (BPA) and related compounds with a saccharide in an aqueous solution are disclosed. Formation of the complex is facilitated by raising the pH of the solution to a higher pH of about 10 or by lowering the pH of the solution to a lower pH of about 2 and then readjusting the pH to a body physiological pH of about 7.4. This BPA saccharide complex can then be delivered by i.v. or other injection or administered orally as a key component of the BNCT cancer treatment process The pH manipulation causes a much higher solubility of BPA or related compounds and thus a higher boron concentration in the tumor, thereby improving the therapy.
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: August 10, 1999
    Assignee: Neutron Technology Corporation
    Inventor: Thomas R. LaHann
  • Dietary composition with lipid binding properties for weight management and serum lipid reduction
    Patent number: 5932561
    Abstract: A dietary supplement is provided that binds lipid to aid in weight loss and reduce cholesterol. The supplement includes chitosan, or a nutritionally acceptable derivative thereof, and aloin (especially aloe saponins); it can include at least one additional ingredient including any of betaine hydrochloride (betaine HCI), oat fiber or beta-glucan.
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: August 3, 1999
    Assignee: Rexall Sundown, Inc.
    Inventors: Andrew E. Meyers, Mark R. Priddy
  • Chondroitin sulfate composition and method for wound treatment
    Patent number: 5929050
    Abstract: A method and composition for treating open wounds. The method includes thorough cleaning of the wound, and application of the composition and a sterile dressing. The composition and dressing may be changed as needed. The composition is an aqueous solution of 90-110 mg/mL glycosaminoglycan. Preferably, chondroitin sulfate will be used. Additional components, that may be added singly or in combination, include collagen, other glycosaminoglycans, glucosamine hydrochloride, glucosamine sulfate, certain buffering agents, and certain preservatives. Using the solution of this invention on acute or chronic open wounds aids the natural healing process, thereby increases the rate of healing.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: July 27, 1999
    Inventor: George D. Petito
  • Methods of chelating or bleaching using phosphonomethylated chitosans
    Patent number: 5922851
    Abstract: Phosophonomethylated chitosans containing repeating units of formula ##STR1## wherein R.sub.1 is hydrogen or a radical of formula ##STR2## R.sub.2 is a radical of formula (1a), X.sub.1 and X.sub.2 are each independently of the other hydrogen, C.sub.1 -C.sub.5 alkyl or an alkali metal ion or ammonium ion and n is 50 to 4000, have versatile utilities as sequestrants, stabilizers for bleaching agents as well as humectants in cosmetic compositions.
    Type: Grant
    Filed: March 24, 1998
    Date of Patent: July 13, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Martin Kuhn, Thomas Maier, Albert Stehlin