Abstract: An injection device includes: a housing with a product container in which a stopper with a bearing face can be moved to a stopper end position and which, proximally to the stopper end position, has a minimum product container cross section; a drive configured to move the stopper, which includes a plunger rod with a drive face that contacts the bearing face; a plunger rod guide is arranged outside the product container and guides the plunger rod, with a plunger rod guide cross section adapted to a plunger rod cross section. The product container only incompletely guides movement of the plunger rod and the plunger rod cross section is not prevented from moving in a tilting direction by the minimum product container cross section, and a plunger rod centering aid a distal end of the plunger rod limits the movement of the plunger rod in the tilting direction.

Abstract: A method of performing a medical procedure in a cerebral vessel of a patient including advancing a first catheter system towards an embolus within a cerebral blood vessel and a second catheter system towards the embolus through the first catheter, applying aspiration pressure through the lumen of the second catheter; anchoring a distal end of the second catheter onto the embolus via the aspiration pressure; applying a proximally-directed force on the second catheter; and advancing the first catheter over the second catheter towards the embolus while the distal end of the second catheter remains anchored onto the embolus; and automatically applying aspiration pressure within the first catheter upon the second catheter portion entering into the first catheter.

Abstract: Some embodiments of a medical device anchor system include an anchor device that secures a medical instrument (such as a catheter or the like) in place relative to a skin penetration point using subcutaneous anchors.

Abstract: An insertion mechanism for a drug delivery device. The insertion mechanism includes a proximal end, a distal end, a first opening disposed near the proximal end, and a second opening disposed in the distal end. A needle or cannula assembly is disposed within a housing and has a base with a proximal surface and a distal surface and a needle or cannula coupled to the distal surface. A retraction member is disposed within the housing to maintain the needle or cannula assembly in a retracted position before movement to an extended position, the retraction member in contact with the base. Upon supplying pressure through the first opening until an amount of pressure P1 applies an application force to the proximal surface of the base that surpasses a resistive force of the retraction member, the needle or cannula assembly is moved from the retracted position to the extended position.

Abstract: Apparatus and methods for delivering medicament to a patient. The apparatus may include elements with different capacities to attenuate or absorb sterilizing radiation. The apparatus may include a medicament delivery assembly with interactive elements for dose-setting, priming and medicament ejection. The assembly may include a chamber housing a radiation-sensitive medicament present in the apparatus during sterilization by electron beam. The assembly may include an actuator chassis, a drive mechanism, a needle-priming mechanism and a fluid-displacement mechanism including a fluid-displacement member. The chassis may be fixed, relative to an outlet, to the chamber. The member may be slidingly and/or threadingly engaged with the chassis, and may be configured to move relative to the outlet to deliver the medicament through the outlet. Assembly elements may be nested coaxially and/or stacked axially. The assembly may include at least one hollow region.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is presented having an elongate case, a carrier subassembly comprising a tubular carrier slidably arranged inside the case, where the carrier adapted to contain a syringe with a hollow injection needle. The injector also has, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for advancing the needle beyond a proximal end of the auto-injector, and a trigger button is used for releasing the control spring on actuation.

Abstract: Disclosed is a device for facilitating placement of a central line in a patient, said device comprising: a housing having proximal and distal ends and a central portion therebetween, said housing having an upper portion and a lower portion; a handgrip provided on the proximal end of the housing, said handgrip having at least one of a channel and a through hole extending from the proximal end to the central portion, wherein the channel or through hole is sized to receive a guidewire; a feeder tip receiver provided on a proximal end of the handgrip in communication with the channel or through hole in said handgrip; a stabilizer provided on the lower portion of said housing; a luer slip tip provided on the distal end of the housing, said luer slip tip having a mounting portion for attachment to a needle hub, said luer slip tip having a lumen aligned with the channel or through hole in said handgrip; and a wire slide platform provided on the central portion of the housing.

Abstract: A dosing syringe comprising a barrel and a piston is provided. The piston is slidably receivable in the barrel and can move within the barrel from a maximum inserted position to a withdrawn position to draw a dose of a product into the barrel. The syringe comprises means for pre-setting the withdrawn position, which defines a maximum dose which can be drawn into the barrel.

Abstract: A coaxial stabilizing and sealing catheter provides increased support to a guide catheter that is seated in an ostium of a branch artery by extending through and out of a distal end of the guide catheter and anchoring in position within the branch artery that is being treated. The stabilizing and sealing catheter includes, as part of a relatively flexible distal section, a balloon that locks a distal end of the stabilizing and sealing catheter in place to provide support to therapeutic devices that are introduced and further seals the branch artery to prevent blood from entering the branch artery. A sealing cuff at a proximal end of the stabilizing and sealing catheter provides a seal between an exterior of the stabilizing and sealing catheter and an interior of the guide catheter. In addition, a fixing mechanism is utilized to lock the guide catheter in place to exchange therapeutic devices.

Abstract: Devices, systems, and methods are provided herein for delivering medication (e.g., insulin) via a wearable pump having a patch-style form factor for adhesion to a user's body. The reusable pump may be coupled to a disposable cap housing a microdosing system for delivering precise, repeatable doses of medication to a cannula configured to deliver medication to a target infusion area beneath the user's outer skin layer. The system further may include an applicator for inserting the cannula into the user's skin and/or applying an adhesive pad to the skin.

Abstract: A drug delivery device includes a container for storing a drug having a longitudinal axis. A plunger rod aligned with the longitudinal axis of the container has a first end and a second end, where the second end is disposed within the container. A stopper is disposed in and movable relative to the container for expelling the drug, and a drive mechanism is operatively coupled to the first end of the plunger rod. The drive mechanism is configured to deliver a drive force to move the plunger rod along the longitudinal axis and through the container. A chamber disposed between a plunger rod and the stopper is adapted to oppose the drive force of the drive mechanism.

Abstract: An introducer sheath assembly having a handle portion including a front end and a rear end, and a introducer sheath extending outwardly from the front end of the handle portion, the introducer sheath including a device lumen configured to slidably receive a corresponding device, a guidewire lumen configured to slidably receive a corresponding guidewire, a first steering cable lumen, a second steering cable lumen, a first steering cable disposed in the first steering cable lumen and a second steering cable disposed in the second steering cable lumen, wherein the first steering cable lumen, the second steering cable lumen and the guidewire lumen are disposed radially outwardly from the device lumen.

Abstract: A device for coupling to a fluid connector of an IV administration set to resist contamination of the fluid connector and IV administration set and permit priming of the IV administration set. The device including a cover body having a cavity for receiving the fluid connector, a priming passage for priming fluid from the IV administration set through the fluid connector, and a coupling tab extending from the cover body, the coupling tab permitting the cover body to be coupled to a length of an IV line or other portion of the IV administration set to resist contamination and permit priming of the IV administration set.

Abstract: System and methods for stimulating cartilage formation at a first tissue site through a second tissue site is presented. The system includes a fluid source for supplying a therapeutic solution, a reduced pressure source for supplying reduced pressure, a fluid delivery manifold for deploying adjacent the first tissue site, and a vacuum manifold for deploying within the second tissue site. The fluid delivery manifold extends between a proximal end fluidly coupled to the fluid supply and a distal end having at least one aperture for delivering the therapeutic solution to the defect adjacent the articulating surface of the first tissue site. The vacuum manifold extends between a proximal end fluidly coupled to the reduced pressure source and a distal end having at least one aperture for delivering the reduced pressure to the first tissue site adjacent the opposing surface of the first tissue site.

Abstract: One embodiment is a medical device with a flexibly deformable external hose. The external hose includes multiple openings, at least one of them arranged in a first end of the external hose. It includes a flexible internal hose, which is arranged on the inside of the external hose. The internal hose, in an expanded state, has an external diameter that is at least equal to the internal diameter of the external hose, closing the openings of the external hose. The external diameter of the internal hose can be transitioned from the expanded state into a radially contracted state, exposing the openings. A connection firmly connects the external hose and the internal hose on the first end of the external hose, and closes them in fluid-tight manner. A connector supplies the fluid into the intervening space between the external and the internal hose.

Abstract: A surgical system comprises a pressurized irrigation fluid source; an irrigation line fluidly coupled to the pressurized irrigation fluid source; a hand piece fluidly coupled to the irrigation line; and a controller for controlling the pressurized irrigation fluid source. The controller controls the pressurized irrigation fluid source based on an estimated flow value modified by a compensation factor.

Abstract: The present teachings may generally include a sealing device disposed within a connector (e.g., a patient connector) at an end of catheter tubing, where the sealing device is structurally configured to form a releasable seal for the catheter tubing. That is, when unengaged with a contact portion of another connector or device, the sealing device may be disposed in a first position establishing the seal. Specifically, a channel disposed through a body of the sealing device may be obstructed when in the first position. However, through predetermined engagement with the contact portion of another connector or device, the sealing device may be moved (e.g., rotated) to a second position to establish a fluid pathway through the channel. And, when the predetermined engagement is removed, the sealing device may be structurally configured to automatically move back into the first position to reestablish the seal for the catheter tubing.

Abstract: An injection device includes a cylinder having a cavity for receiving a liquid. A passage is connected to the cavity for inflow and/or outflow of the liquid. The passage can be connected to an injection component. A shut-off valve has a valve body and a flexible sealing ring with an opening. The valve body, proceeding from a release position in which the passage is freed, is at least partially movable through the opening of the sealing ring to a blocking position in which the valve body engages behind the opening so that movement of the valve body to the release position is blocked and the passage is sealed off against proximally directed flow. An adapter body is connected to the cylinder. The shut-off valve is arranged at a proximal end of the adapter body and at a distal end of the cylinder. The device can be used in a syringe.

Abstract: An electronic assembly includes a casing to conduct electricity flowing between at least some electronic components disposed within the casing. The electronic components include an ultrasonic transducer coupled to emit ultrasonic signals, and a battery to provide the electricity. A controller is coupled to the ultrasonic transducer and the battery, and the controller includes logic that when executed by the controller causes the electronic assembly to perform operations, including: instructing the ultrasonic transducer to emit the ultrasonic signals.

Abstract: A skin surface indwelling device for guiding punctures includes: an indwelling tube (13) having an inside tunnel (P) substantially extending along the longitudinal direction of the indwelling tube (13), the tunnel (P) is used for guiding needle (N), the indwelling tube (13) has a proximal end positioned above the skin surface (S) and a distal end positioned under the skin surface (S) in indwelling state; a support (11) having a bottom surface on its bottom that directly or indirectly contacts with the skin surface (S), the support (11) supports and fixates the indwelling tube (13); and a sealing elements (141,142) configured to seal the tunnel (P). The skin surface indwelling device for guiding punctures can shorten the time of establishing a puncture tunnel in the buttonhole puncture method, and help to build the puncture tunnel. In addition, the skin surface indwelling device can also guide the puncture needle (N) when puncturing, and protect the immature puncture tunnel.