Abstract: Disclosed is an auto injector and a related method, and a related system, for administering injection of a medicament comprising a first medicament component and a second medicament component. The auto injector comprising a housing, a receiving part, an operational module and a processing unit. The processing unit being configured to operate a syringe operational part to move a carrier to mix the first medicament component and the second medicament component to obtain a mixed medicament. The movement of the carrier having a time varying acceleration profile. The time varying acceleration profile having a first maximum acceleration in a first mixing direction and a second maximum acceleration in a second mixing direction. The first maximum acceleration and/or the second maximum acceleration is larger than a predetermined acceleration threshold.

Abstract: A catheter, more particularly an endovascular catheter, with a catheter shaft including a first lumen and a shaft opening, a deflection element and a controlling element. The first lumen and the shaft opening communicate with each other. The deflection element is rotatably arranged inside the catheter shaft, and configured to deflect a guidewire through the shaft opening. The controlling element is operably connected with the deflection element and configured to rotate the deflection element in a first rotating direction . Furthermore, the present invention refers to a catheter assembly with such a catheter and a guidewire.

Abstract: An injection device, comprising an interface for mounting on a syringe body, the interface comprising an internal passage delimited by an inner wall, a needle and a sheath for receiving said needle, said sheath comprising an outer wall provided with a contact portion of said sheath in contact with an attachment portion of the inner wall of the interface, wherein the contact portion comprises a first bead and in that the attachment portion comprises a second bead, the first and second beads each forming a ring protruding respectively on the contact portion and the attachment portion, the first bead being in contact with the second bead.

Abstract: A male luer connector includes a body having a first end configured to be connected to a fluid line, a second end opposed to the first end, and a body longitudinal axis. The second end is configured to be inserted into and form a luer slip connection with a female luer connector. The male luer connector also includes a locking collar that is connected to the body in a manner such that the locking collar rotates about the longitudinal axis. In some cases, the body second end does not protrude beyond a plane that is transverse to the longitudinal axis and that includes an end face of the locking collar, and/or when male and female connectors are engaged, the locking collar engages an outer surface of the female fluid line connector and is deformed by the engagement.

Abstract: The present invention is directed to a device for expression of a hemostatic powder having an elongated reservoir with a manual air pump, such as a bellows, at a proximal end and an expression port at a distal end. A porous filter is slidably disposed within the elongated reservoir between the bellows, a plunger, and the expression port, and a spring is disposed within the elongated reservoir between the manual air pump and the plunger. The hemostatic powder is disposed within the elongated reservoir between the porous filter and the expression port, and the manual air pump is in a fluid communication with the expression port through the porous filter and through the hemostatic powder.

Abstract: Infusion devices, systems, and related operating methods are provided. A method of detecting an occlusion in a fluid path involves a control module of an infusion device operating a driver module to provide energy to an actuation arrangement to achieve a commanded actuation state, wherein the actuation arrangement is coupled to a plunger configured to deliver fluid via the fluid path, obtaining a measured actuation state of the actuation arrangement via a sensing arrangement, and detecting an occlusion condition based on a relationship between the commanded actuation state and the measured actuation state.

Abstract: Examples of catheter devices, removable needle devices and kits are disclosed. Also methods for accessing a hollow organ are disclosed. The catheter devices include a body extending longitudinally from a proximal end to a distal end, wherein the body includes an elongated channel along a longitudinal length of the body extending from the proximal end to the distal end of the body, wherein the elongated channel is configured to receive an elongated needle of the removable needle device, and the body includes one or more cutting edges extending in a proximal direction from the distal end of the body. The body of the catheter devices includes one or more recesses adapted to mate with one or more catches of the removable needle device for coupling the needle device to the catheter device. Methods of using the catheters, removable needle devices and the kits are also disclosed.

Abstract: An injector includes a needle movable from a retracted position to an injection position. A rotary biasing assembly is stabilized in a stored energy state and releasable into an energy releasing state and includes a cam. A cam follower couples the rotary biasing assembly with the needle and is configured to transform rotation of the rotary biasing assembly in the energy releasing state thereof into translation of the needle from the retracted position to the injection position. An activation switch is rotatable from an unactivated position, stabilizing the rotary biasing assembly in the stored energy state thereof, to an activated position, releasing the rotary biasing assembly into the energy releasing state thereof. An activation button is movably mounted to the injector housing and is translatable from an unactuated position to an actuated position, whereby the translation rotates the activation switch from the unactivated position to the activated position thereof.

Abstract: A piercing conduit to deliver medications to a user in a painless method including a placement phase, an inserting phase and an injection phase which are performed by the piercing conduit. The placement phase includes a penetrating bottom distal end of the piercing conduit which is inserted through a user's skin of the abdomen portion to place a middle aperture in the inside of the user's skin and then leave exposed the penetrating bottom distal end and a top distal end. The inserting phase passes through a sealing cap from the top distal end which has an aperture in which a needle is inserted along a conduit portion and then reaches the middle aperture that is placed inside of the user's skin. The injection phase delivers the medication with the syringe by the needle allowing to apply medication in a painless method. The piercing conduit is configured to be applied to users with constant medication such as diabetes or dialysis.

Abstract: An injection device includes: a housing with a product container in which a stopper with a bearing face can be moved to a stopper end position and which, proximally to the stopper end position, has a minimum product container cross section; a drive configured to move the stopper, which includes a plunger rod with a drive face that contacts the bearing face; a plunger rod guide is arranged outside the product container and guides the plunger rod, with a plunger rod guide cross section adapted to a plunger rod cross section. The product container only incompletely guides movement of the plunger rod and the plunger rod cross section is not prevented from moving in a tilting direction by the minimum product container cross section, and a plunger rod centering aid a distal end of the plunger rod limits the movement of the plunger rod in the tilting direction.

Abstract: A method of performing a medical procedure in a cerebral vessel of a patient including advancing a first catheter system towards an embolus within a cerebral blood vessel and a second catheter system towards the embolus through the first catheter, applying aspiration pressure through the lumen of the second catheter; anchoring a distal end of the second catheter onto the embolus via the aspiration pressure; applying a proximally-directed force on the second catheter; and advancing the first catheter over the second catheter towards the embolus while the distal end of the second catheter remains anchored onto the embolus; and automatically applying aspiration pressure within the first catheter upon the second catheter portion entering into the first catheter.

Abstract: Some embodiments of a medical device anchor system include an anchor device that secures a medical instrument (such as a catheter or the like) in place relative to a skin penetration point using subcutaneous anchors.

Abstract: An insertion mechanism for a drug delivery device. The insertion mechanism includes a proximal end, a distal end, a first opening disposed near the proximal end, and a second opening disposed in the distal end. A needle or cannula assembly is disposed within a housing and has a base with a proximal surface and a distal surface and a needle or cannula coupled to the distal surface. A retraction member is disposed within the housing to maintain the needle or cannula assembly in a retracted position before movement to an extended position, the retraction member in contact with the base. Upon supplying pressure through the first opening until an amount of pressure P1 applies an application force to the proximal surface of the base that surpasses a resistive force of the retraction member, the needle or cannula assembly is moved from the retracted position to the extended position.

Abstract: Apparatus and methods for delivering medicament to a patient. The apparatus may include elements with different capacities to attenuate or absorb sterilizing radiation. The apparatus may include a medicament delivery assembly with interactive elements for dose-setting, priming and medicament ejection. The assembly may include a chamber housing a radiation-sensitive medicament present in the apparatus during sterilization by electron beam. The assembly may include an actuator chassis, a drive mechanism, a needle-priming mechanism and a fluid-displacement mechanism including a fluid-displacement member. The chassis may be fixed, relative to an outlet, to the chamber. The member may be slidingly and/or threadingly engaged with the chassis, and may be configured to move relative to the outlet to deliver the medicament through the outlet. Assembly elements may be nested coaxially and/or stacked axially. The assembly may include at least one hollow region.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is presented having an elongate case, a carrier subassembly comprising a tubular carrier slidably arranged inside the case, where the carrier adapted to contain a syringe with a hollow injection needle. The injector also has, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for advancing the needle beyond a proximal end of the auto-injector, and a trigger button is used for releasing the control spring on actuation.

Abstract: Disclosed is a device for facilitating placement of a central line in a patient, said device comprising: a housing having proximal and distal ends and a central portion therebetween, said housing having an upper portion and a lower portion; a handgrip provided on the proximal end of the housing, said handgrip having at least one of a channel and a through hole extending from the proximal end to the central portion, wherein the channel or through hole is sized to receive a guidewire; a feeder tip receiver provided on a proximal end of the handgrip in communication with the channel or through hole in said handgrip; a stabilizer provided on the lower portion of said housing; a luer slip tip provided on the distal end of the housing, said luer slip tip having a mounting portion for attachment to a needle hub, said luer slip tip having a lumen aligned with the channel or through hole in said handgrip; and a wire slide platform provided on the central portion of the housing.

Abstract: A dosing syringe comprising a barrel and a piston is provided. The piston is slidably receivable in the barrel and can move within the barrel from a maximum inserted position to a withdrawn position to draw a dose of a product into the barrel. The syringe comprises means for pre-setting the withdrawn position, which defines a maximum dose which can be drawn into the barrel.

Abstract: A coaxial stabilizing and sealing catheter provides increased support to a guide catheter that is seated in an ostium of a branch artery by extending through and out of a distal end of the guide catheter and anchoring in position within the branch artery that is being treated. The stabilizing and sealing catheter includes, as part of a relatively flexible distal section, a balloon that locks a distal end of the stabilizing and sealing catheter in place to provide support to therapeutic devices that are introduced and further seals the branch artery to prevent blood from entering the branch artery. A sealing cuff at a proximal end of the stabilizing and sealing catheter provides a seal between an exterior of the stabilizing and sealing catheter and an interior of the guide catheter. In addition, a fixing mechanism is utilized to lock the guide catheter in place to exchange therapeutic devices.

Abstract: Devices, systems, and methods are provided herein for delivering medication (e.g., insulin) via a wearable pump having a patch-style form factor for adhesion to a user's body. The reusable pump may be coupled to a disposable cap housing a microdosing system for delivering precise, repeatable doses of medication to a cannula configured to deliver medication to a target infusion area beneath the user's outer skin layer. The system further may include an applicator for inserting the cannula into the user's skin and/or applying an adhesive pad to the skin.

Abstract: A drug delivery device includes a container for storing a drug having a longitudinal axis. A plunger rod aligned with the longitudinal axis of the container has a first end and a second end, where the second end is disposed within the container. A stopper is disposed in and movable relative to the container for expelling the drug, and a drive mechanism is operatively coupled to the first end of the plunger rod. The drive mechanism is configured to deliver a drive force to move the plunger rod along the longitudinal axis and through the container. A chamber disposed between a plunger rod and the stopper is adapted to oppose the drive force of the drive mechanism.