Abstract: A pants-type disposable diaper (1) having a front body part (P), a back body part (Q) and a crotch part (R) positioned therebetween and formed in a pants shape, comprising an absorbent body (7) situated at least at the crotch part (R) and comprising a top sheet, a back sheet and an absorbent core (10) disposed therebetween, and an exterior member (2) provided on an outer side of the absorbent body (7) and situated at least at the front body part (P) and the back body part (Q), wherein the exterior member (2) comprises an outer sheet (5) and an inner sheet (6) provided on a skin-facing side of the outer sheet (5), and the outer sheet (5) is made of a nonwoven fabric having a meltblown nonwoven layer and a printed part is provided to the skin-facing side of the outer sheet (5).
Abstract: The present disclosure relates to 2-(3-indoyl)indolin-3-one derivatives of the natural product isatisine A, synthesized from dual catalytic synthesis on metallocarbene-azide cascade chemistry, useful for treating a subject having or suspected of having an infectious disease, wherein the infection disease is caused by a virus, wherein the virus is from the family flaviviridae or paramyxoviridae.
Type:
Grant
Filed:
March 27, 2019
Date of Patent:
January 31, 2023
Assignee:
The Governors of the University of Alberta
Inventors:
Frederick Glenn West, David J. Marchant, Bren Jordan P. Atienza, Lionel D. Jensen
Abstract: Disclosed herein are drug delivery punctal implants and methods of using the implants for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The physical arrangement of drugs within the punctal plugs disclosed herein results, in several embodiments, in advantageous controlled delivery of one or more drugs to the eye of a patient.
Type:
Grant
Filed:
September 23, 2016
Date of Patent:
January 31, 2023
Assignee:
GLAUKOS CORPORATION
Inventors:
Thomas W. Burns, Douglas Daniel Crimaldi, David Applegate, Kenneth Martin Curry
Abstract: Provided is a tampon applicator having one or more insertion indicators to gauge and/or control the insertion depth of a tampon. The one or more insertion indicators may be located on the tampon applicator barrel, plunger, tampon, removal string, or any combinations thereof. As a result of the one or more insertion indicators, a woman can adjust the insertion depth of the tampon to her body's requirements ensuring leakage protection, comfort, or both.
Type:
Grant
Filed:
January 23, 2020
Date of Patent:
January 31, 2023
Assignee:
EDGEWELL PERSONAL CARE BRANDS, LLC
Inventors:
Eugene P Dougherty, Phillip Ebert, Keith Edgett
Abstract: An absorbent article includes a topsheet, an absorbent core, and a backsheet. The absorbent article has a visually perceptible functional enhancement indicator and a functionally-distinguishable portion of the article with one or more channels. The visually perceptible functional enhancement indicator corresponds to the one or more channels, and the functional enhancement indicator is visually perceptible from a body-facing side of the absorbent article but the one or more channels are not visually perceptible.
Type:
Grant
Filed:
October 6, 2016
Date of Patent:
January 17, 2023
Assignee:
THE PROCTER & GAMBLE COMPANY
Inventors:
Peter Charles Mason, Jr., Ronald Bosman Visscher, Jeanne Marie Hughes, Folke Schlueter, Emma Somma, Giovanni Carlucci, Paul Thomas Weisman
Abstract: An absorbent article with a fastening system with reduced waste and method of manufacturing such an absorbent article is disclosed. The method of manufacturing an absorbent article can include cutting a first web of ear tab material to provide a first ear tab that is registered and cutting a second web of ear tab material to provide a second ear tab that is registered. The method can also include providing a web of ear panel material, coupling the first and second ear tabs to the web of ear panel material, cutting the web of ear panel material to provide first and second ear panels to form first and second ears, and coupling the first and second ears to the absorbent assembly to form at least a portion of the fastening system for the absorbent article. The first and second ears can be configured to be different from one another.
Type:
Grant
Filed:
June 5, 2020
Date of Patent:
January 17, 2023
Assignee:
KIMBERLY-CLARK WORLDWIDE, INC.
Inventors:
Jason Gene Csida, Rebecca Suzanne Walter, Patrick Robert Lord, Kyle Mark Barriger, Eric-John Raoul Gilgenbach
Abstract: An absorbent article (10, 110, 210, 310, 410) can include a waist containment member (54) and an absorbent body (34, 134, 234, 334, 434). The waist containment member (54) can include a proximal portion (76) and a distal portion (78) configured to freely move with respect to the chassis (11) when the absorbent article (10, 110, 210, 310, 410) is in a relaxed configuration to provide a containment pocket (82). The absorbent body (34, 134, 234, 334, 434) can be configured to provide improved access for exudates into the containment pocket (82) of the waist containment member (54).
Type:
Grant
Filed:
December 4, 2019
Date of Patent:
January 17, 2023
Assignee:
KIMBERLY-CLARK WORLDWIDE, INC.
Inventors:
David F. Bishop, Patsy A. Benedict, Joseph D. Coenen, Kaitlyn E. Mast, Michael J. Faulks
Abstract: The present invention provides new prodrugs of therapeutically active compounds, including oligomeric prodrugs, and compositions to treat medical disorders, for example glaucoma, a disorder or abnormality related to an increase in intraocular pressure (IOP), a disorder requiring neuroprotection, age-related macular degeneration, or diabetic retinopathy.
Type:
Grant
Filed:
September 20, 2019
Date of Patent:
January 10, 2023
Assignee:
Graybug Vision, Inc.
Inventors:
Ming Yang, John G. Bauman, Jeffrey L. Cleland, Nu Hoang, Emmett Cunningham
Abstract: There are provided new heterobifunctional agents designed to mediated formation of protein-protein dimers and promote ubiquitination of a protein of the dimer. Also provided are methods of synthesizing the agents, pharmaceutical formulations including the agents, and methods of using the agents to treat, ameliorate or cure diseases characterized by protein over-expression or malfunction.
Type:
Grant
Filed:
September 23, 2021
Date of Patent:
January 3, 2023
Assignee:
Agency for Science, Technology and Research (A*STAR)
Inventors:
Wei Hung, Thomas Hugo Keller, Wei Ling Wang, Gang Wang, Congbao Kang
Abstract: Provided are a compound superior in a cytotoxic action on cancer cells, an action inducing degradation of BET protein in cancer cells, and an inhibitory action on the binding of BET protein and acetylated histone, and useful as an anticancer agent, a BET protein degradation inducer or a BET protein inhibitor. A compound represented by the following formula (I) wherein each symbol is as defined in the specification, or a pharmacologically acceptable salt thereof.
Abstract: An absorbent sheet for a pet toilet is provided. The pet toilet includes: a sheet accommodating portion that accommodates the absorbent sheet in a space surrounded by a bottom portion and side walls standing from the bottom portion; and an excretion receiving portion that receives excretions above the sheet accommodating portion and guides the excretions to the sheet accommodating portion. The absorbent sheet includes: a topsheet on a top side of the absorbent sheet and that includes fibers; a backsheet on a back side of the absorbent sheet; an absorber between the topsheet and the backsheet; a central region in which the absorber is disposed in plan view; and side regions that extend outside the central region and in which at least the topsheet is disposed.
Abstract: The present invention relates to heterobicyclic amides and related compounds which are inhibitors of CD38 and are useful in the treatment of cancer.
Type:
Grant
Filed:
July 30, 2020
Date of Patent:
December 27, 2022
Assignee:
Ribon Therapeutics, Inc.
Inventors:
Laurie B. Schenkel, Melissa Marie Vasbinder, Kevin Wayne Kuntz, Nicholas Robert Perl, Jennifer Downing
Abstract: The present invention relates to a method for preparing Asenapine. In particular, the present invention relates to a method for preparing pharmaceutically acceptable Asenapine free base and new crystal form thereof, and also relates to methods for preparing the intermediate compounds used in said method.
Abstract: Disclosed are inhibitors for the ?-catenin/T-cell factor interaction. The inhibitors are selective for ?-catenin/T-cell factor over ?-catenin/cadherin and ?-catenin/APC interactions. Methods of using the disclosed compounds to treat cancer are also disclosed.
Type:
Grant
Filed:
March 28, 2019
Date of Patent:
December 20, 2022
Assignee:
H. Lee Moffitt Cancer Center and Research Center Institute, Inc.
Abstract: An applicator for a tampon is provided. The applicator has an inner tube and an outer tube and the inner tube is slideable within the outer tube. The applicator has a forward end, and the inner surface of the outer tube has an annular protrusion near to the rear end of the outer tube. The internal diameter of the outer tube is smaller rearward of the annular protrusion than forward of the annular protrusion.
Abstract: The present invention relates to novel and secure tampons that overcome the problems associated with conventional non-secure tampons, and methods of using the novel and secure tampons.
Abstract: A urine collection device includes a collection member extending from a proximal end to a distal end. The proximal end includes an opening that provides access to an internal cavity of the collection member. The internal cavity includes a first chamber in fluid communication with a second chamber. The urine collection device includes a spacer in the second chamber, a first attachment member extending from a bottom wall of the collection member at the proximal end, a second attachment member extending from a top wall of the collection member at the proximal end, and an outlet for egressing urine from the internal cavity of the collection member. The first attachment member defines an aperture. The collection member is suitable to (i) direct urine from the first chamber to the second chamber and (ii) direct the urine in the second chamber distally toward the outlet.
Type:
Grant
Filed:
December 21, 2020
Date of Patent:
December 13, 2022
Assignee:
Sage Products, LLC
Inventors:
Brian J. Ecklund, Kristin M. Sexton, Alex D. Kea, Daniel R. Ulreich
Abstract: The present invention provides processes and synthetic intermediates for the synthesis of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4 {3H)-one or a salt, hydrate, or tautomer thereof, or any combination thereof, which are Cdc7 kinase inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with Cdc7 activity.
Type:
Grant
Filed:
April 1, 2019
Date of Patent:
December 13, 2022
Assignee:
Takeda Pharmaceutical Company Limited
Inventors:
Lei Zhu, John Daniel Bailey, Landon Durak, Joshua David Waetzig, Masahiro Mizuno, Kazuhiro Maeda, Tsuneo Yasuma, Hiroshi Yamaguchi, Koichiro Fukuoka, Kazuyuki Akiyama
Abstract: This replacement necessity assessment apparatus for an absorbent member includes: a power generator which is configured to generate power as a result of contact with liquid absorbed in the absorbent member, and of which power generation amount changes in accordance with an amount of the liquid; a signal output unit configured to output a detection signal according to the power generation amount; and a processing unit configured to acquire a parameter regarding the amount of the liquid based on the detection signal, the processing unit configured to determine, based on the parameter, whether or not replacement of the absorbent member is necessary.
Type:
Grant
Filed:
October 26, 2017
Date of Patent:
December 13, 2022
Assignees:
The Ritsumeikan Trust, ABLIC Inc.
Inventors:
Takakuni Douseki, Ami Tanaka, Ryota Suematsu, Hiroya Sakamoto
Abstract: The present disclosure is directed to indicating systems and methods for incontinence products. The indicating system may include an indicator panel for an incontinence product that is adapted to provide a qualitative or quantitative indication of a characteristic of a liquid absorbed by the indicator panel.
Type:
Grant
Filed:
February 1, 2017
Date of Patent:
December 6, 2022
Assignees:
New York University, Pixie Scientific TTC
Inventors:
Andrew D. Hollingsworth, Scott Meek, William Gotimer