Patents Examined by L. Anderson
  • Apparatus and method for deploying a surgical preparation
    Patent number: 11511094
    Abstract: A device used for applying an antiseptic preparation, such as an antibiotic solution or water, or all other substance deemed necessary in treating a wound prior to arrival at a hospital or other treatment facility or for continuing wound therapy and maintenance while hospitalized, in an out-patient facility or at home. A loose-fitting bag is provided which encloses the wound by securing the open end(s) to the patient by closing means. The bag further includes ports or resealable flaps that allow access to the wound for treatment and cleaning while containing all fluids resulting therefrom. A high friction scrub surface is provided in the bag. A method and apparatus are also provided for wound maintenance with a lavage system.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: November 29, 2022
    Inventor: Mark R. Moore
  • Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
    Patent number: 11505564
    Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: November 22, 2022
    Assignee: COMPASS PATHFINDER LIMITED
    Inventors: Derek John Londesbrough, Christopher Brown, Julian Scott Northen, Gillian Moore, Hemant Kashinath Patil, David E. Nichols
  • Absorbent articles having channels and wetness indicator
    Patent number: 11497657
    Abstract: An absorbent article, such as a diaper or a training pant, having a wearer-facing side and a garment-facing side and a longitudinal axis. The absorbent article comprises a topsheet on the wearer-facing side, a backsheet on the garment-facing side, and an absorbent core between the topsheet and backsheet. The absorbent core comprises a generally longitudinally-extending channel. The absorbent article further comprises a wetness indicator at least partially superposed with the channel, as seen from the garment-facing side of the article.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: November 15, 2022
    Assignee: The Procter & Gamble Company
    Inventors: John Andrew Strasemeier, Theodore Cory Fites, Sarah Ann Sanborn
  • Diaper changing and disposal kit
    Patent number: 11497661
    Abstract: A diaper changing and disposal kit is disclosed. The diaper changing and disposal kit has a diaper with a pocket. The pocket stores a variety of diaper changing supplies such as baby wipes, disposable gloves, and an airtight disposal bag. The diaper also has a wetness indicator strip to aid a user in determining when the diaper needs to be changed. Preferably, the diaper changing and disposal kit is stored in a package until it is ready to be used.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: November 15, 2022
    Inventor: Norena Tina Sullivan
  • Compound acting as antibiotics
    Patent number: 11498909
    Abstract: The present invention provides a novel antibiotic compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, an ester thereof, a prodrug thereof, a solvate thereof, or a deuterated analog thereof, or a stereoisomer thereof. The compound of the present invention exhibits excellent antibacterial activity, especially against Gram bacteria. wherein each group is defined as in the description.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: November 15, 2022
    Assignee: KBP BIOSCIENCES CO., LTD.
    Inventors: Zhenhua Huang, Li Li, Min Zhang
  • Combinatorial drug delivery device
    Patent number: 11497685
    Abstract: In one aspect, a combinatorial drug delivery device is provided for delivering a predetermined selection of drug components. The device includes a plurality of modules, each including: a body having an interior volume; a spike plate movably disposed in the interior volume, the spike plate having a protruding cannula and first and second ports. The device also includes a base tray which includes: a framework defining a plurality of wells, each of the wells formed to insertingly receive one of the modules; for each of the wells, first and second inlet ports formed to interface with the first and second ports of the module being received in the respective well; passageways to connect certain wells with adjacent wells to permit fluid flow therebetween. For each of the wells, the spike plate of the respective module being maintained in a stationary position with the module being inserted into the well.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: November 15, 2022
    Assignee: Bristol-Myers Squibb Company
    Inventors: Martin John McLoughlin, Chester Larrow, Mariano Mumpower
  • Chemokine CXCR4 receptor modulators and uses related thereto
    Patent number: 11497744
    Abstract: The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. The receptor modulators can be formulated to form pharmaceutical compositions comprising the disclosed compounds or pharmaceutically acceptable salts or prodrugs thereof. The compositions may be used for managing CXCR4 related conditions, typically prevention or treatment of viral infections abnormal cellular proliferation, retinal degeneration, inflammatory diseases, or as an immunostimulant or immunosuppressant or for managing cancer and may be administered with another active ingredient such as an antiviral agent or chemotherapeutic agent.
    Type: Grant
    Filed: February 21, 2018
    Date of Patent: November 15, 2022
    Assignee: Emory University
    Inventors: Dennis Liotta, Edgars Jecs, Robert James Wilson, Huy Hoang Nguyen, Michelle Bora Kim, Lawrence Wilson, Eric James Miller, Yesim Altas Tahirovic, Valarie Truax
  • Medical device
    Patent number: 11491084
    Abstract: Medical devices are provided comprising a spike including proximal and distal ends, and a central axis extending from the proximal to the distal end; a valve body; a biasing body which biases the valve body; a distal tube that moves integrally with the valve body to both sides in the axial direction relative to the spike; a proximal tube fixed in the axial direction relative to the spike, the distal tube comprising a guided portion guided toward the proximal tube, and an engagement control unit which moves the guided portion toward one side in the radial direction by connection of the different medical device to the distal tube allowing the guided portion to engage with the proximal tube, and moves the guided portion toward the other side in the radial direction releasing engagement with the proximal tube when the different medical device is detached from the distal tube.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: November 8, 2022
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yasuhiro Ueda, Kazuya Akiyama
  • Protein degraders and uses thereof
    Patent number: 11485743
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: November 1, 2022
    Assignee: KYMERA THERAPEUTICS, INC.
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Kluge
  • Absorbent products for articles of clothing
    Patent number: 11478386
    Abstract: The present technology relates to an absorbent product for attachment to an article of clothing. The absorbent product comprises a wearer-facing surface and a garment-facing surface opposite the wearer-facing surface. The absorbent product comprises a main body, wherein the main body comprises: a central absorbent core; an external envelope placed around the central core and having a front extremity and a rear extremity; a first attachment line located at the front extremity of the external envelope; and a second attachment line located at the rear extremity of the external envelope; wherein the first attachment line and the second attachment line are for attachment of the absorbent product to the article of clothing; and wherein the absorbent product is free of means for adhesively attaching the garment-facing surface to the article of clothing.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: October 25, 2022
    Assignee: BOUTIQUE LA VIE EN ROSE INC.
    Inventors: Steve Leduc, Fanny-Maude Theberge
  • Folded disposable absorbent articles
    Patent number: 11478387
    Abstract: Disposable absorbent articles are disclosed herein having a first and second fold line. The disposable absorbent articles have a topsheet, a backsheet, and an absorbent system disposed therebetween. The absorbent system has a first absorbent core and a second absorbent core which may be configured in an offset manner. And, the absorbent system and/or the first and second fold lines may be configured with respect to the absorbent article to effect a caliper change in the folded article.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: October 25, 2022
    Assignee: THE PROCTER & GAMBLE COMPANY
    Inventors: Stephen Lebeuf Hardie, Ronda Lynn Glassmeyer
  • Small molecule modulators of the BTB domain of Keap1
    Patent number: 11479539
    Abstract: The present application relates to compounds of formula (I?) or formula (I), such as formula (Ia), and their pharmaceutical compositions/preparations. This application further relates to methods of treating or preventing neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington disease (HD) and other CAG-triplet repeat (or polyglutamine) diseases, amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease), diffuse Lewy body disease, chorea-acanthocytosis, primary lateral sclerosis, multiple sclerosis (MS), frontotemporal dementia, Friedreich's ataxia, acute head injury, and epilepsy (repression of microglia activation).
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: October 25, 2022
    Assignee: MedImmune Limited
    Inventors: Johan Bartholomeus, Roland Bürli, Rebecca Jarvis, Shawn Johnstone, Thor Ostenfeld, Ina Terstiege, Massimiliano Travagli, Stephane Turcotte
  • 1,4-diphenyl-1H-imidazole and 2,4-diphenylthiazole derivatives and preparation method therefor and use thereof
    Patent number: 11472815
    Abstract: Provided are 1,4-diphenyl-1H-imidazole and 2,4-diphenylthiazole derivatives having a structure represented by Formula I, a preparation method therefor and uses thereof: wherein R1 is any one of H, OH, and OCH3, R2 is any one of H, NO2, CH3, CF3, SO2CH3, COOCH3, or CONHCH3, R3 is any one of H, NO2, OCH3, or CF3, R4 is selected from H, CF3, or Cl, R5 is any one of H, Cl, CF3, or NHCH3, and R6 is any one of OCF3, CF3, or CN; V is either C or N, W is either CH or N, X is a C atom, Y is either CH or N, and Z is either CH or S. This compound can be used in preparation of anti-inflammatory adjuvants, TLR1 or TLR2 agonists, and anti-tumor agents and for regulating the activity activation level of TLR1 and TLR2 alkaline phosphatases in vitro and in vivo.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: October 18, 2022
    Assignee: SOUTHERN MEDICAL UNIVERSITY
    Inventors: Kui Cheng, Shuwen Liu, Gengzhen Zhu
  • Unitary storage layer for disposable absorbent articles
    Patent number: 11471340
    Abstract: A unitary storage layer for an absorbent article, being formed by at least two sub-layers in which a first outermost sub-layer forms said first surface and includes cellulose pulp fibers and cross linked cellulose fibers and includes less than 5% of SAP by weight of the sub-layer, and a second sub layer which includes cellulose pulp fibers and SAP and is immediately adjacent to said first sub-layer.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: October 18, 2022
    Assignee: The Procter & Gamble Company
    Inventors: Martin Schnabel, Carola Elke Beatrice Krippner, Norbert Matthias Stelzer, Michele Mazzeo, Dirk Saevecke
  • Negative pressure wound therapy device, system and method
    Patent number: 11471585
    Abstract: The present invention relates to a negative pressure wound therapy device, system and method. The negative pressure wound therapy device is connected with a dressing, and comprises a housing, a control circuit board, a pump, and an aspiration conduit. The pump generates negative pressure. The pump may comprise a voltage-actuated deformation element (such as piezoelectric vibration element) to push fluid from an aspiration end to a discharge end. The aspiration conduit has a pump end and a dressing end. The pump end is fluidly connected to the aspiration end of the pump, and the dressing end is fluidly connected to the dressing used for covering a wound. The control circuit board is disposed in the housing, controls the pump to generate the negative pressure in the aspiration conduit, and applies negative pressure to the wound covered by the dressing via the aspiration conduit.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: October 18, 2022
    Assignee: XIAMEN SUNEETEK MEDICAL EQUIPMENT CO., LTD.
    Inventors: Po-Han Chang, Shih Hua Hsiao, Bo Cheng Huang, Chi Yuan Chen, Ting Hsuan Chung
  • Disposable baby changing pad system and method of making the same
    Patent number: 11464683
    Abstract: A disposable baby changing pad system includes a changing pad body extending from a top end to a bottom end and being composed of a thin, flexible material, the changing pad body further having a pocket formed on a top surface of the changing pad body, the pocket having a top layer sealing an interior area of the pocket; an opening extending into the interior area from the top layer; one or more wipes sealed within the pocket; and a diaper positioned on the top surface of the changing pad body; the changing pad body folds around the pocket and the diaper.
    Type: Grant
    Filed: June 10, 2019
    Date of Patent: October 11, 2022
    Inventor: Matthew Joseph
  • TGF-? inhibitors
    Patent number: 11466018
    Abstract: Disclosed are pyrazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein A, X, Z, m, p, and R2 are as described herein. In certain embodiments, a compound disclosed herein inhibits the activity of one or more members of the TGF-? superfamily, and can be used to treat disease by blocking such activity.
    Type: Grant
    Filed: November 2, 2020
    Date of Patent: October 11, 2022
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Marina Gelman, Todd Kinsella, Somasekhar Bhamidipati, Ihab Darwish, Rajinder Singh, Jiaxin Yu
  • Combined trocar and cannula bone marrow aspiration device with integral valve and ports for aspiration, and methods for using same
    Patent number: 11464500
    Abstract: A device comprising a trocar having a first end and comprising a cannulation and at least one fenestration proximal the first end; and a housing comprising a first port configured for the attachment of a first syringe and a second port configured for the attachment of a collection vessel, a first valve configured to selectively permit fluid flow through the cannulation of the trocar to the first port, and a second valve configured to selectively permit fluid flow through the cannulation of the trocar to the second port. The device allows the first syringe to draw up bone marrow in small volumes with high vacuum and then transfer the small draws into the collection vessel. The device may increase the recovery of desired cells residing in the bone marrow to be recovered during a bone marrow aspiration procedure.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: October 11, 2022
    Assignee: SpineSmith Holdings, LLC
    Inventors: Robert James Jones, Kevin John Patrick Dunworth, John B. Rossman, Richard J. Kana
  • Wearable device
    Patent number: 11464681
    Abstract: The present disclosure relates generally to a wearable device, and more specifically to a wearable device for detecting biological events, monitoring health condition of an individual, and for providing automatic alerts and analytics reporting. An exemplary wearable device for monitoring health condition of an individual comprises a puck component attachable to the individual's clothing, wherein the puck component comprises a circuit of a moisture sensor; a strip component configured to be placed within the individual's clothing, wherein a proximal end portion of the strip comprises a pair of conductive pads, and wherein the pair of conductive pads is configured to interface with the circuit of the moisture sensor while the proximal end portion of the strip is enclosed within the puck via a coupling mechanism.
    Type: Grant
    Filed: November 12, 2021
    Date of Patent: October 11, 2022
    Assignee: SMARDII, INC.
    Inventors: Vikram S. Mehta, Sebastien Gaddini, Mathieu Gaddini
  • Chassis design for absorbent article
    Patent number: 11458046
    Abstract: A disposable absorbent article may include a first waist region, a second waist region, a crotch region disposed between the first and the second waist regions, and a chassis having a topsheet, backsheet, absorbent core, and chassis periphery. The chassis periphery has a varying width, Wv.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: October 4, 2022
    Assignee: The Procter & Gamble Company
    Inventors: Kumardipti Chatterjee, Jeromy Thomas Raycheck, Michael Devin Long