Patents Examined by Lewis Gotts
  • Process for producing cyclopropyl substituted organosulfides
    Patent number: 3998889
    Abstract: Pesticidal and anti-inflammatory cyclopropyl compounds, cyclopropyl intermediates for the preparation of pesticidal compounds, especially chrysanthemic acid-like intermediates, and a process for preparing same.
    Type: Grant
    Filed: June 12, 1975
    Date of Patent: December 21, 1976
    Assignee: The Procter & Gamble Company
    Inventors: Donald John Peterson, Medford Dwight Robbins
  • 13-Oxatetracyclo[8.2.1.sup.2,9.0.0.sup.3,8 ]tridec-5-ene-1,5,6,10-tetracarbonitrile
    Patent number: 3998853
    Abstract: 13-Oxatetracyclo[8.2.1.sup.2,9.0.0.sup.3,8 ]tridec-5-ene-1,5,6,10-tetracarbonitrile; clathrates thereof with monocyclic unsubstituted aromatic compounds; and methods of separating organic admixtures.
    Type: Grant
    Filed: December 4, 1975
    Date of Patent: December 21, 1976
    Assignee: Phillips Petroleum Company
    Inventor: Raymond L. Cobb
  • 4-Aminoalkyl-4-cyano-4-phenyl-butanoic acid esters
    Patent number: 3998965
    Abstract: Alkyl esters, dialkylamides and heterocyclic amides of 4-amino-alkyl-4-cyano-4-phenyl-butanoic and but-2-enoic acids substituted in at least one of the 2 and 3 positions by a C.sub.1 -C.sub.4 alkyl group or by a divalent alkylene radical which together with at least one of the carbon atoms at said 2 and 3 positions forms a carbocyclic ring of 3 to 8 carbon atoms are novel intermediates involved in the preparation of pharmacologically active compounds. They also have pharmacological, in particular central nervous system, especially anti-depressant or cardiovascular activity. Several methods are disclosed for preparing the novel compounds.
    Type: Grant
    Filed: December 11, 1974
    Date of Patent: December 21, 1976
    Assignee: Aspro-Nicholas Limited
    Inventors: Maurice Ward Gittos, David Anthony Amey
  • Method for making polyetherimides using a sodium chloride or ferric sulfate catalyst
    Patent number: 3998840
    Abstract: A method is provided for enhancing the rate of formation of polyetherimides by using either a sodium chloride catalyst, or ferric sulfate catalyst in a mixture of an aromatic bis(ether anhydride) and an organic diamine under melt polymerization conditions.
    Type: Grant
    Filed: April 16, 1976
    Date of Patent: December 21, 1976
    Assignee: General Electric Company
    Inventors: Frank J. Williams, III, Howard J. Klopfer
  • Method for protecting guanidino group and restoring the same
    Patent number: 3997516
    Abstract: A guanidino group in an amino acid or a peptide can be protected with a specific protective group, i.e. lower alkoxybenzenesulfonyl group or tri-lower alkylbenzenesulfonyl group, and the protective group may easily be removed without affecting the amino acid or the peptide to be derived from the protected amino acid or peptide. Thus, the method is useful in the related chemical industries, especially in the peptide synthesis.
    Type: Grant
    Filed: June 27, 1975
    Date of Patent: December 14, 1976
    Assignee: Takeda Chemical Industries, Ltd.
    Inventor: Osamu Nishimura
  • Process of producing 1-acyl-2-methyl-indolyl-3-alkanoic acids
    Patent number: 3997558
    Abstract: The process is directed to the production of 1-acyl-2-methyl-indolyl-3-alkanoic acids having the general formula ##STR1## wherein R.sub.1 represents hydrogen, halogen, an alkoxy group or an aryloxy group, n is 1, 2 or 3, and R.sub.2 represents an aromatic group. A lactone having the general formula ##STR2## wherein R.sub.1 and n have the meanings stated above, is acylated by being reacted in a polar solvent in the presence of sodium hydride with an acid derivative having the general formula ##STR3## wherein R.sub.2 has the meaning stated above and X represents a halogen, to form a compound having a lactone ring and having the general formula ##STR4## wherein R.sub.1, R.sub.2, and n have the meanings stated above. The last-mentioned compound is hydrogenolyzed in the presence of a hydrogenation catalyst to open the lactone ring.
    Type: Grant
    Filed: July 24, 1975
    Date of Patent: December 14, 1976
    Inventor: Werner J. Frantsits
  • Polythiaformals
    Patent number: 3997614
    Abstract: Water-insoluble polythiaformals having substantial antioxidant activity are produced by the liquid phase reaction of primary thiadiols with formaldehyde and mono-alcohol in the presence of an acid catalyst.
    Type: Grant
    Filed: December 6, 1974
    Date of Patent: December 14, 1976
    Assignee: Reichhold Chemicals, Inc.
    Inventors: Gerd M. Lenke, Kent B. McReynolds
  • Phenyl-pyrimidines
    Patent number: 3997536
    Abstract: Phenyl-pyrimidines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are as hereinafter set forth, are described. The end products are useful as liquid crystals.
    Type: Grant
    Filed: October 21, 1975
    Date of Patent: December 14, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Arthur Boller, Marco Cereghetti, Hanspeter Scherrer
  • 1-Dioxolanylpropyl-3-indoleacrylic acid esters
    Patent number: 3997670
    Abstract: 1-dioxolanylpropyl-3-indoleacrylic acid esters, e.g., 1-[3-(2-methyl-2-dioxolanyl)propyl]-3-indoleacrylic acid ethyl ester, are prepared by reacting a corresponding 1-dioxolanylpropyl-3-indolecarboxaldehyde with carbalkoxymethylene triphenylphosphorane and are useful as hypolipidemic agents.
    Type: Grant
    Filed: February 6, 1975
    Date of Patent: December 14, 1976
    Assignee: Sandoz, Inc.
    Inventor: Marcel K. Eberle
  • Cyclic somatostatin disulfide analogues
    Patent number: 3997517
    Abstract: Cyclized somatostatin analogues containing the Cys-Cys disulfide linkage, their pharmaceutically acceptable acid addition salts as well as their cyclic disulfhydryl precursors and intermediates therefor are disclosed. The cyclized analogues of somatostatin selectively reduce blood serum concentrations of growth hormone without materially affecting the concentrations of glucagon or insulin.
    Type: Grant
    Filed: January 30, 1976
    Date of Patent: December 14, 1976
    Assignee: American Home Products Corporation
    Inventor: Dimitrios Sarantakis
  • Polyacetal and polyketal compositions
    Patent number: 3997613
    Abstract: Water-insoluble compositions having substantial antioxidant activity which may be used as plasticizers are produced by liquid phase reaction of (a) dimercaptans or mercapto alcohols or combination of these with diols or polyols, (b) aldehydes and/or ketones, and (c) monomercaptans and/or mono-alcohols in the presence of an acid catalyst.
    Type: Grant
    Filed: December 6, 1974
    Date of Patent: December 14, 1976
    Assignee: Reichhold Chemicals, Inc.
    Inventors: Gerd M. Lenke, Kent B. McReynolds
  • 3'-Chloro-4'- thiocyanatohydrocinnamanilide
    Patent number: 3997583
    Abstract: 3'-Chloro-4'-thiocyanatohydrocinnamanilide is an effective antibacterial agent.
    Type: Grant
    Filed: January 16, 1976
    Date of Patent: December 14, 1976
    Assignee: Morton-Norwich Products, Inc.
    Inventor: Stanford S. Pelosi, Jr.
  • Substituted glycines and intermediates thereof
    Patent number: 3997584
    Abstract: A new process is disclosed for the preparation of N-acyl-.alpha.-aromatic and N-acyl-.alpha.-heteroaromatic glycines by reaction of an .alpha.-ester or ether of an N-acylglycine ester or acid with an aromatic or heteroaromatic compound. Also disclosed are new intermediates for preparing N-acyl-.alpha.-aromatic and N-acyl-.alpha.-heteroaromatic glycines.
    Type: Grant
    Filed: October 3, 1975
    Date of Patent: December 14, 1976
    Assignee: SmithKline Corporation
    Inventors: John G. Gleason, Kenneth G. Holden, Nelson C. F. Yim
  • Herbicidal N-(N'-alkynylcarbamylmethyl) 2,6-dialkyl-alpha-haloacetanilides
    Patent number: 3997326
    Abstract: N-(N'-alkynylcarbamylmethyl)-2,6-dialkyl-alpha-haloacetanilides have herbicidal activity, particularly in preemergent applications against grassy weeds.
    Type: Grant
    Filed: February 23, 1976
    Date of Patent: December 14, 1976
    Assignee: Chevron Research Company
    Inventor: David Cheong King Chan
  • Polythiaformal compositions
    Patent number: 3997612
    Abstract: Water-insoluble compositions are produced by the liquid phase reaction of primary thiadiols with formaldehyde and a monothiol in the presence of a protonic acid catalyst. These compositions have utility as plasticizers.
    Type: Grant
    Filed: December 6, 1974
    Date of Patent: December 14, 1976
    Assignee: Reichhold Chemicals, Inc.
    Inventors: Gerd M. Lenke, Kent B. McReynolds
  • Preparation of aqueous dispersions of blocked aromatic polyisocyanates
    Patent number: 3997592
    Abstract: Aqueous dispersions of aromatic polyisocyanates blocked with phenolic compounds are prepared by mixing the polyisocyanate and an aqueous solution containing an excess of the phenolic compound in the presence of a basic catalyst at a temperature above the melting point of the polyisocyanate.
    Type: Grant
    Filed: November 24, 1975
    Date of Patent: December 14, 1976
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Carl Albert Aufdermarsh, Jr.
  • Compounds containing fluorocarbon residues and azido groups as textile-finishing agents
    Patent number: 3997571
    Abstract: Textile-finishing agents are provided by compounds of the formula(Rf).sub.m --A-- (X).sub.nwherein Rf represents a fluorocarbon chain, A represents a linking group, X represents a sulphonazide or azidoformate group and m and n are integers. The Rf group may be a linear or branched fluorocarbon chain containing 2 to 12 carbon atoms, and the linking group A may be a simple organic linking group or it may be a macromolecular linking group. The simple linking groups may have one or more fluorocarbon chains and one or more azido groups attached thereto, while the macromolecular linking groups may have a considerable number of fluorocarbon and/or azido groups attached thereto.
    Type: Grant
    Filed: September 3, 1974
    Date of Patent: December 14, 1976
    Assignee: Imperial Chemical Industries Limited
    Inventors: John Buckley, Richard Budziarek, Andrew John Nicholas, Edward Jervis Vickers
  • Tetra-.sup.125 iodo-di-tyramine of digitalis derivative and process for making the same
    Patent number: 3997525
    Abstract: Tetra.sup.125 Iodo-di-tyramine of digitalis derivatives having the formula: ##STR1## wherein R is hydrogen or hydroxyl; and process for producing the same.
    Type: Grant
    Filed: January 16, 1974
    Date of Patent: December 14, 1976
    Assignee: Bio-Tec, Inc.
    Inventor: Terrance Judd Guy
  • Alkoxybenzylidene-aminobenzonitriles
    Patent number: 3996260
    Abstract: Liquid crystal cells containing mixtures of cholesteric optically active p-alkoxybenzylidene-p'-aminobenzonitrile compounds with nematic liquid crystal compounds form cholesteric liquid crystals which change to the nematic stage upon application of an electric field. Electro-optic devices including such liquid crystals have low voltage requirements and rapid response times.
    Type: Grant
    Filed: September 8, 1975
    Date of Patent: December 7, 1976
    Assignee: RCA Corporation
    Inventors: Chan Soo Oh, Edward Francis Pasierb
  • Oxidation of organic compounds by aqueous hypohalites using phase transfer catalysis
    Patent number: 3996259
    Abstract: Organic compounds oxidizable by hypohalite ion, such as amines, amides, primary and secondary alcohols, and alkanals are efficiently oxidized in a biphasic mixture comprising:A. a water immiscible, liquid organic phase comprising an organic compound oxidizable by hypohalite ion; withB. an aqueous phase containing hypohalite ion; andC. a catalytic amount of a quaternary ammonium salt and/or a quaternary phosphonium salt.
    Type: Grant
    Filed: November 6, 1975
    Date of Patent: December 7, 1976
    Assignee: The Dow Chemical Company
    Inventors: George A. Lee, Harold H. Freedman